udgenomed 5p v2NGS applications: • Clinical genomics including cancer genomics analysis to gain critical insights into tumour progressions and genetic diseases • Microbial genomics

UD-GenoMed�Medical�Genomic�Technologies�Ltd.

4032�Debrecen,�Hungary,�Nagyerdei�krt.�98.

Phone:�+36�(52)�411-717�ext.�66548

Email:�[email protected]

UD-GenoMed Ltd. is an innovative R&D SME and service laboratory offering large scale clinical genomics studies, molecular testing, related consulting and training services to both Academy and Industry. UD-GenoMed’s services are based on the unique know-how of the Biochemistry and Molecular Biology Institute of the University of Debrecen Medical and Health Science Center. UD-GenoMed Ltd. was founded by University of Debrecen with the ultimate goal to commercialize its genomic technology base and additional services previously provided exclusively by the Clinical Genomic Center of the University. In 2010 the company’s capital had been increased by the managing private individuals who acquired 50% as shareholders in the company.

UD-GenoMed acts as an integrated testing lab and clinical study provider with dedicated focus on patient recruitment and has references in the following fields:i.) chronic inflammatory diseases e.g. COPD, rheumatoid arthritis, inflammatory bowel disease ii.) tumor diseases including lung cancers, colon cancers, lymphoid leukemia and iii.) schizophrenia and other mental disorders.Using functional genomics applications, UD-GenoMed is developing novel diagnostics biomarkers in these fields.

About UD-GenoMed


Who we are now...Since the changes in the ownership structure in 2010 UDG successfully participated in FP7 EU and several Hungarian tenders and projects as an SME.By the sixth year of its operation UD-GenoMed became the most progressive and developing R&D spin-off company originating from the era of the University of Debrecen.

To date we are pleased to welcome more than a hundred partners from life science academy research groups to leading industrial biotech and pharma companies.

With a large number of successful projects over the six years of operation we intend to extend our portfolio to suit the needs of our valued customers.

Our future...We are continuously looking for: • collaborating partners for R&D projects in the field of biomarker discovery;• customers for our „fee-for-services” in functional genomics and bioinformatics;• partners with products looking for distribution cooperation to Hungary and CEE region;• partners and projects for participating in new EU funded projects.

Our long term plans are: • to extend our R&D services portfolio with diagnostics services even for private customers (DTC) and to enter the diagnostics services market;• we are dedicated to strengthen our collaboration with further pharma and biotechcompanies in the near future;• based on our recent research results a new diagnostics procedure development and many more projects are to be launched in 2013;• continuous development of our service portfolio.

What we offer...• management of your project idea, involving genomic applications; • patient recruitment, sample collection, processing and storing of samples;• functional genomics, epigenetics and epigenomics services;• proteomics from protein identification to data evaluation; • bioinformatics from basic interpretation to biostatistics and QC;• cell line and recombinant protein engineering and production; • wide range of antibodies and related molecular biology kits.


www.ud-genomed.com

www.ud-genomed.com

Study design and consulting:• create your research plan• optimize your patient's criteria, instruments and material requirements• define your quality specification• training sessions for your interest

Patient recruitment:• one of our major benefits is our proximity to a large number of patient groups• unique collaboration with the Medical and Health Science Centre treating yearly 150 000 patients and more than 100 clinical studies managed yearly• nearly 10 years of experience

Biobanking:• create biobanks by collecting, processing and archiving primer samples• construction of clinical and molecular biology databases • ensure access and provide consultation• training in biobanking protocols

Database management:• collect data, create data warehouse • design and management of large biological databases• data mining and interpretation

Choose UD-GenoMed as your partner in genomic studies and as a services provider and we will do our best to achieve your goals.

B2C productsservicesown IP

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Study design and consulting

Patient recruitment

Biobanking

Database management

Functional analysis

Bioinformatics


www.ud-genomed.com

Functional analysis servicesFull processing of your samples by:• sample QC with Agilent Bioanalyzer• real-time PCR• Affymetrix, Illumina and Agilent microarray services• capillary sequencing and fragment analysis• new generation sequencing

Fully automated Affymetrix applications:• hundreds of successfully analyzed microarrays to date• whole genome gene expression analysis for more than 20 species available• chip on ChIP analysis• genotyping of single nucletide polymorphisms (SNP’s)• resequencing of known genes and mitochondrial genome• detection of chromosomal abnormalities

Genotyping of samples:• high quality customizable genotyping solutions from a single to millions of SNPs across multiple platforms for a large scale of species• whole genome analysis to determine associations between geneticvariability, drug response and diseases• variant discovery to identify genotype/phenotype correlations• targeted genotyping to analyze targeted SNPs of your choice • various custom chips to suit your research project

UD-GenoMed sequencing and genotyping services are designed to support your research.


Upstream

Midstream

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Patient recruitment

Biobanking

Database management

Functional analysis

Bioinformatics


www.ud-genomed.com

NGS applications:• Clinical genomics including cancer genomics analysis to gain critical insights into tumour progressions and genetic diseases• Microbial genomics for genetic insight to viruses and bacteria• Agrigenomics to characterize and improve animal and plant genomesFor the above listed fields of NGS we offer:• full genom sequencing: high-quality characterization of any genome• targeted sequencing: variant discovery; deep sequencing of the genomic region of interest or regulatory elements; exome sequencing• RNA sequencing: deep sequencing of RNA; identification of transcript or splice variant; differential expression analysis• metagenomic sequencing: analysis of microbial samples of differentorigin (e.g. enteric-, soil-, water-, and thermal water related samples)• ChIP Seq: the combination of chromatin immunoprecipitation and NGSto discover DNA-protein interactions, epigenetic mechanisms in living cells• all-inclusive data management with bioinformatics follow-up (see below)

Bioinformatics:• basic services for first interpretation of genome data• advanced services to explore NGS and genomics data in more detail• gene expression data biostatistics• genotyping data QC and interpretation• biomarker discovery from biomarker test development to test validation• analysis software- and pipeline development for complex data analysis• customized data analysis (data formating, advanced statistics)

Own IP:• development and commercialization of own IP portfolio

Thank you for trusting UD-GenoMed with your research!

UD-GenoMed sequencing and genotyping services are designed to support your research.


Upstream

Midstream

Dow

nstream


Patient recruitment

Biobanking

Database management

Functional analysis

Bioinformatics


Documents

udgenomed 5p v2NGS applications: • Clinical genomics including cancer genomics analysis to gain critical insights into tumour progressions and genetic diseases • Microbial genomics