Traineeships's offer for international students · Traineeships's offer for international students ... Traineeships's offer for international students ... Vicente-Rodríguez,

Traineeships's offer for international students

Faculty of Pharmacy

Madrid (SPAIN)

Faculty of Pharmacy Traineeships's offer for international students

Presentation

Dear student,

We are proud to present you the offer of the Faculty of Pharmacy of the University CEU-San Pablo of

Traineeships for ERASMUS and other International students.

We offer both research and hospital or community pharmacy traineeships.

The Research Groups of our Faculty are widely recognized for their excellence and are used to receiving

international students. Within our research groups the international students are warmly hosted and

receive personalized attention (read the testimonials of some of our former international students). All

our researchers are fluent in English, so don’t be afraid if you don’t speak Spanish, however we

strongly recommend you to join the free Spanish courses that we offer for our international students.

Our Pharmacy Traineeships are held in Hospitals and Community Pharmacies of Madrid metropolitan

area. All these Pharmacies are selected by our Faculty because of the high quality of their teaching

program. For these traineeships a B2 level of Spanish is required.

If you are interested in carrying out a traineeship in our Faculty, please follow the instructions of the box

bellow.

Do not hesitate to contact us if you need further information. Looking forward to seeing you in our

Faculty,

Carmen Pérez ([email protected]) & Ana Gradillas ([email protected])

International Relations Coordinators

Faculty of Pharmacy. University CEU-San Pablo.

HOW TO APPLY: Please, send the following information at least 3 months before the starting date of your traineeship:

CV

Motivation letter indicating the dates and the type of traineeship desired (research or hospital or community pharmacy).

In the case of research traineeships, include a selection of 3 of our research groups in order of preference.

Pharmacy students must send this information to Carmen Pérez ([email protected]), students from other related health sciences must send it to Ana Gradillas ([email protected]). Students should not contact directly the research group’s leaders.

http://www.uspceu.com/es/alumnos/facultad-farmacia/presentacion/index.aspx

mailto:[email protected]





What our former international students say…

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presentation


Traineeships’s Offer

Research Groups

1. Perinatal Biochemistry

2. Regulation of Metabolism

3. Physiopathology of Obesity

4. Neurodegenerative Diseases, Addiction and Neuroinflammation

5. Drug Addiction and Learning

6. Translational research in addictive disorders

7. Nutrition and Food Science

8. Biotechnology in Plant Products

9. Pharmaceutical Development - School of Industrial Pharmacy

10. Centre of Metabolomics and Bioanalysis (CEMBIO)

11. Drug Design and Synthesis

12. Organometallics Chemistry

13. ESYMAT

14. Diagnostics of Laser Plasmas

15. Neuro-Oncology

16. Pathophysiology of Bone Metastasis

17. Physiopathological mechanisms of age-associated neurodegeneration

18. Bone Pathophysiology

19. Parasitology

20. Virus-host interaction in human pathogenesis

Hospital and Community Pharmacies

Requisites for student’s placements:

o Knowledge of Spanish: level B2 (according to EU languages common framework)

o Duration of the placement: 2-6 months

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Perinatal Biochemistry

1. Group leader: Emilio Herrera

(http://www.researcherid.com/rid/D-9143-2012)

2. Group members: Encarnación Amusquivar, Henar Ortega-Senovilla, Clara Sanchez-Blanco

3. Research lines: Short- and long-term on offspring of dietary fatty acids during pregnancy

4. Selected publications:

• Sardinha, F.L., Ferrnandes, F.S., Tavares do Carmo, M.G., Herrera, E.: Sex-dependent

nutritional programming: fish oil intake during early pregnancy in rats reduces age-

dependent insulin resistance in male, but not female, offspring. Am. J. Physiol. Integr.

Comp. Physiol. 304, R313-R320, 2012

• Ortega-Senovilla, H., Shaeffer-Graf, U., Meitzner, K., Abou-Dakn, M. and Herrera, E.:

Decreased concentrations of the lipoprotein lipase inhibitor angiopoietin-like protein 4 and

increased serum triacylglycerol are associated with increased neonatal fat in pregnant

women with gestational diabetes mellitus. J. Clin. Endocrinol. Metabol. 98, 3430-3437,

2013

• Amusquivar, E., Sánchez-Blanco, C., Clayton, J., Cammarata, J., Herrera, E.: Maternal

consumption of trans-fatty acids during the first half of gestation are metabolically available

to suckled newborn rats. Lipids 49, 265-273, 2014

• Herrera, E., Ortega-Senovilla, H.: Lipid metabolism during pregnancy and its implications for

fetal growth. Current Pharmaceutical Biotechnology 15, 24-31, 2014

5. Funding: Grants from Fundación Ramón Areces to Dr. E. Herrera and from University San Pablo

CEU to E. Amusquivar

6. Former Erasmus students hosted: Susanne Schiffner (Germany), Jamie Clayton (UK), Joana

(Portugal) and Steven Li (UK)

7. Requisites for Erasmus student’s placements:

a. Duration of the placement : 6 - 12 months

b. Max. number of students hosted per year: 1

Return to research groups list

http://www.researcherid.com/rid/D-9143-2012


Regulation of Metabolism

1. Group leader: Pilar Ramos Álvarez

(http://www.researchgate.net/profile/M_de_Pilar_Ramos_Alvarez)

2. Group members: Dr. Marta Viana Arribas, Dr. Julio Sevillano Fernández, Dr. Judith Cacho, Dr.

María Haro García, Dr. María Limones Cornejo, Dr. Jimena Pita Santibáñez, Dr. María Gracia

Sánchez Alonso, Dr. Isabel Sánchez-Vera Gómez-Trelles, Dr. Martín Alcalá Díaz-Mor, Mónica

