Upload
others
View
4
Download
0
Embed Size (px)
Citation preview
Research ArticleTraditional Herbal Knowledge among the Inhabitants A CaseStudy in Urgam Valley of Chamoli Garhwal Uttarakhand India
Ankit Singh 1 Robbie Hart 2 Sudeep Chandra1
M C Nautiyal1 and Alexander K Sayok 3
1High Altitude Plant Physiology Research Centre (HAPPRC) HNB Garhwal University Post Box 14Srinagar Garhwal 246174 Uttarakhand India2William L Brown Center Missouri Botanical Garden PO Box 299 St Louis MO 63166 USA3Institute of Biodiversity and Environmental Conservation Universiti Malaysia Sarawak 94300 Kota Samarahan SarawakMalaysia
Correspondence should be addressed to Alexander K Sayok ksalexenderunimasmy
Received 23 January 2019 Accepted 2 May 2019 Published 3 June 2019
Academic Editor Nunziatina De Tommasi
Copyright copy 2019 Ankit Singh et al This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited
The Indian Himalaya is rich in plant species including many medicinal plants greatly valued by local inhabitants for health careneeds The study in Urgam Valley of Uttarakhand India is to identity and document traditional knowledge of medicinal plantsThe study revealed high consensus on medicinal plant usage with 51 species belonging to 31 families used for local health careNumber of species and uses known increases with age and elders and specialist healers retain higher levels of traditional medicinalplant knowledge having unique knowledge of medicinal plants and their uses as well as preparation
1 Introduction
India is rich in floral diversity with more than 17000angiosperm species 64 gymnosperms 1200 pteridophytes2850 bryophytes and 2021 lichens [1] Out of the total7500 species have been reported to have medicinal uses[2] Diverse topography and climatic conditions provide theIndian Himalaya with an especially rich medicinal plantswhereby alpine areas being the major source of importantmedicinal plants
Inhabitants of rural and remote areas still rely on plants asa major component of their health care systems Indigenousmedicines provide considerable economic benefits to localpeople [3] The World Health Organization (WHO) men-tioned that about 25 of modern medicines are developedfrom plant sources used traditionally and research on tradi-tional medicinal herbal plants leads to discovery of 75 ofherbal drugs [3 4]
Locals acquire knowledge of the economic values andmedicinal properties of many plants through need obser-vation trial and error and the transmitted experiencesof elders Often knowledge is concentrated in specialisthealers Most diseases cured by local herbalist are common
problems such as respiratory diseases aches and painswounds and musculoskeletal ailments Inhabitants often uselocalmedicinal plantswithout prior advice of local traditionalhealers because they are using these plants since generations[5] This knowledge may be passed secretively from onegeneration to the next throughword ofmouth [6] or inheritedvia medico-spiritual manuscripts [7] Although knowledgeof these valuable plants is often restricted within lineagesor in other ways ensuring that the younger generations inthese areas acquire this knowledge is essential to its continuityin use and sustainability Medicinal plant richness of theIndian Himalaya is exemplified in Garhwal Himalaya withinnorthwestern India This study focused on traditional herbalmedicines of Urgam a mountain valley in the GarhwalHimalaya rich inmedicinal plants which are still used by localinhabitants and specialist healers
2 Materials and Methods
21 The Study Area Urgam Valley (30∘301015840209310158401015840 to30∘341015840123510158401015840N and 79∘261015840140210158401015840 to 79∘301015840172610158401015840 E) is locatedin north-eastern Chamoli district in Uttarakhand India
HindawiEvidence-Based Complementary and Alternative MedicineVolume 2019 Article ID 5656925 21 pageshttpsdoiorg10115520195656925
2 Evidence-Based Complementary and Alternative Medicine
31∘
30∘
29∘
31∘
30∘
29∘
78∘00 78
∘0079
∘00 80
∘00
79∘25
30
79
∘28
30
79
∘27
0 79
∘28
0
79∘25
30
79
∘28
30
79
∘27
0 79
∘28
0
30∘3430
N30∘3130
N30∘330
N30∘300
N
30∘3430
N30∘3130
N30∘330
N30∘300
N
78∘00 78
∘0079
∘00 80
∘00
NN
0 25 50 100Km
0
0 05
175 350 750 1052 1400
Kilometers
1cm=252 km
1 cm=1 km
W E
S
1 2 3 4
High 3307
Low 1240
Study Sites
URGAM VALLEY
Figure 1 Urgam Valley in Chamoli District of Uttarakhand India
(Figure 1) The valley joins the Kalp Ganga Valley at 1300m amsl to the surrounding mountain tops above 3000 mamsl Crops consist mainly of three types namely RabiKharif and Zaid The main Rabi crops of the region areWheat and Mustard and Kharif crop are Rice MaizeFinger millet Barnyard grasses and Amaranthus Zaidcrops include Beans Cucumber and pumpkin Amongthe fruits are Apple Peach Cherry and Walnut Annualrainfall ranges from 2000 to 2500 mm while temperatureranges from 15 to 35∘C during summer and -2 to 15∘Cin winter Urgam Valley spans over a wide spread oftopographic and climatic conditions namely alpinesubalpine and temperate zones provide a range of plant habi-tats
22 Field Survey and Data Collection Local surveys includ-ing uses of medicinal plants of Urgam Valley were donebetween August 2015 and July 2016 Ninety-six informantswere randomly selected in 11 villages After giving priorinformed consent informants answered questionnaires (seethe Appendix) in the local language (Garhwali) with photos
of 110 medicinal plants as references Answers were elicitedbased on plant species (ldquowhat do you know about [plantsname]rdquo and based on disease condition (ldquowhich plants youuse when suffering from [disease name]rdquo)
The questionnaires were then compiled detailed infor-mation for each plant on local name life form local usesmethod of use or drug preparation and amount of use (dose)Apart from the general population survey of villagers andshepherds local male (Vaidyas) and female specialists (Daai)were also sought to compare their knowledge to that of thegeneral population
23 Plant Collection and Identification Voucher specimenswere prepared for the traditionally used plants documentedin this study Specimenswere identified using Flora ofDistrictGarhwal [8] and Flora of Chamoli [9] and in comparisonwith the specimens of Garhwal University Herbarium Sri-nagar Garhwal (GUH) Plant specimens were mounted onherbarium sheets and preserved in HAPPRC HerbariumPlant names reported here were matched usingThe Plant List[10]
Evidence-Based Complementary and Alternative Medicine 3
24 Data Analysis
241 Comparing Consensus in Plant Use across Categories ofUse An informant consensus factor (ICF) was used to mea-sure the consensus in plant use for a given illness treatment inthe study area To develop this consensus all treated diseaseswere grouped into nine categories (a) gastrointestinal disor-ders (b) fever and aches (c) diseases of the skin (d) removeweakness immunomodulator anaemia (e) ophthalmologiccomplaints (f) poisonous bite (g) dental problems (h) earache and (i) hearing problems Within these categories ICFwas calculated according to the following formula [11]
ICF = (119873119906119903 minus 119873119905119886119909119886)(119873119906119903 minus 1)
(1)
whereNur refers to the number of use-reports for a particularailment category andNtaxa refers to the number of taxa usedfor a particular ailment category by all informants ICF valueranges from 0 to 1 A high ICF value (close to 10) indicatesldquoconsensusrdquo indicating relatively few taxa is reported by alarge proportion of informants for an ailment category
242 Comparing Plants and Uses across Informants To testwhether the traditional medicinal plant knowledge variedwith age the total plants or total uses reported by each infor-mant (excluding healers) were summed up and ran linearregressions and natural spline regressions using the packagesplines [12] in the R statistical framework (Version 330)
To test whether healers reported a different set of plantsand uses altogether the 89 informants who had reportedmore than 10 species were compared A matrix with plants ascolumns and informants were constructed as rows calculatedBray-Curtis distances among each pair of informants basedon how similar their answers were and used nonmetricmultidimensional scaling to plot informants based on thesedistances To calculate the significance of specialist healerstatus the fit of this factor on the location of informants inthe ordination spacewas compared to that of 999 randomizedshuffles using the R package vegan [13]
3 Results
31 Demographic Features of Informants A total of 96 peoplewere interviewed consisting of seven local healers fromboth female (Daai) and male (Vaidyas healers) Most (48participants or 50) were 41-60 years old with 27 informantsor 281 were 40 years old and younger Seventeen wereilliterate while 4 young practitioners held a tertiary education(degreediploma) (Table 1)
32 Traditional Medicinal Plants Diversity Fifty-one speciesrepresenting 31 families are used by local inhabitants ofUrgam Valley in Chamoli Garhwal for local health care (seeTable 2) Out of 31 families most (21 families) were dicotyle-dons 9 were monocotyledons and 1 was gymnospermThe most represented families were asteraceae (7 species)followed by lamiaceae amaryllidaceae and apiaceae (3species each) (Figure 2) Most species (39 species 77) were
Table 1 Demographic characteristic of informants
Variables Categories NumberAge 20-30 9
31-40 1741-50 2251-60 2661-70 1971-80 3
Gender specialist Male (general) 72Female (general) 17
Male specialist healer 4Female specialist healer 3
Education level Illiterate 171-5 276-10 2210-12 26gt12 4
Source of knowledge By parents 71By other 20
Self-experiments 5Total 96
herbaceous plants though trees (7 species 14) climbers (3species 6) and shrubs (2 species 4) were also included
33 Plant Part Use and Drug Preparation Plant parts usedwere mostly roots (18 species 32) and leaves (13 species23) Also recorded were aerial parts (7 species 13) seeds(4 species 7) fruits rhizome bark and whole plants eachtwo species (5) (Figure 3)
The different type of formulations prepared by localinhabitants of Urgam recorded during the study was primar-ily plant powder (42 of formulations) Other preparationsare paste (23) extractjuice (17) decoction and raw (7)and herbal tea (2) (Figure 4) All formulations are preparedby local practitioner (Vaidyas) elders or those with moreexperience in herbal medicines
34 Informant Consensus Factor The highest consensusamong informants (ICF) is found forAconitum balfourii Stapffor poisonous bite (PB) followed by Berberis aristataDC andBerberis lycium Royle for ophtalmologic complaints (OP)and Potentilla lineata Trevor for dental problems (DP) (099)(Table 3)
35 Comparing Plants and Uses across Informants Inhabi-tants of Urgam Valley have a generally strong knowledgeof medicinal plants with informants reporting on average18 plant species and 13 uses This knowledge increaseswith age linear regressions on age significantly increasefor uses (y=018lowastage+53 plt001 r-squared = 039) and forplant species (y=024lowastage+55 plt001 r-squared = 037)The natural spline regressions show that this effect is lesssteep at higher ages (significantly nonlinear) that is there isless increase in knowledge after about age 50 (Figure 6(a))
4 Evidence-Based Complementary and Alternative Medicine
Table2Herbalm
edicinea
ndmod
eofadm
inistratio
nby
inhabitantso
fUrgam
ValleyinCh
amoliG
arhw
alU
ttarakh
andIndia
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
1
Aconitu
mbalfouriiStapf
Syn
Aconitu
mlethale
Griff
Ranu
nculaceae
HAPP
RCASR
4103
Figu
re5(a)
MeethaBh
ngwa
Herb
Root
Decoctio
n(in
cowurine)
Paste
12drop
once
aday
Snakeb
ite11
Diaph
oreticdiuretic
analgesic
febrifu
geanti-infl
ammatory
anti-rheumaticanti-p
yretic
verm
ifugepow
erfulsedative
narcoticandpo
ison[14
15]
2
Aconitu
mheterophyllum
WallexRo
yle
Ranu
nculaceae
HAPP
RCASR
4104
Figu
re5(b)
Atees
Herb
Root
JuicePo
wder
12teaspo
onwith
lukewarm
water
Stom
achache
fever
69
Anti-infl
ammatory
antip
yreticA
ntibacteria
lIm
mun
omod
ulatory
Anthelm
inthic
Antihyperlip
idem
icanalgesic
[1416ndash
19]
3AjugaparvifloraBe
nth
Lamiaceae
HAPP
RCASR
4168
Neelkanthi
Herb
Who
leplant
Powd
eror
decoction
12-1teaspo
on3
times
aday
with
water
Stom
achache
fever
29
Hypertensionmalaria
pneumon
iaedemaas
anthelmintic
antifu
ngal
hypo
glycem
ic
anti-inflammatoryantitussiv
eexpectorantantitum
orand
antim
icrobialagents[2021]
4Alliu
mcepa
LAmaryllid
aceae
HAPP
RCASR
4120
Pyaj
Herb
Bulb
Juice
1-3drop
sEa
rache
48
Antitu
morantidiabetic
antio
xidantantibacteria
lanti-allergicandmolluscicidal
activ
ity[2223]
5Alliu
msativ
umL
Amaryllid
aceae
HAPP
RCASR
4121
Lehsun
Herb
Who
leplants
Paste
12teaspo
onBu
rntCu
t23
