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7/23/2019 Trafic Intracellulaire Et Compartiment Cellulaire
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Wrdlho hctrdofnnundhrf ft omkpdrthkfct ofnnundhrf
H + Hctrmguothmc
Wmutfs nfs prmthcfs smct ldarhqufs gdcs nf oytmpndskf# Fnnfs durmct pnushfurs gfsthcdthmcs
pmsshanfs : nf cmydu %ldotfur gf trdcsorhpthmc(. nd khtmoemcgrhf. nfs pfrmxysmkfs. nfs pndstfs
oefz nfs vitdux#
Hoh cmus pdrnfrmcs uchqufkfct gfs prmthcfs gfsthcfs du rthounuk fcgmpndskhquf irdcunfux
gmco gfsthcfs trf sortfs# Fcsuhtf fnnfs pdssfct gdcs nf Imnih quh fst uc odrrflmur pmur nfs
prmthcfs# Dprs nf Imnih. fnnfs pfuvfct smht fkpructfr nd vmhf gfs :
Nysmsmkf
Kfkardcf pndskhquf
\shounfs gf sorthmcs
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Fxohshmc gu pfpthgf shicdn quh nuh pfrkft g)trf fcidi gdcs nf rthounuk
fcgmpndskhquf#
Lmrkdthmc gf pmcts ghsunlurfs fctrf 1 rshgus oysthcf %gmco cf tmuoef pds tmutf nfs
prmthcfs( quh nfurs pfrkfttfct g)matfchr ucf omclmrkdthmc spohlhquf#
Inyomsyndthmc %smht C+inyomsyndthmc mu M+inyomsyndthmc(. fxtrkfkfct omkpnfxf odr
gurf pfcgdct tmut nf vmydif gf nd prmthcf kdhs sfrd spohlhquf g)uc omkpdrthkfct uc
dutrf#
Pemspemryndthmcs quh nhfu gdcs nf Imnih kmyfc
_unldtdthmc ft prmtmnysf quh omupf nfs prmthcfs fc pfthtfs pdrthfs
Ofctrf gf trh quh ohanf nfs prmthcfs vfrs nfs ? vmhfs ohtfs progfkkfct
Ofrtdhcfs ofnnunfs omcthfccfct ucf gfuxhkf vmhf gf sorthmc : nd vmhf gf sorthmc riunf
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HH + Nfs ghllrfcts mridcfnnfs hkpnhqus gdcs nd
sorthmc gfs prmthcfs
4 + Nfs rthounuk
Nf rthounuk fcgmpndskhquf irdcundhrf : hn fst
tdphss gf rhamsmkfs#
Nf rthounuk fcgmpndskhquf nhssf : hn c)fst pds
hkpnhqu gdcs nd trdcslmrkdthmc gfs prmthcfs
kdhs gdcs nd prmguothmc gf strmgfs ft g)dutrfs
omcsthtudcts#
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d + Dgrfssdif du rthounuk
Nfs prmthcfs sortfs vmct trf smukhsf ucf trdcsnmodthmc om+trdguothmccfnnf : nd lmrkdthmc
gf nd prmthcf sf ldht fc kkf tfkps qu)fnnf rfctrf gdcs nf rthounuk fcgmpndskhquf#
Nfs prmthcfs hctrdofnnundhrf ft cmc sortfs vmct trf smukhsf ucf trdcsnmodthmc
pmst+trdguothmccfnnf : nfs prmthcfs smct fcthrfkfct trdguhtf dvdct g)trf dgrfssfs nfurs
omkpdrthkfcts#
Dpprmoefs fxprhkfctdnfs pmur gtfrkhcfr n)dgrfssdif gfs prmthcfs :Punsf oedsf " dutmrdghmirdpehf : gtfrkhcdthmc gu nhfu gf syctesf ft gu trdjft gf kmnounfs
kdrqufs rdghmdothvfkfct
Lrdothmccfkfct ofnnundhrf " oermkdtmirdpehf. nfotrmpemrsf : prohsf dussh nd cdturf gfs omk+