Díez-Hochleitner (PhD. student)

3. Research lines: Molecular mechanism of insulin resistance in normal and pathological gestation/

Molecular basis of obesity/ Fetal programming, placental function and fetal growth/ Oxidative

stress and intrauterine development/ Role of inflammation and oxidative stress in age-

associated hormonal and metabolic changes. /Matrix remodelling and insulin signalling


• Vitamin E reduces adipose tissue fibrosis, inflammation, oxidative stress and improves

metabolic profile in obesity. Martín Alcalá, Isabel Sánchez-Vera, Julio Sevillano, Laura Herrero,

Dolors Serra, M. Pilar Ramos, Marta Viana. Obesity 23(8): 1598-606, 2015

• Pleiotrophin differentially regulates the rewarding and sedative effects of ethanol. Marta

Vicente-Rodríguez, Carmen Pérez-García, Marcel Ferrer-Alcón, María Uribarri, María G.

Sánchez-Alonso, María P. Ramos and Gonzalo Herradón J Neurochem 131 (5): 688-695, 2014

• Metabolic fingerprint of gestational diabetes mellitusD. Dudzik, M. Zorawski, M. Skotnicki, W.

Zarzycki, G.Kozlowska, K. Bibik-Malinowska, M.Vallejo, A. García, C. Barbas, M.P. Ramos. J

Proteomics, 103: 57-71, 2014

• Genetic inactivation of midkine modulates behavioural responses to ethanol possibly by

enhancing GABA(A) receptor sensitivity to GABA(A) acting drugs. Marta Vicente-Rodríguez,

Carmen Pérez-García, Marcel Ferrer-Alcón, María Uribarri, María G. Sánchez-Alonso, María P.

Ramos and Gonzalo Herradón. Behavioural Brain Research 274, 258-263, 2014

5. Funding: This group is funded by public and private grants: Ministery of Science and Innovation,

Programas de I+D en Biomedicina (Comunidad Autónoma de Madrid) and Universidad San Pablo-

CEU

6. Former Erasmus students hosted: Alexandra Poxleitner (Univ. Regensburg, Germany), Jessi

Agostinni (Univ. Pisa, Italy)

7. Requisites for Erasmus students placements:

a. Duration of the placement: 6 - 12 months



http://www.researchgate.net/profile/M_de_Pilar_Ramos_Alvarez


Physiopathology of Obesity

1. Group leader: Mariano Ruiz Gayo

(http://www.researchgate.net/profile/Mariano_Ruiz-Gayo)

2. Group members: Victoria Cano, Beatriz Merino

3. Research lines/s: Physiopathology of Obesity


Involvement of the dorsomedial prefrontal cortex in high-fat food conditioning in

adolescent mice. Del Rio D, Cano V, Martín-Ramos M, Gómez M, Morales L, Del Olmo N,

Ruiz-Gayo M. Behav Brain Res. 2015 Apr 15; 283:227-32. doi: 10.1016/j.bbr.2015.01.039.

Epub 2015 Jan 29

Morphological changes in glial fibrillary acidic protein immunopositive astrocytes in the hippocampus of dietary-induced obese mice. Cano V, Valladolid-Acebes I, Hernández-Nuño F, Merino B, Del Olmo N, Chowen JA, Ruiz-Gayo M. Neuroreport. 2014 Jun 6

Circadian feeding drive of metabolic activity in adipose tissue and not hyperphagia triggers overweight in mice: is there a role of the pentose-phosphate pathway? Stucchi P, Gil-Ortega M, Merino B, Guzmán-Ruiz R, Cano V, Valladolid-Acebes I, Somoza B, Le Gonidec S, Argente J, Valet P, Chowen JA, Fernández-Alfonso M, Ruiz-Gayo M. Endocrinology. 2012 Feb; 153(2):690-9. doi: 10.1210/en.2011-1023. Epub 2011 Dec 6

High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission. Valladolid-Acebes I, Merino B, Principato A, Fole A, Barbas C, Lorenzo MP, García A, Del Olmo N, Ruiz-Gayo M, Cano V. Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E396-402. doi: 10.1152/ajpendo.00343.2011.

5. Funding: Ministerio de Economía y Competitividad. Fundación Universitaria San Pablo-CEU

6. Former Erasmus students hosted: Alessandra Blonda (Univ. of Lovaina, Belgium), Giorgia

Parisella (Univ. of Rome, Italy) and Federica Neri (Univ. of Rome, Italy)





http://www.researchgate.net/profile/Mariano_Ruiz-Gayo

http://www.ncbi.nlm.nih.gov/pubmed/25639544










Neurodegenerative Diseases, Addiction and Neuroinflammation

1. Group leader: Gonzalo Herradón

(http://www.researcherid.com/rid/C-8305-2012)

2. Group members: Carmen Pérez García, Esther Gramage Caro, Marta Vicente Rodríguez, Rosalía

Fernández Calle

3. Research lines/s: Neurodegenerative diseases, addiction, neuroinflammation


• Targeting midkine and pleiotrophin signaling pathways in addiction and neurodegenerative

disorders: Recent progress and perspectives. Gonzalo Herradón, Carmen Pérez-García. British

Journal of Pharmacology, 171(4) (2014) 837-48

• Pleiotrophin differentially regulates the rewarding and sedative effects of ethanol. Marta

Vicente-Rodríguez, Carmen Pérez-García, Marcel Ferrer, María Uribarri, María G. Sánchez-

Alonso, María P. Ramos, Gonzalo Herradón. Journal of Neurochemistry 131(5) (2014) 688-95

