Regression of Mantle Cell Lymphoma Involving the Stomach

Before CAR-T cells Day 29 after CAR-T cells

Regression of Diffuse B Cell Lymphoma

Before CAR-T cells Day 32 after CAR-T cells

Tumor regressions observed in Phase 1/2 clinical trials for patients with B-cell cancers after infusion of CAR (Chimeric Antigen Receptor) T cells engineered at Fred Hutch.

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TUMOR-MELTING T CELLSChimeric Antigen

Receptor

T CELL Schematic ofa CAR-T cell

Regression of Advanced Acute Leukemia Involving Bone Marrow and Kidneys

Before CAR-T cells Day 37 after CAR-T cells

Bone Marrow (Before CAR-T cells)

83.6% blasts

Bone Marrow (Day 28 after CAR-T cells)

Complete remission

Scapular lesion

Para-aortic tumor

Retroperitoneal

Iliac tumor

Regression of Extramedullary Acute Leukemia

Before CAR-T cells Day 31 after CAR-T cellsBefore CAR-T cells Day 30 after CAR-T cells Day 60 after CAR-T cells

Regression of B Cell Lymphoma Involving the Kidney

Source: Riddell, Turtle and Maloney Labs, Fred Hutchinson Cancer Research Center