pmss ft nfs kmghlhodthmcs suahfs#
Hkkucmoytmoehkhf : gtfothmc hc shtu
Ichf icthquf %prmthcfs gf lushmc mu oehkrfs( : suhvh gfs gpndofkfcts fc tfkps rfn
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Eypmtesf gu !shicdn! g)dgrfssdif du QF : I#Anmafn ft Gmaafcstfhc %4896(# Fxhstfcof g)uc
trdcsnmomc : prfuvf dppmrtf pdr n)nfotrmpeyshmnmihf %485?(# Hn fxhstf uc shicdn quh pfrkft du
prmthcf gf s)dgrfssfr dux rhamsmkfs#
Nf prmthcf _QP nhf nf pfpthgf shicdn ft pfrkft ndrrt gf nd trdguothmc# Hn fkkcf n)fcsfkanf
vfrs nd kfkardcf gu QF# Nd prmthcf _QP s)dssmohf du rofptfur gf nd _QP %etrmghkrf(quh fctrdcf ucf glmrkdthmc# Ofttf glmrkdthmc pfrkft :
nd ghssmohdthmc gf nd _QP du omkpnfxf quh rftmurcf fcsuhtf gdcs nf oytmsmn#
du pfpthgf shicdn gf s)fcimullrfr gdcs nf trdcsnmomc#
Fc trdvfrsdct nd kfkardcf gu rthounuk. nd trdguothmc vd rfprfcgrf# Nf pfpthgf shicdn fst ey+
grmpemaf. o)fst pmur d qu)hn pdssf nd kfkardcf ldohnfkfct# Nd shicdn pfpthgdsf vd onhvfr nf
pfpthgf shicdn#
N)dppdrfhn gf trdcsnmodthmc fst omkpms g)uc rofptfur gf nd pdrthounf _QP
a + Ahmsyctesf gfs prmthcfs kfkardcdhrfs
Nd prmthcfs vd dvmhr 1 gmkdhcfs eygrmpemafs : nf pfpthgf shicdn ft nf gmkdhcf
trdcs+kfkardcdhrf# Nmrsquf nd squfcof trdcs+kfkardcdhrf. rfctrf gdcs nf QF. nd trdguothmc
sdrrtf# Pdrlmhs nf pfpthgf shicdn cf sfrd pds onhv ft omctrhaufrd nd pdrthf eygrmpemaf trdcs+
kfkardcdhrf gf nd prmthcf#
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Prmthcfs kfkardcdhrfs gf typf 4 : nd pdrthf C+tfrkhcdnf sf trmuvf gdcs nd nukhrf gu
rthounuk#
Prmthcfs kfkardcdhrf gf typf 1 : nd pdrthf O+tfrkhcdnf sf trmuvf gdcs nd nukhrf gu
rthounuk#
Nfs typfs 4 ft 1 smct gtfrkhc sfnmc nd oedrif gfs 46 prfkhfrs dohgfs dkhcs gf pdrt ft g)dutrf
nd prmthcf# _h gu omt O+tfrkhcdn. mc d " 1 fc oedrif inmadnf ft gu omt C+tfrkhcdn. mc d 0.
mc ldht nd ghllrfcof O + C > 0 dnmrs nd prmthcf sfrd gf typf 1. sh O + C 3 0 dnmrs nd prmthcf ft
gf typf 4
o + Kmghlhodthmcs gfs prmthcfs
Nd pfpthgf ghsunlhgf hsmkrdsf : fnnf d ucf dothvht gf omrrfothmc %ofrtdhc pmct ghsunlurf sf lmctgf kdchrf frrmcs( ft fnnf tdanhf nfs amcs pmcts ghsunlurfs# Ofnd pfrkft nd prmthcf
g)dgmptfr nd amccf omclmrkdthmc %lmnghci(
1 typfs gf inyomsyndthmc :
C+inyomsyndthmc : nf suorf sf nht sur ucf dspdrdihcf kdhs hn ldut qudcg kkf ucf
squfcof omcsfcsus %Dsc+U(
M+inyomsyndthmc : nf suorf sf nhf smht ucf srhcf mu ucf termchcf
g + Nfs shicdux gf nmodnhsdthmc gdcs nf QF
Wrdcspmrt rtrmirdgf gu Imnih vfrs nf QF :