• Phosphoproteomic analysis of the striatum from pleiotrophin knockout and midkine

knockout mice treated with cocaine reveals regulation of oxidative stress-related proteins

potentially underlying cocaine-induced neurotoxicity and neurodegeneration. Esther

Gramage, Marta Vicente-Rodríguez, Gonzalo Herradón, Carmen Pérez-García. Toxicology,

314 (2013) 166-173

• Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the substantia

nigra and enhances amphetamine neurotoxicity in the striatum. Esther Gramage, Luca Rossi,

Noelia Granado, Rosario Moratalla, Gonzalo Herradón. Neuroscience 170(1) (2010) 308-16

5. Funding: Ministerio de Economía y Competitividad. SAF2014-56671-R (2015-2018)

6. Former Erasmus students hosted: Priyah Ramanah (Univ. Surrey, UK); Dinah Sakir (King’s

College, UK); Rhian-Marie Ford (Univ. Surrey, UK); Alessia Putelli (Univ. Genova, Italy)





http://www.researcherid.com/rid/C-8305-2012


Drug Addiction and Learning

1. Group leader: Nuria del Olmo

(http://www.researcherid.com/rid/K-8789-2014)

2. Group members: Lidia Morales

3. Research lines/s: Drug addiction, learning and memory and synaptic plasticity


• Fole A, Miguens M, Higuera-Matas A, Alguacil LF, Ambrosio E, Del Olmo N, Cocaine facilitates

protein synthesis-dependent LTP: the role of metabotropic glutamate receptors, Eur

Neuropsychopharmacol. 2014 Apr;24(4):621-9

• Valladolid-Acebes I, Fole A, Martín M, Morales L, Cano MV, Ruiz-Gayo M, Del Olmo N, Spatial

memory impairment and changes in hippocampal morphology are triggered by high-fat diets

in adolescent mice. Is there a role of leptin?, Neurobiol Learn Mem. 2013 Nov;106:18-25

• Fole A, González-Martín C, Huarte C, Alguacil LF, Ambrosio E, Del Olmo N., Effects of chronic

cocaine administration on spatial learning and hippocampal spine density in two genetically

different strains of rats, Neurobiol Learn Mem. 2011 May;95(4):491-7

• Valladolid-Acebes I1, Stucchi P, Cano V, Fernández-Alfonso MS, Merino B, Gil-Ortega M, Fole

A, Morales L, Ruiz-Gayo M, Del Olmo N., High-fat diets impair spatial learning in the radial-

arm maze in mice., Neurobiol Learn Mem. 2011 Jan;95(1):80-5

5. Funding: Plan Nacional sobre Drogas, Ministerio de Sanidad, Servicios Sociales e Igualdad

6. Former Erasmus students hosted: Sara Prakash (Univ. Tubingen, Germany); Stefani

Magallahes (Univ. Sao Paulo, Brasil); Daniella Ruggieri (Univ. Roma "La Sapienza, Italy) and

Popat (King’s College, UK)





http://www.researcherid.com/rid/K-8789-2014


Translational research in addictive disorders

1. Group leader: Luis Fernando Alguacil Merino

(http://www.researcherid.com/rid/J-6466-2016)

2. Group members: Carmen González Martín, Isabel Martín Antoniano, Victoria Iglesias Dorado,

Carmen Pérez-García, Iñigo Pallardo Fernández, Carmen Rodríguez Rivera 3. Research lines/s:

Biomarkers and drug targets in addictive disorders Neurobiology of addiction vulnerability


Pérez-Ortiz JM, Galiana-Simal A, Salas E, González-Martín C, García-Rojo M, Alguacil LF. A high-fat diet combined with food deprivation increases food seeking and the expression of candidate biomarkers of addiction. Addict Biol 2016 (in press)

Alguacil LF, González-Martín C. Target identification and validation in brain reward dysfunction. Drug Discov Today 2015; 20:347-52.

5. Funding: Fundación Mutua Madrileña 6. Former Erasmus students hosted: Elizabeth Pook (Cardiff, UK) 7. Requisites for Erasmus students placements:

a. Duration of the placement: 3-6 months



Nutrition and Food Science

http://www.researcherid.com/rid/J-6466-2016


1. Group leader: Gregorio Varela Moreiras

2. Group members: Elena Alonso Aperte, PhD, Natalia Úbeda Martín, PhD, María Achón y Tuñón,

PhD, Ángela García González, MD, Teresa Partearroyo Cediel, PhD, Purificación González

González, PhD, Ana Montero Bravo, PhD, Lourdes Samaniego Vaesken, PhD, Esther Carrera

Puerta, PhD, Violeta Fajardo Martín, PhD, Elena Sánchez Campayo, María Serrano Iglesias

3. Research lines: New Functions of folic acid in relation to health and disease prevention

(prevention of neural tube defects, homocysteine regulation, colorectal cancer, hearing loss)/

Cycle regulation of methionine and homocysteine metabolism through folic acid and vitamin B6

and B12/ Assessment of nutritional status and potential risks in older people/ Bioavailability of

food folate/ Assessment of nutritional status in celiac population/ Development and evaluation

of functional foods/ Food folate fortification


• Fajardo V, Alonso-Aperte E, Varela-Moreiras G. Folate content in fresh-cut vegetable packed products by 96-well microtiter plate microbiological assay. Food Chem. 2015 Feb 15; 169:283-8

• Partearroyo T, Úbeda N, Montero A, Achón M, Varela-Moreiras G. Vitamin B(12) and folic acid imbalance modifies NK cytotoxicity, lymphocytes B and lymphoprolipheration in aged rats. Nutrients. 2013 Nov 26; 5(12):4836-48