Antibacteria
lantivira
lantifun
galanti-parasitic
cardiovascular
[24]
6Alliu
mwa
llichiiKu
nth
Amaryllid
aceae
HAPP
RCASR
4125
Lainka
Herb
Leaves
Powd
er12
-1teaspo
onwith
water
Gastric
12Anti-m
icrobialanti-o
xidant
andanti-cancer
[25]
Evidence-Based Complementary and Alternative Medicine 5
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
7An
gelicagla
ucaEd
gew
Apiaceae
HAPP
RCASR
4146
Choru
Herb
Root
Powd
er12
teaspo
onwith
water
Gastric
9Antioxidantantim
icrobial
andph
ytotoxic[26]
8
Artemisianilagir
ica(C
BClarke)P
amp
Aste
raceae
HAPP
RCASR
4136
Kunja
Herb
Leaves
Juice
1teaspoo
nCu
tand
woun
ds24
Antim
icrobialantifu
ngal
antib
acteria
lantifi
laria
linsecticidalantiulcer
antic
ancerantio
xidant
and
anti-asthmatic[27]
9
Asparagusfi
licinus
Buch-H
amexDDon
Asparagaceae
HAPP
RCASR
4126
Jhirn
aHerb
Root
Powd
er12
-1teaspo
onwith
cowmilk
Remove
weakness
13Hypolipidem
ic[28]
10BerberisaristataDC
Berberidaceae
HAPP
RCASR
4163
Kingod
Shrub
Root
Decoctio
n1-2
drop
Eyea
ilments
87
Antim
icrobialantidepressant
diabetes
mellitus
hepatoprotectiv
eim
mun
omod
ulatory[
29]
11Berberislyciu
mRo
yle
Berberidaceae
HAPP
RCASR
4164
Chotru
Herb
Bark
Decoctio
n1teaspoo
nthric
eaday
Diabeteseye
ailm
ents
92
Antidiabetic
hepatoprotectiv
eantih
yperlip
idem
ic
Antim
icrobialantim
utagenic
pesticidalwo
undhealing[30]
12
Bergenia
ciliata
(Haw
)Sternb
Saxifragaceae
HAPP
RCASR
4112
Syalph
adi
Herb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e45
Anti-tussiv
eantiu
lcer
anti-neop
lasticantio
xidant
antib
acteria
lhypo
glycaemic
[3132]
13
Bergenia
stracheyi
(Hoo
kfamp
Thom
son)
Engl
Figu
re5(c)
Saxifragaceae
HAPP
RCASR
4113
Pashanbh
edHerb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e61
Anti-a
rthriticantim
icrobial
[32]
6 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
14
Centellaasiatica(L)
Urb
Apiaceae
HAPP
RCASR
4174
Brahmi
Herb
Leaves
JuicePo
wder
12-1teaspo
onwith
water
Coo
lant
26
Stim
ulatory-nervineton
ic
rejuvenantsedative
tranqu
ilizera
ndintelligence
prom
otingprop
erty
antie
pilepticleprosy
antin
ociceptiv
eand
anti-inflammatory[
33ndash35]
15
Cinn
amom
umtamala
(Buch-H
am)TNeesamp
Eberm
Lauraceae
HAPP
RCASR
4169
Tejpat
Tree
Leaves
bark
Powd
er12
-1teaspo
onwith
water
Con
trolblood
pressure
49Antidiabetic
antibacteria
lanti-ulcerantim
icrobial[36]
16Cirsium
wallichiiDC
Aste
raceae
HAPP
RCASR
4138
Kanjelu
Herb
Root
Powd
erJuice
12-1teaspo
onthric
eadaywith
water
Fever
2Antim
icrobialand
Antioxidant
[37]
17Cu
cumissativ
usL
Cucurbita
ceae
HAPP
RCASR
4153
Kakd
iClim
ber
Seeds
Powd
er12
teaspo
onwith
water
Diuretic
40Antim
icrobialA
ntioxidant
Hypocholesterolemic[38]
18Cu
rcum
alongaL
Zing
iberaceae
HAPP
RCASR
4165
Haldu
Herb
Rhizom
ePaste
12teaspo
ontwicea
day
Cutand
woun
ds86
Anti-H
IVantioxidant
anti-inflammatoryanti-tumor
[39]
19
Dactylorhizahatagir
ea(D
Don
)Soo
Orchidaceae
HAPP
RCASR
4162
Figu
re5(d)
Hathajadi
Herb
Root
Paste
Pow
der
12teaspo
onCu
tand
woun
dsfever
stomachache
39Antibacteria
laphrod
isiac
antip
yretic[14
]
20Dioscorea
bulbifera
LDioscoreaceae
HAPP
RCASR
4139
Tairu
Clim
ber
Tuber
Powd
er12
teaspo
onwith
water
Coo
lant
3
Antihyperlip
idem
ic
antitum
orantioxidant
anorexiantanalgesic
anti-inflammatoryplasmid
curin
ganti-diabeticand
antih
yperglycem
ic[40]
Evidence-Based Complementary and Alternative Medicine 7
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
21
Eupatoriu
madenophorum
Sprengel
Aste
raceae
HAPP
RCASR
4157
Basya
Herb
Leaves
Juice
12-1
teaspo
onCu
tand
woun
d29
Analgesicantifu
ngal[4142]
22
Girardiniadiversifolia
(Link)
Friis
Urticaceae
HAPP
RCASR
4118
Kand
ali
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
water
Fever
1Antibacteria
lantifu
ngal[43]
23
Hippophae
salicifolia
DDon
Elaeagnaceae
HAPP
RCASR
4140
Figu
re5(e)
Amesh
Tree
Fruits
Juice
5-10
teaspo
onin
1glasswater
Coo
lant
6
Antibacteria
lantifu
ngal
antic
anceranti-inflammatory
immun
omod
ulatory
radio-protectiv
eadaptogenic
anti-atherosclerosisand
anti-ste
rility
[44]
24Jugla
nsregiaL
Juglandaceae
HAPP
RCASR
4150
Akh
rot
Tree
Fruitp
eel
Paste
12teaspo
onSkin
diseases
56
Antioxidantantim
icrobial
anti-atherogenic
anti-inflammatorya
ndantim
utagenicprop
ertie
s[45ndash47]
25
Jurin
eamacrocephala
DC
Aste
raceae
HAPP
RCASR
4116
Bishkand
ara
Herb
Root
Powd
er12
teaspo
onthric
eaday
water
Fever
2Antioxidant
andAntibacteria
l[48]
26
Macrotylomaun
iflorum
(Lam
)Ve
rdc
Fabaceae
HAPP
RCASR
4114
Gahat
Herb
Seeds
Boiledsoup
1bow
lthricea
day
Ston
e96
Hepatop
rotectiveanti-ob
esity
antic
alcifyingantid
iabetic
antim
icrobial[49ndash
53]
27
Megacarpaea
polyan
dra
Benthex
Madden
Brassic
aceae
HAPP
RCASR
4111
Figu
re5(f)
Barm
olu
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
lukewarm
water
Gastric
4Not
repo
rted
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
2 Evidence-Based Complementary and Alternative Medicine
31∘
30∘
29∘
31∘
30∘
29∘
78∘00 78
∘0079
∘00 80
∘00
79∘25
30
79
∘28
30
79
∘27
0 79
∘28
0
79∘25
30
79
∘28
30
79
∘27
0 79
∘28
0
30∘3430
N30∘3130
N30∘330
N30∘300
N
30∘3430
N30∘3130
N30∘330
N30∘300
N
78∘00 78
∘0079
∘00 80
∘00
NN
0 25 50 100Km
0
0 05
175 350 750 1052 1400
Kilometers
1cm=252 km
1 cm=1 km
W E
S
1 2 3 4
High 3307
Low 1240
Study Sites
URGAM VALLEY
Figure 1 Urgam Valley in Chamoli District of Uttarakhand India
(Figure 1) The valley joins the Kalp Ganga Valley at 1300m amsl to the surrounding mountain tops above 3000 mamsl Crops consist mainly of three types namely RabiKharif and Zaid The main Rabi crops of the region areWheat and Mustard and Kharif crop are Rice MaizeFinger millet Barnyard grasses and Amaranthus Zaidcrops include Beans Cucumber and pumpkin Amongthe fruits are Apple Peach Cherry and Walnut Annualrainfall ranges from 2000 to 2500 mm while temperatureranges from 15 to 35∘C during summer and -2 to 15∘Cin winter Urgam Valley spans over a wide spread oftopographic and climatic conditions namely alpinesubalpine and temperate zones provide a range of plant habi-tats
22 Field Survey and Data Collection Local surveys includ-ing uses of medicinal plants of Urgam Valley were donebetween August 2015 and July 2016 Ninety-six informantswere randomly selected in 11 villages After giving priorinformed consent informants answered questionnaires (seethe Appendix) in the local language (Garhwali) with photos
of 110 medicinal plants as references Answers were elicitedbased on plant species (ldquowhat do you know about [plantsname]rdquo and based on disease condition (ldquowhich plants youuse when suffering from [disease name]rdquo)
The questionnaires were then compiled detailed infor-mation for each plant on local name life form local usesmethod of use or drug preparation and amount of use (dose)Apart from the general population survey of villagers andshepherds local male (Vaidyas) and female specialists (Daai)were also sought to compare their knowledge to that of thegeneral population
23 Plant Collection and Identification Voucher specimenswere prepared for the traditionally used plants documentedin this study Specimenswere identified using Flora ofDistrictGarhwal [8] and Flora of Chamoli [9] and in comparisonwith the specimens of Garhwal University Herbarium Sri-nagar Garhwal (GUH) Plant specimens were mounted onherbarium sheets and preserved in HAPPRC HerbariumPlant names reported here were matched usingThe Plant List[10]
Evidence-Based Complementary and Alternative Medicine 3
24 Data Analysis
241 Comparing Consensus in Plant Use across Categories ofUse An informant consensus factor (ICF) was used to mea-sure the consensus in plant use for a given illness treatment inthe study area To develop this consensus all treated diseaseswere grouped into nine categories (a) gastrointestinal disor-ders (b) fever and aches (c) diseases of the skin (d) removeweakness immunomodulator anaemia (e) ophthalmologiccomplaints (f) poisonous bite (g) dental problems (h) earache and (i) hearing problems Within these categories ICFwas calculated according to the following formula [11]
ICF = (119873119906119903 minus 119873119905119886119909119886)(119873119906119903 minus 1)
(1)
whereNur refers to the number of use-reports for a particularailment category andNtaxa refers to the number of taxa usedfor a particular ailment category by all informants ICF valueranges from 0 to 1 A high ICF value (close to 10) indicatesldquoconsensusrdquo indicating relatively few taxa is reported by alarge proportion of informants for an ailment category
242 Comparing Plants and Uses across Informants To testwhether the traditional medicinal plant knowledge variedwith age the total plants or total uses reported by each infor-mant (excluding healers) were summed up and ran linearregressions and natural spline regressions using the packagesplines [12] in the R statistical framework (Version 330)
To test whether healers reported a different set of plantsand uses altogether the 89 informants who had reportedmore than 10 species were compared A matrix with plants ascolumns and informants were constructed as rows calculatedBray-Curtis distances among each pair of informants basedon how similar their answers were and used nonmetricmultidimensional scaling to plot informants based on thesedistances To calculate the significance of specialist healerstatus the fit of this factor on the location of informants inthe ordination spacewas compared to that of 999 randomizedshuffles using the R package vegan [13]
3 Results
31 Demographic Features of Informants A total of 96 peoplewere interviewed consisting of seven local healers fromboth female (Daai) and male (Vaidyas healers) Most (48participants or 50) were 41-60 years old with 27 informantsor 281 were 40 years old and younger Seventeen wereilliterate while 4 young practitioners held a tertiary education(degreediploma) (Table 1)
32 Traditional Medicinal Plants Diversity Fifty-one speciesrepresenting 31 families are used by local inhabitants ofUrgam Valley in Chamoli Garhwal for local health care (seeTable 2) Out of 31 families most (21 families) were dicotyle-dons 9 were monocotyledons and 1 was gymnospermThe most represented families were asteraceae (7 species)followed by lamiaceae amaryllidaceae and apiaceae (3species each) (Figure 2) Most species (39 species 77) were
Table 1 Demographic characteristic of informants
Variables Categories NumberAge 20-30 9
31-40 1741-50 2251-60 2661-70 1971-80 3
Gender specialist Male (general) 72Female (general) 17
Male specialist healer 4Female specialist healer 3
Education level Illiterate 171-5 276-10 2210-12 26gt12 4
Source of knowledge By parents 71By other 20
Self-experiments 5Total 96
herbaceous plants though trees (7 species 14) climbers (3species 6) and shrubs (2 species 4) were also included
33 Plant Part Use and Drug Preparation Plant parts usedwere mostly roots (18 species 32) and leaves (13 species23) Also recorded were aerial parts (7 species 13) seeds(4 species 7) fruits rhizome bark and whole plants eachtwo species (5) (Figure 3)
The different type of formulations prepared by localinhabitants of Urgam recorded during the study was primar-ily plant powder (42 of formulations) Other preparationsare paste (23) extractjuice (17) decoction and raw (7)and herbal tea (2) (Figure 4) All formulations are preparedby local practitioner (Vaidyas) elders or those with moreexperience in herbal medicines
34 Informant Consensus Factor The highest consensusamong informants (ICF) is found forAconitum balfourii Stapffor poisonous bite (PB) followed by Berberis aristataDC andBerberis lycium Royle for ophtalmologic complaints (OP)and Potentilla lineata Trevor for dental problems (DP) (099)(Table 3)
35 Comparing Plants and Uses across Informants Inhabi-tants of Urgam Valley have a generally strong knowledgeof medicinal plants with informants reporting on average18 plant species and 13 uses This knowledge increaseswith age linear regressions on age significantly increasefor uses (y=018lowastage+53 plt001 r-squared = 039) and forplant species (y=024lowastage+55 plt001 r-squared = 037)The natural spline regressions show that this effect is lesssteep at higher ages (significantly nonlinear) that is there isless increase in knowledge after about age 50 (Figure 6(a))
4 Evidence-Based Complementary and Alternative Medicine
Table2Herbalm
edicinea
ndmod
eofadm
inistratio
nby
inhabitantso
fUrgam
ValleyinCh
amoliG
arhw
alU
ttarakh
andIndia
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
1
Aconitu
mbalfouriiStapf
Syn
Aconitu
mlethale
Griff
Ranu
nculaceae
HAPP
RCASR
4103
Figu
re5(a)
MeethaBh
ngwa
Herb
Root
Decoctio
n(in
cowurine)
Paste
12drop
once
aday
Snakeb
ite11
Diaph
oreticdiuretic
analgesic
febrifu
geanti-infl
ammatory
anti-rheumaticanti-p
yretic
verm
ifugepow
erfulsedative
narcoticandpo
ison[14
15]
2
Aconitu
mheterophyllum
WallexRo
yle