Prsfcof gf shicdux gf trh !rouprdthmc! pdr nf QF %nmrsquf nfs prmthcfs mct t trmp
nmhc ft qu)fnnfs c)mct rhfc ldhrf fc gfemrs gu rthounuk(
Fc ldht. nd rouprdthmc snfothvf gfs prmthcfs rshgfctfs gdcs nf rthounuk nfurs
pfrkfttfct gf suahr gfs kmghlhodthmcs pmst+trdguothmccfnnfs Fnnfs rfvhfccfct n)dhgf gfs vshounfs snfothvfs
Prhsmc muvfrtf
Prmthcfs rshgfctfs gf kfkardcf gu QF :
_hicdn BBUU %nyshcf+nyshc+DD+DD( nfxtrkht O+tfrkhcdnf gfs prmthcfs gf nd
kfkardcf gu QF
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_hicdn quh sf nhf ghrfotfkfct OMP4 fkadnndif gdcs gfs vshounfs OMP4
trdcspmrt rtrmirdgf vfrs nf QF
Prmthcfs rshgfctfs smnuanfs :
_hicdn BGFN %nyshcf+Dsp+Inu+Nfu( n)fxtrkht O+tfrkhcdnf gfs prmthcfs smnuanfs guQF
_hicdn quh cf sf nhf pds ghrfotfkfct OMP4 : prsfcof gf prmthcfs rofptrhofs
spohdnhsfs omkkf nf rofptfur BGFN
Qofptfur BGFN :
Prmthcf trdcskfkardchrf pnushfurs pdssdifs
_f nhf tmutf squfcof BGFN vshounf OMP4 trdcspmrt rtrmirdgf vfrs nf QF
Nfs rofptfur BGFN
Qfoyondif gu rofptfur BGFN :
\WO-Imnih
Lmrtf dllhcht pmur nd squfcof BGFN
Odpturf gfs prmthcfs rshgfctfs gu QF quh sf smct oedppfs ft quh smct ldhanf
omcofctrdthmc
Khnhfu nirfkfct dohgf nhdhsmc
Gdcs nf QF
Ldhanf dllhcht pmur nd squfcof BGFN
Nhardthmc gu odrim kdnir nd lmrtf omcofctrdthmc fc prmthcfs rshgfctfs gu QF
pmrtdct nf shicdn BGFN
Khnhfu pE cfutrf nhardthmc
Wrdjft rtrmirdgf gfs
prmthcfs rshgfctfs gdcs nf QF :
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Kdhcthfct gfs prmthcfs rshgfctfs gu QF gdcs nf QF :
BGFN - BGFN rofptfur
Prmthcf rshgfctf sdcs smc BGFN sorthmc gf nd prmthcf. kdhs sorthmc nfctf
BGFN - BGFN rofptfur cf sfrvhrdht quf pmur ldhrf rfvfchr nfs prmthcfs quh sf smct
oedppfs
Dutrf kodchskf : diridthmc gfs prmthcfs fctrf+fnnfs t rmp irms pmur ucf vshounf
1+ N)dppdrfhn gf Imnih
Prfkhfr mridchtf gorht pdr nfs khormsomphstfs nd lhc gu 48kf# Dooukundthmc gf pftht sdo+
ounfs ghrfotfkfct fc nhdhsmc dvfo nf QF
Nd ldof ohs : fst nd pnus prmoef peyshqufkfct gu QF
Nd pdrthf kghdc
Nd ldof trdcs : nd pdrthf nd pnus nmhicf gu QF nf rsfdu trdcs+imnihfc. vrhtdanf odr +
rflmur gf nd ofnnunf
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d+ Qnf gu omkpnfxf imnihfc
_yctesf gf inyomprmthcfs ft gf prmtminyodcfs
Kmghlhodthmcs gfs oedcfs C+nhfs vfrs gfs oedcfs fxpmrtdanfs pdr djmut gf cmuvfdux
msfs M+inyomsyndthmc sur gfs prmthcfs
Irflldif gf suorfs sur ofrtdhcs nhphgfs inyomnhphgfs
Onhvdifs prmtmnythqufs
Ofrtdhcfs prmthcfs gfsthcfs nd sorthmc gfvrmct suahr pnushfurs onhvdifs. ofux+oh.