• Partearroyo T, Pérez-Miguelsanz J, Úbeda N, Valencia-Benítez M, Alonso-Aperte E, Varela- Moreiras G. Dietary folic acid intake differentially affects methionine metabolism markers and hippocampus morphology in aged rats. Eur J Nutr. 2013 Apr; 52(3):1157-67

• Ubeda N, Achón M, Varela-Moreiras G. Omega 3 fatty acids in the elderly .Br J Nutr. 2012 Jun; 107 Suppl 2:S137-51

5. Funding: Fundación MAPFRE, BIOSEARCH AS, UNIVERSIDAD CEU SAN PABLO, Fundación Thao,

Coca-Cola España

6. Former Erasmus students hosted: Clemens Egger (FH Joanneum, Austria); Katharina Holzer (FH

Joanneum, Austria); Nadia Le Bon (Sup Biotech, France) and Floor Minnema (HVA Amsterdam,

Netherlands)






Biotechnology in Plant Products and Plant Microbe Interactions

1. Group leader: Javier Gutierrez Mañero

2. Group members: Dr. Beatriz Ramos-Solano, Dr. Jose Antonio Lucas, Dr. Ana García-Villaraco Predoctoral students: Alfonso Bonilla, Enrique Gutiérrez

3. Research lines:

• Biotechnology: Bioactives and phytopharmaceuticals. Elicitation of secondary metabolism of plants with pharmacologically active metabolites in vivo and in vitro. Rubus sp. (blackberry), Glycine max (Soybean), Isoflavones; Hypericum perforaturm (St.Jhon’s wort) Hipericin; Digitalis, Digoxin. Identification of new active molecules. Identification of genes involved in induction (bacterial and plants). Unraveling biosynthetic pathways. Responsible researcher: Beatriz Ramos

• Sustainable agriculture. Study of Plant growth promoting rhizobacteria as biofertilizers and enhancers of plant’s defensive metabolism. Increasing productivity in low yield areas (salt). Evaluation of ecological consequences. Field trials in tomato, rice, bean, corn

• Metagenomics. Isolation of soil rhizosphere bacterial genes for different purposes (antibiotic production, enzyme…). Bacterial communication “quorum sensing”


• Gutiérrez Mañero FJ García-Villaraco, A, Gutiérrez Albanchez E, Lucas JA, Ramos Solano, B. 2015. Inoculant/elicitation technology to improve bioactive/phytoalexin contents in functional foods. International Journal Current Microbiology and Applied Sciences 4(6):224- 241

• Garcia-Seco, D., Zhang Y., Gutiérrez-Mañero, F.J., Trick M., Martin, C., Ramos-Solano, B. 2015. RNA-Seq analysis and transcriptome assembly of Blackberry (Rubus sp. Var. Lochness). BMC Genomics 1(5):1 -11, 2015. DOI 10.1186/s12864-014-1198-1

• Garcia-Seco, D., Zhang Y., Gutierrez-Mañero, F.J., Martin, C., Ramos-Solano, B. Application of P. fluorescens to blackberry under field conditions improves fruit quality by modifying flavonoid metabolism, PONE-D-15-32602 revista: PLOS ONE (accepted 11 sept 2015)

5. Funding: Contracts with pharmaceutical industries, contracts with agrochemical industries, national funds, USP-CEU grants

6. Former Erasmus students hosted: 2014-2015: Connor Fielder (U.Cardiff, UK), Danilo Cagnina (U.Torino, It), Yoshua Eardley (U.Surrey UK). 2013-2014: Melanie Hoste (U. Surrey, UK), Justus Schollmeier (U.Regensburg, D), Andrea Eoli (U. Torino IT). 2012-2013: Ann Cubitt (U. Surrey, UK), Magda Galazka and Szymon Filip (U. Gdansk, Poland). 2011-2012: E.Verri (IItaly), Khwaja Ahmad (UK), 2010-2011: E. Molska (U. Gdansk, Poland), G. Myring (U. of Surrey, UK). 2009-2010: J. Walz (Germany), J. Butler (UK). 2008-2009. Anne Marie Waal (Amsterdam)

7. Requisites for Erasmus student’s placements: a. Duration of placement: preferable annual (9-10 months); mínimum semester (4 months) b. Maximum number of placements: 3 anual (3 studens x 1 year) or 6 semestral 3 students x

4 months)



Pharmaceutical Development - School of Industrial Pharmacy

1. Group leader: Luis Alberto del Río

2. Group members: Carmen Trives and Nuria Salazar

3. Research lines: Pharmaceutical development of Oral Forms/ Quality Assurance in agreed

collaboration with Spanish Association of Industrial Pharmacists (AEFI)/ Cosmetics in agreed

collaboration with National Association of Cosmetics Laboratories (STANPA)/ Pharmaceutical

Compounding in agreed collaboration with Spanish Association of Compounder Pharmacists

(AEF2)

The School of Industrial Pharmacy is regulated by The Spanish Ministries of Education and

Health within the framework of the specialized formation for pharmacists. It is approved by

national resolution and contest. It maintains collaboration with more than 50 experts from

industry, regulatory and academics and organizes periodically professional events


• Trives C, del Río LA, Salazar N, Jáudenes E, Olleros T, Fernandez de Gatta R; Patente mundial

WO2011121160A1 (6.XI.2011) : Formulación farmacéutica a base de ibuprofeno y Codeína de

estabilidad mejorada

• del Río LA, y Trives ; Patente española ES 2 357 209 B1 (26.V.2009): Composición

farmacéutica sólida a base de famotidina contra la hipersecrección gástrica y otras

enfermedades relacionadas, con mayor eficacia sinérgica y más rápida actuación

• del Río LA, Pérez M, Trives C y Salazar N ; Patente española ES 2 316 308 B1 (30.IV.2008) :