Ranu
nculaceae
HAPP
RCASR
4104
Figu
re5(b)
Atees
Herb
Root
JuicePo
wder
12teaspo
onwith
lukewarm
water
Stom
achache
fever
69
Anti-infl
ammatory
antip
yreticA
ntibacteria
lIm
mun
omod
ulatory
Anthelm
inthic
Antihyperlip
idem
icanalgesic
[1416ndash
19]
3AjugaparvifloraBe
nth
Lamiaceae
HAPP
RCASR
4168
Neelkanthi
Herb
Who
leplant
Powd
eror
decoction
12-1teaspo
on3
times
aday
with
water
Stom
achache
fever
29
Hypertensionmalaria
pneumon
iaedemaas
anthelmintic
antifu
ngal
hypo
glycem
ic
anti-inflammatoryantitussiv
eexpectorantantitum
orand
antim
icrobialagents[2021]
4Alliu
mcepa
LAmaryllid
aceae
HAPP
RCASR
4120
Pyaj
Herb
Bulb
Juice
1-3drop
sEa
rache
48
Antitu
morantidiabetic
antio
xidantantibacteria
lanti-allergicandmolluscicidal
activ
ity[2223]
5Alliu
msativ
umL
Amaryllid
aceae
HAPP
RCASR
4121
Lehsun
Herb
Who
leplants
Paste
12teaspo
onBu
rntCu
t23
Antibacteria
lantivira
lantifun
galanti-parasitic
cardiovascular
[24]
6Alliu
mwa
llichiiKu
nth
Amaryllid
aceae
HAPP
RCASR
4125
Lainka
Herb
Leaves
Powd
er12
-1teaspo
onwith
water
Gastric
12Anti-m
icrobialanti-o
xidant
andanti-cancer
[25]
Evidence-Based Complementary and Alternative Medicine 5
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
7An
gelicagla
ucaEd
gew
Apiaceae
HAPP
RCASR
4146
Choru
Herb
Root
Powd
er12
teaspo
onwith
water
Gastric
9Antioxidantantim
icrobial
andph
ytotoxic[26]
8
Artemisianilagir
ica(C
BClarke)P
amp
Aste
raceae
HAPP
RCASR
4136
Kunja
Herb
Leaves
Juice
1teaspoo
nCu
tand
woun
ds24
Antim
icrobialantifu
ngal
antib
acteria
lantifi
laria
linsecticidalantiulcer
antic
ancerantio
xidant
and
anti-asthmatic[27]
9
Asparagusfi
licinus
Buch-H
amexDDon
Asparagaceae
HAPP
RCASR
4126
Jhirn
aHerb
Root
Powd
er12
-1teaspo
onwith
cowmilk
Remove
weakness
13Hypolipidem
ic[28]
10BerberisaristataDC
Berberidaceae
HAPP
RCASR
4163
Kingod
Shrub
Root
Decoctio
n1-2
drop
Eyea
ilments
87
Antim
icrobialantidepressant
diabetes
mellitus
hepatoprotectiv
eim
mun
omod
ulatory[
29]
11Berberislyciu
mRo
yle
Berberidaceae
HAPP
RCASR
4164
Chotru
Herb
Bark
Decoctio
n1teaspoo
nthric
eaday
Diabeteseye
ailm
ents
92
Antidiabetic
hepatoprotectiv
eantih
yperlip
idem
ic
Antim
icrobialantim
utagenic
pesticidalwo
undhealing[30]
12
Bergenia
ciliata
(Haw
)Sternb
Saxifragaceae
HAPP
RCASR
4112
Syalph
adi
Herb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e45
Anti-tussiv
eantiu
lcer
anti-neop
lasticantio
xidant
antib
acteria
lhypo
glycaemic
[3132]
13
Bergenia
stracheyi
(Hoo
kfamp
Thom
son)
Engl
Figu
re5(c)
Saxifragaceae
HAPP
RCASR
4113
Pashanbh
edHerb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e61
Anti-a
rthriticantim
icrobial
[32]
6 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
14
Centellaasiatica(L)
Urb
Apiaceae
HAPP
RCASR
4174
Brahmi
Herb
Leaves
JuicePo
wder
12-1teaspo
onwith
water
Coo
lant
26
Stim
ulatory-nervineton
ic
rejuvenantsedative
tranqu
ilizera
ndintelligence
prom
otingprop
erty
antie
pilepticleprosy
antin
ociceptiv
eand
anti-inflammatory[
33ndash35]
15
Cinn
amom
umtamala
(Buch-H
am)TNeesamp
Eberm
Lauraceae
HAPP
RCASR
4169
Tejpat
Tree
Leaves
bark
Powd
er12
-1teaspo
onwith
water
Con
trolblood
pressure
49Antidiabetic
antibacteria
lanti-ulcerantim
icrobial[36]
16Cirsium
wallichiiDC
Aste
raceae
HAPP
RCASR
4138
Kanjelu
Herb
Root
Powd
erJuice
12-1teaspo
onthric
eadaywith
water
Fever
2Antim
icrobialand
Antioxidant
[37]
17Cu
cumissativ
usL
Cucurbita
ceae
HAPP
RCASR
4153
Kakd
iClim
ber
Seeds
Powd
er12
teaspo
onwith
water
Diuretic
40Antim
icrobialA
ntioxidant
Hypocholesterolemic[38]
18Cu
rcum
alongaL
Zing
iberaceae
HAPP
RCASR
4165
Haldu
Herb
Rhizom
ePaste
12teaspo
ontwicea
day
Cutand
woun
ds86
Anti-H
IVantioxidant
anti-inflammatoryanti-tumor
[39]
19
Dactylorhizahatagir
ea(D
Don
)Soo
Orchidaceae
HAPP
RCASR
4162
Figu
re5(d)
Hathajadi
Herb
Root
Paste
Pow
der
12teaspo
onCu
tand
woun
dsfever
stomachache
39Antibacteria
laphrod
isiac
antip
yretic[14
]
20Dioscorea
bulbifera
LDioscoreaceae
HAPP
RCASR
4139
Tairu
Clim
ber
Tuber
Powd
er12
teaspo
onwith
water
Coo
lant
3
Antihyperlip
idem
ic
antitum
orantioxidant
anorexiantanalgesic
anti-inflammatoryplasmid
curin
ganti-diabeticand
antih
yperglycem
ic[40]
Evidence-Based Complementary and Alternative Medicine 7
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
21
Eupatoriu
madenophorum
Sprengel
Aste
raceae
HAPP
RCASR
4157
Basya
Herb
Leaves
Juice
12-1
teaspo
onCu
tand
woun
d29
Analgesicantifu
ngal[4142]
22
Girardiniadiversifolia
(Link)
Friis
Urticaceae
HAPP
RCASR
4118
Kand
ali
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
water
Fever
1Antibacteria
lantifu
ngal[43]
23
Hippophae
salicifolia
DDon
Elaeagnaceae
HAPP
RCASR
4140
Figu
re5(e)
Amesh
Tree
Fruits
Juice
5-10
teaspo
onin
1glasswater
Coo
lant
6
Antibacteria
lantifu
ngal
antic
anceranti-inflammatory
immun
omod
ulatory
radio-protectiv
eadaptogenic
anti-atherosclerosisand
anti-ste
rility
[44]
24Jugla
nsregiaL
Juglandaceae
HAPP
RCASR
4150
Akh
rot
Tree
Fruitp
eel
Paste
12teaspo
onSkin
diseases
56
Antioxidantantim
icrobial
anti-atherogenic
anti-inflammatorya
ndantim
utagenicprop
ertie
s[45ndash47]
25
Jurin
eamacrocephala
DC
Aste
raceae
HAPP
RCASR
4116
Bishkand
ara
Herb
Root
Powd
er12
teaspo
onthric
eaday
water
Fever
2Antioxidant
andAntibacteria
l[48]
26
Macrotylomaun
iflorum
(Lam
)Ve
rdc
Fabaceae
HAPP
RCASR
4114
Gahat
Herb
Seeds
Boiledsoup
1bow
lthricea
day
Ston
e96
Hepatop
rotectiveanti-ob
esity
antic
alcifyingantid
iabetic
antim
icrobial[49ndash
53]
27
Megacarpaea
polyan
dra
Benthex
Madden
Brassic
aceae
HAPP
RCASR
4111
Figu
re5(f)
Barm
olu
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
lukewarm
water
Gastric
4Not
repo
rted
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 3
24 Data Analysis
241 Comparing Consensus in Plant Use across Categories ofUse An informant consensus factor (ICF) was used to mea-sure the consensus in plant use for a given illness treatment inthe study area To develop this consensus all treated diseaseswere grouped into nine categories (a) gastrointestinal disor-ders (b) fever and aches (c) diseases of the skin (d) removeweakness immunomodulator anaemia (e) ophthalmologiccomplaints (f) poisonous bite (g) dental problems (h) earache and (i) hearing problems Within these categories ICFwas calculated according to the following formula [11]
ICF = (119873119906119903 minus 119873119905119886119909119886)(119873119906119903 minus 1)
(1)
whereNur refers to the number of use-reports for a particularailment category andNtaxa refers to the number of taxa usedfor a particular ailment category by all informants ICF valueranges from 0 to 1 A high ICF value (close to 10) indicatesldquoconsensusrdquo indicating relatively few taxa is reported by alarge proportion of informants for an ailment category
242 Comparing Plants and Uses across Informants To testwhether the traditional medicinal plant knowledge variedwith age the total plants or total uses reported by each infor-mant (excluding healers) were summed up and ran linearregressions and natural spline regressions using the packagesplines [12] in the R statistical framework (Version 330)
To test whether healers reported a different set of plantsand uses altogether the 89 informants who had reportedmore than 10 species were compared A matrix with plants ascolumns and informants were constructed as rows calculatedBray-Curtis distances among each pair of informants basedon how similar their answers were and used nonmetricmultidimensional scaling to plot informants based on thesedistances To calculate the significance of specialist healerstatus the fit of this factor on the location of informants inthe ordination spacewas compared to that of 999 randomizedshuffles using the R package vegan [13]
3 Results
31 Demographic Features of Informants A total of 96 peoplewere interviewed consisting of seven local healers fromboth female (Daai) and male (Vaidyas healers) Most (48participants or 50) were 41-60 years old with 27 informantsor 281 were 40 years old and younger Seventeen wereilliterate while 4 young practitioners held a tertiary education(degreediploma) (Table 1)
32 Traditional Medicinal Plants Diversity Fifty-one speciesrepresenting 31 families are used by local inhabitants ofUrgam Valley in Chamoli Garhwal for local health care (seeTable 2) Out of 31 families most (21 families) were dicotyle-dons 9 were monocotyledons and 1 was gymnospermThe most represented families were asteraceae (7 species)followed by lamiaceae amaryllidaceae and apiaceae (3species each) (Figure 2) Most species (39 species 77) were
Table 1 Demographic characteristic of informants
Variables Categories NumberAge 20-30 9
31-40 1741-50 2251-60 2661-70 1971-80 3
Gender specialist Male (general) 72Female (general) 17
Male specialist healer 4Female specialist healer 3
Education level Illiterate 171-5 276-10 2210-12 26gt12 4
Source of knowledge By parents 71By other 20
Self-experiments 5Total 96
herbaceous plants though trees (7 species 14) climbers (3species 6) and shrubs (2 species 4) were also included
33 Plant Part Use and Drug Preparation Plant parts usedwere mostly roots (18 species 32) and leaves (13 species23) Also recorded were aerial parts (7 species 13) seeds(4 species 7) fruits rhizome bark and whole plants eachtwo species (5) (Figure 3)
The different type of formulations prepared by localinhabitants of Urgam recorded during the study was primar-ily plant powder (42 of formulations) Other preparationsare paste (23) extractjuice (17) decoction and raw (7)and herbal tea (2) (Figure 4) All formulations are preparedby local practitioner (Vaidyas) elders or those with moreexperience in herbal medicines
34 Informant Consensus Factor The highest consensusamong informants (ICF) is found forAconitum balfourii Stapffor poisonous bite (PB) followed by Berberis aristataDC andBerberis lycium Royle for ophtalmologic complaints (OP)and Potentilla lineata Trevor for dental problems (DP) (099)(Table 3)
35 Comparing Plants and Uses across Informants Inhabi-tants of Urgam Valley have a generally strong knowledgeof medicinal plants with informants reporting on average18 plant species and 13 uses This knowledge increaseswith age linear regressions on age significantly increasefor uses (y=018lowastage+53 plt001 r-squared = 039) and forplant species (y=024lowastage+55 plt001 r-squared = 037)The natural spline regressions show that this effect is lesssteep at higher ages (significantly nonlinear) that is there isless increase in knowledge after about age 50 (Figure 6(a))
4 Evidence-Based Complementary and Alternative Medicine
Table2Herbalm
edicinea
ndmod
eofadm
inistratio
nby
inhabitantso
fUrgam
ValleyinCh
amoliG
arhw
alU
ttarakh
andIndia
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
1
Aconitu
mbalfouriiStapf
Syn
Aconitu
mlethale
Griff
Ranu
nculaceae
HAPP
RCASR
4103
Figu
re5(a)
MeethaBh
ngwa
Herb
Root
Decoctio
n(in
cowurine)
Paste
12drop
once
aday
Snakeb
ite11
Diaph
oreticdiuretic
analgesic
febrifu
geanti-infl
ammatory
anti-rheumaticanti-p
yretic
verm
ifugepow
erfulsedative
narcoticandpo
ison[14
15]
2
Aconitu
mheterophyllum
WallexRo
yle
Ranu
nculaceae
HAPP
RCASR
4104
Figu
re5(b)
Atees
Herb
Root
JuicePo
wder
12teaspo
onwith
lukewarm
water
Stom
achache
fever
69
Anti-infl
ammatory
antip
yreticA
ntibacteria
lIm
mun
omod
ulatory
Anthelm
inthic
Antihyperlip
idem
icanalgesic
[1416ndash
19]
3AjugaparvifloraBe
nth
Lamiaceae
HAPP
RCASR
4168
Neelkanthi
Herb
Who
leplant
Powd
eror
decoction
12-1teaspo
on3
times
aday
with
water
Stom
achache
fever
29
Hypertensionmalaria
pneumon
iaedemaas
anthelmintic
antifu
ngal
hypo
glycem
ic
anti-inflammatoryantitussiv
eexpectorantantitum
orand
antim
icrobialagents[2021]
4Alliu
mcepa
LAmaryllid
aceae
HAPP
RCASR
4120
Pyaj
Herb
Bulb
Juice
1-3drop
sEa
rache
48
Antitu
morantidiabetic
antio
xidantantibacteria
lanti-allergicandmolluscicidal
activ
ity[2223]
5Alliu
msativ
umL
Amaryllid
aceae
HAPP
RCASR
4121
Lehsun
Herb
Who
leplants
Paste
12teaspo
onBu
rntCu
t23
Antibacteria
lantivira
lantifun
galanti-parasitic
cardiovascular
[24]
6Alliu
mwa
llichiiKu
nth
Amaryllid
aceae
HAPP
RCASR
4125
Lainka
Herb
Leaves
Powd
er12
-1teaspo
onwith
water
Gastric
12Anti-m
icrobialanti-o
xidant
andanti-cancer
[25]
Evidence-Based Complementary and Alternative Medicine 5
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
7An
gelicagla
ucaEd
gew
Apiaceae
HAPP
RCASR
4146
Choru
Herb
Root
Powd
er12
teaspo
onwith
water
Gastric
9Antioxidantantim
icrobial
andph
ytotoxic[26]
8
Artemisianilagir
ica(C
BClarke)P
amp
Aste
raceae
HAPP
RCASR
4136
Kunja
Herb
Leaves
Juice
1teaspoo
nCu
tand
woun
ds24
Antim
icrobialantifu
ngal
antib
acteria
lantifi
laria
linsecticidalantiulcer
antic
ancerantio
xidant
and
anti-asthmatic[27]
9
Asparagusfi
licinus
Buch-H
amexDDon
Asparagaceae
HAPP
RCASR
4126
Jhirn
aHerb
Root
Powd
er12
-1teaspo
onwith
cowmilk
Remove
weakness
