Training and Supporting the Biomedical Research Workforce Richard A. Baird, Ph.D. Director, Division of Interdisciplinary Training Natl. Inst. Biomedical

Training and Supporting the Training and Supporting the Biomedical Research WorkforceBiomedical Research Workforce

Richard A. Baird, Ph.D. Richard A. Baird, Ph.D. Director, Division of Interdisciplinary Training Director, Division of Interdisciplinary Training

Natl. Inst. Biomedical Imaging and Bioengineering (NIBIB)Natl. Inst. Biomedical Imaging and Bioengineering (NIBIB)

Co-Chair, NIH Training Advisory Committee (TAC)Co-Chair, NIH Training Advisory Committee (TAC)Co-Chair, NIH TAC Workforce Committee (NTW)Co-Chair, NIH TAC Workforce Committee (NTW)

National Institutes of Health (NIH)National Institutes of Health (NIH)

Minority Faculty Development Workshop Minority Faculty Development Workshop Georgia Tech Global Learning CenterGeorgia Tech Global Learning Center

March 15-18, 2012March 15-18, 2012

National Institute of Biomedical Imaging and Bioengineering

The NIH mission is The NIH mission is science in pursuit of science in pursuit of fundamental knowledgefundamental knowledge about the nature and about the nature and behavior of living behavior of living systems and the systems and the application of that application of that knowledgeknowledge to extend to extend healthy life and reduce healthy life and reduce the burdens of illness the burdens of illness and disability. and disability.

The NIH MissionThe NIH Mission


NIH FY2012 Budget NIH FY2012 Budget

Most of the NIH budget goes to its 27 institutes or centers, with <4% allocated to trans-NIH initiatives.

NCI

NIAID

NHLBI

NIGMSNIDDK

NINDS

NIMH

NICHD

NCRR

NIAOD/CF

NCCAM

NIDANIEHS

NIAMS

NHGRINIDCRNIAAA

NIDCDNIMHDNLM

NIBIB

FIC

Total = $32.0 B

NEI

NINR


What WeWhat We’’d All Like to See…d All Like to See…


Individual Fellowships:Individual Fellowships:

Feeding the PipelineFeeding the Pipeline

F31 – Predoctoral FellowshipsF31 – Predoctoral Fellowships F32 – Postdoctoral FellowshipsF32 – Postdoctoral Fellowships Receipt Dates:Receipt Dates: April/August/December 8 April/August/December 8

T32 T32 – Full-time Institutional Training– Full-time Institutional Training T35 – Short-term Institutional TrainingT35 – Short-term Institutional Training Receipt Date:Receipt Date: May 25 May 25

Institutional Training Grants:Institutional Training Grants:

Mentored support for graduate students working toward Mentored support for graduate students working toward their doctoral degrees and postdoctoral fellows obtaining their doctoral degrees and postdoctoral fellows obtaining additional research experience in a mentoradditional research experience in a mentor’’s laboratory.s laboratory.


Disciplinary Disciplinary

Multidisciplinary Multidisciplinary

Interdisciplinary Interdisciplinary

Multidisciplinary and Multidisciplinary and Interdisciplinary Training Interdisciplinary Training


Mentored support for basic and clinical Mentored support for basic and clinical investigators who are transitioning to investigators who are transitioning to independence, changing their research independence, changing their research focus, or need protected research time.focus, or need protected research time.

K99/R00 – Pathway to Independence Award K99/R00 – Pathway to Independence Award ---------- K01 – Research Scientist Development Award K01 – Research Scientist Development Award K25 – Quantitative Scientist Development AwardK25 – Quantitative Scientist Development Award

---------- K08K08 – Clinical Scientist Development Award– Clinical Scientist Development Award K23 – Patient-Oriented Development AwardK23 – Patient-Oriented Development Award

Receipt Dates:Receipt Dates: Feb/June/Oct 12 (Mar/July/Nov resubmissions) Feb/June/Oct 12 (Mar/July/Nov resubmissions)

K Kiosk: K Kiosk: http://grants1.nih.gov/training/careerdevelopmentawards.htm

Career Development Programs Career Development Programs



Increasing DiversityIncreasing Diversity

High School Students - Early-career Faculty:High School Students - Early-career Faculty:--Diversity Supplements: Diversity Supplements: supports individuals from under-represented racial and supports individuals from under-represented racial and ethnic groups; individuals with disabilities; and individuals from disadvantaged ethnic groups; individuals with disabilities; and individuals from disadvantaged backgrounds.backgrounds.