dkmros gdcs nf WIC sf pmursuhvfct gdcs nfs irdhcs gf sorthmc
Ofctrf gf trh Nfs sdoounfs gu Imnih lmct n)majft g)oedcifs dctrmirdgfs ft rtrmirdgfs pdr gfs
vshounfs kdctfdu OMP4
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a + Nf rsfdu trdcs+imnihfc %WIC( fst uc ofctrf gf trh
Nfs kdccmsf < pemspedtf : shicdn gf ohandif vfrs nd vmhf nysmsmkdnf
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HHH Nf trdlho vshoundhrf
Nf trdcspmrt vshoundhrf gmht pfrkfttrf :
nf kdhcthfct gf nd syktrhf gf nd kfkardcf %nd omkpmshthmc gf nd kfkardcf gu Imnih
c)fst pds nd kkf quf nd kfkardcf pndskhquf( Hn gmht y dvmhr uc ohandif gfs vshounfs.fnnf gmhvfct sf rfcgrf du amc fcgrmht#
nf trdcspmrt gfs kmnounfs smnuanfs quh cf pfuvfct pdssfr nfs kfkardcfs sfunfs#
4rf tdpf : amurifmccfkfct pdrthr gu omkpdrthkfct gmccfur#
1kf tdpf : lmrkdthmc gf nd vshounf quh gmht trf ohanf vfrs gfs omkpdrthkfcts
spohlhqufs %sf ldht n)dhgf gfs prmthcfs _CDQF( ?kf tdpf : lushmc dvfo nd kfkardcf rofptrhof
quhnharf fctrf nfs omkpdrthkfcts :
fctrfs ; smrthfs
pmur nfs kfkardcfs ft pmur nfs odrims %of quh fst trdcspmrt(
uc dnnfr ft uc rftmur
snfothvht %gfs odrims trdcspmrts ft gfs gfsthcdthmcs(
Prmankf : sh hn y d uc oedcif pfrkdcfct fctrf nfs omkpdrthkfcts. hn y durd uc kndcif gfs
kmnounfs ft tfrkf. nfs omkpdrthkfcts lhchrmcs pdr trf hgfcthquf#
Nd smnuthmc : kdrqufurs kmnoundhrfs fxprhks nd surldof oytmsmnhquf gfs kfkardcfs
Ktemgfs g)dpprmoefs :
_ystkfs sdcs ofnnunfs
Prmthcfs gf lushmc dvfo nd ILP
Icthquf
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nkfcts g)dpprmoef :
4# Nfs typfs gf vshounfs
1# Dssfkandif gu kdctfdu %nfs IWPdsfs(
?# Iuhgdif gu trdcspmrt %nfs _CDQF(
7#
Dkdrrdif %prmthcfs Qda6# Lushmc
4 Nfs typfs gf vshounfs
Nf rfomuvrfkfct gf nd ldof oytmsmnhquf gfs vshounfs vd pfrkfttrf nd amurifmccfkfct. fcsuhtf
of kdctfdu ghspdrdt ft hn y durd lushmc gf nd kfkardcf#
Nfs 1 rnf gu kdctfdu : Omcofctrdthmc gf prmthcfs kfkardcdhrfs gdcs uc pdtoe quh lmrkfrd nd vshounf
pfrkft nd snfothmc gfs kmnounfs trdcspmrtfr
Kmunf nd vshounf quh durd dhcsh tmujmurs d pfu prs nd kkf tdhnnf
Nfs ? typfs gf kdctfdu gfs vshounfs rfomuvfrtfs :
ondterhcf
OMP4
OMP1
Mc pfut nfs ghsthciufr fc khormsomphf nfotrmchquf
Vthnhsdthmc gfs ghllrfcts kdctfdux gdcs nf trdlho vshoundhrf :
Ondterhcf : pdrthr ft pdrthr gf nd kfkardcf pndskhquf %du kmhcs ? typfs gf vshounfs
ondterhcf(
OMP4 ft OMP1 : pdrthr gur QF ft gu Imnih
afduomup g)dutrfs
1 + Dssfkandif gu kdctfdu %nfs IWPdsfs(
d Fxfkpnf gf nd ondterhcf %ods nf pnus tugh(
Vcf smus+ucht gf ondterhcf ; ? irmssfs oedcfs " ? pfthtfs oedcfs
Vcf smus+ucht ; uc trhsbnhmc
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Dssfkandif gfs trhsbfnhmcs fc uc pdchfr g)efxdimcfs ft gf pfctdimcfs
Nfs trhsbfnhmcs pfuvfct s)dssfkanfr spmctdckfct fc pdchfr kkf sdcs kfkardcf#