Medicamento a base de Metronidazol y Ácido azelaico para el tratamiento por vía tópica de

la enfermedad Rosácea de mejor asimilación, y procedimientos de preparación

• Pérez, E y del Río LA: Formulación de soluciones oftálmicas de ciclosporina en colirio al 2%

para la práctica clínica. Anal. R. Acad. Nac. Farm. (2009), 75, 4, 911-922

5. Funding: The School of Industrial Pharmacy manages own annual budget for teaching activities

coming from its pharmacist fees and retains an amount for research projects and necessities

6. Former Erasmus students hosted: Thomas Pfeifle (Tübingen Universität, Germany)


a. Duration of the placemen : 2 - 9 months




Centre of Metabolomics and Bioanalysis (CEMBIO)

1. Group leader: Coral Barbas

(http://www.researcherid.com/rid/K-3871-2014)

2. Group members: Lecturers: Antonia García; Ana Gradillas, Joanna Godzien; Mª Ángeles López;

Mª Paz Lorenzo; Mª Paz Martínez; Francisco Javier Rupérez; Mª Fernanda Rey-Stolle.

Postdoctoral researchers: Emily G. Armitag, Danuta Dudzik, David Rojo. Predoctoral researchers:

Carolina González, Alejandro B. Lanzón, Annalaura Mastrangelo. Technician: Vanesa Alonso

3. Research lines: Metabolomic Platform based on mass spectrometry coupled to chromatographic

techniques (LC&GC&CE) and Bioanalysis capabilities collaborating in research projects with other

groups or with pharmaceutical and biotechnological industries


• Rojo D, Canuto GA, Castilho-Martins EAet al. A Multiplatform Metabolomic Approach to the Basis of Antimonial Action and Resistance in Leishmania infantum. PLoS One. 2015 Jul 10;10(7):e0130675

• Naz S, Calderón ÁA, García A et al. Unveiling differences between patients with acute coronary syndrome with and without ST elevation through fingerprinting with CE-MS and HILIC-MS targeted analysis. Electrophoresis. 2015 doi: 10.1002/elps.201500169

• Dudzik D, Zorawski M, Skotnicki M et al. Metabolic fingerprint of Gestational Diabetes Mellitus. J Proteomics. 2014 May 30; 103:57-71

• Naz S, García A, Barbas C. Multiplatform analytical methodology for metabolic fingerprinting of lung tissue. Anal Chem. 2013 Nov 19; 85(22):10941-8

5. Funding: Contracts with industries, national and international research grants, USP-CEU grants

6. Former Erasmus students hosted (last two years): Victor Truong (Kings College London, UK);

Rockson Yeboah (Univ. Paris Descartes, France); Sara Argentieri and Gaya Romeo (Univ. Modena

e Reggio Emilia); Alice Demelenne (Univ. Liege, Belgium); Laura Ravanetti and Giulia Fava (Univ.

Modena e Reggio Emilia, Italy); Natalia Laszcz and Simon Macioszek (Medical Univ. Gdansk,

Poland)



b. Max. number of students hosted per year: 6 More info: www.metabolomica.uspceu.es


http://www.researcherid.com/rid/K-3871-2014

http://www.metabolomica.uspceu.es/


Drug Design and Synthesis

1. Group leaders: Beatriz de Pascual-Teresa (http://www.researcherid.com/rid/J-4318-2012)

Ana Ramos (http://www.researcherid.com/rid/E-8740-2012)

2. Group members: José María Zapico, Claire Coderch, Miryam Pastor, PhD student: Bruno Di

Geronimo Quintero

3. Research lines:

• Design, synthesis and biological evaluation of anticancer agents. We work with different drug

targets: Metalloproteinases (MMP2, MMP9), protein kinase CK2, histone deacetilases

(HDAC), and Estrogen Receptor, among others

• Identification of small molecules capable of binding and stimulating CIRP (cold inducible RNA-

binding protein)

• Design and synthesis of small molecule inhibitors of PTPRZ1 (Protein Tyrosine-Phosphatase

Receptor Z1) as a novel therapeutic strategy for Parkinson’s disease (PD)


• Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the

gelatinase family. José María Zapico, Anna Puckowska, Kamila Filipiak, Claire Coderch, Beatriz

de Pascual-Teresa, Ana Ramos. Organic and Biomolecular Chemistry 2015, 13, 142–156. DOI:

10.1039/C4OB01516A

• Exploring the dynamics of the S1’ pocket in the design of selective, small molecule inhibitors.

Benjamin Fabre, Ana Ramos, Beatriz de Pascual-Teresa. Targeting Matrix Metalloproteinases:

Journal of Medicinal Chemistry 2014, 57, 10205-10219. DOI: 10.1021/jm500505f

• Human Protein Kinase CK2 Phosphorylates Matrix Metalloproteinase-2 and Inhibits its

Activity. Kamila Filipiak, Konrad Kubiński, Ulf Hellman, Ana Ramos, Beatriz de Pascual-Teresa.

