A COMPARISON OF TRANSURETHRAL SURGERY WITH WATCHFUL WAITING FORMODERATE SYMPTOMS OF BENIGN PROSTATIC HYPERPLASIA

OLEH : MARSHAL AGRENO

PEMBIMBING : DR. DAHRIL, SP.U

BACKGROUND

Transurethral resection of the prostate is the most common surgical treatment for benign prostatic hyperplasia.

conducted a multicenter randomized trial to compare this surgery with watchful waiting in men with moderate symptoms of benign prostatic hyperplasia.

METHODS

Selection of Patients

consecutive male veterans referred to urology clinics because of symptoms of benign prostatic hyperplasia were asked to participate in the study.

All participants gave written informed consent.

Urinary symptoms were scored on a scale ranging from 0 to 27 points with the use of a nine-question interview.

Symptoms with scores of 10 to 20 are considered moderate or somewhat severe on the basis of their correlation with a more recently developed symptom index.

Men with serious medical conditions that would have made surgery inappropriate or follow-up unlikel, serum creatinine concentration was higher than 3.0 mg per deciliter (265 umol per liter) or had doubled in the previous year y were excluded.

Assignment to Treatment and Follow-up

Men assigned to the surgery group underwent surgery within two weeks after randomization

All the study participants were seen in a general medical clinic six to eight weeks after randomization and then twice a year for three years of follow-up.

All participants were told to avoid ingesting coffee, alcohol, and other liquids after dinner and were informed about medications that might make their symptoms worse.

Statistical Analysis

The primary outcome measure was treatment failure, defined as the occurrence of any of the following events during follow-up: death; repeated or intractable urinary retention; a residual urinary volume over 350 ml; the development of a bladder calculus; new, persistent incontinence requiring the use of a pad, penile clamp, or condom; a symptom score of 24 or higher at one visit or scores of 21 or higher at two consecutive visits; or a doubling of the base-line serum creatinine concentration.

RESULTS

Screening

Of the 800 men over the age of 54 years who were screened and had symptoms consistent with benign prostatic hyperplasia

The study therefore included 556 men: 280 in the surgery group and 276 in the watchful-waiting group.

Characteristics of

the Patients

Postoperative Events

Of the 280 men randomly assigned to the surgery group, complete information about the surgical procedure was obtained for 242 of the men.

91% of the men had no complications during the first 30 days after surgery.

The most frequent complications :

1. Need for placement of another urinary catheter (in 9 of the 242 patients [4 percent])

2. Perforation of the prostate capsule (in 5 [2 percent])

3. Hemorrhage requiring transfusion (in 3 [1 percent])

4. 2 patients had postoperative urinary tract infections

5. 1 patient had thrombophlebitis

Three years after surgery :

1. 9 had a contracture of the bladder neck requiring endoscopic surgery

2. 9 had a urethral stricture that required dilation

3. 8 underwent a second transurethral resection

4. 4 because of adenocarcinoma.

Treatment Outcomes

after Three Years

Change in Symptoms

and Quality of Life

Factors Influencing Outcomes

after Treatment

DISCUSSION

1. surgery was more effective than watchful waiting in reducing the rate of treatment failure and mitigating genitourinary symptoms, the degree of bother from urinary difficulties, and interference with the activities of daily living.

2. complications and retreatment after surgery is low

3. men with moderate symptoms of benign prostatic hyperplasia that substantially reduce the quality of their lives have the most to gain from transurethral resection.

TERIMA KASIH