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Trans-Disciplinary Hybrid Electronics in the UCLA CHIPS Ecosystem Tzung Hsiai Medicine and Engineering, UCLA + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

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Page 1: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

Trans-Disciplinary Hybrid Electronics in the UCLA

CHIPS Ecosystem

Tzung HsiaiMedicine and Engineering, UCLA

+ ++++++++++++++++++++++++++++++++++++++++++++++ +

Page 2: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

UCLA Trans-Disciplinary Research

a. 1997 c. 2008 d. 2014 e. 2015 b. 2007 cccc.... 22220000000088882222000000008888bbbb. 2222000000007777bbbb 200000007777

Page 3: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

Our Vision

Inconspicuous, invisible… Compassionate,

predictive, preventive…

Transformation of Patient-Centered Care

Cardiac index… Wage pressure… VE/VCO2… QTc intervals… SVT vs. VT….

Metabolic states…. Sympathetic vs.

parasympathetic tone… Body weight…

L/min mmHg VE rates/L/min sec/cycle beats/min

ROS/O2.-

Beats/min oC �� Kg/m2

OOOOOOuuuuuur Vision

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rararaaaasysysysysysympmpmpmpmpmpatatatatatathehehehehehetitititittic cc c cconenenenenene………………

Body weigh

Page 4: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

Integration with UCLA Health and School of Medicine

School of Medicine

• Basic Science – Biological Chemistry – Biomathematics – Human Genetics – Microbiology, immunology &Molecular

Genetics – Molecular & Medical Pharmacology – Neurobiology – Physiology

• Labs, Institutes and Centers • Atherosclerosis Research Units • Cardiovascular Research Lab • Clinical Trials • Emergency Medicine • Human Gene Therapy Center • Immunity, Inflammation, Infection, &

Transplant (I3T) Research Initiative • Integrated Substance Abuse Programs • Ronald S. Hirschberg Translational

Pancreatic Cancer Research Laboratory • UCLA Donated Body Program

Clinical Departments • Anesthesiology • Department of Medicine

– Cardiology, Clinical Nutrition, Dermatology, Digestive Diseases, Endocrinology, General Internal Medicine and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater LA, VA Sepulveda

– Centers-CARE (AIDS) Center, Center for East-West Medicine, Clinical Immunology and Allergy, Clinical Epidemiology and Preventive Medicine

• Head and Neck Surgery • Neurology • Obstetrics and Gynecology • Pathology and Laboratory Medicine • Pediatrics • Psychiatry and Biobehavioral Sciences • Radiation Oncology • Surgery • Urology

http://people.healthsciences.ucla.edu/institution/groups-new

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acology

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Page 5: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

UCLA Health and School of Medicine

UCLA Affiliated Teaching Hospitals

• Ronald Reagan Medical Center • Greater Los Angeles VA Healthcare

System • Olive View Medical Center • Harbor-UCLA Medical Center • Santa Monica-UCLA Medical Center

hing H

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System• Olive VVVVVViiiieeeewwwwww MMMMMMeeeeddddiiiiiccccccaaaaaalllll CCCCCCeeeeeennnnnntttttteeeeeerrrrrr• HHHHHHaaaaaarrrrrbbbbbboooooor----UUUUCCCCCCLA MMMMMMeeeeeeddddddiiiiiiccccccaaaaaallllll CCCCCCen•••••• SSSSSSannnnnnta MMMMoooooonnnniccccccaaaaaa------UUUUUUCCCCCCLLLLLLAAAAAA M

Page 6: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

Clinical and Translational Science Institutehttp://people.ctsi.ucla.edu/institution/personnel?personnel_id=8744

• Supports Training in Multidisciplinary Research and Integrates Community Priorities – New investigator program – Junior faculty program – Pre-doctoral program – High school & Undergrad programs

• Training and Resources for Career Development to Conduct Innovative and Translational Research – Training program in translational science – Educational videos, tools & workshops – Course catalog – Commercialization & entrepreneurship

l?pers

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aaattttaaaaallllooooogggggalization

Page 7: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

• Heart Transplant Program – Since1984, 2,000 patients have undergone this life-saving

procedure at UCLA. The scientific advances and clinical trials that have come from UCLA have advanced knowledge in the field and improved the clinical results for all patients.

• Cardiac Arrhythmia Center– The Center is dedicated to utilizing state-of-the-art medical technologies

with compassionate care to address the needs of arrhythmia patients.

• Adult Congenital Heart Disease Program– The Center is a national and international tertiary care resource that

provides services to the growing number of patients with congenital heart disease who reach adulthood.

• Ahmanson UCLA Cardiomyopathy Center (Congestive Heart Failure Program) • Interventional and Structural Heart Disease• Cardiac Surgery

medical technolooogigig eseses of arrhythmia patiiienee tststs.

ase Programmmmmmnternational tertiaryyy yy caaaarrre resourccce thththat

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Page 8: Trans-Disciplinary Hybrid Electronics in the UCLA …...and Health Sciences Research, Geriatrics, Hematology-Oncology, Nephrology, Pulmonary, Critical Care, Rheumatology, VA Greater

A Trans-Disciplinary Approach to Assess Unstable Plaque

(a) (b) (c)

*

aorticarch

descendingaorta

Greater curvature

200 µm(b) (c)

Concentric bipolar micro senor

cable

balloon CConConCConcencencencencenntritritritririric bipoooooolarlarlarlarrlar mim m m mm crocrocrcrcr senornornonornor

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