13Hypolipidem
ic[28]
10BerberisaristataDC
Berberidaceae
HAPP
RCASR
4163
Kingod
Shrub
Root
Decoctio
n1-2
drop
Eyea
ilments
87
Antim
icrobialantidepressant
diabetes
mellitus
hepatoprotectiv
eim
mun
omod
ulatory[
29]
11Berberislyciu
mRo
yle
Berberidaceae
HAPP
RCASR
4164
Chotru
Herb
Bark
Decoctio
n1teaspoo
nthric
eaday
Diabeteseye
ailm
ents
92
Antidiabetic
hepatoprotectiv
eantih
yperlip
idem
ic
Antim
icrobialantim
utagenic
pesticidalwo
undhealing[30]
12
Bergenia
ciliata
(Haw
)Sternb
Saxifragaceae
HAPP
RCASR
4112
Syalph
adi
Herb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e45
Anti-tussiv
eantiu
lcer
anti-neop
lasticantio
xidant
antib
acteria
lhypo
glycaemic
[3132]
13
Bergenia
stracheyi
(Hoo
kfamp
Thom
son)
Engl
Figu
re5(c)
Saxifragaceae
HAPP
RCASR
4113
Pashanbh
edHerb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e61
Anti-a
rthriticantim
icrobial
[32]
6 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
14
Centellaasiatica(L)
Urb
Apiaceae
HAPP
RCASR
4174
Brahmi
Herb
Leaves
JuicePo
wder
12-1teaspo
onwith
water
Coo
lant
26
Stim
ulatory-nervineton
ic
rejuvenantsedative
tranqu
ilizera
ndintelligence
prom
otingprop
erty
antie
pilepticleprosy
antin
ociceptiv
eand
anti-inflammatory[
33ndash35]
15
Cinn
amom
umtamala
(Buch-H
am)TNeesamp
Eberm
Lauraceae
HAPP
RCASR
4169
Tejpat
Tree
Leaves
bark
Powd
er12
-1teaspo
onwith
water
Con
trolblood
pressure
49Antidiabetic
antibacteria
lanti-ulcerantim
icrobial[36]
16Cirsium
wallichiiDC
Aste
raceae
HAPP
RCASR
4138
Kanjelu
Herb
Root
Powd
erJuice
12-1teaspo
onthric
eadaywith
water
Fever
2Antim
icrobialand
Antioxidant
[37]
17Cu
cumissativ
usL
Cucurbita
ceae
HAPP
RCASR
4153
Kakd
iClim
ber
Seeds
Powd
er12
teaspo
onwith
water
Diuretic
40Antim
icrobialA
ntioxidant
Hypocholesterolemic[38]
18Cu
rcum
alongaL
Zing
iberaceae
HAPP
RCASR
4165
Haldu
Herb
Rhizom
ePaste
12teaspo
ontwicea
day
Cutand
woun
ds86
Anti-H
IVantioxidant
anti-inflammatoryanti-tumor
[39]
19
Dactylorhizahatagir
ea(D
Don
)Soo
Orchidaceae
HAPP
RCASR
4162
Figu
re5(d)
Hathajadi
Herb
Root
Paste
Pow
der
12teaspo
onCu
tand
woun
dsfever
stomachache
39Antibacteria
laphrod
isiac
antip
yretic[14
]
20Dioscorea
bulbifera
LDioscoreaceae
HAPP
RCASR
4139
Tairu
Clim
ber
Tuber
Powd
er12
teaspo
onwith
water
Coo
lant
3
Antihyperlip
idem
ic
antitum
orantioxidant
anorexiantanalgesic
anti-inflammatoryplasmid
curin
ganti-diabeticand
antih
yperglycem
ic[40]
Evidence-Based Complementary and Alternative Medicine 7
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
21
Eupatoriu
madenophorum
Sprengel
Aste
raceae
HAPP
RCASR
4157
Basya
Herb
Leaves
Juice
12-1
teaspo
onCu
tand
woun
d29
Analgesicantifu
ngal[4142]
22
Girardiniadiversifolia
(Link)
Friis
Urticaceae
HAPP
RCASR
4118
Kand
ali
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
water
Fever
1Antibacteria
lantifu
ngal[43]
23
Hippophae
salicifolia
DDon
Elaeagnaceae
HAPP
RCASR
4140
Figu
re5(e)
Amesh
Tree
Fruits
Juice
5-10
teaspo
onin
1glasswater
Coo
lant
6
Antibacteria
lantifu
ngal
antic
anceranti-inflammatory
immun
omod
ulatory
radio-protectiv
eadaptogenic
anti-atherosclerosisand
anti-ste
rility
[44]
24Jugla
nsregiaL
Juglandaceae
HAPP
RCASR
4150
Akh
rot
Tree
Fruitp
eel
Paste
12teaspo
onSkin
diseases
56
Antioxidantantim
icrobial
anti-atherogenic
anti-inflammatorya
ndantim
utagenicprop
ertie
s[45ndash47]
25
Jurin
eamacrocephala
DC
Aste
raceae
HAPP
RCASR
4116
Bishkand
ara
Herb
Root
Powd
er12
teaspo
onthric
eaday
water
Fever
2Antioxidant
andAntibacteria
l[48]
26
Macrotylomaun
iflorum
(Lam
)Ve
rdc
Fabaceae
HAPP
RCASR
4114
Gahat
Herb
Seeds
Boiledsoup
1bow
lthricea
day
Ston
e96
Hepatop
rotectiveanti-ob
esity
antic
alcifyingantid
iabetic
antim
icrobial[49ndash
53]
27
Megacarpaea
polyan
dra
Benthex
Madden
Brassic
aceae
HAPP
RCASR
4111
Figu
re5(f)
Barm
olu
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
lukewarm
water
Gastric
4Not
repo
rted
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
4 Evidence-Based Complementary and Alternative Medicine
Table2Herbalm
edicinea
ndmod
eofadm
inistratio
nby
inhabitantso
fUrgam
ValleyinCh
amoliG
arhw
alU
ttarakh
andIndia
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
1
Aconitu
mbalfouriiStapf
Syn
Aconitu
mlethale
Griff
Ranu
nculaceae
HAPP
RCASR
4103
Figu
re5(a)
MeethaBh
ngwa
Herb
Root
Decoctio
n(in
cowurine)
Paste
12drop
once
aday
Snakeb
ite11
Diaph
oreticdiuretic
analgesic
febrifu
geanti-infl
ammatory
anti-rheumaticanti-p
yretic
verm
ifugepow
erfulsedative
narcoticandpo
ison[14
15]
2
Aconitu
mheterophyllum
WallexRo
yle
Ranu
nculaceae
HAPP
RCASR
4104
Figu
re5(b)
Atees
Herb
Root
JuicePo
wder
12teaspo
onwith
lukewarm
water
Stom
achache
fever
69
Anti-infl
ammatory
antip
yreticA
ntibacteria
lIm
mun
omod
ulatory
Anthelm
inthic
Antihyperlip
idem
icanalgesic
[1416ndash
19]
3AjugaparvifloraBe
nth
Lamiaceae
HAPP
RCASR
4168
Neelkanthi
Herb
Who
leplant
Powd
eror
decoction
12-1teaspo
on3
times
aday
with
water
Stom
achache
fever
29
Hypertensionmalaria
pneumon
iaedemaas
anthelmintic
antifu
ngal
hypo
glycem
ic
anti-inflammatoryantitussiv
eexpectorantantitum
orand
antim
icrobialagents[2021]
4Alliu
mcepa
LAmaryllid
aceae
HAPP
RCASR
4120
Pyaj
Herb
Bulb
Juice
1-3drop
sEa
rache
48
Antitu
morantidiabetic
antio
xidantantibacteria
lanti-allergicandmolluscicidal
activ
ity[2223]
5Alliu
msativ
umL
Amaryllid
aceae
HAPP
RCASR
4121
Lehsun
Herb
Who
leplants
Paste
12teaspo
onBu
rntCu
t23
Antibacteria
lantivira
lantifun
galanti-parasitic
cardiovascular
[24]
6Alliu
mwa
llichiiKu
nth
Amaryllid
aceae
HAPP
RCASR
4125
Lainka
Herb
Leaves
Powd
er12
-1teaspo
onwith
water
Gastric
12Anti-m
icrobialanti-o
xidant
andanti-cancer
[25]
Evidence-Based Complementary and Alternative Medicine 5
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
7An
gelicagla
ucaEd
gew
Apiaceae
HAPP
RCASR
4146
Choru
Herb
Root
Powd
er12
teaspo
onwith
water
Gastric
9Antioxidantantim
icrobial
andph
ytotoxic[26]
8
Artemisianilagir
ica(C
BClarke)P
amp
Aste
raceae
HAPP
RCASR
4136
Kunja
Herb
Leaves
Juice
1teaspoo
nCu
tand
woun
ds24
Antim
icrobialantifu
ngal
antib
acteria
lantifi
laria
linsecticidalantiulcer
antic
ancerantio
xidant
and
anti-asthmatic[27]
9
Asparagusfi
licinus
Buch-H
amexDDon
Asparagaceae
HAPP
RCASR
4126
Jhirn
aHerb
Root
Powd
er12
-1teaspo
onwith
cowmilk
Remove
weakness
13Hypolipidem
ic[28]
10BerberisaristataDC
Berberidaceae
HAPP
RCASR
4163
Kingod
Shrub
Root
Decoctio
n1-2
drop
Eyea
ilments
87
Antim
icrobialantidepressant
diabetes
mellitus
hepatoprotectiv
eim
mun
omod
ulatory[
29]
11Berberislyciu
mRo
yle
Berberidaceae
HAPP
RCASR
4164
Chotru
Herb
Bark
Decoctio
n1teaspoo
nthric
eaday
Diabeteseye
ailm
ents
92
Antidiabetic
hepatoprotectiv
eantih
yperlip
idem
ic
Antim
icrobialantim
utagenic
pesticidalwo
undhealing[30]
12
Bergenia
ciliata
(Haw
)Sternb
Saxifragaceae
HAPP
RCASR
4112
Syalph
adi
Herb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e45
Anti-tussiv
eantiu
lcer
anti-neop
lasticantio
xidant
antib
acteria
lhypo
glycaemic
[3132]
13
Bergenia
stracheyi
(Hoo
kfamp
Thom
son)
Engl
Figu
re5(c)
Saxifragaceae
HAPP
RCASR
4113
Pashanbh
edHerb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e61
Anti-a
rthriticantim
icrobial
[32]
6 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
14
Centellaasiatica(L)
Urb
Apiaceae
HAPP
RCASR
4174
Brahmi
Herb
Leaves
JuicePo
wder
12-1teaspo
onwith
water
Coo
lant
26
Stim
ulatory-nervineton
ic
rejuvenantsedative
tranqu
ilizera
ndintelligence
prom
otingprop
erty
antie
pilepticleprosy
antin
ociceptiv
eand
anti-inflammatory[
33ndash35]
15
Cinn
amom
umtamala
(Buch-H
am)TNeesamp
Eberm
Lauraceae
HAPP
RCASR
4169
Tejpat
Tree
Leaves
bark
Powd
er12
-1teaspo
onwith
water
Con
trolblood
pressure
49Antidiabetic
antibacteria
lanti-ulcerantim
icrobial[36]
16Cirsium
wallichiiDC
Aste
raceae
HAPP
RCASR
4138
Kanjelu
Herb
Root
Powd
erJuice
12-1teaspo
onthric
eadaywith
water
Fever
2Antim
icrobialand
Antioxidant
[37]
17Cu
cumissativ
usL
Cucurbita
ceae
HAPP
RCASR
4153
Kakd
iClim
ber
Seeds
Powd
er12
teaspo
onwith
water
Diuretic
40Antim
icrobialA
ntioxidant
Hypocholesterolemic[38]
18Cu
rcum
alongaL
Zing
iberaceae
HAPP
RCASR
4165
Haldu
Herb
Rhizom
ePaste
12teaspo
ontwicea
day
Cutand
woun
ds86
Anti-H
IVantioxidant
anti-inflammatoryanti-tumor
[39]
19
Dactylorhizahatagir
ea(D
Don
)Soo
Orchidaceae
HAPP
RCASR
4162
Figu
re5(d)
Hathajadi
Herb
Root
Paste
Pow
der
12teaspo
onCu
tand
woun
dsfever
stomachache
39Antibacteria
laphrod
isiac
antip
yretic[14
]
20Dioscorea
bulbifera
LDioscoreaceae
HAPP
RCASR
4139
Tairu
Clim
ber
Tuber
Powd
er12
teaspo
onwith
water
Coo
lant
3
Antihyperlip
idem
ic
antitum
orantioxidant
anorexiantanalgesic
anti-inflammatoryplasmid
curin
ganti-diabeticand
antih
yperglycem
ic[40]
Evidence-Based Complementary and Alternative Medicine 7
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
21
Eupatoriu
madenophorum
Sprengel
Aste
raceae
HAPP
RCASR
4157
Basya
Herb
Leaves
Juice
12-1
teaspo
onCu
tand
woun
d29
Analgesicantifu
ngal[4142]
22
Girardiniadiversifolia
(Link)
Friis
Urticaceae
HAPP
RCASR
4118
Kand
ali
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
water
Fever
1Antibacteria
lantifu
ngal[43]
23
Hippophae
salicifolia
DDon
Elaeagnaceae
HAPP
RCASR
4140
Figu
re5(e)
Amesh
Tree
Fruits
Juice
5-10
teaspo
onin
1glasswater
Coo
lant
6
Antibacteria
lantifu
ngal
antic
anceranti-inflammatory
immun
omod
ulatory
radio-protectiv
eadaptogenic
anti-atherosclerosisand
anti-ste
rility
[44]
24Jugla
nsregiaL
Juglandaceae
HAPP
RCASR
4150
Akh
rot
Tree
Fruitp
eel
Paste
12teaspo
onSkin
diseases
56
Antioxidantantim
icrobial
anti-atherogenic
anti-inflammatorya
ndantim
utagenicprop
ertie
s[45ndash47]
25
Jurin
eamacrocephala
DC
Aste
raceae
HAPP
RCASR
4116
Bishkand
ara
Herb
Root
Powd
er12
teaspo
onthric
eaday
water
Fever
2Antioxidant
andAntibacteria
l[48]
26
Macrotylomaun
iflorum
(Lam
)Ve
rdc
Fabaceae
HAPP
RCASR
4114
Gahat
Herb
Seeds
Boiledsoup
1bow
lthricea
day
Ston
e96
Hepatop
rotectiveanti-ob
esity
antic
alcifyingantid
iabetic
antim
icrobial[49ndash
53]
27
Megacarpaea
polyan
dra
Benthex
Madden
Brassic
aceae
HAPP
RCASR
4111
Figu
re5(f)
Barm
olu
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
lukewarm
water
Gastric
4Not
repo
rted
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 5
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
7An
gelicagla
ucaEd
gew
Apiaceae
HAPP
RCASR
4146
Choru
Herb
Root
Powd
er12
teaspo
onwith
water
Gastric
9Antioxidantantim
icrobial
andph
ytotoxic[26]
8
Artemisianilagir
ica(C
BClarke)P
amp
Aste
raceae
HAPP
RCASR
4136
Kunja
Herb
Leaves
Juice
1teaspoo
nCu
tand
woun
ds24
Antim
icrobialantifu
ngal
antib
acteria
lantifi
laria
linsecticidalantiulcer
antic
ancerantio
xidant
and
anti-asthmatic[27]
9
Asparagusfi
licinus
Buch-H
amexDDon
Asparagaceae
HAPP
RCASR
4126
Jhirn
aHerb
Root
Powd
er12
-1teaspo
onwith
cowmilk
Remove
weakness
13Hypolipidem
ic[28]
10BerberisaristataDC
Berberidaceae
HAPP
RCASR
4163
Kingod
Shrub
Root
Decoctio
n1-2
drop
Eyea
ilments
87
Antim
icrobialantidepressant
diabetes
mellitus
hepatoprotectiv
eim
mun
omod
ulatory[
29]
11Berberislyciu
mRo
yle
Berberidaceae
HAPP
RCASR
4164
Chotru
Herb
Bark
Decoctio
n1teaspoo
nthric
eaday
Diabeteseye
ailm
ents
92
Antidiabetic
hepatoprotectiv
eantih
yperlip
idem
ic
Antim
icrobialantim
utagenic
pesticidalwo
undhealing[30]
12
Bergenia
ciliata
(Haw
)Sternb
Saxifragaceae
HAPP
RCASR
4112
Syalph
adi
Herb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e45
Anti-tussiv
eantiu
lcer
anti-neop
lasticantio
xidant
antib
acteria
lhypo
glycaemic
[3132]
13
Bergenia
stracheyi
(Hoo
kfamp
Thom
son)
Engl
Figu
re5(c)
Saxifragaceae
HAPP
RCASR
4113
Pashanbh
edHerb
Root
Decoctio
n1teaspoo
non
cead
aywith
lukewarm
water
Ston
e61
Anti-a
rthriticantim
icrobial
[32]
6 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
14
Centellaasiatica(L)
Urb
Apiaceae
HAPP
RCASR
4174
Brahmi
Herb
Leaves
JuicePo
wder
12-1teaspo
onwith
water
Coo
lant
26
Stim
ulatory-nervineton
ic
rejuvenantsedative
tranqu
ilizera
ndintelligence
prom
otingprop
erty
antie
pilepticleprosy
antin
ociceptiv
eand
anti-inflammatory[
33ndash35]
15
Cinn
amom
umtamala
(Buch-H
am)TNeesamp
Eberm
Lauraceae
HAPP
RCASR
4169
Tejpat
Tree
Leaves
bark
Powd
er12
-1teaspo
onwith
water
Con
trolblood
pressure
49Antidiabetic
antibacteria
lanti-ulcerantim
icrobial[36]
16Cirsium
wallichiiDC
Aste
raceae
HAPP
RCASR
4138
Kanjelu
Herb
Root
Powd
erJuice
12-1teaspo
onthric
eadaywith
water
Fever
2Antim
icrobialand
Antioxidant
[37]
17Cu
cumissativ
usL
Cucurbita
ceae
HAPP
RCASR
4153
Kakd
iClim
ber
Seeds
Powd
er12
teaspo
onwith
water
Diuretic
40Antim
icrobialA
ntioxidant
Hypocholesterolemic[38]
18Cu
rcum
alongaL
Zing
iberaceae
HAPP
RCASR
4165
Haldu
Herb
Rhizom
ePaste
12teaspo
ontwicea
day
Cutand
woun
ds86
Anti-H
IVantioxidant
anti-inflammatoryanti-tumor
[39]
19
Dactylorhizahatagir
ea(D
Don
)Soo
Orchidaceae
HAPP
RCASR
4162
Figu
re5(d)
Hathajadi
Herb
Root
Paste
Pow
der
12teaspo
onCu