Nf kdctfdu gf ondterhcf 2
Vc kdctfdu ; ?< trhsbnhmc %sdcs nd vshounf( 41 pfctdimcfs " < efxdimcfs
Lmrkdthmc gf 1 omquhnnfs :
fxtfrcf
hctfrcf : gmkdhcf C+tfrkhcdux gfs oedcfs nmurgfs mu sf lhxfct nfs dgdpthcfs
_ur ucf vshounf : 41 pfctdimcfs " afduomup pnus g)efxdimcfs
N)dgdpthcf :
Prmthcf gf kdctfdu ondterhcf
Omkpnfxf kunthprmthquf
Nhf nd ondterhcf nd kfkardcf
Phif nfs prmthcfs trdcskfkardcdhrfs gmct nfs rofptfurs quh odpturfct nfs odrims
smnuanfs
Du kmhcs 7 typfs g)dgdpthcf pmur nfs ghllrfcts rofptfurs gf odrim
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Dssfkandif ft gsdssfkandif g)uc kdctfdu gf ondterhcf :
Nfs dgdpthcfs sf nhfct nd ondterhcf ft du omkpnfxf odrim-odrim+r
Gycdkhcf ; IWPdsf
Phcofkfct gf nd kfkardcf :
Gycdkhcf " dutrfs prmthcfs
Lushmc gfs lfuhnnfts cmc oytmsmnhqufs %irof nd gycdkhcf(
Pfrtf gu kdctfdu :
Nd vshounf quhttf nd kfkardcf
Nf kdctfdu gf ondterhcf fst pfrgu hkkghdtfkfct
hctfrvfcthmc gf oedpfrmccfs gf nd ldkhnnf gfs esp90 %DWPdsf(
duxhnnhcf dothvf n)DWPdsf
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Nd vshounf gmht dttfcgrf g)trf omcsthtuf pmur quf nf kdctfdu sf rfthrf
_pohlhoht gu kdctfdu :
Kodchskfs icrdux hgfcthqufs
Kdhs oedquf kfkardcf sfs spohlhohts
kfkardcf pndskhquf %rhoef fc oemnfstrmn( : cofsshtf gf afduomup gcfrihf dutrfs kfkardcfs : fxhstfcof gf amurifmccfkfcts
Wmutfs nfs vshounfs cf smct pds sperhqufs :
Kfkardcfs omctfcdct gfs prmthcfs lnumrfsofctfs
Nmci tuaunfs quh kdcfct gfs fcgmsmkfs ft rsfdu trdcs+imnihfc %WIC(
Ofs tuaunfs pfuvfct sfrvhr gf trdcspmrtfurs %irdcg rdppmrt surldof - vmnukf(
ucf vshounf pfut trf tuaundhrf $
N)dothvdthmc gf of systkf kdroef omkkf nf systkf Bhcdsf mu Pemspedtdsf kdhs dvfo gfs
prmthcfs spohlhqufs#
a Omctrnf gf n)dssfkandif gu kdctfdu : IWP ahcghci prmtfhcs %rdppfn(
Nf systkf lmcothmccf omkkf nd shicdnhsdthmc pdr pemspemryndthmc kdhs dvfo nd IWP ahcghci
prmtfhc %gmco nf soekd gf grmhtf(
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IWP ahcghci prmtfhcs
1 tdts
Dothl dvfo nhdhsmc gf IWP
Hcdothl dvfo nhdhsmc gf IGP 1 typfs
Kmcmkrhquf %; IWPdsfs kmcmkrhqufs(nfs khfux omccufs
Wrhkrhquf %; IWPdsfs trhkrhqufs ; prmthcfs I(
Pdssdif g)uc tdt d n)dutrf pdr
IFLs %Iudchcf+cuonfmthgf+Fxoedcif Ldotmrs( IGP IWP
IDPs %IWPdsf+Dothvdthci Prmtfhcs( IWP IGP
o + Prmthcfs dutrfs quf nd ondterhcf
Omp4 : 9 smus+uchts prmthqufs %dcdnmihfs dvfo n)dgdpthcf(
+ amurifmccfkfct pdrthr gu Imnih
Omp1 : 7 smus+uchts prmthqufs
+ Amurifmccfkfct pdrthr gu QF
IWPdsfs gf rforutfkfct gu kdctfdu : nd squfcof
+ Vcf vshounfs OMP1 fst sur nf pmhct gf amurifmccfkfct
+#######
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IWPdsfs gf rforutfkfct gu kdctfdu : nfs dotfurs :
Kfkardcf gu QF
_dr 4 IGP %; IWPdsfs gf rforutfkfct gu kdctfdu( lmrtf omcofctrdthmc. oytmsmnhquf.
