Tuberculosis is a disease caused by an infection with the bacteria Mycobacterium tuberculosis.

Typical signs of tuberculosis are:Chronic or persistent cough and sputum production. If the

disease is at an advanced stage the sputum will contain

blood.

Fatigue.

Lack of appetite.

Weight loss.

Fever.

Night sweats.

Today, treatment involves three or four different kinds of

antibiotics given in combination over 6 to 12 months.

Multiple medicines are necessary to prevent the emergence of

resistance, which would lead to treatment failure.

The main cause of treatment failure is non-compliance with

what is perceived as a demanding and prolonged programme of

therapy.

For positive culture do susceptibilities and report results to Health Department

begin taking four medications — isoniazid, rifampicin , ethambutol pyrazinamide and streptomycin .

The standard "short" course treatment for tuberculosis (TB), is: isoniazid, rifampicin, pyrazinamide, and ethambutol for two

months, Then isoniazid and rifampicin alone for a further four months.

This regimen may change if tests later show some of these drugs to be ineffective.

Hepatitis Peripheral neuropathy

Lupus

Liver function tests

Clinical signs of hepatic toxicity

Numbness/tingling of extremities

Alcohol Phenytoin Disulfiram Aluminum Salts Carbamazepine Benzodiazepines Anticoagulants Ketoconazole

Hepatitis

Orange discoloration of secretions

Drug interactions

Immunologic mediated illness

Liver function tests

Clinical signs of hepatic toxicity

CBC, platelets, serum creatinine, bilirubin

Bleeding abnormalities

Warfarin Digoxin Beta-blockers Ketoconazole Verapamil Quinidine Methadone Phenytoin.

Corticosteroids Oral

Contraceptives Dapsone Theophylline Sulfonylureas Cyclosporine Protease

Inhibitors

Gout Rash Peripheral neuritisOptic neuritis

Visual acuity

Uric acid levels

Aluminum salts

Hepatitis

Gout

Liver function tests Clinical signs of hepatic toxicity Uric acid levels

Auditory Vestibular Nephrotoxicity Hypersensitivity

Signs of Ototoxicity Vertigo Ataxia Hearing Loss

Loop diuretics

Neuromuscular blockers