tand
woun
dsfever
stomachache
39Antibacteria
laphrod
isiac
antip
yretic[14
]
20Dioscorea
bulbifera
LDioscoreaceae
HAPP
RCASR
4139
Tairu
Clim
ber
Tuber
Powd
er12
teaspo
onwith
water
Coo
lant
3
Antihyperlip
idem
ic
antitum
orantioxidant
anorexiantanalgesic
anti-inflammatoryplasmid
curin
ganti-diabeticand
antih
yperglycem
ic[40]
Evidence-Based Complementary and Alternative Medicine 7
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
21
Eupatoriu
madenophorum
Sprengel
Aste
raceae
HAPP
RCASR
4157
Basya
Herb
Leaves
Juice
12-1
teaspo
onCu
tand
woun
d29
Analgesicantifu
ngal[4142]
22
Girardiniadiversifolia
(Link)
Friis
Urticaceae
HAPP
RCASR
4118
Kand
ali
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
water
Fever
1Antibacteria
lantifu
ngal[43]
23
Hippophae
salicifolia
DDon
Elaeagnaceae
HAPP
RCASR
4140
Figu
re5(e)
Amesh
Tree
Fruits
Juice
5-10
teaspo
onin
1glasswater
Coo
lant
6
Antibacteria
lantifu
ngal
antic
anceranti-inflammatory
immun
omod
ulatory
radio-protectiv
eadaptogenic
anti-atherosclerosisand
anti-ste
rility
[44]
24Jugla
nsregiaL
Juglandaceae
HAPP
RCASR
4150
Akh
rot
Tree
Fruitp
eel
Paste
12teaspo
onSkin
diseases
56
Antioxidantantim
icrobial
anti-atherogenic
anti-inflammatorya
ndantim
utagenicprop
ertie
s[45ndash47]
25
Jurin
eamacrocephala
DC
Aste
raceae
HAPP
RCASR
4116
Bishkand
ara
Herb
Root
Powd
er12
teaspo
onthric
eaday
water
Fever
2Antioxidant
andAntibacteria
l[48]
26
Macrotylomaun
iflorum
(Lam
)Ve
rdc
Fabaceae
HAPP
RCASR
4114
Gahat
Herb
Seeds
Boiledsoup
1bow
lthricea
day
Ston
e96
Hepatop
rotectiveanti-ob
esity
antic
alcifyingantid
iabetic
antim
icrobial[49ndash
53]
27
Megacarpaea
polyan
dra
Benthex
Madden
Brassic
aceae
HAPP
RCASR
4111
Figu
re5(f)
Barm
olu
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
lukewarm
water
Gastric
4Not
repo
rted
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
6 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
14
Centellaasiatica(L)
Urb
Apiaceae
HAPP
RCASR
4174
Brahmi
Herb
Leaves
JuicePo
wder
12-1teaspo
onwith
water
Coo
lant
26
Stim
ulatory-nervineton
ic
rejuvenantsedative
tranqu
ilizera
ndintelligence
prom
otingprop
erty
antie
pilepticleprosy
antin
ociceptiv
eand
anti-inflammatory[
33ndash35]
15
Cinn
amom
umtamala
(Buch-H
am)TNeesamp
Eberm
Lauraceae
HAPP
RCASR
4169
Tejpat
Tree
Leaves
bark
Powd
er12
-1teaspo
onwith
water
Con
trolblood
pressure
49Antidiabetic
antibacteria
lanti-ulcerantim
icrobial[36]
16Cirsium
wallichiiDC
Aste
raceae
HAPP
RCASR
4138
Kanjelu
Herb
Root
Powd
erJuice
12-1teaspo
onthric
eadaywith
water
Fever
2Antim
icrobialand
Antioxidant
[37]
17Cu
cumissativ
usL
Cucurbita
ceae
HAPP
RCASR
4153
Kakd
iClim
ber
Seeds
Powd
er12
teaspo
onwith
water
Diuretic
40Antim
icrobialA
ntioxidant
Hypocholesterolemic[38]
18Cu
rcum
alongaL
Zing
iberaceae
HAPP
RCASR
4165
Haldu
Herb
Rhizom
ePaste
12teaspo
ontwicea
day
Cutand
woun
ds86
Anti-H
IVantioxidant
anti-inflammatoryanti-tumor
[39]
19
Dactylorhizahatagir
ea(D
Don
)Soo
Orchidaceae
HAPP
RCASR
4162
Figu
re5(d)
Hathajadi
Herb
Root
Paste
Pow
der
12teaspo
onCu
tand
woun
dsfever
stomachache
39Antibacteria
laphrod
isiac
antip
yretic[14
]
20Dioscorea
bulbifera
LDioscoreaceae
HAPP
RCASR
4139
Tairu
Clim
ber
Tuber
Powd
er12
teaspo
onwith
water
Coo
lant
3
Antihyperlip
idem
ic
antitum
orantioxidant
anorexiantanalgesic
anti-inflammatoryplasmid
curin
ganti-diabeticand
antih
yperglycem
ic[40]
Evidence-Based Complementary and Alternative Medicine 7
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
21
Eupatoriu
madenophorum
Sprengel
Aste
raceae
HAPP
RCASR
4157
Basya
Herb
Leaves
Juice
12-1
teaspo
onCu
tand
woun
d29
Analgesicantifu
ngal[4142]
22
Girardiniadiversifolia
(Link)
Friis
Urticaceae
HAPP
RCASR
4118
Kand
ali
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
water
Fever
1Antibacteria
lantifu
ngal[43]
23
Hippophae
salicifolia
DDon
Elaeagnaceae
HAPP
RCASR
4140
Figu
re5(e)
Amesh
Tree
Fruits
Juice
5-10
teaspo
onin
1glasswater
Coo
lant
6
Antibacteria
lantifu
ngal
antic
anceranti-inflammatory
immun
omod
ulatory
radio-protectiv
eadaptogenic
anti-atherosclerosisand
anti-ste
rility
[44]
24Jugla
nsregiaL
Juglandaceae
HAPP
RCASR
4150
Akh
rot
Tree
Fruitp
eel
Paste
12teaspo
onSkin
diseases
56
Antioxidantantim
icrobial
anti-atherogenic
anti-inflammatorya
ndantim
utagenicprop
ertie
s[45ndash47]
25
Jurin
eamacrocephala
DC
Aste
raceae
HAPP
RCASR
4116
Bishkand
ara
Herb
Root
Powd
er12
teaspo
onthric
eaday
water
Fever
2Antioxidant
andAntibacteria
l[48]
26
Macrotylomaun
iflorum
(Lam
)Ve
rdc
Fabaceae
HAPP
RCASR
4114
Gahat
Herb
Seeds
Boiledsoup
1bow
lthricea
day
Ston
e96
Hepatop
rotectiveanti-ob
esity
antic
alcifyingantid
iabetic
antim
icrobial[49ndash
53]
27
Megacarpaea
polyan
dra
Benthex
Madden
Brassic
aceae
HAPP
RCASR
4111
Figu
re5(f)
Barm
olu
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
lukewarm
water
Gastric
4Not
repo
rted
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 7
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
21
Eupatoriu
madenophorum
Sprengel
Aste
raceae
HAPP
RCASR
4157
Basya
Herb
Leaves
Juice
12-1
teaspo
onCu
tand
woun
d29
Analgesicantifu
ngal[4142]
22
Girardiniadiversifolia
(Link)
Friis
Urticaceae
HAPP
RCASR
4118
Kand
ali
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
water
Fever
1Antibacteria
lantifu
ngal[43]
23
Hippophae
salicifolia
DDon
Elaeagnaceae
HAPP
RCASR
4140
Figu
re5(e)
Amesh
Tree
Fruits
Juice
5-10
teaspo
onin
1glasswater
Coo
lant
6
Antibacteria
lantifu
ngal
antic
anceranti-inflammatory
immun
omod
ulatory
radio-protectiv
eadaptogenic
anti-atherosclerosisand
anti-ste
rility
[44]
24Jugla
nsregiaL
Juglandaceae
HAPP
RCASR
4150
Akh
rot
Tree
Fruitp
eel
Paste
12teaspo
onSkin
diseases
56
Antioxidantantim
icrobial
anti-atherogenic
anti-inflammatorya
ndantim
utagenicprop
ertie
s[45ndash47]
25
Jurin
eamacrocephala
DC
Aste
raceae
HAPP
RCASR
4116
Bishkand
ara
Herb
Root
Powd
er12
teaspo
onthric
eaday
water
Fever
2Antioxidant
andAntibacteria
l[48]
26
Macrotylomaun
iflorum
(Lam
)Ve
rdc
Fabaceae
HAPP
RCASR
4114
Gahat
Herb
Seeds
Boiledsoup
1bow
lthricea
day
Ston
e96
Hepatop
rotectiveanti-ob
esity
antic
alcifyingantid
iabetic
antim
icrobial[49ndash
53]
27
Megacarpaea
polyan
dra
Benthex
Madden
Brassic
aceae
HAPP
RCASR
4111
Figu
re5(f)
Barm
olu
Herb
Root
Powd
er12
-1teaspo
ontwicea
daywith
lukewarm
water
Gastric
4Not
repo
rted
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
8 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
28MenthapiperitaL
Lamiaceae
HAPP
RCASR
4148
Pudina
Herb
Leaves
Paste
12-1teaspo
onwater
Coo
lant
9Antim
icrobial[54]
29Mira
bilis
jalapa
LNyctaginaceae
HAPP
RCASR
4117
Herb
Leaves
Paste
-Cu
tand
woun
ds12
Antim
icrobial[55]
30
Nardosta
chysjataman
si(D
Don
)DC
Caprifoliaceae
HAPP
RCASR
4156
Maasi
Herb
Rhizom
ePo
wder
12teaspo
onthric
eadaywith
lukewarm
water
Jaun
dice
1
Toniclaxativ
ediuretic
spasmod
ichepatoprotectiv
ecardio
protectiv
e[56ndash58]
31Ocim
umtenu
iflorum
LLamiaceae
HAPP
RCASR
4115
Tulsi
Herb
Leaves
Powd
eror
raw
3-5leaves
with
water
Fevercoug
handcold
75Antim
icrobial
radio-protectiv
eantd
iabetic
anti-carcinogenic[5960]
32Oxalis
cornicu
lataL
Oxalid
aceae
HAPP
RCASR
4133
Alm
odu
Herb
Aeria
lpart
Paste
12teaspo
onBo
ils26
Anti-infl
ammatory
refrigerantand
antiscorbutic
hypo
glycem
ic
antih
ypertensive
antip
sychoticstim
ulant
chrono
tropicamp
inotropic
effect[61ndash6
3]
33
Paeoniaem
odiR
oyle
Paeoniaceae
HAPP
RCASR
4172
Figu
re5(g)
Chandra
Herb
Leaves
Juice
1teaspoo
nthric
eadaywith
water
Fever
87
Backachedropsy
epilepsyton
icemetic
cathartic
blood
purifi
erand
colicpurgativ
e[64
]
34
Picrorhiza
kurrooaRo
yle
exBe
nth
Plantaginaceae
HAPP
RCASR
4105
Figu
re5(h)
Kadw
iHerb
Root
Powd
er12
teaspo
onthric
eadaywith
water
Fever
96
Immun
omod
ulatory
cardiotonicantip
yretic
anthelmintic
laxativea
ndanti-asthmatic
hepatoprotectiv
eantic
holesta
tic
anti-ulcerogenic
anti-asthmaticand
immun
e-regu
latory
functio
ns[6566]
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 9
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
35
Polygonatum
verticillatum
(L)All
Asparagaceae
HAPP
RCASR
4127
Figu
re5(i)
Maham
aidaSalam
panja
Herb
Rhizom
ePo
wder
12-1teaspo
onthric
eadaywith
water
Fever
3
Anti-infl
ammatory
antim
alarialantip
yretic
insecticidalantibacteria
lantifun
galantid
iarrheal
[67ndash70]
36
Potentillalin
eata
Trevir
Syn
Potentillafulgens
LRo
saceae
HAPP
RCASR
4173
Bajrd
anti
Herb
Root
Powd
er12
teaspo
onCleansingteeth
26Anthelm
intic
[71]
37
Prun
uspersica
(L)
Batsch
Rosaceae
HAPP
RCASR
4177
Aaru
Tree
Seeds
peric
arp
Paste
12teaspo
onInfectionaft
erbreakage
ofhair
(Baalto
d)2
Anthelm
intic
insectic
idal
sedativ
ediureticdem
ulcent
expectorantverm
icidaland
areu
sedin
leucod
ermaa
ndin
piles[72]
38Pu
nica
gran
atum
LLythraceae
HAPP
RCASR
4142
Anar
Tree
Fruits
Raw
1fruit
Anemia
8
Antim
icrobial
anti-inflammatory
anti-diabeticanticancer
[7374]
39
Rheum
moorcroftian
umRo
yle
Polygonaceae
HAPP
RCASR
4160
Figu
re5(j)
Dolu
Herb
Root
Powd
erpaste
12teaspo
onInternalinjury
cutand
woun
ds24
Purgativea
ntim
icrobial
anti-inflammatory[
1475]
40
Rhododendron
campanu
latumDD
onEricaceae
HAPP
RCASR
4178
Syam
ruTree
Leaves
Paste
with
oil
12-1teaspo
onSkin
disease
6Analgesicanti-infl
ammatory
[76]
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
10 Evidence-Based Complementary and Alternative Medicine
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
41
Rumex
nepalen
sisSpreng
Po
lygonaceae
HAPP
RCASR
4167
Khu
ldya
Herb
Root
Powd
erpaste
12-1teaspo
onthric
eadaywith
lukewarm
water
Pneumon
iaC
utandwo
unds
1Antioxidantantitu
mou
ranti-inflammatory
purgative[
77ndash79]
42
Saussureacostu
s(Falc)
Lipsch
Aste
raceae
HAPP
RCASR
4109
Kuth
Herb
Root
and
leaves
Paste
-Cu
tand
woun
ds27
Anti-infl
ammatory
antic
ancerhepatoprotectiv
eantim
icrobial[8081]
43
Saussureaobvallata
(DC)
Edgew
Aste
raceae
HAPP
RCASR
4110
Figu
re5(k)
Kaun
lHerb
Aeria
lpart
Raw
-To
keep
atho
me
forincreasing
immun
ity29
Antioxidantantim
icrobial
[82]
44
Selin
umvagin
atum
(Edgew
)CB
Clarke
Apiaceae
HAPP
RCASR
4144
Bhutkesh
Herb
Root
Powd
er12
teaspo
onwith
water
Coo
lant
2Antibacteria
l[83]
45
Swertia
chira
yita
(Roxb)
Buch-H
amex
CBClarke
Gentia
naceae
HAPP
RCASR
4154
Figu
re5(l)
Chira
ituHerb
Who
leplant
Powd
er12
-1teaspo
onthric
eadaywith
water
Feversto
mach
ache
78
Antibacteria
lantifu
ngal
antileishmaniaantim
alaria
anti-inflammatory
antid
iabetic
hepatop
rotective
antiv
iral[84ndash88]
46
Swertia
ciliata
(DDon
exGDon
)BLBurtt
Gentia
naceae
HAPP
RCASR
4166
Chira
taHerb
Aeria
lpart
Powd
er12
teaspo
onwith
water
Feversto
mach
ache
12Antifu
ngal[89]
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 11
Table2Con
tinued
SN
Scientificn
ameFamily
andcollectionnu
mber
Localn
ame
Life
form
sPartsu
sed
Mod
eof
preparation
Doses
and
administratio
nDise
ases
treated
UR
Pharmacologicalactiv
ity
47TageteserectaL
Aste
raceae
HAPP
RCASR
4147
Gaind
aHerb
Leaves
Juice
1-2drop
sEa
rache
1Antipyreticanalgesicand
anti-inflammatory[
90]
48Ta
xusw
allichian
aZu
cc
Taxaceae
HAPP
RCASR
4151
Thun
erTree
Bark
Tea
1cup
once
aday
Highbloo
dpressure
25
Immun
omod
ulatory
anti-bacterialanti-fung
al
analgesic
anti-p
yreticand
anti-convulsancea
ctivities
anti-cancer
[9192]
49
Tinosporasin
ensis
(Lou
r)Merr
Syn
Tino
spora
cordifo
lia(W
illd)M
iers
Menisp
ermaceae
HAPP
RCASR
4132
Gilo
eClim
ber
Aeria
lpart
Juice
1teaspoo
nwith
water
FeverStom
ach
ache
87
Anti-c
ancer
immun
omod
ulatory
anti-diabeticanti-toxicity
[93ndash95]
50Ur
ticadioica
LUrticaceae
HAPP
RCASR
4130
Kand
ali
Herb
Aeria
lpart
Rawvegetable
-Anaem
ia
remove
weakness
81
Antidiabetic
hepatoprotectiv
eantiv
iral
antim
icrobialanticancer
immun
omod
ulatory[
96ndash101]
51
Zanthoxylum
armatum
DC
Rutaceae
HAPP
RCASR
4107
Timru
Shrub
SeedsStem
oraeria
lpart
Powd
er12
teaspo
onCleansingteeth
andtoothache
95Anti-infl
ammatory
antib
acteria
lantifun
gal
[102ndash104
]
SNseria
lnum
berSynsynon
ymU
Ruser
eports
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
12 Evidence-Based Complementary and Alternative Medicine
012345678
Am
aryl
lidac
eae
Apia
ceae
Asp
arag
acea
eA
stera
ceae
Berb
erid
acea
eBr
assic
acea
eCa
prifo
liace
aeCu
curb
itace
aeD
iosc
orea
ceae
Elae
agna
ceae
Eric
acea
eFa
bace
aeG
entia
nace
aeJu
glan
dace
aeLa
mia
ceae
Laur
acea
eLy
thra
ceae
Men
isper
mac
eae
Nyc
tagi
nace
aeO
rchi
dace
aeO
xalid
acea
ePa
eoni
acea
ePl
anta
gina
ceae
Poly
gona
ceae
Ranu
ncul
acea
eRo
sace
aeRu
tace
aeSa
xifr
agac
eae
Taxa
ceae
Urt
icac
eae
Zing
iber
acea
e
Num
ber o
f pla
nts
FamiliesFigure 2 Number of medicinal plants in different families
02468
1012141618
Num
ber
FruitsSeed
sRoot
Rhizome
TuberBulb
Aerial p
artLeav
esBark
Whole plan
t
Plant partsFigure 3 Plant parts used to cure different ailments by inhabitants of Urgam Valley
Juice17
Powder42
Decoction 7
Paste23
Boiled soup2
Raw7
Tea2
Figure 4 Traditional drug preparations by inhabitants of UrgamValley