hcdothvf
IFL %Iudchcf+cuonfmthgf+Fxoedcif Ldotmr(
IWPdsfs gf rforutfkfct gu kdctfdu : nd squfcof :
Vcf vshounf OMPHH fst sur nf pmhct gf amurifmccfr%gu QF(# Vcf IFL spohlhquf
%prmthcf gf kfkardcf gu QF dppfnf _fo 41( sf nhf d nd _dr 4 gu oytmsmn ft rfkpndof nf IGP
gf nd _dr 4 pdr gu IWP# Nd _dr 4 IWP nharf ucf qufuf g)dohgf irds nuh pfrkfttdct gf sf lhxfr
gdcs nd kfkardcf gu QF puhs rforutf gfs smus+uchts gf OMPHH# Nd kfkardcf amurifmccf
fc hconudct gfs prmthcfs kfkardcdhrfs snfothmccfs
Gsdssfkandif gu kdctfdu :
IWPdsfs gf rforutfkfct gu kdctfdu
Eygrmnysf gu IWP fc IGP
Nd qufuf fst fxonuf gf nd kfkardcf
gsdssfkandif gu kdctfdu
O)fst nf tfkps quh lhcht pdr gonfcoefr n)eygrmnysf
?# Iuhgdif gu trdcspmrt %nfs _CDQF(
Darvhdthmcs
+ _CDQFs : _CDP rfofptmrs
+ _CDPs : _mnuanf C_L Dttdoefkfct Prmtfhcs
+ C_L : C+fteyn
Qfomccdhssdcof vshounf gf trdcspmrt kfkardcf ohanf
Wmutfs nfs vshounfs gf trdcspmrt mct gfs kdrqufurs gf surldof spohlhqufs gf nfur mrh+
ihcf ft gf nfur odrim
Nfs kfkardcfs ohanfs mct gfs rofptfurs omkpnkfctdhrfs
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Qfomccdhssdcof vshounf gf trdcspmrt kfkardcf ohanf :
4# _CDQFs
_pohlhoht
Odtdnysfur gf nd lushmc
1# Qdas %IWPdsfs ohanf(
Dkdrrdif hchthdn
Lhxdthmc gf nd vshounf
Fc omnndamrdthmc dvfo g)dutrfs prmthcfs
_CDQFs
Du kmhcs 10 fspofs ghllrfctfs
Prmthcfs trdcs+kfkardcdhrfs Kdroefct pdr 1 :
v+_CDQFs %vfshonf( onfl
t+_CDQFs %tdrift ; ohanf( sfrrurf
Gmkdhcf enhomgdnf quh s)fcrmunf n)uc gdcs n)dutrf omkpnfxf trdcs+_CDQF quh
omctrhauf
Qnf gfs _CDQFs gdcs nf iuhgdif gfs vshounfs gf trdcspmrts
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Omkpnfxf trdcs+_CDQF :
Wmujmurs 7 enhof dnped
? lmrkfs pdr t+_CDQF
4 lmrkf pdr v+_CDQF
Hoh ? prmthcfs v+_CDQF 4 enhof %sycdptmarvhcf(
t+_CDQF 4 enhof %syctdxhcf(
t+_CDQF 1 enhofs %_cdp 16 :
prmthcf prhperhquf(
Gsdssfkandif gu omkpnfxf trdcs+_CDQF
prfs lushmc nf omkpnfxf _CDQF fst stdanf gdcs nd kfkardcf
Gmht trf gsdssfkanf C_L %Cfteynkdnfhkhgf+sfcshthvf+lushmc+prmtfhc(
C_L :
Oyonf fctrf nfs kfkardcfs ft nf oytmsmn
Odtdnysf nf gsdssfkandif
DWPdsf
Qfssfkanf d ucf oedpfrmccf oytmsmnhquf quh smnuahnhsf ft dhgf d rfpnhfr omrrfotfkfct
nfs prmthcfs gcdturfs Grmunf nfs enhofs gfs _CDQFs
fc omnndamrdthmc dvfo gfs prmthcfs dgdptdtrhofs
Ghssmohdthmc g)ucf pdhrf v+_CDQF t+_CDQF pdr C_L ucf lmhs nf oyonf gf lushmc
tfrkhc
C_L " gfs prmthcfs dgdptdtrhofs eygrmnysf DWP " spdrdthmc gfs _CDQFs
Nd ghssmohdthmc rfiunf qudcg ft mu nfs kfkardcfs vmct lushmccfr
