Depression Grand Challenges UCLA Brain Research Study for Volunteers diagnosed with treatment resistant depression to evaluate their response to the drug ketamine Are you considering ketamine infusion for depression? Are you between 20-64 years old? ● If so, you may be interested in hearing about a study that looks at how ketamine relates to changes in gene regulaon and brain chemistry and funcon. ● The study includes screening tests, receiving up to 4 ketamine infusions at UCLA, having 4 brain scans (1 scan before treatment, and 1 scan the day after the ﬁrst treatment, 1 day after the last treatment, and approximately 5 weeks after treatment completion), and having blood drawn ● This study involves logging mood regularly on your phone during and after treatment. ● Patients must be diagnosed with depression, able to undergo MRI scanning, and not be using illicit substances. A letter from your treating psychiatrist is required. ● The procedures will be at no cost to you and will occur over a 2-week period with the enre study lasng up to 2 months. Parking at UCLA will be paid for each research visit. Please email [email protected] or call 310-794-0305 to speak to the Ketamine Study Coordinator. Protocol ID:IRB#15-001173 UCLA IRB Approved Approval Date: 6/26/2017 Through: 6/7/2018 Committee: Medical IRB 3

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Page 1: UCLA Brain Research Study for Volunteers diagnosed with

Depression

Grand Challenges

UCLA Brain Research Study for Volunteers diagnosed with treatment resistant depression to evaluate their

response to the drug ketamine

Are you considering ketamine infusion for depression?Are you between 20-64 years old?

● If so, you may be interested in hearing about a study that looks at how ketamine relates to changesin gene regulation and brain chemistry and function.

● The study includes screening tests, receiving up to 4 ketamine infusions at UCLA, having 4 brainscans (1 scan before treatment, and 1 scan the day after the first treatment, 1 day after the lasttreatment, and approximately 5 weeks after treatment completion), and having blood drawn

● This study involves logging mood regularly on your phoneduring and after treatment.

● Patients must be diagnosed with depression, able to undergoMRI scanning, and not be using illicit substances. A letter fromyour treating psychiatrist is required.

● The procedures will be at no cost to you and will occur over a 2-week period with the entire studylasting up to 2 months. Parking at UCLA will be paid for each research visit.

Please email [email protected] or call 310-794-0305 to speak to the Ketamine Study Coordinator.

Protocol ID:IRB#15-001173 UCLA IRB Approved Approval Date: 6/26/2017 Through: 6/7/2018 Committee: Medical IRB 3