Undergraduate Students:Undergraduate Students:

-Expanding Diversity in Engineering and the Physical Sciences:-Expanding Diversity in Engineering and the Physical Sciences: supports supports undergraduate diversity students in STEM fields at UMBC and savannah State undergraduate diversity students in STEM fields at UMBC and savannah State University.University. -Enhancing Neuroscience Diversity Through Undergraduate Research Education -Enhancing Neuroscience Diversity Through Undergraduate Research Education Experiences (ENDURE) (R25):Experiences (ENDURE) (R25): co connects activities at undergraduate minority-nnects activities at undergraduate minority-serving institutions with neuroscience graduate training programsserving institutions with neuroscience graduate training programs. .

Graduate Students:Graduate Students:Diversity Predoctoral FellowshipsDiversity Predoctoral Fellowships (F31)(F31)

Minority Biomedical Research Support (MBRS) - Support of Competitive Research (SCORE) - Research Initiative for Scientific Enhancement (RISE) - Initiative for Maximizing Student Development (IMSD)

Institutional Research Development & Support Awards (S06) - $100K/year for 4 years - support core facilities, shared equipment, seminars, workshops

Investigator-initiated Research Project Awards: SC1 – 4 year renewable award ($125-250K/year) (like R01) SC2 – 3 year nonrenewable award ($100K/year) (like R15) SC3 – 4 year renewable award ($50-$75K/year) (like R03)

Minority Biomedical Research Minority Biomedical Research Support Program (MBRS)Support Program (MBRS)

Strengthens research capabilities; supports faculty research; increases interest, skills and competitiveness of faculty and students at minority-serving institutions.


Research Grants Have Research Grants Have Different PurposesDifferent Purposes

R03 (Small – Proof of Concept)R03 (Small – Proof of Concept) - $50K per year for 2 years- $50K per year for 2 years - Not used by all NIH institutes- Not used by all NIH institutes

R21 (Exploratory/Developmental – Not Renewable) R21 (Exploratory/Developmental – Not Renewable) - $275K per year for 2 years- $275K per year for 2 years - Not used by all NIH Institutes- Not used by all NIH Institutes - No preliminary data required/Not intended to be a starter grant - No preliminary data required/Not intended to be a starter grant

R01 (Standard) R01 (Standard) - $400K-$500K per year for 4-5 years- $400K-$500K per year for 4-5 years - Preliminary data required - Preliminary data required

R15 (R15 (AAcademiccademic RResearchesearch EEnhancementnhancement AAwardswards) ) - $300K per year for 3 years- $300K per year for 3 years - Supports Preliminary data required - Supports Preliminary data required


New and Early-stage InvestigatorsNew and Early-stage Investigators

New and early-stage investigator R01 paylines can be up to New and early-stage investigator R01 paylines can be up to 5 percentile points beyond the regular institute payline.5 percentile points beyond the regular institute payline.

New investigators submitting their first competing R01 renewal and scoring close to the institute payline are eligible for an additional year of bridge funding.

New Investigator (NI) – Applicant who has not previously been a PI on a significant NIH research award.

Early-Stage Investigator (ESI) - New Investigator within 10 years of completing their terminal degree.

Peer reviewers expect less preliminary data and focus more on the approach of early-stage investigators than their track record.


