CALIFORNIA TUMOR TISSUE REGISTRY

"TUMORS OF THE KIDNEY & BLADDER"

Study Cases, Subscription A

February 2007

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Loma Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: ct!!@linkline.com

2

Target audience: Practicing pathologist~ aod pathology residents.

Coal: To acquaint the participant with the histologic featwes of a variety of benign and

malignant neoplasms aod tumor-like conditions.

Obiedives: The participant will be able to recognize morphologic features of a variety of benign

and malignant neoplasms and tumor-like conditions and relate those processes to pertinent references in the medical literature.

Educational methods and media: Review of representative glass slides with associated histories. Feedback on consensus diagnoses from participating pathologists. Listing of selected refer:eoces from the medical literature.

Principal faeultv: Donald R. Chnse, MD

CMECredit: Lorna Linda University School of Medicine designates this continuing medical

education activity for up to 2 hours of Category 1 of the Physician's Recognition Award of the American Medical Association.

CME credit is offered for the subscription year only.

Accreditation: Lorna Linda University School of Medicine is accredited by the Accreditation

Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

Study Cases, february 2007, Subscription A

Contributor: Carol Solomon, M.D. Case No. 1 - February 2007 A San Diego, CA

Tissue from: Urinary Bladder Accession #30272

Clinical Abstract: A 57 year old man presented with a six month history of intermittent hematuria. Cystoscopy

showed a large tumor within the bladder.

Gross Pathology: The 15.5 x 13.7 x 9.5 em bladder was filled by an 8.0 x 4.3 x '"3.7 em fungating papillary tan­

pink mass, circumferentially adherent to the lower two-thirds of the posterior and anterior bladder walls.

Contributor: Lorna Linda Pathology Group (np) Lorna Linda, CA

Tissue from: Urinary Bladder

Clinical Ab~tract:

Case No. 2 - February 2007 A

Accession #30203

This 83 year old man presented with gross painless hematuria. He had no elevation of his PSA. Cystoscopy showed a large tumor with.in the urinary bladder.

Gross Pathology: The specimen consisted of an 8 x 6 x 1.5 em aggregate of transurethrally removed tumor chips.

SIUdy Cases. February 2007. Subscription A 3

Contributor: Lester Thompson, M.D. Case No.3 - February 2007 A Woodland Hills, CA

Tissue from : Urinary Bladder Aeeession #30250

C linical Abstract: This 32 yc;ar old woman presented with vague lower abdominal pain, associated with a history

of urinary tract infection. Antibiotics failed to resolve the symptoms and urinalysis showed microscopic hemaruria. Colonoscopy was normal and intraoperative evaluation of ovaries, uterus and appendix showed no abnormal.ities.

Gross Pathology: Not available.

Contributor: Mark Janssen, M.D. Case No. 4 - February 2007 A Auaheim,CA

T issue from: Rigbt kidney Accession #30 147

C linical Abstract After two months of worsening right flank pain, this 73 year old woman was found on CT scan

to have a right renal mass. She had had no hematuria or weight loss.

Gross Pathology: The kidney resection specimen was received in fragments. In addition to grossly apparent renal

parenchyma, several of the pieces, ranging from 2.7 to 3.2 em in greatest diameter, had firm tan-white cut surfaces. Other fragments were largely fatty and yellow.

Special Studies: Tumor cells positive: Tumor cells negative:

4

vimentin, smooth muscle actin, muscle specific actin, desmin, HMB45 pankeratin

Study Cases, February 2007, Subscription A

Contributor: Jin Wang, M.D. Case No. 5 - February 2007 A Hangzhou, People's Republic of China

Tissue from: Right kidney Accession #30115

Clinical Abstract: A 35 year old woman presented with vague pain in the right lumbar region and a 20 day history

oflow grade fever. Work-up found a right kidney mass.

Gross Pathology: The kidney resection specimen was 14 x 8 x 8 em and contained a 9 x 7 em well-defmed mass

in the lower pole. The cut surface was variable, ranging from gray, to pink-tan to dark red. There was extensive necrosis.

Special Studies: Strongly positive: Focally positive: Negative:

Desmin, SMA, virnentin Actin Cytokeratin, EMA, MyoD-1

Contributor: Anne Drejet, M.D. Santa Barbara, CA

Tissue from: Kidney

<:::linical Abstract:

Case No. 6 - February 2007 A

Accession #30289

A 58 year old woman was found to have cystic masses involving the right kidney and adrenal gland.

Gross Pathology: Not available .

. Study Cases, February 2007, Subscription A 5

Contributor: Michele Cosgrove, M.D. Case No. 7 - February 2007 A Glendale, CA

Tissue from: Left Kidney Accession #30364

Clinical Abstract: Follow up of aS I year old diabetic man in renal failure revealed a mass in his left kidney.

Gross Pathology: In the mid portion of the 190 gram kidney was a 4.3 x 4.0 X 3.0 em well~ircumscribed hard

pale tan mass.

Special Studies: Positive: Negative:

CD99, CD34, Vimentin AEI /AE3, CDII7, Desmin, actin

Contributor: Anne Drejet, M.D. Santa Barbara, CA

Tissue from: Kidney

Clinical Abstract: A 41 year old woman bad a right kidney mass.

Gross Pathology:

Case No. 8 - February 2007 A

Accession #30290

The right kidney resection specimen with perinephric fat was 121 0 grams. It was distorted by a 14 x 12 x 10 em tumor which left a thin rim of kidney at one pole. The tumor penetrated the renal capsule, extending into surrounding fat. The cut surface was lobulated dense white parenchyma with focal yellow necrosis.

Special Studies: Positive: Negative:

6

C099, vimentin, SMA (focal), CD I 0 CK-7, CK-20, CAM5.2, EMA, Ber-EP4, myo-DI, CD56, HMB-45, FLI- 1, S-1 00, desmin, CD23, CD 117, Estrogen & Progesterone receptors

Srudy Cases, February 2007, Subscription A

Contributor: Phillip Gordon, M.D. Case No. 9 - February 2007 A Winter Haven, FL

Tissue from: Left kidney Aroession #30185

Clinical Abstract: A 69 year old woman bad a left renal mass.

Gross Pathology: The 244 gram resection specimen included a 2.5 x 2.3 x 1.5 em _fleshy dark. red-brown mass in

the upper pole of the kidney, filling one of the calyces. The mass was diffusely hemorrhagic, well encapsulated and confined to the kidney.

Contributor: Dawn Ellerson, M.D. Case No. 10 - February 2007 A San Luis Obispo, CA

Tissue from: Kidney Accession #30233

Clinical Abstract: An 86 year old woman presented with hematuria. lmaging studies showed a right renal pelvic

mass involving the collecting system extending into the mid portion of the kidney.

Gross Pathology: The 284 gram kidney contained a 5 x 4 x 3.5 em ill-defined infiltr.rting mass that extended

nearly to the renal capsule.

Study Cases. Febru:uy 2007, Subscription A 7

CALIFORNIA TUMOR TISSUE REGISTRY

•

. tUMORS-OF THEKJDNEY"AND. BL:A:DDER PA'THOLOlJY

Mjnut~s - Sub.scrip.tion A

-Febl.1laty; 2001

SUGGESTED READING (General Topics from Recent Literature):

IZil.

Lymphoma Is the Most Common Malignancy of the Ocular Adnexa. Ferry JA, Fnng.CY, el at Am J Surg Pathol 2007; 31:170-184.

Women More Likely to Have New or Missed CRC After Colonoscopy. Bressler B, Paszat LF, ct al. Gaiitroenterol 2007; 132:96- 102. ..

Mammaglobin Is a Specific Marker for Breast Cancer. Sasaki E,.Tsunoda N, et al. Mod Patilo/2006; 22. T.LE I Ts a Sensitive & Specific Marker for Synovial Sarcomas. Terry J, Saito T, er al. Am J Sw-gPatho/2007; 31:240-

246. Clear Cell Sarcoma. Clinical Fearures, Therapy, & Prognosi.s. Kawai A, Hosono A, et al. Cancer 2007; I 09:109-116.

California Tumor Tissue. Registry c/o: Department of Pathology aod Human Anatomy

Lama Linda University School of Medicine 11 021 Campus A venue, AH 33 5 Loma Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cttrliillinkline.com Web site & Case of the Month: www·.cttr.org

Case 1:

Case 2:

FILE DIAGNOSES

(Preferably submitted on website at www.etir.ore. Click "subscriptions", dten submit answers".)

CTTR Subscription A

Papillary urothe)jaJ carcinoma, bladder T-71000, M-80503

l"ebrua•·y, 2007

Carcinosarcoma (sarcomatoid high grade urothelial carcinoma with chondrosarcoma and osteosarcoma, bladder

Case3:

Case4:

Case 5:

Case6:

Case 7:

Case 8:

Case9:

T-77100,M-92203

Mucinous adenocarcinoma, bladder T-71000, M-81403

Angiomyolipoma, kidney T-71000, M-88600

Leiomyosarcoma, kidney T-71000, M-88903

Mixed epithelial and stromal tumor, kidney T-71000, M-81003

Solitary fibrous tumor, kidney T-71000, M-90510

High grade sarcoma, (NOS), kidney T-71000, M-88103

Renal cell carcinoma with papi llary and tubulocystic features, l<idney T-71000, M-83123

Case JO:

2

Collecting duct carcinoma, kidney T-71000, M-83123

CITR, Fcbnmry 2007 "Minutes" (Subscrip(ion A)

Case No. l, Accession No. 30272 February 2007

Alameda (Alameda County Medical Center) - Papillary urothclial coroinoma, low grade Eon!3!!a (Kaiser PctlJ!AOrntel - 'l'nlnsitional cell can:inoma, grade 213 Granada Hj!ls - Invasive transitional cell carcinoma. no muscle involvement L&ng peach • Invasive papillary urothelial carcinoma, high grade Long Beach CLone Beach Veterans HosoitaD - Papillary urothelial carcinoma, WHO 2/J L&s Ansclcs • Transitional cell caroinoma Monterey !Community Hospjral of Monterey Peninsula) • Papillary urothe!inl earcinoma, high grade (2); Low grodc (I) ~ • Low grade J>apillary caroinoma Orange IQawge Coumy Pathology Medical Grouo) • Pupillary ~tansitiooal cell carcinoma, low grade Oxnard CSt John's Regjo!l!ll Medical U:ntcc) • Papillary transitional ct:U ClUCinoma, grndc VU, low gl'lde papillary carcinoma (I);