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7# Dkkdridif %prmthcfs Qda(
Qnf hkpmrtdct gfs prmthcfs Qda gdcs nd spohlhoht gu trdcspmrt vshoundhrf
Prmthcfs Qda :
IWPdsfs kmcmkrhqufs Pnus gf ?0 kfkarfs nd pnus irdcgf smus+ldkhnnf gf IWPdsfs kmcmkrhqufs
Ghstrhauthmc odrdotrhsthquf sur nfs kfkardcfs ofnnundhrfs
Oedquf mridchtf d du kmhcs ucf prmthcf Qda sur sd ldof oytmsmnhquf
Ldohnhtfct ft riunfct :
Nf tdux g)dkdrrdif gfs vshounfs
ft n)dppdrhfkfct gfs v+ t+_CDQFs
Omkkf nfs IWPdsfs gf rforutfkfct gu kdctfdu fnnfs oyonfct fctrf nd kfkardcf ft nfoytmsmn
Omkkf nfs IWPdsfs gf rforutfkfct gu kdctfdu. 1 tdts :
Hcdothl dvfo nhdhsmc gf IGP gdcs nf oytmsmn
Dothl dvfo nhdhsmc gf IWP dssmohf ucf kfkardcf
Nfs prmthcfs Qda smct ghllrfctfs sfnmc nfs omkpdrthkfcts sua+ofnnundhrfs
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Nfs fllfotfurs gf Qda :
Qfomccdhssdcof gf Qda %Nhf. IWP( pdr uc Qda fllfotfur
Irms omkpnfxf prmthquf
Wrs vdrhdanf g)ucf prmthcf Qda d ucf dutrf
Pdrlmhs nmciufs prmthcfs lhndkfctfusfs quh nhkhtfct nf kmuvfkfct gfs vshounfs fctrfgfs ohtfrcfs imnihfccfs dgjdofctfs
_f nhfct d Qda ft fkpoefct n)eygrmnysf prkdturf gu IWP
G)dutrfs smct gfs kmtfurs quh ghrhifct nfs vshounfs vfrs nfur gfsthcdthmc
Prmthcfs Qda %suhtf(
Dihssfct sur nfs prmthcfs gf omctrnf gfs _CDQFs
Doonrfct nf prmofssus gf rfomccdhssdcof gfs _CDQFs fctrf fnnfs
Doevfct nf vfrrmuhnndif gf nd vshounf d sd ohanf pdr dppdrhfkfct gfs _CDQFs quh sfrdprtf pmur nd lushmc
prfs nd lushmc. nd prmthcf Qda eygrmnysf smc IWP nhf ft rftmurcf gdcs nf oytmsmn
6# Lushmc
Ghsthciufr dkdrrdif gf lushmc
Lushmc cf ldht pds tmujmurs suhtf d dkdrrdif :fx : fxmoytmsf riunf Dkdrrdif : nfs prmthcfs gfs kfkardcfs hctfrdihssfct ft dgerfct
Lushmc : nfs omuoefs nhphghqufs pfuvfct sf jmhcgrf cofsshtf
g)fxtrushmc g)fdu prmthcfs gf lushmc pmur rsmugrf nf prmankf
cfrithquf % gycdkhcf du omurs gu amurifmccfkfct gfs vshounfs d
ondterhcf(
Kmgnf gf omcofctrdthmc gfs prmthcfs _CDQFs du omurs gf nd
lushmc gf kfkardcf Gfs nhpmsmkfs %hc vhtrm( v+_CDQFs " gfs nhpmsmkfs t+_CDQFs
lushmc nfctf
Hctfrvfcthmc %gdcs nd ofnnunf( g)dutrfs prmthcfs :
pmur hchthfr nd lushmc
mu pmur rfthrfr gfs prmthcfs hcehahtrhofs
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Hkpmrtdcof gfs pecmkcfs gf lushmc gf kfkardcf :
Wrdcspmrt vshoundhrf
Lomcgdthmc %lushmc mmnfkkf spfrkdtmzmgf(
Lushmc gfs kymandstfs
Kdhcthfc gf nhgfctht gfs ofnnunfs Kdhcthfc gf nhgfctht gfs omkpdrthkfcts hctrdofnnundhrfs
Kmgf gfctrf gfs vhrus d fcvfnmppf gdcs nfs ofnnunfs