Clinical and Clinical and TranslationalTranslational

Science Awards Science Awards

Public-PrivatePublic-PrivatePartnershipsPartnerships

High-riskHigh-riskResearchResearch

InterdisciplinaryInterdisciplinary ResearchResearch

NanomedicineNanomedicine

Bioinformatics andBioinformatics and Computational BiologyComputational Biology

StructuralStructuralBiologyBiology

Building Blocks,Building Blocks, Biological PathwaysBiological Pathways

and Networksand Networks

MolecularMolecular LibrariesLibraries

and Imagingand Imaging

NIHNIHCommon Common

Fund Fund Research Teams Research Teams of the Futureof the Future

Re-engineering the Re-engineering the Clinical ResearchClinical Research

EnterpriseEnterprise

Early Independence AwardsEarly Independence AwardsNew Innovator AwardsNew Innovator AwardsPioneer AwardsPioneer AwardsTransformative R01 AwardsTransformative R01 Awards

EpigenomicsEpigenomics

Genotype-Genotype-TissueTissue

ExpressionExpression

Human Human MicrobiomeMicrobiome

New Pathways New Pathways to Discoveryto Discovery

http://commonfund.nih.gov/


NIH Director's NIH Director's Early Independence AwardsEarly Independence Awards

Inspired by programs at Carnegie, Inspired by programs at Carnegie, Whitehead, UCSF, and other Whitehead, UCSF, and other institutions. institutions.

Helps exceptional early-career Helps exceptional early-career scientists scientists skip traditional post-skip traditional post-doctoral trainingdoctoral training..

Reduces time it takes early-career Reduces time it takes early-career scientists to launch independent scientists to launch independent research careers.research careers.

Receipt date: Receipt date: January 31, 2012 January 31, 2012



Take Home LessonsTake Home Lessons

NIH wants to fund the best science by the best scientists. Help is available, but you have to connect with it.

Writing the perfect grant takes focused attention and coordination, NOT just creativity. NIH evaluates your ideas through your written grant application - MAKE it count!

NIH use electronic oversight to strictly apply the rules. Stand out with your ideas, NOT your presentation.

Most grants are NOT funded on the first try. Respond appropriately to critiques and be persistent.



NIBIB Mission

To improve human health by leading the development and accelerating the application of biomedical technologies.

The Institute is committed to integrating the physical, engineering, and computer sciences with the life sciences to advance basic research and medical care.


Design by Biomedical Undergraduate Design by Biomedical Undergraduate Teams (DEBUT) ChallengeTeams (DEBUT) Challenge

Design by Biomedical Undergraduate Design by Biomedical Undergraduate Teams (DEBUT) ChallengeTeams (DEBUT) Challenge

Open to domestic Open to domestic undergraduate studentsundergraduate students

Team-based design projects in three categories:Team-based design projects in three categories:– Diagnostic Devices/MethodsDiagnostic Devices/Methods

– Therapeutic Devices/MethodsTherapeutic Devices/Methods

– Technology to Aid Underserved Populations andTechnology to Aid Underserved Populations and

Individuals with Disabilities.Individuals with Disabilities.

Winners in each category receive:Winners in each category receive:– $10,000 $10,000 prizeprize

– Up to Up to $2,000 $2,000 in travel costs in travel costs to attend award ceremony to attend award ceremony

at BMES Annual Meeting at BMES Annual Meeting

Entry deadline: May 26, 2012; Winners announced: July 31, 2012Entry deadline: May 26, 2012; Winners announced: July 31, 2012

http://debut.challenge.gov/http://debut.challenge.gov/


Multidisciplinary and Multidisciplinary and Interdisciplinary TrainingInterdisciplinary Training

Biological, clinical, and physical Biological, clinical, and physical scientists speak scientists speak differentdifferent languages.languages.

Biologists and clinicians may Biologists and clinicians may not know what is technically not know what is technically possible; engineers may not be possible; engineers may not be aware of the biological and aware of the biological and clinical issues.clinical issues.

Multidisciplinary and inter-Multidisciplinary and inter-disciplinary mentoring and disciplinary mentoring and training is training is essentialessential to insure to insure successful collaboration.successful collaboration.