Healers who were excluded from this analysis report moreplants and more uses than the average predicted value fortheir age (Figure 6(b)) Elders also tendmore to report learn-ing from their parents as a source of knowledge and tend toeasily identify plants and their localities and characters whilesome younger informants struggled to give information
Ordinations show similarity between informants by plot-ting those who reported more similar lists of plants or
more similar lists of species are closer together (Figure 7)Although there is a great deal of overlap specialist healersdo report a significantly different set of plants (p=001 r-squared=006) and uses (plt001 r-squared=007) than non-specialists For instance Dioscorea bulbifera Polygonatumverticillatum Jurinea macrocephala and Prunus persica wereonly reported by healers Bergenia ciliata Allium cepa andCinnamomum tamala were more widely reported but mostfrequently by healers (all healers reported these plantscompared to only lt50 of nonhealers) Likewise infectionafter breakage of hair in body ldquoBaaltodrdquo was only reportedby healers and Control blood pressurersquo and ldquoEar acherdquowere reported more widely but much more frequently byhealers (all healers reported these uses compared to lt50of nonhealers)
4 Discussion
Medicinal plants are globally used in local health care byethnic communities of the world and the knowledge of folkmedicine is being documented throughout the world
Our results show strong consensus on plant uses inUrgam Valley with high informant consensus values acrossall categories Further we show that knowledge of traditional
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 13
(a) (b) (c)
(d) (e) (f)
(g) (h) (i)
(j) (k) (l)
Figure 5 (a) Aconitum balfourii (b) Aconitum heterophyllum (c) Bergenia stracheyi (d) Dactylorhiza hatagirea (e)Hippophae salicifolia (f)Megacarpaea polyandra (g) Paeonia emodi (h) Picrorhiza kurrooa (i) Polygonatum verticillatum (j) Rheum moorcroftianum (k) Saussureaobvallata (l) Swertia chirayita
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
14 Evidence-Based Complementary and Alternative Medicine
Table 3 Informants consensus factor for different ailment categories
Ailment category Number of usereports (Nur) of use reports Number of taxa
(Nt) of taxaInformants
consensus factor(ICF)
Gastrointestinal disorders 271 1446 11 2156 096
Fever and aches 580 3094 13 2549 097
Diseases of the skin 318 1696 10 1960 097Remove weaknessimmunomodulatoranaemia
131 699 4 784 097
Ophthalmologiccomplaints 179 955 2 392 099
Poisonous bite 11 058 1 196 1
Dental problems 121 645 2 392 099
Ear ache 49 261 2 392 097
Hearing problems 74 394 2 392 098
Others 140 747 4 784 097
Total 1874
10
20
30
40
50
spec
ies
age
10
20
30
20 40 60
uses
(a)healer
no
10
20
30
40
50sp
ecie
s
10
20
30
uses
yes
(b)
Figure 6 Species and uses reported by the general populace (red) increase with age (a) and are greatest for specialist healers (blue b) Theline indicates a natural spline regression in which the increase in knowledge with age flattens above age 50
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 15
species
10203040
healer
NoYes
(a)
uses
510152025
healerNoYes
(b)Figure 7 A nonmetricmultidimensional scaling of points (informants) which are plotted closer together when species (a) or uses (b) reportedare more similar and sized by the count for each informant of species or uses Although there is overlap healers (blue) occupy a significantlydifferent section of the ordination spaces showing that they report particular plants and uses
uses and of medicinal plants is higher in elders (bujurg)who learnt this knowledge from their parents or forefathersand associated plant medicine with positive attitudes butalso with regular practice of identifying and using plants totreat different ailments We also showed that specialists tendto report different and unique species and were associatedwith some species that were widely reported but mostconsistently reported by specialist For instance Bergeniaciliata (Haworth) Sternberg was reported here used for stonesby every healer This is a widely used plant with similar usecitations reported locally [8 105] but also across the greaterHimalayan region for a variety of uses [106]
Most commonly mentioned plants across the generalpopulation have also been reported previously for similaruses from the region For instance Picrorhiza kurrooa Benthwhich was reported by nearly every informant is used forfever similar to Bhat et al [107] where it was reportedfor fever and stomach ache Zanthoxylum armatum DCreported by 95 informants for cleaning teeth and toothachewas reported for similar uses locally [108] and more distantlyby Abbasi et al [109] Berberis lycium Royle DC reportedby 92 informants for conjunctivitis was also reported byGaur [8] for ophthalmia and Bhat et al [107] for eye irri-tation Aconitum heterophyllum Wallex Royle root powderreported by 69 informants for stomach ache and feverwas also reported elsewhere [107 108] for the same usesMore distantly the species is also reported for dysentery[106] in Northern Pakistan Juglans regia L reported by 56for cleaning teeth and treatment of skin diseases was alsoreported for similar uses from Northern Pakistan [106 110]while in Uttarakhand Gaur [8] reported its use as fisherydye fungicide and insecticide Dactylorhiza hatagirea (Don)Soo reported by 39 for cut and wounds and stomach achewas also reported for similar uses locally [107] Aconitum
balfourii Stapt which was uncommonly reported for snakebites in this study was reported previously for similar usesuse in poisonous skin diseases [107] as antidote of snake andscorpion sting and for rheumatism arthritis and paralysisfrom Nanda Devi Biosphere reserve [111] and leprosy [108]
5 Conclusion
The study suggests that while there remains a rich knowledgeof medicinal plants in Urgam Valley most knowledge isheld by elders (bujurg) and specialist healers (vaidyas anddaai) Knowledge of medicinal plants is important andfrequently used by local inhabitants to support their healthcare Pharmacological activity on most of the plants is yetunknown so medicinal plants use in Urgam might be helpfulin new drug discovery and pharmacological properties Mostof the highly useful plants of Himalaya are threatened withoverexploitation and irregular harvesting and now limited tofew pockets Ex situ and in situ conservation should be imple-mented to conserve biodiversity and these valuable medicinalplants Cultivation rather than wild-harvest of threatenedvaluable medicinal plants may support the traditional usesdocumented here while also protecting wild populations
Appendix
Questionnaires
Informantsrsquo Details
(1) What is your name
Gender MaleFemale
(2) How old are you
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
16 Evidence-Based Complementary and Alternative Medicine
(3) What is your Education Illiterate5thHigh schoolIntermediatesgraduation
(4) What is your occupation(5) Locationresidence(6) Altitude(7) Do you know about medicinal plants Yesno
If yes(8) Which plants do you know
(81) Plant (Local name)(82) Habit (Tree Herb ShrubClimber)(83) Number name of disease (s) treated(84) How you identify particular diseaseSymptoms(85) Plant part used (Rootleaves stem flow-ers fruit aerial partwhole plants)(86) Method of crude drug preparation andadministration(87) Dosage(88) How you collect and stored medicinalherbs and their preparation(89) How much time we can use these storedpreparation (About expiry date )(810) Have you ever used this or just youknowledge from forefather or elsewhere(811) Other importance(812) Cultivated Wild(813) Wild availabilityCommonscatteredrare very rare(814) Natural location High altitude middlealtitude lower altitude every where(815) Natural pockets where you seen or col-lected (Place name)(816) Availability of particular medicinal plantsincreases or decreases
If increasesdecreases(817) What is your opinion for why increase ordecrease(818) Conservation required YesNo
If yes(819) How can we conserve these importantspecies
Remarks
Plants identified as (Botanical name and family)Signature of Researcher
Informantsrsquo Consent
I (Informants name)declare that information given byme is true completeand accurate and I am fully consent for it
Table 4
SNo Disease (Local name) Disease (Englishname)
1 Anidra Insomnia2 Ankh ki bimariyan Eye problems3 Aankh aana Eye flue4 Apach Indigestion5 Baal jhadna Hair fall
6 Baaltod Boils after breakage ofhair
7 Bukhar Fever8 Daant dard Tooth ache9 Diabetes Diabetes10 Gum chot Wounds11 Haddi tootna Bon fracture12 Jalna Burnt13 Jodo ka dard Joint pain14 Jukam Cold15 Kaan dard Ear ache16 Kamjori Nutritive17 KatnaKatyon Cuts18 Khasi Cough19 MakraDaad Herpes20 Paichis Dysentery21 Pathri Stone22 Peelia Jaundice23 Pet dard Stomach ache24 Pet ke keede Stomach worms25 Phati Biwain Feet crack26 Phode funsi Boils27 Pradar Leukorrhea28 Sar dard Head ache29 Syalbai Kind of fever30 TB Tuberculosis
Date (SignatureThumb im-pression of Informant)
(i) Photographic base survey (N=110)(9) To show one by one photograph to informants
and ask have ever saw this plantsIf informants know about plants (Repeat from(81) to (819))
(ii) List of medicinal plants with local name(10) What do you know about plants (Local
name)If informants know about plants (Repeat from(81) to (819))
(iii) Disease base information(11) What do you know about (diseases name)
If they know and use some medicinal plant forparticular diseases
The diseases list used to collect information is shownin Table 4 (Repeat (81) to (819))
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 17
Table 5
No Botanical name
+=Yes-
=No1 Aconitum balfourii syn Aconitum lethale Griff2 Aconitum heterophyllumWall ex Royle3 Aconitum violaceum Jacquem ex Stapf
4 Aconogonon rumicifolium syn Pleuropteropyrumrumicifolium (Royle ex Bab) Munshi amp Javeid
5 Acorus calamus L6 Aesculus indica (Wall ex Cambess) Hook7 Ajuga parviflora Benth8 Allium cepa L9 Allium sativum L10 Allium stracheyi Baker11 Allium wallichii Kunth12 Angelica archangelica L13 Angelica glauca Edgew14 Arisaema tortuosum (Wall) Schott15 Arnebia benthamii (Wall ex GDon) IMJohnst16 Asparagus filicinus Buch-Ham ex DDon17 Barleria cristata L18 Berberis aristata DC19 Berberis chitria Buch-Ham ex Lindl20 Bergenia ciliata (Haw) Sternb21 Bergenia stracheyi (Hook f ampThomson) Engl22 Betula utilis D Don23 Boehmeria rugulosaWedd24 Cedrus deodara (Roxb ex DDon) GDon25 Centella asiatica (L) Urb26 Cinnamomum tamala (Buch-Ham) TNees amp Eberm27 Cirsium wallichiiDC28 Citrus aurantiifolia (Christm) Swingle29 Cucumis sativus L30 Curcuma longa L31 Cynodon dactylon (L) Pers32 Dactylorhiza hatagirea (DDon) Soo33 Delphinium vestitumWall ex Royle34 Dioscorea bulbifera L35 Drymaria cordata (L) Willd ex Schult36 Duchesnea indica (Jacks) Focke37 Echinochloa frumentacea Link38 Eleusine coracana (L) Gaertn
39 Eupatorium adenophorum Spreng Syn Ageratinaadenophora (Spreng) RMKing amp HRob
40 Ficus palmata Forssk41 Fritillaria roylei Syn Fritillaria cirrhosa DDon42 Geranium wallichianumDDon ex Sweet43 Girardinia diversifolia (Link) Friis44 Habenaria intermedia DDon45 Hedera nepalensis KKoch46 Hedychium spicatum Sm47 Hippophae salicifolia DDon48 Juglans regia L
Table 5 Continued
No Botanical name
+=Yes-
=No49 Jurinea macrocephalaDC50 Lyonia ovalifolia (Wall) Drude51 Macrotyloma uniflorum (Lam) Verdc52 Malaxis muscifera (Lindl) Kuntze53 Megacarpaea polyandra Benth ex Madden54 Mentha times piperita L55 Morina longifoliaWall ex DC56 Nardostachys jatamansi (DDon) DC57 Nicandra physalodes (L) Gaertn58 Ocimum tenuiflorum L59 Oxalis corniculata L60 Paeonia emodi Royle61 Paris polyphylla Sm62 Persicaria capitata (Buch-Ham ex DDon) HGross63 Picrorhiza kurrooa Royle ex Benth
64 Podophyllum hexandrum Syn Sinopodophyllumhexandrum (Royle) TSYing
65 Polygonatum verticillatum (L) All66 Potentilla fulgens L Syn Potentilla lineata Trevir67 Pouzolzia hirta Blume ex Hassk68 Primula denticulate Sm69 Prunus cerasoides Buch-Ham ex DDon70 Prunus persica (L) Batsch71 Punica granatum L
72 Quercus leucotrichophora ACamus Syn Quercusoblongata DDon
73 Rheum austral D Don74 Rheum moorcroftianum Royle75 Rhododendron campanulatumD Don76 Roscoea alpina Royle77 Rubia cordifolia L78 Rubus ellipticus Sm79 Rumex hastatus DDon80 Rumex nepalensis Spreng81 Satyrium nepalenseDDon82 Saussurea costus (Falc) Lipsch83 Saussurea gossypiphora DDon84 Saussurea obvallata (DC) Edgew85 Selinum vaginatum CB Clarke86 Skimmia laureola Franch89 Solanum americanumMill87 Solanum khasianum CB Clarke88 Solanum nigrum L Syn90 Stellaria media (L) Vill91 Swertia chirayita (Roxb) Buch-Ham ex CBClarke92 Swertia ciliata (D Don ex G Don) BL Burtt93 Swertia cordata (Wall ex G Don) CB Clarke94 Tagetes erecta L95 Tanacetum longifolium Syn Athanasia linifolia BurmF96 Taraxacum officinale Syn T campylodesGEHaglund