Papillary transitional cell carcinoma(2) San Dicgq • Papillary tra.tlsitional ccU carcinoma. focally invasive, grade IJ bladder S;m Diego CNaval Modica! Center San Diego) • Infiltrating urotheliol carcinoma San DicgoiScripos HCi!hhl • Low grade papillary urothclial can:inoltl3 San Diego (l/CSD) • Papillary and sessile urothelial carcinoma, low grade San Francjsco !San Francisco General Hospjual) - Low srade ~rothclial carcinoma San~• Badlam • Low grade papillary urolhellal carcinon~a Santa RosgiSanra Rosa Mcmonal HospitaO • Transitional cell caroinoma (I); Papillary urothclial carcinoma, low grade (I)

Papillary transitionnl cell carcinoma, low gmdc (papillary urothclial tumor) (I) Woodland Hms CKaiscr Pcpnsnente) . Non-invasive papillary urothelial carcinoma, low grade Wosxlland Hills <Suda's Snldiea) • Urorheli>l carcinoma, grade 2, (non-invasive) Arkansa.o:; <University oCArkansa4 for Mecliql Sciences) . Non-invasive pap1llary urothelial carcinoma, high grade, urinary bladder Georgia. Dccmur - Papillary urothelial carcinorna Illinois. Burr Rtdoe . Papillary urothelial cu.rcinoma (I); Urorhelial carcinoma, grnde J.J I, non-invasive or microinvasive ( 1) ll!jnojs l!.ovola Unjymjty Medical Q;nrer) • Diffuse large B-celllympboma Indiana (Howard Regignal Me<lical Center) • Low grade papillary neoplasm Mnryland <Northwesrliospital Center) . fligh 0..-ade papillary urothclial carcinoma Maniand IIJniversity gf Marvlaodl • Infiltrating urothclial carcinoma, high grade MassachuS£1\$ CBerkshirt Medical Center) · P3pillary carcinoma~ non-invasive Massachyscw~ ffievcr!y Hospital> · Non-invasive low gr:1de p2pillary urorhclial carcinom:1 Michigan !Oakwood Hosoital) - Papillary urolhelial carcinoma> non-invasive Minnesota <Fairview Rjdge.10 Hospjtp!) - Papillary urothelial carcinorna, low-grade Nebraska ICrsjghton Unjvcrsjty School ofModjcine)- Low grade papillary urolhelial carcinoma New Mexjco CUniycrsjty of New Mexjco)- Pupillary urothelial carcinoma New York Cl.ong Tsland Jewish Medical Center) - Jnvosivc low grade papillary urotheliol curcinorna Nt'\' York <Nesseu University Medical Ccnu:rl - Urothclia1 carcinoma. papillary Nsw VOrk CStony Brook lJnhmjry Hospital) - Transitional oell c.1rcinoma. carcinoma in-sllu New York CSUNY Downstate Medjcal Center) • PopiUury Lransitional c-ell carcinoma North Camljna (Mountajn Area PaLhology) - liigh grade papillary transitional cell carcinoma ( I); Transitional cell cal'cinoma, lo'v

grade ( I) Ohio (McCullough-Hyde Mcmoriol Hospital) • Papillary urotheliol carcinoma Ok!abo!J11l, Tulsa • Popillaryurothelial carcinoma, low grade J>ennsvlvaojn CDrexel Uojycrsiw College of Medicine) · Non-invasive papi11ary urothelial carcinoma, low grade Pglns-;IWJ!j• CL@jsh valley Homj1a0 - Papillary transitional cell carcinoma, grade U/111 Pt.nnsvlwanja <Magee Women's tlo~pitall • Low grade papillary urotheliaf carcinomZ4 non-inva.s:i11e Pc:nnsvlvanja CMt. Njuany Medjcql Cente.r) .. Low grade papillary urothelial carcinoma Pgwsylvania CPennsylynnia Hospjtql R£~ide0f&) .. Low grade tn:msitional.cal'cinoma Puerto Rico (University gr Py¢rto Rico) · Invasive urorhelial earcmoma, high grade South DakoJp CUnjversjrv of South Qakom Resjdcpts) - Pnpdlary urothefial carcinoma, gmdt Ill Tennessee. Kjngspon - Low grade, superficially invasive papillary transitional cell carcino·ll'la Texas lScon & White Memorial Hosoital) • Low grade p:tpillary ur()lheliaJ carcinoma Ic&as. Houson · Papillary tnmsitional carcinoma, high 8Jllde Texas. Lubbock • Low arode papillo.ry urothelial carcinoma in-situ Washington !Madigan t\rmy Mcdicul Center) • Papillary urothe!ial curcinomn, low grade (9); High grade (3) WcsJ Vjrsinig CGrcenbrjc.r Valley Medical Csnter) · Papillary-non-infiltrative urotheHa.l carcinoma AUS!!alia <Roval Hob!l!l Hosniral) • Low gnode papillary urothelial caroinoma with a partially invertod tvowth pattern &ts!tlllia CRowl. Prjncc Alfred Hospilal) • Non-invasive papillary urothelial carcinoma, low grade Australja cs,,!Jivan Nicolnjdes Pathology) - Papillary urothclial carcinoma, low gmde llmil (labomlorio Anntomia Patologica Ecilologia - Papillary urothelialJcsion of low grade potenlial

CTIR. February 2007 "Mimllcs·· (Subscription A} 3

Brazil. Sao Pnulo - Papillary urothelial carcinoma, high ,gmde Canada !Pasqua Hosoital) • Inverted papilloma Canada, Saskatoon · Papillary urothelial (ITansitional cell carcinoma) carcinoma, low grade Canada £Sherhmoke University Hospital) - Low grade papillary invasive carcinoma lndia,Kamataka - Papillary urothelial neoplasm oflow malignant potential freland CKerry Genera] Hospital) .. Transitional cell carcinoma ofbladdcr Jamaica <The Unjv,rsity of WeSl Indies) - Low gtade urothelial carcinoma Japan <Kyoto University Hospita]) - Urothelial carcinoma, non-invasive, papillary> low grade ·oman fKhoula Hosoital) - Non invasive papillary urothelial carcinoma, low grade Oatar (Hamad Medical Cornoration} .. Papillary urothclial carcinoma. IO\V grade, non-invasive Saudi Arabia (King Fahad National Guard Rosnital) - Non-invasive papillary urothelial carcinoma (low-grade) Saudi Arabia {Maternity and Children's Hospital) ·- Papillary urothclial carcinoma, lo1v grade The Ne[hcl'lands. Amsrelveen · Low grade urothcliaJ cell carcinoma United Kingdom (Oxford Study Group} - Low grade papillary urothclial carcinoma

Case 1 - Diagnosis: Papillary urothelial carcinoma, bladder.

T-71000, M-80503

Case 1 - References: Choi YL, Lee SH, Kwon GY, et al. Overexpression ofC024- Association with Invasiveness In Urothelial Carc.inomaof<he

Bladder. Ardr Patlwl Lab Med200?; 131(2):275-2SL Malkowlcz SB, vun Poppe! H, M.ickisch G, et al. Muscle-Invasive Urothelial Carcinoma of the Bladder. Uro/2007; 69:3-I 6. Raghavan 0, Shipley WU. Gamick Mil, et al. Biology and Management ofBiadder Cancer. N EngJ Mcd 1990; 322:1129·1138. Hrabon RH, Vanderriet P, Erozom YS, et al. Brie(Report- Molecular Biology and Early Detection of Carcinoma of the Bladder.

'111e Case of Hub<Jt Humphrey.· N EngJ Med 1994; 330:1276- 1278. Mostofi 1'1<. and Sesterhcnn ·IA. Pathology of Epithelial Tumors and Carcinoma Tn·Situ of the Bladder. Prog Clin Bioi Res; 1984;

162A:55-74_

Case No. 2, Accession No- 30203 February 2007

Alameda <Alameda County Medical Center) - Iniiltrating urothclial carcinoma, sarcomatoid variant, with h<m:rologous e lements Fontana <Kaiser Pemtaneme) . Sarcoma vs. carcinosarcoma Granada Hills .. Carcinosarcoma vs. leiomyosarcoma Long Beach - Carcinosarcoma with canitagenous elements L<;!ng Beach (Long Beach Veternns Hospjtal ) - Carcinosarcoma Los Angeles - Undifferentiated urothclial carcinoma Monre·reVCCommunitv Hospital ofMontercv Peninsula) · Sarcomatoid urothelial carcinoma Oakland - Carcinosarcoma Qolng£ (Orange Coumv Pa<ho!osv Medical Group) - Invasive high-grade urothelialimetaplastic carcinoma Oxnard 1St John's Regional Medical Center) • High grade transitional cell carcinoma (2); Papillary ll'ansitional cell carcinoma ( I) San Diego . Urothelial carcinoma, sarcomatoid, bladder San Diego <Naval Medical Center San 'Dieeo) .. High grade sarComa San Oje.go <Scrinns He.ahh) - Carcinosarcoma San Dieso IUCSD) - Sarcomatoid cal'cinoma San Prancisco (San Francisco General Hospital) - Rhabdomyosarcoma Santa Barbara - Poorly differentiated small cell carcinoma Santa Rosa (Santa Rosa Memorial Hospital) - Carcinosarcoma (3) Woodland Hills CKaiser J>ennanente) · Hfgh grade urothelial carcinoma, sarc.omatoid variant (with heterologous elemenrs) Woodland Iilii< (Sud a's Soldiers) - Carcinosarcoma (chondrosarcoma) Arkansa.~ (Unjvern!cv of Arkapsgs for Medical Sden~es) - Urolhelial carcinoma, sarcomaloid varisnl (heterologous), urinary bladder Georgia. Decatur - Urothclial c-arcinoma with sarcomatoid change ll! jnojs. Burr Rjdge - Urothclial ca•cfnoma, high grade with sarcomatoid features (I); Jnfllll'aling urolhelial carcinoma, grade Ill {1) U!inojs (Loyola Unjycrsjty Medical Center) ~ Medullary thyroid carcinoma lndjana (Howard Regional Medical Center) • High grade papillary urothelial carcinoma