ChemBioChem 2014, 15, 1873-1876. DOI: 10.1002/cbic.201402036

• Towards β-Selectivity in Functional Estrogen Receptor Antagonists. Jose Juan Rodríguez,

Kamila Filipiak, Maciej Maslyk, Jakub Ciepielski, Sebastian Demkowicz, Sonia de Pascual-

Teresa, Sonsoles Martín-Santamaría, Beatriz de Pascual-Teresa, Ana Ramos. Organic and

Biomolecular Chemistry 2012, 10, 7334-7346. DOI: 10.1039/c2ob26062j

5. Funding: Ministerio de Economía y Competitividad. Department of Defense USA (DoD, US)

6. Former Erasmus students hosted: Sunpal Sembi (King’s College London, UK); Rosaria La Barbera

(Univ. Pavia, Italy); Arandeep Hayer (Univ. Cardiff, UK) and Rosa Rubino (Univ. Bari, Italy)


a. Duration of the placement : 3- 9 months



http://www.researcherid.com/rid/J-4318-2012

http://www.researcherid.com/rid/E-8740-2012


Organometallics Chemistry

1. Group leaders: Javier Pérez Castells

(http://www.researcherid.com/rid/F-4894-2015)

2. Group members: Gema Domínguez, Alberto López

3. Research lines:

• Synthesis of carbohydrate derivatives with paramagnetic ions for ·3D studies by NMR

including molecular recognition

• New non-metathetic reactions of ruthenium carbenes

• Pauson-Khand reactions in microreactors (flow chemistry)


• Domínguez G., and Pérez-Castells J. 2014 [2+2+2] Cycloadditions. In: Gary A. Molander and

Paul Knochel (eds.), Comprehensive Organic Synthesis, 2nd edition, Vol 5, Oxford: Elsevier;

pp. 1537-1581. ISBN: 978-0-08-097743-0

• Alvarez, S.; Medina, S.; Dominguez, G.; Perez-Castells, J. 2015 Ruthenium Alkylidene-

Catalyzed Reaction of 1,6-Heptadiynes with Alkenes. J. Org. Chem., 80, 2436-2442.

• Medina, S.; Domínguez, G. Pérez-Castells, J. 2012. Efficient Generation of Pyridines by

Ruthenium Carbene Mediated [2+2+2] Cyclotrimerization. Org. Lett., 14, 4982-4985

• Jimenez-Barbero, J.; Canales, A.; Mallagaray, A.; Berbis, M.; Navarro-Vázquez, A.; Domínguez,

G.; Cañada, F. J.; André, S.; Gabius, H.-J.; Perez-Castells, J. 2014 Lanthanide-chelating

carbohydrate conjugates are useful tools to characterize carbohydrate conformation in

solution and sensitive sensors to detect carbohydrate-protein interactions, J. Am. Chem. Soc.,

136, 8011-8017

5. Funding: Ministerio de Economía y Competitividad





http://www.researcherid.com/rid/F-4894-2015


ESYMAT

1. Group leaders: Flaviano García- Alvarado

(http://www.researcherid.com/rid/B-5071-2011)

2. Group members: Ulises Amador, Alois Kuhn, M. Teresa Azcondo; Mercedes Yuste, Juan Carlos

Pérez Flores, Pilar Díaz, David Ortiz, Alejandro Pérez

3. Research lines: The group is developing two research lines on inorganic energy materials aiming

for two energy efficient and cost effective devices; Lithium Batteries on one hand and Solid

Oxide Fuel Cells on the other. Both research lines involve the synthesis, characterization and

assessment of performances of inorganic materials that may be of use in the aforementioned

devices. In particular the following tasks are usually carried out:

• Synthesis of inorganic materials by ceramic, wet and soft chemistry routes

• Chemical and structural characterization of materials by X-ray, electron and neutron diffraction, transmission and scanning electron microscopy, thermal analysis

• Electrical characterization by ac and dc methods (impedance spectroscopy, dc four probe measurements, ion blocking)

• Electrochemical characterization (cyclic voltammetry, chronoamperommetry, PITT, GIT, etc.)

• Assembly of Lithium coin cells (CR2032), pouch cells and Solid Oxide Fuel Cells

• Prototyping of lithium batteries. Performances evaluation of cells (power rate, cycling behaviour, polarization tests, etc.)


• J. C. Perez-Flores, C. Baehtz, A. Kuhn, F. Garcia-Alvarado, Journal of Materials Chemistry A

2014, 2, 1825-1833

• J. Prado-Gonjal, B. Molero-Sánchez, D. Ávila-Brande, E. Morán, J. C. Pérez-Flores, A. Kuhn, F.

García-Alvarado, Journal of Power Sources 2013, 232, 173-180

• J. C. Pérez-Flores, D. Pérez-Coll, S. García-Martín, C. Ritter, G. C. Mather, J. Canales-Vázquez,

M. Gálvez-Sánchez, F. García-Alvarado, U. Amador, Chemistry of Materials 2013, 25, 2484-

2494

• Basa, E. Gonzalo, A. Kuhn, F. García-Alvarado, Journal of Power Sources 2012, 197, 260-266.

5. Funding: Airbus Space and Defence; Ministerio de Economía y Competitividad (Spanish

Government; Comunidad Madrid (Local Governments of Madrid)

6. Former Erasmus students hosted: Katarzyna Kołodzińska, Paulina German


a. Duration of the placement : 6-12 months



http://www.researcherid.com/rid/B-5071-2011


Diagnostics of Laser Plasmas

1. Group leaders: Carlos Aragón Garbizu

2. Group members: Jose Antonio Aguilera Andoaga, Javier Manrique Rosel

3. Research lines: LIBS: Diagnostics of laser plasmas to the determination of atomic data, in

particular of Transition Probabilities and Stark parameters


• Method for measurement of transition probabilities by laser-induced breakdown spectroscopy based on CSigma graphs- Application to Ca II spectral lines. J. A. Aguilera; C. Aragón; J. Manrique. Journal of Quantitative Spectroscopy and Radiative Transfer 2015, 160, 10-18

• Measurement of Stark widths and shifts of Ca II spectral lines. J. A. Aguilera; C. Aragón; J. Manrique. MNRAS 2014, 444, 1854-1858

• Measurement of Stark broadening parameters of Fe II and Ni II spectral lines by laser induced breakdown spectroscopy using fused glass samples. C. Aragón; J. A. Aguilera; J. Manrique. Journal of Quantitative Spectroscopy and Radiative Transfer 2014, 134, 39-45.

