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Transformation of the ppCRRT to the ppAKI-RG
Stuart L. Goldstein, MD
Founder and Principal InvestigatorThe Prospective Pediatric CRRT Registry Group
The Prospective Pediatric Acute Kidney Injury Research Group
The Center for Acute Care Nephrology
The ppCRRT Registry
• 13 US Centers• Prospective observational CRRT cohort
registry• 2001 to 2005• 370 patients entered• Patients aged 1 day to 25 years• Unrestricted industry funding
– Gambro, Dialysis Solutions Inc, Baxter, B Braun• Jordan Symons, MD – Resident Artist
The Center for Acute Care Nephrology
Bunchman Brophy Goldstein Symons Somers
The Founding Five
The Center for Acute Care Nephrology
Askenazi D et al: PCRRT in Children < 10 kg (J Peds)
The Center for Acute Care Nephrology
The ppCRRT Registry Co-Investigators/Authors
• Michael Somers• Michelle Baum• Pat Brophy• Jordan Symons• Tim Bunchman• Rick Hackbarth• Mark Benfield• David Askenazi• Michael Zappitelli• Geoffrey Fleming
• James Fortenberry• John Mahan• Deepa Chand• Francisco Flores• Kevin McBryde• Steven Alexander• Annabelle Chua• Douglas Blowey• Scott Sutherland
The Center for Acute Care Nephrology
The ppAKI-RG
• Multi-national research collaborative• Web-based registry under development• Interventional trials/FDA 510K planned• AKI studies, not limited to CRRT (no ECMO)• The Center for Acute Care Nephrology
manages contracts with sponsors and registry
• Sites receive PI, patient care and indirect costs
• Jordan Symons, MD, Resident Artist
The Center for Acute Care Nephrology
The Center for Acute Care Nephrology
Admission and Structure
• Signed consortium agreement: – contact S. Goldstein (
[email protected])• Each site with a signed agreement has a
seat on the research committee• Anyone can bring a project to the ppAKI-
RG and they serve as overall project PI if approved by the steering and research committees
The Center for Acute Care Nephrology
Current ppAKI-RG SitesCenter PIAlabama Askenazi
Ann Arbor Selewski
Atlanta Paden
Boston Somers
Cincinnati Goldstein
Grand Rapids Hackbarth
Iowa City Brophy
Kansas City Chadha
Kings, London Deep
Montreal Zappitelli
Nashville Fleming
Palo Alto Sutherland
Richmond Bunchman
Rome Picca
Seattle Symons
Singapore Peilin
St. Petersburg, FL Flores
Sydney Kennedy