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
18 Evidence-Based Complementary and Alternative Medicine
Table 5 Continued
No Botanical name
+=Yes-
=No97 Taxus wallichiana Zucc98 Terminalia bellirica (Gaertn) Roxb99 Terminalia chebula Retz100 Thalictrum foliolosum DC101 Tinospora sinensis (Lour) Merr102 Trichosanthes tricuspidata Lour103 Trillium govanianumWall ex DDon104 Urtica ardens Link105 Urtica dioica L106 Valeriana wallichiiDC Syn Valeriana jatamansi Jones107 Vanda cristataWall ex Lindl108 Viola canescensWall109 Zanthoxylum armatumDC110 Zingiber officinale Roscoe
Plant list (see Table 5)
Data Availability
The data used to support the findings of this study areavailable from the corresponding author upon request
Conflicts of Interest
The authors declare that there are no conflicts of interest
Acknowledgments
The authors are thankful to local inhabitants of Urgam forsharing their valuable knowledge with us
References
[1] B Joshi and S C Pant ldquoEthnobotanical study of some com-mon plants used among the tribal communities of KashipurUttarakhandrdquo Indian Journal of Natural Products and Resources(IJNPR) vol 3 no 2 pp 262ndash266 2012
[2] M P Shiva Inventory of Forestry Resources for SustainableManagement and Biodiversity Conservation Indus PublishingCompany New Delhi India 1996
[3] B Malla D P Gauchan and R B Chhetri ldquoAn ethnobotanicalstudy of medicinal plants used by ethnic people in Parbatdistrict of western Nepalrdquo Journal of Ethnopharmacology vol165 pp 103ndash117 2015
[4] World Health Organization (WHO) WHO TraditionalMedicine Strategy WHO Geneva Switzerland 2002
[5] A Singh M C Nautiyal R M Kunwar and R W BussmannldquoEthnomedicinal plants used by local inhabitants of Jakholiblock Rudraprayag district western Himalaya Indiardquo Journalof Ethnobiology and Ethnomedicine vol 13 no 49 pp 1ndash29 2017
[6] P C M Jansen Spices Condiments and Medicinal Plants inEthiopia Their Taxonomic and Agricultural Significance Centre
for Agricultural Publishing and Documentation WageningenNetherlands 1981
[7] T Teklehaymanot and M Giday ldquoEthnobotanical study ofmedicinal plants used by people in Zegie Peninsula Northwest-ern Ethiopiardquo Journal of Ethnobiology and Ethnomedicine vol 3no 12 2007
[8] R D Gaur Flora of the District Garhwal Northwest Himalayas(With Ethnobotanical Notes) Transmedia Srinagar GarhwalUttarakhand India 1999
[9] B D Naithani Flora of Chamoli vol 1 amp 2 Botanical Survey ofIndia Howrah India 1985
[10] httpwwwtheplantlistorg[11] M Heinrich A Ankli B Frei C Weimann and O Sticher
ldquoMedicinal plants in Mexico healersrsquo consensus and culturalimportancerdquo Social Science ampMedicine vol 47 no 11 pp 1859ndash1871 1998
[12] D M Bates and W N Venables Splines R package version33-0 2016 httpscranr-projectorgwebpackagessplinesindexhtml
[13] J Oksanen B F Guillaume R Kindt et al Vegan Commu-nity Ecology Package R package version 23-0 2016 httpCRANR-projectorgpackage=vegan
[14] M C Nautiyal and B P Nautiyal Agrotechniques for HighAltitudeMedicinal Aromatic Plants Bishen SinghMahendra PalSingh 2004
[15] O StapfThe Aconites of India A Monograph Bengal Secretari-ats Press Calcutta India 1905
[16] S Verma S Ojha andM Raish ldquoAnti-inflammatory activity ofAconitum heterophyllum on cotton pellet-induced granulomain ratsrdquo Journal of Medical Plants Research vol 4 no 15 pp1566ndash1569 2010
[17] MAhmadWAhmadMAhmadM Zeeshan andF ShaheenldquoNorditerpenoid alkaloids from the roots of Aconitum hetero-phyllum Wall with antibacterial activityrdquo Journal of EnzymeInhibition andMedicinal Chemistry vol 23 no 6 pp 1018ndash10222008
[18] M Nagarajan G R Kuruvilla K S Kumar and P Venkata-subramanian ldquoPharmacology of Ativisha Musta and theirsubstitutesrdquo Journal of Ayurveda and Integrative Medicine vol6 no 2 pp 121ndash133 2015
[19] A K Subash and A Augustine ldquoHypolipidemic effect ofmethanol fraction of Aconitum heterophyllum wall ex Royleand the mechanism of action in diet-induced obese ratsrdquoJournal of AdvancedPharmaceutical TechnologyampResearch vol3 no 4 pp 224ndash228 2012
[20] T Baytop Therapy with Medicinal Plants (Past and Present)Istanbul University Publications Istanbul Turkey 1984
[21] M Wessner B Champion J-P Girault N Kaouadji B Saidiand R Lafont ldquoEcdysteroids from Ajuga ivardquo Phytochemistryvol 31 no 11 pp 3785ndash3788 1992
[22] AHelen K Krishnakumar P L Vijayammal andK T AugustildquoAntioxidant effect of onion oil (Allium cepa Linn) on thedamages induced by nicotine in rats as compared to alpha-tocopherolrdquoToxicology Letters vol 116 no 1-2 pp 61ndash68 2000
[23] J W Lampe ldquoHealth effects of vegetables and fruit assessingmechanisms of action in human experimental studiesrdquo Amer-ican Journal of Clinical Nutrition vol 70 no 3 pp 475ndash4901999
[24] M A E Mahmood ldquoEfficacy of crude extracts of garlic (Alliumsativum Linn) against nosocomial Escherichia coli Staphylo-coccus aureus Streptococcus pneumoniea and Pseudomonas
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 19
aeruginosardquo Journal ofMedicinal Plants Research vol 3 pp 179ndash185 2009
[25] J Bhandari B Muhammad P Thapa and B G ShresthaldquoStudy of phytochemical anti-microbial anti-oxidant and anti-cancer properties of Allium wallichiirdquo BMC Complementaryand Alternative Medicine vol 17 no 102 pp 1ndash9 2017
[26] M Irshad Habib-Ur-Rehman M Shahid S Aziz and TGhous ldquoAntioxidant antimicrobial and phytotoxic activities ofessential oil of angelica glaucardquoAsian Journal of Chemistry vol23 no 5 pp 1947ndash1951 2011
[27] J Suresh N Mahesh J Ahuja and K Santilna ldquoReview onArtemisia nilagirica (Clarke) Pamprdquo Journal of BiologicallyActive Products from Nature vol 1 no 2 pp 97ndash104 2011
[28] M Shilpi M Ashish T Mayank S Ajay and S AlokldquoInvestigations on hypolipidemic activity of Asparagus filicinusBuch-Ham ex D Donrdquo International Journal of PharmaceuticalScience and Research vol 8 no 2 pp 813ndash818 2017
[29] MM Papiya S Das S Das andM K Das ldquoPhyto-pharmacol-ogy of Berberis aristata DC a reviewrdquo Journal of Drug DeliveryampTherapeutics vol 1 no 2 pp 46ndash50 2011
[30] A Shabbir M Shahzad Y Arfat et al ldquoBerberis lyciumroyle a review of its traditional uses phytochemistry andpharmacologyrdquoAfrican Journal of Pharmacy and Pharmacologyvol 6 no 31 pp 2346ndash2353 2012
[31] R Chauhan K Ruby and J Dwivedi ldquoBergenia ciliata mineof medicinal properties a reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 15 no 2 pp20ndash23 2012
[32] K M Ruby R Chauhan S Sharma and J Dwivedi ldquoPolyphar-macological activities of bergenia speciesrdquo International Journalof Pharmaceutical Sciences Review and Research vol 13 no 1pp 100ndash110 2012
[33] M H V Kumar and Y K Gupta ldquoEffect of different extracts ofCentella asiatica on cognition andmarkers of oxidative stress inratsrdquo Journal of Ethnopharmacology vol 79 no 2 pp 253ndash2602002
[34] B M Hausen ldquoCentella asiatica (Indian pennywort) an effec-tive therapeutic but a weak sensitizerrdquo Contact Dermatitis vol29 no 4 pp 175ndash179 1993
[35] M N Somchit M R Sulaiman A Zuraini et al ldquoAntinocicep-tive and antiinflammatory effects of Centella asiaticardquo IndianJournal of Pharmacology vol 36 no 6 pp 377ndash380 2004
[36] M Shah and M Panchal ldquoEthnopharmacological propertiesof Cinnamomum tamala - A reviewrdquo International Journal ofPharmaceutical Sciences Review and Research vol 5 no 3 pp141ndash144 2010
[37] A-U Hassan M Ajaib M Anjum S Z Siddiqui and N ZMalik ldquoInvestigation of antimicrobial and antioxidant activitiesof cirsium wallichii DCrdquo Biologia (Pakistan) vol 62 no 2 pp297ndash304 2016
[38] S Gopalakrishnan and T Kalaiarasi ldquoDetermination of bio-logically active constituents of the fruits of Cucumis sativuslinn Using gc-ms analysisrdquo International Journal of Biology andPharmaceutical Research vol 4 no 7 pp 523ndash527 2013
[39] C C Araujo and L L Leon Biological Activities of Curcumalonga L vol 96 Memoir Institute Oswaldo Cruz Rio de JaneiroBrazil 2001
[40] S Ghosh S P Vijay M Piyush D D Dilip and A C BaluldquoPhytochemistry and therapeutic potential of medicinal plantDioscorea bulbiferardquoMedicinal Chemistry vol 5 no 4 pp 160ndash172 2015
[41] S K Mandal R Boominathan B Parimaladevi S Dewanjeeand S C Mandal ldquoAnalgesic activity of methanol extract ofEupatorium adenophorum Spreng Leavesrdquo Indian Journal ofExperimental Biology (IJEB) vol 43 no 7 pp 662-663 2005
[42] A Kundu S Saha SWalia NA Shakil J Kumar andKAnna-purna ldquoCadinene sesquiterpenes from Eupatorium adenopho-rum and their antifungal activityrdquo Journal of EnvironmentalScience and Health Part B Pesticides Food Contaminants andAgricultural Wastes vol 48 no 6 pp 516ndash522 2013
[43] P M Njogu G N Thoithi J W Mwangi et al ldquoPhytochem-ical and Antimicrobial Investigation of Girardinia diversifolia(Link) Friis (Urticaceae)rdquo East and Central African Journal ofPharmaceutical Sciences vol 14 pp 89ndash94 2011
[44] T Kaur G Singh and D K Kapoor ldquoA review on pharma-cognostic phytochemical and pharmacological data of variousspecies of Hippophae (Sea buckthorn)rdquo International Journal ofGreen Pharmacy vol 11 no 1 pp 62ndash75 2017
[45] K J Anderson S S Teuber A Gobeille P Cremin A LWaterhouseand FM Steinberg ldquoWalnut polyphenolics inhibitin vitro human plasma andLDLoxidationrdquo Journal ofNutritionvol 131 no 11 pp 2837ndash2842 2010
[46] M Carvalho P J Ferreira V S Mendes et al ldquoHuman cancercell anti proliferative and antioxidant activities of Juglans regiaLrdquo Food and Chemical Toxicology vol 48 no 1 pp 441ndash4472010
[47] I Oliveira A Sousa I C F R Ferreira A Bento L Estevinhoand J A Pereira ldquoTotal phenols antioxidant potential andantimicrobial activity of Walnut (Juglans regia L) green husksrdquoFood and Chemical Toxicology vol 46 no 7 pp 2326ndash23312008
[48] P Singh R Singh N Satib O P Satia and N Kumar ldquoAntiox-idant and antibacterial activity of jurinea dolomiaea boissextractsrdquo International Journal of Life Sciences and ScientificResearch vol 1 no 2 pp 74ndash78 2015
[49] H B Parmar S K Das and K J Gohil ldquoHepatoprotectiveactivity ofMacrotyloma uniflorum seed extract onparacetamoland d-galactosamine induced liver toxicity in albino ratsrdquoInternational Journal of Pharmacological Research vol 2 no 2pp 86ndash91 2012
[50] S Bhuvaneshwari D K Sushmitha and G V Shastri ldquoInflu-ence of hot extract of Dolichos biflorus (Horse gram) on bodyweight in overweight or obese human volunteersrdquo InternationalJournal of Pharmaceutical and Biological Archives vol 5 no 1pp 29ndash32 2014
[51] A Peshin and S K Singla ldquoAnticalcifying properties ofDolichos biflorus (Horse gram) seedsrdquo Indian Journal of Exper-imental Biology (IJEB) vol 32 no 12 pp 889ndash891 1995
[52] L H Gupta S L Badole S L Bodhankar and S G SabharwalldquoAntidiabetic potential of 120572-amylase inhibitor from the seedsof Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic micerdquo Pharmaceutical Biology vol 49 no 2pp 182ndash189 2011
[53] B Basak S G Majumdar U Bhattacharya S Laskar ABandopadhyay and S K Sen ldquoEffect of different fractions ofmethanolic extract of the seeds of Dolichos biflorus on somemicroorganismsrdquo Indian Journal of Experimental Biology vol32 no 12 pp 889ndash891 1994
[54] M Mahboubi and N Kazempour ldquoChemical compositionand antimicrobial activity of peppermint (Mentha piperita L)Essential oilrdquo Songklanakarin Journal of Science and Technologyvol 36 no 1 pp 83ndash87 2014
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
20 Evidence-Based Complementary and Alternative Medicine
[55] M J Martınez J Betancourt N Alonso-Gonzalez and AJauregui ldquoScreening of some Cuban medicinal plants forantimicrobial activityrdquo Journal of Ethnopharmacology vol 52no 3 pp 171ndash174 1996
[56] G Amatya and V M Sthapit ldquoA note on Nardostachys jata-mansirdquo Journal of Herbs Spices amp Medicinal Plants vol 2 no2 pp 39ndash47 1994
[57] S Ali K A Ansari M A Jafry H Kabeer and G DiwakarldquoNardostachys jatamansi protects against liver damage inducedby thioacetamide in ratsrdquo Journal of Ethnopharmacology vol 71no 3 pp 359ndash363 2000
[58] R Subashini S Yogeeta A Gnanapragasam and T DevakildquoProtective effect of Nardostachys jatamansi on oxidative injuryand cellular abnormalities during doxorubicin-induced cardiacdamage in ratsrdquo Journal of Pharmacy and Pharmacology vol 58no 2 pp 257ndash262 2006