• Experimental Stark widths and shifts of Cr II spectral lines. J. A. Aguilera; C. Aragón; J. Manrique. MNRAS 2014, 438, 841-845

5. Funding: Ministerio de Ciencia e Innovación






Neuro-Oncology

1. Group leader: Angel Ayuso Sacido

(http://www.researchgate.net/profile/Angel_Ayuso-Sacido)

2. Group members: 5

3. Research lines: Neuro-Oncology, cáncer stem cells biology and biomarkers, Nanomedicine


• Elisa Lázaro-Ibáñez, Andrés Sanz-García, Tapio Visakorpi, Carmen Escobedo-Lucea,

Cristobal Belda-Iniesta, Pia Siljander, Ángel Ayuso-Sacido*, Marjo Yliperttula*. Different

gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic

bodies, microvesicles and exosomes. Prostate. 2014. 74(14):1379-90

• Oliver-De La Cruz J, Carrión-Navarro J, García-Romero N, Gutiérrez-Martín A, Lázaro E,

Escobedo-Lucea C, Perona R, Belda-Iniesta C, and Ayuso-Sacido A. SOX2+ cell

population from normal human brain white matter is able to generate mature

oligodendrocytes. PlosOne. 2014. 9(6):e99253

• Natividad Pozo, Cristina Zahonero, Paloma Fernández, Angel Ayuso-Sacido, Angel Pérez,

Jose R. Ricoy, Masatoshi Hagiwara, Aurelio Hernández-Laín, Juan M. Sepúlveda, Pilar

Sánchez- Gómez. DYRK1A inhibition Impairs EGFR Stability and affects the expansion

of tumor initiating cells in receptor-depending glioblastomas. Journal of Clinical

Investigation. 2013. Jun 3; 123(6): 2475-87

• A Ayuso-Sacido*, Stine Rasmussen*, Jaime Imitola*, Yue Wang, Sarah Starossom, Pia

Kivisäkk, Bing Zhu, Erin L. Grady, Morten Meyer, Roderick T. Bronson, Jose Manuel

Garcia- Verdugo and Samia J. Khoury. Reversible neural stem cell niche dysfunction in

a model of multiple sclerosis. Submitted to Annals of Neurology, 2011, 69:878-91

5. Funding: Ministerio de Economía y Competitividad

6. Former Erasmus students hosted: Clare Stokes (King’s College, UK)





http://www.researchgate.net/profile/Angel_Ayuso-Sacido


Pathophysiology of Bone Metastasis

1. Group leader: Verónica Alonso

2. Group members: Irene Gutiérrez, Mª Rosario Rodríguez, José Manuel Pozuelo, Juan Antonio

Ardura

3. Research lines: Identification of premetastasic bone niche and osteomimetism stimulating-

factors in clinical and pre-clinicl models of prostate cancer.

4. Selected publications :

Ubiquitination-regulated G protein-coupled receptor signaling and trafficking. Alonso V, Friedman PA. Mol Endocrinol. 2013 Apr;27(4):558-72.

Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis. Liu L, Alonso V, Guo L, Tourkova I, Henderson SE, Almarza AJ, Friedman PA, Blair HC. J Biol Chem. 2012 Dec 21;287(52):43312-21.

Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. Alonso V, de Gortázar AR, Ardura JA, Andrade-Zapata I, Alvarez-Arroyo MV, Esbrit P.J Cell Physiol. 2008 Dec;217(3):717-27.

Receptor activator of nuclear factor-kappaB ligand (RANKL) as a novel prognostic marker in prostate carcinoma. Pérez-Martínez FC, Alonso V, Sarasa JL, Manzarbeitia F, Vela-Navarrete R, Calahorra FJ, Esbrit P. Histol Histopathol. 2008 Jun;23(6):709-15.

5. Funding: Instituto de Salud Carlos III Expediente-PI12/02390

6. Former Erasmus students hosted:






Physiopathological mechanisms of age-associated neurodegeneration

1. Group leader: José Luis Lavandera Díaz

2. Group members: Esther Escudero Lirola; Isabel Sánchez-Vera Gómez-Trelles, Rima Barhoum,

Enrique Puche García, Ignacio Iturrieta Zualde. PhD students: Concepción Aída Moreno Fernández, Diana Martínez Casanova.

3. Research lines: Mecanismos Fisiopatológicos y Terapéutica de la Neurodegeneración;

Mecanismos Fisiopatológicos y Terapéutica de la Neuroinflamación. Mecanismos

Fisiopatológicos en el Síndrome Metabólico.


An experimental model of partial insulin-like growth factor-1 deficiency in mice, Castilla-Cortazar, I.; Guerra, L.; Puche, J. E.; Munoz, U.; Barhoum, R.; Escudero, E.; Lavandera, J. L. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2014

IGF-I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK-ligand. Guerra-Menendez, Lucia; Sadaba, Maria C.; Puche, Juan E.; Lavandera, Jose L.; de Castro, Luis F.; de Gortazar, Arancha R.; JOURNAL OF TRANSLATIONAL MEDICINE, 2013

Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity. Alcalá M, Sánchez-Vera I, Sevillano J, Herrero L, Serra D, Ramos MP, Viana M. OBESITY (Silver Spring). 2015

Mycobacterium tuberculosis Gyrase Inhibitors as a New Class of Antitubercular D Blanco, D.; Perez-Herran, E.; Cacho, M,; Ballell, Ll.; Castro, J.; Gonzalez del Rio, R.; Luis Lavandera, J. et al.rugs, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015