4 Cl11{. february 2007 otMinutcs" (Subscription A)

Marvland {Northwe~t Hosnital Cenrec) - Sarc·ootaroid urothelial carcinoma Marvland !University of Marvland) • Sarcomatoid carcinoma with high grade urothelial carcinoma component Massachusetts (Berkshire Medical Center) - Sarcomatoid and small cell carcinoma with heterologous elements (chondrosarcoma

and osteosarcoma) Massachustt1S (Beverlv Hospital) · Carcinosurcoma vs. pure sarcoma with sarcoma clements of chondrosarcoma Michigan (Qak·wood Hospital) .. Sarcomatoid carcinoma. with background trilllsitional cell in-siru Minnesota (Fairview Ridees Hospital) - Urothelial carcinoma, hjgh grade, with sarcomatoid differentiation Nebraska !Creig-hlon Unive-rsilv School of Medjcjo~) - Carcinosarcoma Ne,vMexico fUniversit.vofNew M'exico) - Sarcomatoid varian( ofurothelial carcinoma with heterologous clements New York (Long Island Jewish Medical Center) - Sarcomatoid transitional cell carcinoma with heterologous elements New York (Nassau Univcrsitv Medical .Ccnter) • Urothelial carcinoma. sarcomatoid New York (Stony Brook Vniversitv Hospital) - Transitional cell carcinoma (high grade) New York CSliNY Do\\'1'1Sfa1e Medical Center) - Sareomato!d c:areinoma vs. sarcoma with rhabdoid d iffertntiation North Caroljna fMoumajn Area Pathology) - High grade .transitional celf carcinoma and C IS ( I); Sarcomatoid carcinoma (I) Ohio McCullough-Hyde Memorial Hospital) - Chondrosarcoma Oklahoma Tulsa - Urothelial carcinoma heterologous sarcomatoid type (carcinosarcoma) Renosvlyanja (Drexel ()niversitv Colfege ofMedicjoe) - Sarcomatoid (spindle celf) carcinoma of bladder with chondrosarcomatous

differentiation (carcinosarcoma) Pennsvlvania (Lehigh Valley Hospital) - Sarcomatoid carcinoma t>ennS}'Ivania (Magee Women's Hospital) - Sarcomatoid carcinoma Pcnn:wlvania CMt. Nittanv Medical Center) - Urothelial carcinoma, heterologous sarcomatoid type Pcnnsylyanis CPcnpsylyanja Hospjtal Residenrs) - Carcinosarcoma Puerto Rico (Universitv of Puerto Rico) • Sarcomatoid (metaplastic) carcinoma South Dakota (lJnivcrs-itv of South Dakota Re.~ idenrs) - Carcinosarcoma Iepnessoe. Kingsp<trt - Renal sarcomatoid carcinoma Texas (Scott & White Memorial Hospjl'll) - Carcinosarooma Texas Houston • Spindle celJ carcinoma, poorly differentiated Texas. Lubbock .. Me-taplastic.urothelial c·arcinoma Washington <N1adigan Army Medical Center) • UrotheliaJ carcinoma with heterologous sarcomatous cJements ( 12)

Wt$t Virginia (Greenbrier Val lev 1V1edical Center) - Jnfiltrat1ve carcinomatoid urothelial carcinoma Ausrra!ja CRovnl Hobact HospjJal) - Sarcornatoid varian( of urorhcl1aJ carcinoma with he-terologous differentiation (chondrosarcoma) Australia (Roval Prince Alfred Hosoital)- UrolhtliaJ carcinoma, sarc·omatoid variant wilh helerologous elements Atisualia <Sullivan Nicolaides Pathologv) • Mct'.ipl~sric carcinoma Brazil (Laboratorio Anatomia Patologica ECitologia) • High grade sarcoma (osteosarcoma?) BrHt.il. Sao Paulo - High grnde urolh,elial carcinoma, sarcomatoid variant, with heterolog()US elements (c.!tondrosarcon~) Canada £Pasqua Hospital) - Carcinosarcoma vs. sarcoma Canada, Saskatoon - Papillary urothelial (transitional cell) carcinoma, high grade Canada rSherbrooke University Hospital) . Sarcomatoid carcinoma with heterologous elements lodja. Kamnraka - Carcinosarcoma lreJMd CKerry Generai Hospital) - Transitional cell carcinoma of bladder Jamaica<The Unjyersity ofWesrlndies) - Sarcoma(oid renal cell carcinoma Jaoan O<yoto University Hosoital). • Invasive urothelial carcinoma, sarcomatoid variru~t. with -heterologous elements Olnan CKhouta Hospital) • fnfiltrating urothelial carcinoma, sarcomatoid variant with ltctc:roJogous clement Oa1ar CHamad Medical <"'..ornoration) - lnvasive rr.msitional cell carcinoma, high grade with sarcomatoid areas Saudj Al1Jbja <King Fabad Natjonal Guard HoSJ)jtal) - Sarcomatoid carcinoma of the Utillary bladder with heterologous

differentiation Sandi Arabia (Maternity and Children's Hospital) .. Sarcomatoid (metaplastic) carcinoma The Nethe1·lands Ams-telveen - Sarcom-acoid variant of an urothelial cell carcinoma JJnjted Kingdom COx ford Studv Group) . Carcinosarcoma b:adder

Cas-e: 2- Diagnosis: Carcinosarcoma (sarcomatoid bigh grade urotbelial carcinoma with chondrosarcoma.and osteosarcoma),

bladder T-77100, M-92203

C11'R, February 2007 "'Minutes!' (Subscription A) s

Case 2 • References: l:foshi S, Sasaki M, Muto A, et a!. Case of Carcinosarcoma of Urinary Bradder Obtained a Pathologically Complete

Response by Neoadjuvant Chemoradiotherapy. lnl J Uro/2007; 14(1 ):79-81. Shah SK, Lui P.D, Baldwjn DD, eta!. Urothelial C~rcinonia After External Beam Radiation Therapy for Prostate

Cancer. J Uro/2006; 175(6):2063-2066. Rogers CG, Palapattu GS, Shariat SF, et al. Clinical Outcomes Following Radical Cystectomy for Primary

Nontransitional Cell Carcinoma of the Bladder Compared to Transitional Cell Carcinoma of the Bladder. J Urol 2006; 175(6):2048-2053.

Jayamoban Y,"Urs L, Rowland RG, eta!. Periurethral Carcinosarcoma. A Report of2 Cases with a Review of the Literamre. Arch Pmhol Lab Med 2005; 129{4):e91-93.

McKenney JK. An Approach to the Classification of Spindle Cell Proliferations in the Urinary Bladder. Adv ill Alia/ Patho/2005; 12(6):312-323.

Case No. 3, Accession No. 30250

Alameda <Alameda Countv Medical <&nhit)- Adenoeartinoma. mucinous type Fontana CKaiwr Permanentel - Urachal adenocarc-inoma Granada Hills - Mu~cirious adenocarcinoma Long Beach .. Mucinousadcnocarcinoma with signet rings Lone Beach (Long Beach Veterans Hospital)- Mucinous adenoc.arcinoma with s·ignet rfng cells LQs Angeles - Muc.inous s-ignet ring cell carcinoma Montcrcy!Community Hospital of Monterey Peninsula) • Mucinous (colloid) carcinoma Oakland • Signet ring mucinous carcinoma Orange <Orange Coumv Pathologv Medical C'irouo) . A'denoeatcinoma Oxnard 1St, John's Regional Medical Cemer) · Mucinous adenocarcinoma (4) San Diego · Adenocarcinoma, mucinous~ bladder San Diego !Naval Medical Center San Diego) .. Mucinous adenocarcinoma San Diego !Scripps Health) • Poorly differentiated signet ring cell adenocarcinoma San Diego <lJCS~) - Mucinous adenocarcinoma S3D Fran~jsco {San Francisco General Hospjtal) - Mucinous carc.inoid Santa Barbara - Mucinous adenocarcinoma

February 2007

Santa Rosa (Santa Rosa MemOrial Hospital) - .Mucin secreting adenocarcii1oma (colloid carc.i.noma) (1); ~·1udnous/colloid adenocarcinoma (1); Colloid carcinoma ( I)

Woodland Hills CKaiscr Pcm1ancntc) • MUcinous adenocarcinoma Woodland Hills CSuda's Soldiers). Mucinous adenocarcinoma (colloid carcinoma) Arkansas CUnivetsitv or Arkansas ror Medical Sciences) - Urachal carcinoma. ntucinous type, urinary bladder Georoia. Decatur - Mucinous adenocarcinoma lmoojs. Buq Ridge - Mucinous carcinoma, sigDel cel1 ( I); Adenoc-arcinoma with si·gnct ring features and prominent mucin

accumulation, rule out GJ origin (1) fllinois (Loyola University Medical Center) - Insular carcinoma Indiana (Howard Regional Medical Center) - Mucinous adenocarcinoma (signel ring) Maryland CNodhwcst Hospital Center)· Mucinous adenocarcinoma Maryland (University of Maryland) • Mucinous adenocarciTloma Massachusetts CBerkshire Medical Cenler) • Mucinous adenocarcinoma with signet ring fe-atures Mas:;achusett$ (Beverly Hospilal) - AdenocarciJloma, mucinous variant Mjchigan <Oakwood Hospital) - Mucinous adcnc.carcinoma Minncsotn Cfajryjcw Ridges Hospital) - Mucinous adenocarcinoma, urachal Nebraska CCrejgbton Univcrsicv School QfMcdicinc) • lvlucinous adenocarcinOma New Mcxjto CtfnjyersjrvofNcw Mexico)- Urachal c.arcinoma

New York ILoM Island Jewish Medical Center) • Mucinous adenocarcinoma New York <Nassau University Medical Center) .. Mucinous adenocarcinoma Ne.w York <Stonv Brook Universirv Hospital) Urachal carcinoma (mucinous adenocarcinoma)

6 C'rfR, February 2007 "Minutes" (Subsc.ription A}

New york £SUNY Down;uate Medjcp! Center) - Mucinous adenocarcinoma, primary North Cnro1ina (Mountain Area Patholony)- Mucinous adenocarcinoma, urachal origin (2} Ohjo fMcCilllouRh-Hyde Memorial t!osoitnl) - Adcnocan:inoma, muconou.s type Oklahoma Tulsa - Mucinous .adenocarcinoma, lJrachul origin Pennsvtyania ffin;xel Unjvsrsiry College o[Mcdjcinel - Mucinous adenocarcinoma (urachal carcinoma) Pennsylvania tlsbjgh Valley Hospjtu]) - Mucinous adenocarcinoma, bladder Pennsylyonia fMHgee Women's 1-Jnspital) - AdenoCO.I'tinoma, lllucinous 1ype Pennsvtvania (MI. Nittaov Medical Center)- Adenocarcinoma, mucinous and stgnct ring type Pennsylvania tPennsvlvan1a Hospitql Residents) - Mucinous adenocarcinoma Pue.rto Rjco lUmvcrsitvofPuerro Rjco) - Mucinous adenoearcinomulsignet~ring cell adenocarcinoma South Oa!rot;! (Upjygsirv ofSouJb D:!k!!l!! Residents) - Mucinous adenocarcinoma Tennessee Kingsport - Metastatic mucinous (colloid) carcinoma Texas CScott & White Memorial Hosnitall ~ Mucinous adenocnn:inoma Texas Houston • Mucinous adenocarcinoma Texas Lubbock • Muc.inous adenocardnomu Washinmon <Modjgan Amw Medical Ccntq). Mucinous adt'Jiocarcinoma of the bladder (12)