[59] M S Rahman M M H Khan and M A H M Jamal ldquoAnti-bacterial evaluation and minimum inhibitory concentrationanalysis of Oxalis corniculata and Ocimum sanctum againstbacterial pathogensrdquo Biotechnology vol 9 no 4 pp 533ndash5362010
[60] S Rahman R Islam M Kamruzzaman A Khasrul and H MJ Abu ldquoOcimum sanctum L A review of photochemical andpharmacological profilerdquo American Journal of Drug Discoveryand Development pp 1ndash15 2011
[61] K J Achola JW Mwangi and RWMunenge ldquoPharmacolog-ical activity of oxalis corniculatardquo Pharmaceutical Biology vol33 no 3 pp 247ndash249 1995
[62] K R Kırtikara and B D Basu Indian Medicinal Plants TheIndian Press Allahaba India 1st edition 1988
[63] M P Raghavendra S Satish and A Raveesha ldquoPhytochemicalanalysis and antibacterial activity of Oxalis corniculata aknown medicinal plantrdquo Mycological Science vol 1 pp 72ndash782006
[64] Z K Shinwari A A Khan andTNakaikeMedicinal andOtherUseful Plants of District Swat Pakistan Al-Aziz Communica-tions Peshawar Pakistan 2003
[65] A Gupta A Khajuria J Singh et al ldquoImmunomodulatoryactivity of biopolymeric fraction RLJ-NE-205 from Picrorhizakurroardquo International Immunopharmacology vol 6 no 10 pp1543ndash1549 2006
[66] P C Verma V Basu V Gupta G Saxena and L U RahmanldquoPharmacology and chemistry of a potent hepatoprotectivecompound picroliv isolated from the roots and rhizomes ofpicrorhiza kurroa royle ex benth (Kutki)rdquo Current Pharmaceu-tical Biotechnology vol 10 no 4 pp 1ndash9 2009
[67] H Khan M Saeed A H Gilani et al ldquoBronchodilator activityof aerial parts of Polygonatum verticillatum augmented byanti-inflammatory activity attenuation of Ca2+ channels andlipoxygenaserdquo Phytotherapy Research vol 27 no 9 pp 1288ndash1292 2013
[68] H Khan M Saeed A-H Gilani et al ldquoAntispasmodic andantidiarrheal activities of rhizomes of Polygonatum verticil-latum maneuvered predominately through activation of K+channels components identification through TLCrdquo Toxicologyamp Industrial Health pp 1ndash9 2013
[69] H Khan M Saeed M A Khan et al ldquoAntimalarial andfree radical scavenging activities of rhizomes of Polygonatumverticillatum supported by isolated metabolitesrdquo MedicinalChemistry Research vol 21 no 7 pp 1278ndash1282 2012
[70] H KhanM Saeed NMuhammad and S Perviz ldquoPhytochem-ical analysis antibacterial and antifungal assessment of aerial
parts of Polygonatum verticillatumrdquo Toxicology amp IndustrialHealth vol 32 no 5 pp 841ndash847 2016
[71] B Roy A Swargiary D Syiem and V Tandon ldquoPotentillafulgens (Family Rosaceae) a medicinal plant of north-eastIndia A natural anthelminticrdquo Journal of Parasitic Diseases vol34 no 2 pp 83ndash88 2010
[72] K R Kritikar and B D Basu Indian Medicinal Plants BishenSingh Mahendra Pal Singh Dehradun India 1984
[73] A R M R Amin O Kucuk F R Khuri and D M ShinldquoPerspectives for cancer prevention with natural compoundsrdquoJournal of Clinical Oncology vol 27 no 16 pp 2712ndash2725 2009
[74] N Arun and D P Singh ldquoPunica granatum a review on phar-macological and therapeutic propertiesrdquo International Journalof Pharmaceutical Science and Research vol 3 no 5 pp 1240ndash1245 2012
[75] S PDDwivedi V B Pandey AH Shah andY B Rao ldquoChem-ical constituents of Rhamnus procumbens andpharmacologicalactions of emodinrdquo Phytotherapy Research vol 2 no 1 pp 51ndash53 1988
[76] A Paudel S Panthee S Shakya S Amatya T Shrestha andM Amatya ldquoAnalgesic anti-inflammatory and other phar-macological activities of methanol extract of rhododendroncampanulatum from Nepalrdquo European Journal of MedicinalPlants vol 13 no 4 pp 1ndash7 2016
[77] A J Mungole and A Chaturvedi ldquoDetermination of antioxi-dant activity of Hibiscus sabdariffa L and Rumex nepalensissprengrdquo International Journal of Pharma and Bio Sciences vol2 no 1 pp 120ndash127 2011
[78] R Gautam K V Karkhile K K Bhutani and S M JachakldquoAnti-inflammatory cyclooxygenase (COX)-2 COX-1 inhibi-tory and free radical scavenging effects of Rumex nepalensisrdquoPlanta Medica vol 76 no 14 pp 1564ndash1569 2010
[79] L Ghosh J R Gayen T Murugesan S Sinha M Pal and BP Saha ldquoEvaluation of purgative activity of roots of Rumexnepalensisrdquo Fitoterapia vol 74 no 4 pp 372ndash374 2003
[80] M-G Lee K-T Lee S-G Chi and J-H Park ldquoCostunolideinduces apoptosis by ROS-mediated mitochondrial permeabil-ity transition and cytochrome C releaserdquo Biological amp Pharma-ceutical Bulletin vol 24 no 3 pp 303ndash306 2001
[81] M M Pandey S Rastogi and A K S Rawat ldquoSaussureacostus botanical chemical and pharmacological review of anayurvedic medicinal plantrdquo Journal of Ethnopharmacology vol110 no 3 pp 379ndash390 2007
[82] P Semwal and S Painuli ldquoAntioxidant antimicrobial and GC-MS profiling of Saussurea obvallata (Brahma Kamal) fromUttarakhand Himalayardquo Clinical Phytoscience vol 5 no 12 pp1ndash11 2019
[83] D Joshi A B Melkani M Nailwal L Bisht and R PrasadldquoSelinum vaginatum c b clarke terpenoid composition andantibacterial activity of whole aerial parts and root essential oilrdquoJournal of Essential Oil Bearing Plants vol 21 no 5 pp 1176ndash1185 2018
[84] A Laxmi S Siddhartha and M Archana ldquoAntimicrobialscreening ofmethanol and aqueous extracts of Swertia ChiratardquoInternational Journal of Pharmacy and Pharmaceutical Sciencesvol 3 no 4 pp 142ndash146 2011
[85] SMedda S Mukhopadhyay andMK Basu ldquoEvaluation of thein-vivo activity and toxicity of amarogentin an antileishmanialagent in both liposomal and niosomal formsrdquo Journal ofAntimicrobial Chemotherapy vol 44 no 6 pp 791ndash794 1999
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Evidence-Based Complementary and Alternative Medicine 21
[86] S Banerjee T K Sur S Mandal P C Das and S SikdarldquoAssessment of the anti-inflammatory effects of Swertia chiratain acute and chronic experimental models in male albino ratsrdquoIndian Journal of Pharmacology vol 32 no 1 pp 21ndash24 2000
[87] J K Grover S Yadav and V Vats ldquoMedicinal plants of Indiawith anti-diabetic potentialrdquo Journal of Ethnopharmacology vol81 no 1 pp 81ndash100 2002
[88] H Verma P Patil R Kolhapure and V Gopalkrishna ldquoAntivi-ral activity of the Indian medicinal plant extract Swertiachirata against herpes simplex viruses a study by in-vitro andmolecular approachrdquo Indian Journal of Medical Microbiologyvol 26 no 4 pp 322ndash326 2008
[89] D Chandra K Prasad G Kohli M K Devrani G Bishtand B Pandey ldquoAntifungal activity of Swertia ciliata (Family-Gentianaceae) Acorus calamus (Family-Araceae) and Violaserpens (Family-Violaceae) from Pithoragarh UttarakhandHimalayas Indiardquo Journal of Medicinal Plant Studies vol 5 no6 pp 06ndash10 2017
[90] J L Shetty M S Farouk K Al-Obaidy J P Mohammed and SHidayatullah ldquoA brief review on medicinal plant Tagetes erectaLinnrdquo Journal of Applied Pharmaceutical Science vol 5 no 3pp 091ndash095 2015
[91] M Khan S C Verma S K Srivastava et al ldquoEssential oilcomposition of Taxus wallichiana Zucc from the NorthernHimalayan region of Indiardquo Flavour and Fragrance Journal vol21 no 5 pp 772ndash775 2006
[92] M Qayum M Nisar M R Shah et al ldquoAnalgesic and antiin-flammatory activities of taxoids from Taxus wallichiana ZuccrdquoPhytotherapy Research vol 26 no 4 pp 552ndash556 2012
[93] H Ali and S Dixit ldquoExtraction optimization of Tinosporacordifolia and assessment of the anticancer activity of its alkaloidpalmatinerdquo The Scientific World Journal vol 2013 Article ID376216 10 pages 2013
[94] N M Reddy and R N Reddy ldquoTinospora cordifolia chemicalconstituents and medicinal properties a reviewrdquo Scholars Aca-demic Journal of Pharmacy vol 4 no 8 pp 364ndash369 2015
[95] U Sharma M Bala N Kumar B Singh R K Munshi andS Bhalerao ldquoImmunomodulatory active compounds fromTinospora cordifoliardquo Journal of Ethnopharmacology vol 141 no3 pp 918ndash926 2012
[96] M Bnouham F-Z Merhfour A Ziyyat H Mekhfi M Azizand A Legssyer ldquoAntihyperglycemic activity of the aqueousextract of Urtica dioicardquo Fitoterapia vol 74 no 7-8 pp 677ndash681 2003
[97] M S Kataki V Murugamani A Rajkumari P S Mehra DAwasthi and R S Yadav ldquoAntioxidant hepatoprotective andanthelmintic activities of methanol extract of Urtica dioica LLeavesrdquo Pharmaceutical Crops vol 3 p 3846 2012
[98] J Balzarini J Neyts D Schols et al ldquoThe mannosespecificplant lectins fromCymbidium hybrid and Epipactis helleborineand the (Nacetylglucosamine) nspecific plant lectin fromUrticadioica are potent and selective inhibitors of human immun-odeficiency virus and cytomegalovirus replication in vitrordquoAntiviral Research vol 18 no 2 pp 191ndash207 1992
[99] A Brantner and E Grein ldquoAntibacterial activity of plantextracts used externally in traditional medicinerdquo Journal ofEthnopharmacology vol 44 no 1 pp 35ndash40 1994
[100] E R Guler ldquoInvestigation of chemopreventproperties of Urticadioica L in MCF7 and MDA 231 breast cancer cell linesrdquo NewJournal of Medicine vol 30 p 503 2013
[101] U S Harput I Saracoglu and Y Ogihara ldquoStimulation of lym-phocyte proliferation and inhibition of nitric oxide production
by aqueousUrtica dioica extractrdquoPhytotherapy Research vol 19no 4 pp 346ndash348 2005
[102] T P Singh andOM Singh ldquoPhytochemical and pharmacologi-cal profile of Zanthoxylum armatumDCmdashan overviewrdquo IndianJournal of Natural Products and Resources (IJNPR) vol 2 no 3pp 275ndash285 2011
[103] A T Peana P S DrsquoAquila F Panin G Serra P Pippia and MD L Moretti ldquoAnti-inflammatory activity of linalool and linalylacetate constituents of essential oilsrdquo Phytomedicine vol 9 no8 pp 721ndash726 2002
[104] A KhanM Rahman andM S Islam ldquoAntibacterial antifungaland cytotoxic activities of 3 5-diacetyltambulin isolated fromAmorphophallus campanulatus Blume ex Decnerdquo DARU Jour-nal of Pharmaceutical Sciences vol 16 no 4 pp 239ndash244 2008
[105] B Uniyal and V Shiva ldquoTraditional knowledge among medic-inal plants among rural women of the Garhwal HimalayaUttrakhandrdquo Indian Journal of Traditional Knowledge vol 4 no3 pp 259ndash266 2005
[106] H Sher R W Bussmann R Hart and H J De Boer ldquoTra-ditional use of medicinal plants among Kalasha Ismaeliand Sunni groups in Chitral District Khyber Pakhtunkhwaprovince Pakistanrdquo Journal of Ethnopharmacology vol 188 pp57ndash69 2016
[107] J A BhatM Kumar A K Negi andN P Todaria ldquoInformantsconsensus on ethnomedicinal plants in Kedarnath WildlifeSanctuary of Indian Himalayasrdquo Journal of Medicinal PlantsResearch vol 7 no 4 pp 148ndash154 2013
[108] P C Phondani R K Maikhuri L S Rawat et al ldquoEthnobotan-ical uses of plants among the Bhotiya tribal communities of nitivalley in central Himalaya Indiardquo Ethnobotany Research andApplications vol 8 pp 233ndash244 2010
[109] A M Abbasi M A Khan M Ahmed and M Zafar ldquoHerbalmedicines used to cure various ailments by the inhabitants ofAbbottabad district North West Frontier Province PakistanrdquoIndian Journal of Traditional Knowledge vol 9 no 1 pp 175ndash183 2010
[110] H Sher A Aldosari A Ali and H J De Boer ldquoIndigenousknowledge of folk medicines among tribal minorities in KhyberPakhtunkhwa northwestern Pakistanrdquo Journal of Ethnophar-macology vol 166 pp 157ndash167 2015
[111] S C Rana K J Tiwari R L Dangwal and S Gairola ldquoFaithherbal healer knowledge documents of Nanda Devi BiosphereReserveUttrakhand Indiardquo Indian Journal of Traditional Knowl-edge vol 2 pp 308ndash314 2013
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom
Stem Cells International
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
MEDIATORSINFLAMMATION
of
EndocrinologyInternational Journal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Disease Markers
Hindawiwwwhindawicom Volume 2018
BioMed Research International
OncologyJournal of
Hindawiwwwhindawicom Volume 2013
Hindawiwwwhindawicom Volume 2018
Oxidative Medicine and Cellular Longevity
Hindawiwwwhindawicom Volume 2018
PPAR Research
Hindawi Publishing Corporation httpwwwhindawicom Volume 2013Hindawiwwwhindawicom
The Scientific World Journal
Volume 2018
Immunology ResearchHindawiwwwhindawicom Volume 2018
Journal of
ObesityJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Computational and Mathematical Methods in Medicine
Hindawiwwwhindawicom Volume 2018
Behavioural Neurology
OphthalmologyJournal of
Hindawiwwwhindawicom Volume 2018
Diabetes ResearchJournal of
Hindawiwwwhindawicom Volume 2018
Hindawiwwwhindawicom Volume 2018
Research and TreatmentAIDS
Hindawiwwwhindawicom Volume 2018
Gastroenterology Research and Practice
Hindawiwwwhindawicom Volume 2018
Parkinsonrsquos Disease
Evidence-Based Complementary andAlternative Medicine
Volume 2018Hindawiwwwhindawicom
Submit your manuscripts atwwwhindawicom