5. Funding: Ministerio de Economía y Competitividad (MINECO). CTQ2014-56833-R



a. Duration of the placement : 6 - 12 months b. Max. number of students hosted per year: 1



Bone Pathophysiology

1. Group leader: Arancha Rodriguez Gortázar

2. Group members: Beatriz Bravo, Irene Buendía, Daniel Aedo, Alejandro Ordas

3. Research lines: Bone diseases, osteocyte mechanotransduction and osteoclastogenesis


Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival. Maycas M, Ardura JA, de Castro LF, Bravo B, Gortázar AR, Esbrit P.J Bone Miner Res. 2015 Jul;30(7):1231-44

VEGF Receptor 2 (VEGFR2) Activation Is Essential for Osteocyte Survival Induced by Mechanotransduction.de Castro LF, Maycas M, Bravo B, Esbrit P, Gortazar A. J Cell Physiol. 2015 Feb;230(2):278-85

Meniscal repair possibilities using bone morphogenetic protein-7.Forriol F, Ripalda P, Duart J, Esparza R, Gortazar AR.Injury. 2014 Oct;45 Suppl 4:S15-21

5. Funding: CEU grupos Emergentes, FEIOMM 6. Former Erasmus students hosted: 7. Requisites for Erasmus students placements:

a. Duration of the placement : 6 - 12 months b. Max. number of students hosted per year: 1








Parasitology 1. Group leader: Carmen del Aguila

(http://www.researcherid.com/rid/A-6063-2016)

2. Group members: Soledad Fenoy (PhD), Fernando Izquierdo (PhD), Carolina Hurtado (PhD),

Angela Magnet (PhD), Dolores Ollero (PhD), Lucciana Rosalia Vaccaro Munoz (PhD Student), Thiago Dos Santos Gomes (PhD Student)

3. Research lines:

- Parasitology: Oportunistic Parasites: microsporidia, Cryptosporidium, Cyclospora and free living amoeba. Water parasites

- Immunology: Evasion of immunology system, apoptosis and autoimmunity induced by

parasites


C. del Aguila, F. Izquierdo,, A.G. Granja, C. Hurtado, S. Fenoy, M. Fresno, Y. Revilla. 2006,

Encephalitozoon microsporidia modulates p53-mediated apoptosis in infected cells.

International Journal for Parasitology, 36: 869-876

Magnet A, Fenoy S, Galván AL, Izquierdo F, Rueda C, Fernández-Vadillo C, del Aguila C.

2013. A yearlong study of the presence of free living amoeba in Spain. Water Research,

49, 6966-6972.

Galván AL, Magnet A, izquierdo F, Fernández-Vadillo C, Peralta RH, Angulo S, Fenoy S,

del AguilaC. 2014. A year.long study of Cryptosporidium species and subtypes in

recreational, drinking and wastewater from the central area of Spain. Science of the

total environment, 468-469, 368-379

“Magnet A, Peralta RH, Gomes TS, Izquierdo F, Fernández-Vadillo C, Galván AL, Pozuelo

MJ, Pelaz C, Fenoy S, del Águila C. 2015. Vectorial role of Acanthamoeba in Legionella

propagation in water for human use. Science of the total Environment, 505, 889-895

5. Funding: San Pablo CEU University



c. Duration of the placement : 4 - 12 months d. Max. number of students hosted per year: 1


http://www.researcherid.com/rid/A-6063-2016

http://www.sciencedirect.com/science/article/pii/S0020751906001135









http://www.sciencedirect.com/science/journal/00207519


Virus-host interaction in human pathogenesis

1. Group leader: Estanislao Nistal Villán

(https://www.researchgate.net/profile/Estanislao_Nistal-Villan) 2. Group members: María José Pozuelo 3. Research lines:

- Virus-host interaction, type I interferon response, oncolytic viruses


Nistal-Villán E, Poutou J, Rodríguez-Garcia E, Buñuales M, Carte-Abad B, Prieto J,

Gonzalez-Aseguinolaza G, Hernandez-Alcoceba R, Larrea E. A Versatile Vector for In Vivo

Monitoring of Type I Interferon Induction and Signaling. PLoS One. Vol: 11 (3) e0152031.

2016.

Nistal-Villan E, Bunuales M, Poutou J, Gonzalez-Aparicio M, Bravo-Perez C, Quetglas JI,

Carte B, Gonzalez-Aseguinolaza G, Prieto J, Larrea E, Hernandez-Alcoceba R. Enhanced

therapeutic effect using sequential administration of antigenically distinct oncolytic

viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer

model. Mol. Cancer. Vol: 14:210. 2015.

Nistal-Villán E, Rodríguez-García E, Di Scala M, Ferrero-Laborda R, Olagüe C, Vales Á,

Carte-Abad B, Crespo I, García-Sastre A, Prieto J, Larrea E, González-Aseguinolaza G. A

RIG-I 2CARD-MAVS200 Chimeric Protein Reconstitutes IFN-β Induction and Antiviral

Response in Models Deficient in Type I IFN Response. J. Innate Immun. Vol: 7 (5): 466-

481. 2015.

Nistal-Villán E, Gack MU, Martínez-Delgado G, Maharaj NP, Inn K, Yang H, Wang R,

Aggarwal AK, Jung JU, García-Sastre A. Negative Role of RIG-I Serine 8 Phosphorylation

in the Regulation of Interferon-beta Production. J. of Biol. Chem. Vol: 285 (26): 20252-

20261. 2010.

9. Funding: Study of the mitochondrial antiviral signaling protein MAVS complex during viral

infections. FUSPBS-PPC16/2015



e. Duration of the placement : 4 - 12 months f. Max. number of students hosted per year: 1


https://www.researchgate.net/profile/Estanislao_Nistal-Villan

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