Wcsr Yirgjnja CGreenbrjer Valley Medical Center) • Mucinous production urothefial adenocardnoma Australia <Roval Hobart HospiraJ) .. Mucinous adenocarcinoma, probably urachal Austlllha CRowl Prince Alfn:d Hosojtall - Adenocarcinoma (mucinous variant) Australia CSulliynn Nicolgjdcs Patho!ogv)- Mucinous adenocarcinoma of bladder Brazil CLaboratodo Anoromia Pamlogica EcjJologia) .. Mucinous adenocarcinoma of the bladder Bmj!. Spo Pay!o - Mucinous adenocarcinoma (modcroJe!ydifTcrentiatcd) likely to be urachal adenocarcinoma Canadn ()'asgua Hosnital) - Colloid carcinoma CanaAA Saskatoon - v esieaJ adenocarcinoma. Ganada CSbcrhmokc Unjys:rsitv Hgsmtal) .. Invasive mucinous adenocarcinoma [ndjn. K.1matnka • Mucinous carcinoma lrci!I!Jd CKrny General Hospital) - Mucinous adenocarcin01113 Jamajco <The University o( West !ns!jes) .. Urothelial adenocarcinoma Japan <Kyoto Unjyersirv liospital) - Mucinous adenocarcinon"l3 Oman O<boula Hospjta!) • Adenocarcinoma (mucinous type) urac.hal cnrcinoiT13 Qatar C!iamad Medical C0rooration) - Mucinouslco!!ood adenocarcinoma Saudi Arabia OCjng Fahsd National G!!ard Hpspjtal) .. Mucinous adenoc.urcinomA, primary Saudi Ambia fMnremitv nod Children ·s Hospj!ql) - Adcnocnrcinoma The Netherlands. Amstelvccn - Muc:Jnous adenocarcinoma (depend in& upon locnli?..ation, urachal or nonuroehaltypc United Kjpgdom COx ford Study Gn>up) - Bladder mucinous aden~inoma

CaseJ - fJiagno.<ls: Mucinous adenocarcinoma, bladder

T-7 1 000,~-8 1 403

p,se 3 - References:

Lauren! S, Mosca A, D'A!fonso V, ct a!. Primitive Mucinous Adcnoc.areinoma of the Bladder. A Cnsc Repon. Arch Ita/ Urol A11dro/ 2006; 78(1):32-34.

Zagh!ou! MS. Nouh A, Nazmy M, et a!. long-Tenn R=lr.s of Primary Adenocarcinoma of the Urinary B!addct. A Roporlon 192 Patients. Urol Q,co/ 2006; 24( I): 13-20.

TaylorS, Bacchini P and Benoni F. An Isolated Vcncbral Metastasis of Urachal Adenocarcinoma. Arch Patlooll.ab Mcd 2004; 128(9):1043-1045.

Maz.zucchclli R, Scarpelli M and Mont'ir:oni R. Mucinous Adenocarcinoma \!lith Superficial Stromal rnvasion nnd Villous Adenoma of Urachal Remnants. A Case Rcpon. J Clin Patho/2003; 56(6):465-467.

Case No. 4, Accession No. 30147 February 2007

Alam!XIn (Alameda County Medical Center) - Angiomyolipoma

CliR, February 2007 "'Minu1cs" (SubscNption 1\) 7

fool ana (Kaiser Permanen!e) .. Angiomyolipoma Goold• Hills • Angiomyolipoma !.oog Beach - Angiomyolipoma Lope Beach llong Beach Vetemus Hgsoitall . Angiomyolipoma Los Angeles · Angiomyolipoma Mgntcrcy <Community Hospital o( Monterey Peninsula) .. Angiomyolipoma ~ • Angiomyolipomo Orange (Orange County Pathology Medical Group) - Angiomyolipoma OxDDrd (St. John's Reeional Mcdjcnl Center). AngiomyolillOmn (4} San Diego - Angiomyo1ipoma, kidney S;ao Qjcgo CNaval Medical Center SM Diego) .. Angiomyolipoma SAn Djcoo fSe<ipos Health) • Anciom)•olipoma San Djcgo fUCSDl • Angiontyolipoma S~n francisco <San francisco Gcornl Hospjta!l · Angiomyolipomo Soma Ba!bara • Angiomyolipoma Soma Rosa fSanfi Rosa Memorial Hospjta!l - Angjomyolipoma (J) Wooc!laod Hills CKaiscr Pcnnancme>- Angiomyolipoma Wgodland Hills fSuda's Soldier<) • Angiomyolipoma Arkansas fllniversitv pf Arkansas Cor bt,Jq:Jjca! Scjcncc§) ~ Angiomyolipoma, kidney Georgia Decatur .. Angiomyolipoma !llingjs Burr Ridse . Anglomyolipoma (2) !l!jnojs <Loyola University Mc:dicql Center) .. Moderately-differentiated neuroendocrine tumor lndlnnn flioward Regional MediCAl Center) - Spindle cell sarcoma ('lielo) M;~,rv!Qpd (Northwest Hospital Center) - Angiomyoliporm Marvland £l!niver.::itvqfMmland) .. Angiomyolipoma Muqchuscns fBcrl<shire Medical Centq) • Angiomyolipomo Mawchusetts (Beverlv HMpj)Qil - Angiomyolipoma Mjcbjuo COakwood H05!!ital) • Aogiomyolipoma Mjnpqota (fairview Ridges Hp~pugl) .. Ang1omyolipoma Nebraska fQc:jgh(Qn Unjyersi'Y SchoolofMcdjcjne) - Angiomyolipoma New Mexico (University of New Mcxjco) - Angfomyolipoma Nc.w York <Long Island Jewish Mc;djcnl Center) - Angiomyolipoma Nc;w York (N!ruau Uojycrsjty Mcdiepl Center) - Cellular leiomyoma New york (Stony Brook Unjvccyjty Hosoital) .. Angiomyolipoma New York CSUNY DownsUJ!C Mcdjcnl Ccmer} - Angiomyolipoma Nonb Carolina <Mountain Area Pnthology). Angtoyo!ipoma (2) Ohjo £McCullough-Hyde Memorial Hpspjtal) - Leiomyoma vs. lciomyos:lfeoma Q!clj!boma. Tulsa • Angiomyolipoma Pcnpsylwnfa lf)rexel Unittrti'Y CQJ!egc oCMesficjne) - Angiomyolipoma Pennsylvania (Lehigh Valley Hpsrutal} - Angiomyolipoma Pconwlvanja (Magee; \Vnmo"s Hgspj!nl) - Angiomyolipoma Penmylypnja fMt. Nittany Medjea! Center> .. Angiomyolipoma Pennsylvania (pennsylvania Hosn!ral Rssidents) - An.giornyolipomu Pucrtp Rjco OJnjvernjrv of Puerto Rjco) • Angiomyolipoma Soytb Dakota fUniversitv of Soylh Pnkota Residents) . Anglontyollponta Ttnnessee Kingspol'l - Angiomyolii>Oma Texas CSwu & White Memorial Hospjtal) - Angiomyolipoma TcxaJ. Houston • Angiomyolipomu Texas Lubbock - Leiomyosarcoma WMbjnmon IMadi!!aJl Annv Medi<al C<otcr) - Angiomyoliponu ( 12) West Yirainja fGrttpbriq Valley Msdjsal Center) .. Angiomyolipoma Aysu•lia CRoval Hoban Homital) • Angiomyolipoma, kidney Australia CRova! POnce Alfrtd HomjtAJ> - Angiomyolipoma AusD)llja <Sullivan Nicolaides P;uhology) • Angiomyolipotn3 Braz.jl <Laborntorio Anatomia Pptgloqjea E.citologia) - Angiomyo1ipornn , smooth muscle predominant DmzJ! Sao paulo - A.ngiomyolipomu Cqnpdn (pusoua Hospital) • Angiomyolipoma Canada. Saskatoon - Angiomyolipornu Cynodn fSherbrookc Unjye-rsily Hospjtal) - Angiomyolipoma lndja. Kamataka ~ Angiomyolipom3 Ireland (Kerry General HosojiRI) - Angiom)'olipoma J•matsa CThc Uoh·'efSily of West Iodjq) .. Renal 311giomyotipoma Jgoan CKvoto UniversitY HosnitaD - Angiomyolipoma

CTTR, February 2007 "Minutos" (Subscription A)

Om:miKboula Hosoita!l - Angiomyoliporna Qaw !Hamad Medical Comoration) - Angiomyolipoma Saudi A111b1a CKing Fahad National Guan! !losmlal) - Angiom)'>lipoma Saudj Ambja <Maternity and Children's IIO$!)jlall - Angiomyoliporna The Netherlands. ADJStelveen - Angiomyohpoma of the kidney, nonurachat type United Kingdom (Oxford Stud y Grouo) - Angiomyoliporna

Case 4 - Diagnosis: Angiomyo!ipoma, kidney

T-71000, M-88600

Case 4 - References: Bah!11mi A, Schwanz MR. Ayala AG, ct a!. Concum:nt Angiom)'>lipoma and Two Oncoc)~omas in lhe Same Kidney. Ann Diagn

Patltol 2007; 11(2):132-136. Roma AA, Magi-Gulluzzi C and Zhou M. OiO'em~tial Expression ofMelanocyne Markers in Myoid, Lipomatous, and Vascular

Components of Renal Angiomyolipomas. Arch Po tiro/ Lab Med 2007; 131 (I): 122-125. Khan MS, Iram S, O'Brien TS, eta!. Renal Pcrivasculilr Epilheloid Ccli·Omns'. BJU 1111 2006; 98(6):1 146-1 147. Gould Rothberg BE, Grooms MC and Dhamidharka VR. Rapjd Growth ofu Kidney Angiomyolipoma After Initiation of Oral

Contraceptive Therapy. Ob.ftet Gyneco/ 2006; I 08(3 Pt 2):734-736.