Pathway to IndependencePathway to Independence(K99/R00 Program)(K99/R00 Program)

- - US citizens or non-citizens US citizens or non-citizens -- < < 5 years of postdoctoral experience- Must be in dependent position

- - Five years of total support:Five years of total support: K99 Phase - 2 yrs mentored postdoctoral supportK99 Phase - 2 yrs mentored postdoctoral support ($90K/yr total costs with 8% F&A)($90K/yr total costs with 8% F&A)

Must Must secure secure independentindependent faculty position faculty position AND AND pass administrative reviewpass administrative review R00 Phase – 3 yrs independent research support;R00 Phase – 3 yrs independent research support;

($249K/yr total costs with full F&A) ($249K/yr total costs with full F&A)


Developing Clinician-ScientistsDeveloping Clinician-Scientists

Medical StudentsMedical Students MD/PhD Training (NIGMS MSTP program)MD/PhD Training (NIGMS MSTP program)

F30 MD/PhD Fellowships (Not all NIH institutes)F30 MD/PhD Fellowships (Not all NIH institutes)

Residents/FellowsResidents/Fellows Institutional Residency Training (T32)Institutional Residency Training (T32) NIBIB Research Education Programs for NIBIB Research Education Programs for

Residents and Fellows (R25)Residents and Fellows (R25) Clinical Career Development (K08/K23)Clinical Career Development (K08/K23)

Loan Repayment ProgramLoan Repayment Program


Research Education Programs for Research Education Programs for Residents and Fellows (R25) Residents and Fellows (R25)

Integrates education programs of Radiology and other Integrates education programs of Radiology and other clinical departments and suclinical departments and supports residents and fellows in radiology and other NIBIB-relevant residency programs as clinician-scientists.

Parent program based in radiology department. Program participants from radiology and other

residency programs, including cardiology, neurology, oncology, orthopaedics, ophthalmology, and surgery.

12 or 24 month support>75% effort$70k/participant, $10k expenses, $1k travel2 participants/yr


Loan Repayment ProgramLoan Repayment Program

Applicants: (1) must be US citizens or permanent residents; (1) must be US citizens or permanent residents; (2) have a doctoral (MD, MD-PhD, or PhD) degree; and(2) have a doctoral (MD, MD-PhD, or PhD) degree; and(3) educational debt > 20% of their annual salary. (3) educational debt > 20% of their annual salary.

Applicants must be engaged > 50% time in qualified research at (or Applicants must be engaged > 50% time in qualified research at (or funded by) US government or domestic nonprofit institutions.funded by) US government or domestic nonprofit institutions.

Federal employees or individuals who have a Federal or state health Federal employees or individuals who have a Federal or state health service obligation are not eligible.service obligation are not eligible.

NIH will repay half (up to $70K) of your qualified educational debt (and NIH will repay half (up to $70K) of your qualified educational debt (and Federal taxes) over two years.Federal taxes) over two years.

Application Receipt Dates:Application Receipt Dates: May 1 (Intramural) May 1 (Intramural) December 1 (Extramural)December 1 (Extramural)


The NIH Common Fund invests millions of dollars to fund new high-risk research to explore ideas that have strong potential to improve health

Transformative R01 Awards – support creative projects that have the potential to overturn conventionalresearch paradigms (79 awards since 2009).

Pioneer Awards – support scientists of exceptional creativity who propose pioneering approaches to major research challenges (94 awards since 2004).

New Innovator Awards – support promising new investigators and stimulate highly innovative research (164 awards since 2007).

stressprojects

stressindividuals

Investments in InnovationInvestments in Innovation

Early Independence Awards - help early-career investigators skip traditional postdoctoral training and launch independent research careers (10 awards in 2010).New

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Documents

Training and Supporting the Biomedical Research Workforce Richard A. Baird, Ph.D. Director, Division of Interdisciplinary Training Natl. Inst. Biomedical