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*most consistent in drug structure

Amide metabolized in the LiverEster metabolized by esterases in Plasma

fere withum transportthe neuron

only Esters Procaine

Esters:

ProcaineTetracaineCocaine

procaine/tetracaine/cocaine....metabolized in Plasma

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lead tovulsion...

er doses:S depressionlting iniratory depressiondeath

first if more.....then CNS depression

because blocks the reuptake of NE intoadrenergic neurons

facilitate nervimpulse cond

*Nerve impulses are generated by the influx of sodium resulting in depol

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UNionized to get into membraneBUTIONized to get into neuron

A/HA = pH pKa

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20mg/1ml X 1.8ml/1 = 36mg lidocaine

3ml/1 X 1 carpule/1.8ml X 36mg/1 Carpule

0.05% = .5mg/1ml X 1.8ml/1 carpule = 0.9mg a carpule

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penicillin G for thisreason is giving via IV

intra muscularIV?

Cephalsporin and Ampicillin...

what works with penicillin is Erythromycin

Penicillin crossallergenic withCephalsporin (Cephalexin) and Ampicillin...

so like cephalsporins, ampicillin

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not dosendent...son't mattermuch you inject..

et same response*

*because the SPECTRUM of activity is similar to Penicillins

broader spectrum thanpenicillin G

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