Case No. 5, Accession No. 30115 February 2007

Alameda (Alameda County Medical Center) - Lciomyosilreoma FontMp CK!!jtq Pennanerue) - LeiomyoS3rcorna G!jl!!3da Hjl!s - Leiomyoma Long Beach - Degenerating leiomyoma Long Bqsb CLong Beach Veterans Hpsnhal) • Leiomyoma with degenerative: changes Los Angeles .. Leiomyosarcoma Monterey (Communi tv Hospital of Moorerey Peninsula) - Leiomyoma (2); L..tiomyosurcoma (1) !2!!kh!nll - Leiomyoma sarcoma Orange <Oransc County Pathology Mcdjcg! Oroug:) - Leiomyosarcoma Oxnard lSI. John's Regjonal Mcdjenl Cepter) - Angiomyoliponm (4) Son !)jegp .. leaomyosarcoma. kidney rule out angiomyolipoma San Djego CNaygl MMjsa! Center San Diego) .. Leiomyosarcoma Sap pieqo lScrioos Health) .. Leiomyosarcoma San Diego OJCSP> - Smooth muscle tumor of uncenain malignant potentia.! (STUMP) San Francisco !San Francisco General Hospital\ - Partially in &acted eel!ulor lciotnyomll Santo Barlxtm - Leiomyoma SMul Bon CSpnta Rosa Memorial Hospjlq!) .. Leioyosaroorna (3) Wpodland HJ!!s fKajser Permaneme) - Leiomyosarcoma Woodland Hills <Sudo's Soldier:;) - Leiomyosnrcoma ArkBnsgs lUniycrsity of Arkansas for Medjcnl Science$) .. Leiomyomn, kidney Gcorsill Decatur - Leiomyosarcoma Illinois, Burr Rjd•c - Leiomyoma ( I); Leiomyosorcoma ( I) !!Jinojs l !.Qyg!a Unjversitv Medical Center) · Wcll-diffcrentiaLed neuroendocrine tumor Jndiana ll1oward Regjonal Medical Ceolcr) · Leiomyosarcoma Man1an<l CNonhwesr Hosoital Center) - Leiomyosarcoma MaryiBOd Nnjyqsjtv oCMaM3nd) - Leiomyos.arcolll3 Mawshuseus <Berkshire Medical Center> .. Leiomyosarcoma Massachussus <Bcy«lv Hosnital> - Leiomyosarcoma Michigan <Ookwood Hospital) - Leiomyosarcoma Mjnncso1a CFoio•iew Ridees Hospital) - Lceomyosnreorna Nebrask!l <Crcjgbton Unjversjtv School of Medicine) ~ Leiomyosarcoma New Mcxjco CUnjvcrsity ofNcw Mcxjcg) ~ Leiomyosarcoma New York <Lgng Island Jewish Medical Center) - Leiomyosa(coma New York (Nassau UnjvtfSjtv Medical Center) · Leiomyosarc·oma New York (Stony Brook University Hosnital) .. lnflammatory(pseudorumor) myofibroblastic tumors New York ISUNY Oownsoue Medical Center\ - Leiomyoma North Cwo!jna (Mouptajo A~ Patholoey) . Angiomyolipoma (I); Leiomyoma (I) Ohjo (MpCullouob-Hyde Memorial Hospj[a!) - An&iom)'>lipoma Olclaboms. 'DIIsa - Leiom)'>ma

CITR, Fc.bru<~ry 2007 .. Mmutes•' (Subscription A) 9

Pennsylvania rorexel Universicy College of Medicine) . J:.eiomyoma with infarction Pennsylvania (Lehigh Vallev Hospital) · Smooth muscle neoplasm favor Jaw gr.adc leiomyosarcoma Pcnnsvlvania (Magee \Vomen)s Hospital) · Mesoblastic nephroma Pennsylvanjp. CMt. NiUanv Medical Center) • Leiomyosarcoma Pennsylvania (pennsylvania Hospital Re.~; identc;) · Leiomyosarcoma Puerto Rico flJniversiwofPuerto Rico) · Leiomyosarcoma South Dakota (University of South Dakota Residents) - Leiomyosarcoma Tennessee. Kingsport · Leiomyosarcoma Texas (Scott & White Memorial Hospi(!ll) - Leiomyoma Texa.<:.:. Houston . Leiomyosarcoma Texas. Lubbock .. _Lciomyos<ircoma Washington (M'adiean Armv Medical Center> · Leiomyoma (5); Smooth muscle tumor) unknown malignant (4)~ Leiomyosarcoma

(3) West Virginia (Greenbrier Vaflev Medical Center) - Sarcomatoid renal cdl carcinoma Australia (Royal Hobart Hospjtal) - Leiomyosarcoma, kidney Aus1ralja (Royal Prince Alfred Hospital) - Smooth muscle lllmour of uncertain malignant potential (angiomyolipoma) Australia (Sullivan Nicglajdes Pathology) - Leiomyoma Brazjl fLaboratorio AnatomiaPatologica Ecitologia} - Leiomyosarcoma~ renal Brazil. Sao Paulo - Smooth muscle rumor, lei·omyosarcoma vs. nngiomyolipoma vs leiomyoma Canada {Pasqua Hqspital) ~ Leiomyosarcoma Canada. Saskatoon - Leiomyosarcoma Ganada lSberbrookc Universitv Hospital) · Angiomyotipoma wirh predo1ninant lelomyomatous component India. Kamataka · Jntlamotatory myofib~oblastie rumornejomyosareoma Ireland (Kerrv General Hospj1aJ) - Leiomyosarcoma Jam;tica CThe UniversityofWest rndies) · Chronic pyclonephl'itis, maJakoplakis, (differential diagnosis, leiomyosarcoma) Joman <Kvoto tJnjvefSjtv HosRl!Al) - Leiomyosarcoma Oman CKhoula Hospital) • Leiomyosarcoma Oatar <Hamad Medical Comoration) - Leiomyoma Saudi Arabia <King fabad Natjopaf Guard Hospital) • Leiomyoma with infarction Saudi Arabia (Maternitv and Children's Hospital) - lnOammawy myofibroblast:ic tumor The Nethe.rlands. Amstelvccn - Leiomyosarcoma United Kingdom {Oxford Sllld"y Group) • Leiomyoma

Case 5 - Diagnosis: Leiomyosarcoma, kidney

T-71000, M-88903

Case 5 - References: Kendal WS. The Comparative Survcval of Renal Leiomyosarcoma. Can J ()ro/2007; 14( 1):3435-3442. Sharm:1 D, Pradhan S, Aryya NC, et al. Leiomyosarcoma of Kidney. A Case Report with Long Tenn Result After Radiotherapy and

Chemod1crapy. In/ Urol Nephro/2001. Kartsanis G, Douros K, Zolota V, et al. Cas<>Reporr. Leiomyosarcoma of the Renal Pelvis. Int Urol Nephro/2006; 38(2):21 1-21.3. Komi)oan"' M. A Case of Lei·omyosarcoma Involving the Renal Hilu.s. Jp11 J C/in Onco/200~; 36(2): 122.

Case No. 6, AccessiOJI No. 30289

Alameda(Aiameda County Medjcal CcD!CO - ~fullilocularcyst (cystic nephroma) Fontnna (Kaiser Pcnnantnte) - Mixed epithelial. srrom31 tumor bfkidney Granada Hills .. Cystic nephroma Long Beach - Benign polycystic disease Long !3eacb (Long Beach Veterans Hospital) - Polycystic disease, benign Monterey (Community Hospital of'Monterev Peninsula) - Cystic nephroma Oakland - Multi cystic nephroma Orange COrangc County Pathology Medical Group) - Cystic nephroma Oxnard{St. John's Regional Medical Cemer) - Multicyslic nephroma (4} San Diego - Ch.ronic pyelonephritis, spindle cell lesion leg, solitary fibrous tumt>r §;!n Djcgo @yal Medical Center San Dieao) - Cystic nephroma San Diego <Scripps Health} - Benign -ni.ultilocular cyst San p jcgo fUCSDl - Cystic nephroma San Francisco <San Francisco Gene1·al Hospital) - Aduh polycyslic disease Santa Barbara - Cysrie nephroma

10

February 2007

CTTR. February 2007 "MiJiutes" (SubscriptiQn A)

Santa Rosa !Santo Rosn Mem<>rjo! Hosoita!) • Cysnc nephromn(2); Multi!oculor renal cyst (cystic nephroma, .. mlticystic nephroma") ( I)

Woo41ond Hills Q<aiscr Pennonente) • Cystic nephroma Woodland !I ills (Suda's Soldiers) . Cystic nephroma Arkan!;as Nniversitv of Arkansas for Medjcql Science.s) - Cystic nephroma., kidney Georgia, Decatur • Mixed epithelial and stromal rumor Illinois, Burr Rjdse · Cystic nephroma (2) Illinois (Loyola UnivmjN Me!ljea! Center) • Small cell carcinoma Indiana !Howard Recjonal Medical Center) • Mulricystic nephroma Maryland CNorthwes! Hospital Center) · Rcnol cysrie distase vs, cystic nephroma MaJVIand IUniversi!y of Maryland) · Cystic nephroma M1!55llehusens ffierksbire Medig!l Center) • Cystic nephroma (multilocular cyst) Massachusetts (Beverly Hospital) · Cystic kidney disease Mic.higun IOakwqod !iosoital) • Mixed Ct>ithelial and stromal tumor Minns;snta ifairyiew Ridges Hospital) - Mixed epithelial stroma1 tumor of kidney N¢brask::\ CCrejghton UninrSily School of Medicine> • Multilocular cyst (cystic nephroma) New Mexjco CUnjyernjty of New Mexico) . Cystic nephroma New York ( Ieong Island Jewi~h McdisaJ Center) - Cystic nephroma New York <Nassau Unjvcrsily Medical C..enrcr) - Cystic nephromm New Yods /Stonv Brook Universjtv Hospi!ol) · Dysplastic kidney New York CSUNY pownstate Medical Center) • Multicystic nephroma vs. benign cysricdisease North Cnrolina (Mountain Area Pmhplo!!Y) • Multieystic ncphrorno (2) Ol!jo IMcCy!loush-Hvdc Memorial Hospital) • Cystic nephroma O!clahorna, Tulsa • Polycystic kidney disease Pennsylvanja (Drexel Unjver~ily College oC Medicin.c) .. Cystic nephroma Pcnos"lvQOin (Lehigh Valley Hospital) .. Mixed epilhclktl stromal tumor of kidney rennsvlwnia <Magee Women's Ho(pitaJ) .. Muhicysdc ncphronu Pqnsvtvanj11 (Mt. Njnany Medjcpl Ccpter) .. Medullary sponge kidney Pcnnsylynnja (pennsy!yania Hospj!al Resjdcnts) - Solitary -multilocular cyst puerto Rjco runiveqjly ofPuerro Rico) - Cystic nephroma South !?Jilrora /University of South Dakota Residents) • Cystic nephroma Tennessee Kjn•sooa · Multieysti< nephroma (multilocular cyst) Texas (Scott & Wbjr' Memorinl l·losnita1) .. Renal multilocular cyst Texas Houston • Polycystic kidney disease Texas Lybbock · Cystic renal cell carcinoma Washinston /Madignn Annv Medical Centtr) • Multilocular cyst (12) West Virgjnia (Greenbrier Valley Medical Center) ~ Adult type renal polycystic disease Australia (Royal Hoban Hosoi!aD .. Cyslic nephroma Ausmlia/Roval Prince Alfred HospiJ•D . Cystic nephroma 6ustralii1 <Sullivan Njcolajdes Pprhology) .. Multicystic nephroma Brazil {Loborntorio Anotomia Potologica Edtologia) - Mixed epithelial and stromal cel l tumor ofkidncy Brazll Sgo Paulo - Cystic nephroma Csna<la cpasoua Hospjjal) • Multilocular cyst Canada SMk•!OOn • Mi><ed epithelial and strom31tum<>r Canridi! <Sherbrooke University tlpspitall .. Endomctriose India. Kam3taka - Cystic nephroma Ireland <Kmv Gepeml !iospital) • Cystic nephroma Jamaica !The llnivccity q[West lndjes) . Inherited renal cystic disease VHL. type 2 Iapan <Kyoto Unjycrsity Hospjtnl) .. Cystic nephroma Oman /Khoula Hosojjal) . Cystic nephroma QatarfHngmd Medical Corporntiop) . Cysnc nephroma (4); Mixed epithelial and strotn.'lltumor (4) Saudj Arabia CKjng fghad NaUonnl Guard tlpspnaD .. Cystic nephroma Saudi Ambja <Maternity and Children's Hospjtal) - Cystic nephromu The Netherlands Amstcl\'een - Multilocular cystic renaJ cell carcinoma United Kinodom COx Con! Study Grouo> • Mulricysric nephroma

Case 6 · Diagnosis: Mixed epi:hclial and stromal tumor, kidney

T-71000, M-81003

Consullatjon; Stu.nfotd University, Richar<l Kempson, M.D.~ ~·Mixed Epithelial nnd Strom.ul Tumor of Kidney".