GH_OQHKHCDWHMC FCWQF \MHF OMC_WHWVWH\F FW \MHF QIVNF =
O)fst ghrf : qufnnfs smct nfs kodchskfs quh vmct ldhrf quf nfs prmthcfs vmct fkpructfr nd
vmhf omcsthtuthvf mu riunf
Nfs ghllrfctfs tdpfs :
d# Diridthmc
a# Omcofctrdthmc
o# Kdturdthmc
g# Fxmoytmsf
D# Diridthmc gfs kmnounfs
Irof gfs shicdux hcomccus kdhs prmadanfkfct omkkucs tmutf ucf ondssf gf prmthcfs#
Nfs odcghgdts pmtfcthfns smct nfs oermkmirdchcfs %prsfctf gdcs uchqufkfct gdcs nfs ofnnunfs
sorthmc riunf( Wmutfs nfs oermkmirdchcfs. mct uc pmhct hsmnfotrhquf trs dohgfs# _h mc
prfcg uc tuaf. mc kft gfs oermkmirdchcfs dvfo nf pE gu Imnih ft nd omcofctrdthmc dgqudt
fc odnohuk. fnnfs vmct s)dirifr spmctdckfct#
Ofrtdhcfs ldkhnnfs gf oermkmirdchcfs pmssgfct gfs pmcts ghsunlurfs quh pfrkfttfct nf ohandif
gfs prmthcfs vfrs nfs vmhfs gf sorthmcs riunf. ofnd ght. tmutfs nfs prmthcfs gf nd vmhf riu+
nf cf pmssgfct pds gf pmct _+_
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A# Omcofctrdthmc
Du gpdrt shkpnf amurifmccfkfct gu WIC dppfn : vshounfs sortmhrfs hkkdturf
Puhs omcofctrdthmc :
Pdr rftmur gf kfkardcfvfrs nfs fcgmsmkfs
Dohghlhodthmc gu omctfcu
gf nd nukhrf
Wmutflmhs omcofctrdthmc
kmgrf pdr rdppmrt ofnnf
quh survhfct nd smrthf gu
QF
O# Kdturdthmc
_f ldht smuvfct pdr prmtmnysf pfcgdct nd lmrkdthmc gf nd vshounf
Dothvdthmc gfs proursfurs hcdothls fc kmnounfs dothvfs pdr prmtmnysf %emrkmcfs
pmnypfpthghqufs ft cfurmemrkmcfs(
Mu = Gautf gdcs nf WIC omcthcuf gdcs nf irdcunf hkkdturf ft gdcs nfspdof fxtrd
ofnnundhrf
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Dkhgdthmc %djmut guc irmupfkfct dkhgf fc O+tfrkhcdn pdr nd PDK %pfpthgyn dnped
dkhgdthci kmcmmxyifcdsf(# Nd inyohcf fst uc gmccfur gdkhgdthmc U+U+Iny U+U+
CE1
Djmut guc irmupfkfct pyrminu pdr nd pyrminutdkyntrdcslfrdsf %Inc pInu(# Fxfkpnf
gf nd WQE
pInu+Ehs+Prm+CE1 Djmut guc irmupfkfct doftyn fc C+tfrkhcdn %doftyntrdcslfrdsf(# Dnped K_E doftynff
dothvf fc prhperhf kdhs pds gdcs nf ofrvfdu
Vcf prmtmnysf spohlhquf d nd vmhf riunf
Wmutfs ofs kmghlhodthmcs vmct kmgunfr ndothvhtf gfs prmtfhcfs lmrkffs
G# Fxmoytmsf
Omconushmc
Nf trdlho hctrdofnnundhrf fst cofssdhrf d nd amccf nmodnhsdthmc gfs prmthcfs ft pfrkft gf
kmgunfr nfur dothvht ahmnmihquf
Nfs kmghlhodthmcs pmst+trdguothmccfnnfs riunfct ndothvht gfs prmthcfs
Fnnfs smct spohlhqufs guc omkpdrthkfct gmcc
Nf trdlho hctrd+ofnnundhrf sfllfotuf gdcs nfs gfux sfcs pmur kdhctfchr ndroehtfoturf gf nd
ofnnunf
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