Case 6 ~References:

C'rrR, February 2.007 ''Minutes'' (SuburipLion A) II

Bisceglia M, Oalliani CA, Senger C, et al. Renal Cystic Diseases. A Review. Adv in A nat P<uho/2006; 13(1):26-56. Antic T, Perry KT, Harrison 1(, ct al. Mixod Epithelial and Stromal Tumor of the Kidney and Cystic Nephroma Share Overlapping

Features. Reappraisal of 15 Lesions. Arch ofPaJhol & f..ab Med 2006; 130(1):80-85. Michal M, es 0, Bisceglia M, et al. Mixod Epithelial and Stromal Tumors of the Kidney. A Report of 22 Cases. Virclrows Archlv

2004; 445(4):359-367. Pierson CR, Schober MS, Wallis T, et al. Mixed Epithelial !llld Stromal Tumor of the Kidney Lacks the Genetic Alterations of

Cellular Congenital Mesoblastic Nephroma. Hum Patlro/2001; 32(5):5t3-520. Adsay NV, Eblc JN, Sriglcy JR, ct al. Unique Identified. Mixed Epitbcli'd and Stromal Tumor of the Kidney. Am J ofSurg Pat hoi

2000; 24(7):958-970. Michal M and Syrucek M. Benign Mixod Epithelial and S1romai1Umor ofth~ Kidney. Patlwl, Res & l'rac 1998; 194(6):445-448,

Case. No. 7, Accession No. 30364

Alameda {Aiamoda Countv Medical Center) - Solitary fibrous tumor Fontana O<ai~cr Pennanent!}) - Solitary fibrous tumor Granada Hills- Sclerosing hcamgiofibroma Long Beach - Solhary fibrous rumor Long Beach (Long Beach Veterans Hosoital) - Solitary fibrous tumor !.as Angeles - Sclerosing fibrous tumor, NOS Monterey <Community Hospital of!\ofontcrcy Peninsula) - Solitary fibrous tumor Oakland - Solitary fibrous tumor Orange (Orange Countv Pmholggy Medical Group) - Soliu1ry fibrous tumor Oxnard !St. John's Reeional Modica! Center) - Angiomyolipoma (4) San Diego - Solitary fibrous tumor. kidney San Diego fNaval Medical Center San p jego) - Solitary fibrous tumor San Diego (Scripps Health) - Solitary fibrous tumor San Diego IUCSDl - Solitary fibrous tumor .San f rancisco <San Francisco General Hospital) .. Endstage kidney with reactive .fibrosis Santa Barbara - Solitary fibrous tumor · Santa Rosa (Santa Rosa Memoria] Hospital) - Solitary fibrous tumor (3) Woodland Hms <Kaiser fennanent~ - Solitary fibrous rumor W<>odland Hills !Suda's Soldiers) - Solitary fibrous tumor (amyloid in kidney) Arkansac; (lJniversitv of Arkansas for Medical Sciences) .. Solitary fibrous tumor Georgia Decatur - Solitary fibrous tumor Jll jnois Burr Ridge - Solitary tibrous tumor (2) 1Hinois (Lovola University MedjCjl) 'center) - Well-differentiated neuroendocrine- tumor fndiana (Howard Regional Medical Center) - Old infarct ""'ith ~tudosarcomatous reaction Maryland (Nonhwest Hosnita! Cente.r) - Renomcdullary interstitial cell tumor Marvland !University of Marvland) - Solilary fibrous tumor Massachusetts <Berkshire Medical Center) .. Solitary fibrous tumor Massachusetts !Beverly Hosll.ilal) - Solitary Gbrous tumnr Michigan !Oakwood Hosnital) - Solitary fibrous tumor Minnesota '(Fairview Ridges Hosp.illi} - Solitary fibrous tumor Nehraska (Creighton Unive.rsitv School of Medicine) • Solitary fibrous tumor New Mexico fUnivcrsitv of New Mexjco) - Solitary fibrous tumor New York <Long Island Jewish Medica] Ccnte~) .. Solitary fibrous tumor ~cw York CNassSy Univcrsitx lytedicaJ Qcilter) - Solitary fibrous rumor New York <Stony Brook University Hospital) - Solilary fibrous tumor

February 2007

Ne.w York (SUNY 'Downstate Medical Center) . Solitary fibrous tumor vs. desmoplastic nests spindle cell tumor North earoljna (Mountain Area Pathology) -' Solitary fibrous tumor (2) Ohio !McCullough-HVde Memorial Hospital) - Solitary fibrous tumor Oklahoma. Tulsa - Renomcdullary interstitial cell tumor Pennsylvania <Drexel University College-ofMedkjne) - Solitary fibrous tumQr Pennsylvania (Lehigh Valley Hospital) - Solitary fibrous tumor Pcnnsvlvania <Magee Women's HospjJal) - Solitary fibrous tumor Pennsylvania CMt. Nittanv Medical Center) 4 SoJitar¥ fibrous tumor Pennsylvania fPennsvlvania Hosnital Residents) - Solitary fibrous tumor Pueno Rico (University of Puerto Rieo) - Solitary fibrous tumor South Dakota CUniversity of South Dakota Residents) - Soiitary fibrous tumor. Tennessee. Kingsport - Solitary fibrous rumor Texas <Scott & Wbitc Mcmoriql HP§pjtal) - Solilary fibrous wrnor Texas Houston .. Inflammatory myofibrobJastic pscudotumor

12 CTTR. Febtuaty 2007 "'Minutes" (SubS<:riplion A)

Texas Lubboc.k - So Wary fibrous tumor Washington (Madigan Army Medical Center) - Solitary fibrous tumor {12) \Vest Virginia (Qrccnbrjer Vallev Medical Center) · Solitary fibrous tumor Australia !Royal Hobart Hospital) - Solitary fibrous tumor Australia (Royal frjnce AI ired Hospital) · Solitary fibrous tumor Australia (Sullivan Nicolaides Pathology) - Solitary fibrous tumor Brazil <Laboratorio Anatomia Patoloruca Ecitologia) - Solitary fibrous tumor of the kidney Brazil Sao Paulo - Solitary fibrous tumor Canada (Pa.<;qua HospjtaD - Solitary.fibrous tumor canada. Saskatoon - Medullary fibroma (renomedullary interstitial cell tumor) canada ISherbrooke University Hospital) - Solitary fibrous tumor India. Kamataka - Solitary fibrous tumor Ireland (Kerry General Hospital) - Solitary fibrous tumour Jamaica (The University QfWest lndi£li) - Chronic pyelonephritis Jaoan £Kyoto. University HosoitaD .. Solitary fibrous tumor Oman (Khoula HospjJQI) - Solitary fibrous tumour Oatar <Hamad Medical Cornoration) . Solitary tibrous tumor Saudi Arabia (King Fahad Natj9oa! Guard HpsgjJDD · Inflammatory pscudotumor Snudj Arabia (Maternity and ChHdren~s Hospital) . Kaposi sarcoma The Ne~1erlands Amstclvccn - Solitary fibrous tumor Unjled Kjngdom <Oxford Study Group) • Solitary fibrous tumor

Case 7 - Diagnosis: Solitary fibrous tumor, kidney

T-71000, M-90510

Case 7 Reference..'.;: Gengler C and Guillou L. Solitary Fibrous Tumour and Naemangiopericytoma. Evolution of a Concept. Histopatho/2006;

48(1 ):63-74. Fine SW, McCarthy OM; ChanTY, et al. Malignant Solitary Fibrous Tumor of the Kidney. A Report of a Case and ComprehenSive

Review of the Literature. Arch Pathol La~ Ed 2006; 136(6):857-861 . :Kohl SK, Mathews K and Baker J. Renal Hilar Mass in an 85-Year-Oid Woman. Solitary Fibrous Tumor. Arch Patho/ Lab Med

2006; 130(1):1 17-119. Yamaguchi T, Takimoio T, Yamashita T, ct al. ~at-Containing Variant of Solitary fibrous Tumor {Lipomatous

Hemangiopericytoma) Arising on Surface of Kidney. Urol2005; 65(1):175. W~ng J, Aroer DA, Fran~cl K, Cl al. Large Solitary Fibrous Tumor of the Kiditey. Report of Two Cases and Review()( the

Literature. Am J Stu-g Pat/to/ 20~1 ; 25(9): 1194-1199.

Case No. 8, Accession No_ 30290 February 2007

Alameda (Alameda Countv Mcdjcal Center) - Primitive ncurocctodcrrnaJ tumor Fontana <Kaiser Pcnnanentel . Ewing sarcoma/PNE.T Granada Hills - Sarcomatoid renal cell carcinoma Long Beach - Adults Wilms' tumor Lon• Beach (Long Beach Veterans Hospital) - Adult Wilms' tumor (2); Mesoblastic nephroma ( I) Lo!: Angeles - Primitive neuroectodermal rumor Momercy (Community Hosoital of Monterey Peninsula} - Synovial sarcoma Oakland .. Primitive neuroectoder01al rumor vs. rhabdomyosarcoma Orange <Orange County Palhology Medical Group) .. Synovial sarcoma O,,nnrd (St. John's Regional Medical Center) - l,.eiomyosarcoma (4) San b iego - Small blue cell tumor (metanephric stromal tumor vs. mcsopi:JStic nephroma Sao Djcgo {Naval Medical Center San Diego) .. Small rOund blue cell tumor; Ewings sarcomu (3); Wilms' tumor (1) San Diego (Scripps Health) - Monophasic synovial sarcoma San Diego /UCSD) - Primitive neuroectodermal tumor (PNET) San Francisco (San Francisco General Hospital) - Adult Wilms· tumor Santa Jlal'hara - Leiomyosarcoma SaoJa RoSa !Santa Rosa Memorial Hospital) - Ewing's sarcoma (PNET) ( I); Primitive neuroectodermal tumor (2) Woodl:rnd Hills !Kaiser Pennanente) - Primitive neuroel)lodermnl tumor/Ewing's sarcoma Woodland Hills <Sud a'~ Sqldi¢r~) - Primitive ncuroccfod.cnnal tumor · Arkansas (Unjve,rsjty of Arkansas for Medical Sciences) . SynoviaJ·sarcoma, kidney Georgia. Decatur · Suggestive of metastatic endometrial stromal wcorna

c:rTR, February 2007 "t-.•linutes'• (Subscription A) 13

Illinois. Burr Ridge - Primitive neurocctoderrnaltumor(l): Synovial sarcoma ( I) Illinois (Loyola Universitv Medical Center) - Pheochromocytoma Indiana (Howard Regional Medical Center) • Solitary fibrous tumor Marvland Qforrhwest Homjta! Center) - Primitive neuroectodermal tumor Marvland (University ofMarvland) - Solitary fibrous tumor, malignant Massachusetts !Berkshire, Medical Center) - Wilms' rumor, blastema predomhwn1 (\'S. eudometrial stromal sarcoma vs. metanephric

sw)rnal [umor vs. monophasic synovjaJ sarcoma) Massachusetts @everly Hosoital) · Primitive neuroeclodennaJ tumor Michigan COak\vood Hosnilal) - Sarcoma, (a\'or monophasic synovial sarcoma Minpes01a <Fairview Ridges Hospital) - Synovial sarcoma Nebraska (Creighton. University School of Medicine) - Undifferentiated neopla.~m (probably sarcoma) Ne\v Mexico CUnjvCrsjty ofNew Mexico) - Synovial sarComa New York !Long Island Jewish Medical Center) - Monophasic synovial sarcom.a New York (Nassau Unjyersity Medjcal Center) - Primitive neurocctodcnnal tumor New York (Stony Brook University Hospital) • SynoviaJ sarcoma 'New York (SUNY bownsrate Medical Ceorer) - Monophasic synovial sarcoma vs. endometrial stromal sarcoma North Carolina !Mountain Area Pathology) - Cellular mesoblastic nephroma (2) Ohio CMcCullough-Hvde Memorial Hospjta!) - Synovi al sarcoma Oklahoma 'Tulsa • Primitive neuroectodermal tumor/EWing's Pennsvlvania CDrexel University College of Medicine;) - Synovial sarcoma Pcnnsvlyania (Lehigh Valley Hospital) • Monophasic synovia] sarcoma Pennsylvania CMagee Women's Joiosnital) - Blaslema dominant Wilms• tumor Pcnnsylyanjn CMJ. Njnany Mcdjcal Center) - PrimiLive neuroectodermal t~;~mor Pennsylvania CPcnnsylvania Hospital Residents) .. Spindle cell sarcoma Puerto Rioo CUniversiO' of Puerto Rico) - Endomerrial stromal sarcoma South Dakota (University of South Dakota Residents) - PPNET Tennessee Kingspon - Metastatic endometrial stromal sarcoma Texas (Scott & Wbjte Memorial Hosoital) - Monophasic syno .. •ial sarcoma Texas. Houston - Spindle ·ce.JI neoplaSm Texas. Lubbock · Sarcomatoid renal cell carcinoma Washington (Madioan Anny Medical Center) - Synovial sarcoma (12) West Vjrcinja CGreenbrjer Valley Medjcal Cemer) - Fibrosarooma Australia (Royal Hoban Hosoital) - Monophasic synovial sarcoma Australia fl~oyal Prince. Alfred Hospital) - Monophasic synovial sarcOma Austrul ja. CSulljvan Njcolajdcs Pathologv) - Synovial sarcoma Brazil <Labora£orio Anatomia Palologica Ecitolo!!ia) - Monophasic synovial sarcoma or the k:idncy Brazil Sao Paulo - Stromal endometrial snrcoma; DDx: S}1l<wial sarcoma Canada (Pasqua Hospital) .. Syno\~al sarc01na Canada. Saskatoon - Endometrial stromal sarcoma metastatic to the kidney Canada CSherorooke Universitv Hospital) - High grade sarcoma (synovial sarcoma) India. Kamataka - Primitive synovial sarcoma, kidney Ireland CKcrry General Hosoital) .. Primitive neuroectodem1aJ tumour Jamaica <The Universiry of West Indies) - Cellular mesoblastic nephroma (adult) '"'· solitary fibroid tumour, MEST J..ruwn CKyoto Unjyersjry Hosoitall ·- Synovial sarcoma Oman fKhoula Hospital) - Synovial sarcoma Qamr !Hamad MC<Iical Comoration) - Synovial sarcoma(4); Leiomyosarcoma (4) Saudi Arabia CKing F3had National Guard Hospital) - MonophasiC synovial snrcoma Saudi Arabia <Maternity and Chjldre.n 's Hospj!al) - Primitive neuroectodermal tumor The Netbcrh)Dds. Amstclyccn - Stromal cell sarcoma United Kingdom COx ford Studv Groun) - Synovial sarcoma

Case 8 .. Diagnosis: High grade sarcoma (NOS), kidney

T-71000, M-88 103

Directors Note: "Tumor has striking similarity to monophasic synovia! sarcoma. but is keratin negative. Mole.cular studies were not done." (dre)

Consuluujon: St;mford University. Anne-E. DrejeL, M.D .• 1'High Grade SHrcoma. NOS"

Case 8 Referenc~:

14 CITR, February2007 "Minutes" (Subscription,\)

Dotan ZA, Tal R, Golijanin D, Snyder ME, ct al. Adull Genitourinary Sarcoma. The 25,Year Memorial Sloan-Kettering Experience. J Uro/2006; 176(5):2033-2038,

Dnii'Oglio MF, Licbcrknecht M, Gouveia V, et al. Sarcomatoid Differentiation in Renal Cell Carcinoma. Prognostic Implications. lnt Braz J Urol2005; 3 1(1):10-16.

Deyrup AT, Montgomery E and Fisher· C. Leiomyosarcoma of the Kidney. A Clinicopathologic Swdy. Am J Surg Patlro/2004; 28(2):178-182.

Chen PC, Chang YH, Yen CC, et aJ. Primary Renal Synovial' Sarcoma with Inferior Vena Cava and Right An·ium Jnvasion. ltrt.l Uro/2003; 10(12):657-660.

Case No. 9, Accession No. 30185

A1amcd!l (Alameda County Medjcal Cemer) - Renal cell carcinoma Fontana £Kaiser Permanente) - Rena) cell carcinoma, chromophobe type Granada HillS - Oncocytoma Long Beach .. Oncocytoma l,smg Beach (Long Beach Ve.terans Hospital) ~ Oncocytic neoplasm, favor oncocytoma Los Angeles • Oncocytoma Monterey (Community Hosnital of Monterey Pe'ninsula) · 'Papillary renal cell carcinoma Oakland - Oncocytoma Orange (Orange County Pathology Medical Groun) - Oncocytoma Oxnard 1St John's Regional Medical Center) · Renal cell carcinoma (4) San Diego - Oncoc}1oma vs. renaJ·ceJI carc!noma San Dieqo (Naval Medical Center San Dicso) - Papillary renal cell carcinomJl San DiegO (Scripps Heahh.} - Renal cell carcinoma, .papillary type San Diego (UCSDl - Papillary renal cell carcinomJl, typo 2 San FQ)nd~eo CSan Fr3nC.isco General Hospital) • Eosinophilic chromophobe renal carcinoma Santa Barbara • Oncocytoma Santa Rosa (Santa Rosa Memorial Hosoiml) - o ncocytoma (3) Woodland Hills (Kaiser Pcrmanente) - Oncocytoma Woodland Hills (Suda's Soldiers) - Oncocytoma . Arkansas (Unjycrsjty of ArkAOSB5: for Medical Science.~) • Oncocytoma. kidney Georgia Decatur .. Tubulocystic. carcinoid Wjnojs, Burr Ridge - Papillary carcinoma (2) Illinois <Loyola Unjvcrsi!Y Medjoal Center) - Paraganglioma Indiana (Howard Regional Medical Center) .. Papillary renal carcinoma 'Marvland (Northwest HospiJal C.enter) - .Papillary renal ceJI carcinoma Maryland OJniversityofMarvland) • Papillary renal ccllcareinoma> oncocysti·c variant Massachusetts £Beverly Hospital) - Renal oncoCytoma Michigan (Oakwood Hospital)- Renal cell carcinoma, clear cell type Minnesota (fairy jew Ridge.o; Hospital) - Renal cell cardnoma, papillary Nebraska (Creighton Uriiversity School of Medjcine) - -Renal cell carcinoma, oncocytic type New Mcxjco <Universitvof New Mexico) • Rena] cell carcinoma> ch:ar cell or classical type New York (LOng Island Jewish Medical Cenrer) - Chromophobe reo~l cell carcinoma. eosinophilic vwlnnt Ne\V York (Na~o;au UniverSity Medical Center) - Renal cell carcinoma New York (Stony Bropk University Hospital) · Oncocy1oma New York <SUNY Downstate Mcdjcal Gente-r) - Papillary renal carcinoma. type II vs. renaJ oncocytoma North Camljna <Mountain Area Pathology)- Oncocytoma (2) Ohio <McCullough-Hvdc, Memorial Hospiull) - Oococ)'1oma Oklahoma, Tulsa - Renal cell carcinoma, granular cell type Pennsy]vanja <Dre:xt:ltJniver5:itv College of Medicine) • Renal cell papillary carcinoma* oncocylic type Pennsylvania. (Lehigh Valley Hospital) · Onc~cyt·oma

Pennsylvania fMagee Women •s Hospital) - Oncocytoma Pennsylvania <Mt. Nittany Mcdjcal Cen!e(} - Onc;ocytoma with hclllorrbage PennsylvaniaCPennsylvania Hos-pital Residents) - Papillary renal cell carcjnoma Puerto Rico (UnjyeCsjty of puerto Rico) - Papillary rena) ce,Jl carcinoma Soulh Dakota CUniversitv of South Dakota Residents) - Oncocytoma Tenne:;see Kingsport • Oncocytoma Texas CScon & -white Memorial Hospital) • Oncoc)'loma Texas Hous.toil · Renal cell c~rcinoma · TeK:i5:' Lubbock . Renal cell carcinoma., oncocytic type Wasl1jngton (Mpdjsan Am>y Medical Center) - Papillary renal cell ( LO); Oncoc)'1oma {2) West Virginia <Grcenbrjcr Yllllcy Medieitl Cerltet) - ChrQmophobe renal cell carcinoma

ClTR, FebnJBI)' 20.07 ''Minu!cs" (Subscriptjon A)

February 2007

t;

•

Australia (Roval Hobart Hospital) - Papillary renal cell carcinoma, cype-2 Australia IRowl Prince Alfred Hospitall - Papillary renal cell carcinoma Austrnlia !Sullivan Nicolaides Pathology) - Renal oncocytoma Brnzil <Laboratorio Anatomia Patologica Ecitqlogja) - Papillary renal ee11 carcinoma, type 2 Brazil Sao Paulo .. Renal cell carcinoma, type 2 /papillary variant Canada CPasoua Hospital) - Papillary renal cell carcinoma. Canada Saskatoon .. Hcmang·ioma Canada <Sherhrooke Unlversitv Hospital) .. Oncoc5'toma India. Kamallllm - Papilla!)' renal cell careinoma Ireland CKerry-General Hospital) .. Papillary rena] cell carcinoma1 type 2 Jamaica IThc University of We§llndjes) - Papillary renal cell carcinoma Japan <Kyoto University Hospital) · Oncocytoma Oman !Khoyla Hospjtal) - Oncocytoma OatarCHamad Medical Corporation} - Renal cell carcinoma Saudj A@bja (Kjng Fahad Natjonal Guard Hospital) - Papillary renaJ cell carcinoma Saudi Arabia <Matemitv·and Children's Hospital) · Oncocytoma The Netbedands Amste!veen · Oncocytoma United Kingdom fOx ford Study GrouQ) - Oncocytoma

Case 9- Diagnosis: Renal cell carcinoma with papillary and tubulocystjc features, kidney

T-71000, M-83123

Case 9 - Refc·renccs: Mizutaoi Y, Nakanisbl H, Li YN,.et al. Overexpression ofXIAP Expression in Renal Cell Carcinoma Predicts a Worse Prognosis.

In~ J Oncol 2007; 30(4}:919-925 . Antonelli A, Cozzoli A, Zani D, et al. The Follow-Up Management of Non-Metastatic Renal Cell Carcinoma. Definition of a

Surveillance ProtocoL BJU lnt 2007; 99(2):296-300. Maclennan GT and Bostwick DG. Tubulocysric Carcinoma, Mucinous Tubular and Spindle Cell Carcinoma aod Other Recently

Described Rare Renal Tumors. Clrn i" Lab Med 2005; 25(2):393-4 I 6.

Case No. 10, Accession No. 30233

Alameda (Alameda County Medical Ccnt<;r) - Colle<:ting duct carcinoma Eo!)!nna (Kajser Permanence) ~ Mucinous tubular and spindle cell carcinoma of kidney Granada Hills • Collecting duct carcinoma Long Beach . (nvasive urotheliaJ carcinoma, high grade

February 2007

Long Beach <Long Beach Vctcrilgs Hospital) · Collecting duct carcinoma (2): High grade transitional (urothelial) carcinoma (1) Los Angeles - Carcinosarcoma Monterey <Communjty Hqspjlal of Monterey Peninsula) ~ Urothelja] cell carcinoma (2); Carcinoma of collecting duct of Bellini (I) Oakland . Alveolar rhabdomyosarcoma Orange lOrf!nge C<lun!V Pathology Medical Group) - Jnvasive high grade urothcHaJ carcinoma Oxnard <St. John'§ Rcgjonsl Mcdjcal Center) · Sarcomatoid carcinoma(!); Collecting duct carcinoma (3) San Die.go · Renal cell carcinoma, collecting duct type San Diego CNaval Medical Cemcr San n jeno) - Transitional cell carcinoma of the ren.al pelvis San Diego (Scripps Health) • Collecting duct carcinoma San Djcgo llJCSD) . ·collecting duc.t carcinoma San Francisco !San Francisco General Hospjhtl) · Collecting duet carcinoma Santa Barbara - Collecting duct reJ,tal cell carcinoma Santa Rosa !Santa Rosa Memorial Hospital) · Transitional cell carcinoma (2); Urothellal carcinoma, invading kidney ( I) \Voodland Hilts (Kaiser Pennanente) . Sarcomatoid renal cell carcinoma Woodland Hjlls (Suda's So!djqsl · Synovial sarcoma vs. collecting duet carcinoma Arkansa.o:: (University of Arkansas for Medical Sciences) · Collecting duct Carcinoma, kidney Gcorgja Decatur - Co !leering duct carcinoma Illinois Burr Rjdgc - Collecting duct carcinoma ( I); Mucinous tubular ond spindle cell carcinoma (I) Illinois (Loyola Univcrsitv Medical Center) - Merkei cell tumor Maryland CNonhwest Hospital Center) . Collecting duct rumor Maryland CUnjvcrsilv ofMarvland) · Collecting duc.l carcinoma Massachusetts CBeverly Hospital) • Collecting duct renal cell carcinoma Michigan (Oakwood Hosnital) . Invasive urothelial carcinoma, high grade Mjgnespta lfajryie.w Ridges Hospjtal . CoJiccting duct carcinoma

t6 CrrR, Februat}' 2007 "Minutes" (Subscription A)

•

Nebraska (Creighton University School ofMcshcinc) • Collecting duct carcinoma New Mexico CUniversjtv of New Mexico) . Carcinoma of the collecting ductS of'Bcllinl New York <(,ong lslnpd Jewish Medical Ccmer) • Carcinoma of the collecting duct of Bellini New York <Nassau Unjversitv Medicgl Center) ~ Urorhelial carcinOn13, high grade, invaSIVe New York (Stonv Brook Universitv Hospjtal) · Otrtii\Oma or the collecting duces of Bellin i New York ISVNY OownS(ote Mc<lical Centet) • Angi...,.eom> vs. collecting duel carcinoma Noah Carolina (Mountain Area Pathology)· Collecting duct c~inoma (2) Ohio !McCullough-Hyde Memorial Hospital} • Collecting duct renal cell carcinoma Oklabomo. Tulsa • Urothclial carcinoma, high grade Pennsylvania CDrexc!l}niversity Col!pgc of Medicine) · Mucinous tubular spindle cell corcinoma Pennsvh'!Dja (Lehigh Valley Hosoitnl> • Collecting duct carcinoma Pennsylvania CMagec Women"! Hosnh,al) - Sarromatokl variBnl of tranSitional cell carcinoma Pennsylvania CMt. Niuam• Medical Center) • Xonthogranulomntous pyelonephritis PeoosyJvania CPennsvJvapia Hospital Residents) . Collecting duct careinoma Pueao Rico Wniycrsjty ofPucao Rjco) • Collecting duct carcinoma South Dakotn fUnivcrsjrv of South DnMta Re._\jdcnts) · CoUeenng duct cartinonl:l Tennnsee Kjngsnoa - Collecting duct carcinoma Texgs (Scon & Wbjrs Memorial Hospjtnl) · Mucinous tubular nnd spindled cell carcinoma Texas Hou.s1on - Sarcomatoid renal cell carcinoma Tex;u, Lubbock · High grade urotbelial carcinoma Wnshjngton (Madiggq Armv Medical Center) • Collecting duel carcinoma (12) West Virginia (Greenbrier Volley Mcdjcal Center) · Co11ecting duct renal cell cnrcinomu Ausuplia <Royal Hoban Rosojtal) • High grade invasive uro~telial caroinoma Au.ura[ja fRoynl Prince Alfred Hosojral> - lnws:ive urorhcliaJ carcinom3 Auslrolia <Sulljvan Nicolaides pathologX) • Collecting duct carcinoma Bmjlll...aboratorio AoqtomitJ PamlogiQ Eeiro!ogia) - High gl"3dc urothclial carcinoma Brazil. Sao Ppulo • High grude urothelial carcinoma vs. carcinoma of the collecting ducts Canada (Pasqua HospjtaD · Urothelinl carcinomu Qnada Sas!satoon • Collecting duct renal cell carcinoma Caoqda CShcrbrooke Universuy HospjJal) . Collecting duct can:moma Jndja Kamataka · Ul'othelinl carcinoma renal pelvis Ireland (J(cay Gcnernl Hospjmll - Collecting duct carcinom3 Jamnka <The Univcrsjtyof\Vest Indies) - Col1ec:ringduclcarcinoma Janan (Kvoto Unjver1jty Ho~njtul) - Collect in~ duel enrcinoma Oman IKhoula Hospital) • Infiltrating urotbelial carcinoma, high grade Oatgr (HamaJ! Medical COmormion) • Collecnng duct carcinoma Saudj Arabjn (King Fahad Nptional Gynrd Hospital) • Co11ecting duct cnrcinoma Saudi AJ3bjo (Matemjty 8Qd Childr¢J's Hosni(nl) - Metanephric adenosarcoma The Netherlands Amstelveen · Collecting duct carcinoma Unju..-d Kingdom (Oxford Srudy Group) - Collecting duc:c carcinoma

Cnsr 10. Diagnosis ; Collecting duct carcinoma, kidney

T-71000,~·83123

Case I 0 - References: Swartz MA, K:uth ], Schneider DT, et al. Renal Medu!!nryCan:moma. Clinical, Patboloaic, Immunohistochemical ond Genetic

Analysis with Pathogenetic Implications. Uro/2002; 60(()):1083-1 089. Steele ELand MacLenll31\ GT. Renal Medullary Carcinoma. J of Uro/2005; 174(4 Pt 1): 1449. Assad L, Rcsctkow E, Olivcirn Vl, ct•!. Cytologic Features of Renal Medullary Carcinoma Olncer 200S; lOS( I ):28-34. Vargos-Gon:w.lcz R, Sotclo-A vila C and Corin AS. Renal Medullary Carcinoma In A SiX· Year-Old Boy with Sickle Cell Trun.

PtJJhol Oncol Res 2003; 9(3): 193·195. Pe)'\'omaure M, Thiounn N, Scotte F, ct of. Collecting Duct Carcinoma of the Kidney. A Clinicopathological Study of9 Case.. J of

Uro/2003; I 70(4 Pt I): 1138-1140. Polascik TJ, Bostwick DG and Cairns P. Molecular Genetics and Histopathologic Fcatur~s of Adult Distal Nephron Tumors. Urol

2002; 60(6):941-946 .

C11'R, Febtuary 2007 "M'inute~ .. (Subscription A) 11