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UK Clinical Research Network (UKCRN)
UK Clinical Research Network
Maxine Stead PhD
UKCRN Assistant Director – Clinical Trials
UK Clinical Research Network (UKCRN)
Background
DoH announcement March 2004 : extra £100m p.a. by 2008 for research (in England) building on successful model for cancer research
Targeted research funding• Medicines for Children• Diabetes• Alzheimer's disease (now Dementias and Neurodegenerative Disease)• Stroke• Cancer• Mental Health
Clinical Research Network model(UKCRN)
UK Clinical Research Collaboration (UKCRC)
UK Clinical Research Network (UKCRN)
What is the UKCRC?
Partnership between government, the NHS, the voluntary sector, the private sector and the public
Aim is to transform the clinical research environment in the UK by: Taking strategic oversight of clinical research Identifying gaps in clinical research capability and opportunities for
action Developing coordinated approaches to addressing gaps/responding
to opportunities Monitoring progress in implementing plans and achieving objectives Providing leadership to develop the profile of clinical research and
enhance the research culture of the NHS
UK Clinical Research Network (UKCRN)
What is the UKCRN?
UKCRN will consist of a managed set of Clinical Research Networks to facilitate the conduct of randomised trials of interventions (including prevention, diagnosis, treatment, and care) and other well designed studies
Research projects funded by both commercial and non-commercial organisations will be incorporated
6 initial priority areas - cancer, mental health, medicines for children, diabetes, stroke and dementias and neurodegenerative disease
Future intention to extend UKCRN to cover full spectrum of disease and clinical need
Aim: to provide a world-class health service infrastructure to support clinical research and to make clinical research part of routine care
UK Clinical Research Network (UKCRN)
Organisational Structure of UKCRC/N
UK Clinical Research Network (UKCRN)
Role of UKCRN Coordinating Centre
National coordination of UKCRN activities Performance management of Topic-Specific Coordinating
Centres Financial management of UKCRN Links with UKCRC Development and provision of national systems and
approaches to trial development and management Conduit for addressing barriers to trials at a national level Central team of ~30-35 staff with leads for different
workstreams
UK Clinical Research Network (UKCRN)
Organisational Structure of UKCRC/N
UK Clinical Research Network (UKCRN)
Topic Specific Network Directors
Mental HealthDirector
Prof Til Wykes Cancer Director (acting) Prof Rick Kaplan
Medicines for ChildrenDirector
Prof Ros Smyth
DiabetesDirector
Prof Des Johnston
StrokeDirector
Prof Gary Ford
DenDRoNDirector
Prof Martin Rossor
UKCRN National CCCo- Directors
Prof Janet DarbyshireProf Peter Selby
UK Clinical Research Network (UKCRN)
Role of Topic-Specific Coordinating Centres
Portfolio development Management of Research Networks Performance management of Research Networks Provision of topic-specific training Coordination of consumer involvement Links with relevant trials units Main point of contact with UKCRN Coordinating Centre
UK Clinical Research Network (UKCRN)
Benefits of the UKCRN
Improved national coordination of clinical research Provision of national systems and advice structures
reduction in duplication of effort National coordinated approach to trial development
and trial portfolios Increased profile of research Improved trials benefits for patients
UK Clinical Research Network (UKCRN)
Development of research portfolios - National Clinical Studies Groups
Remit to develop a balanced portfolio of research studies that address uncertainties in patient care
Multi-disciplinary membership, transparent appointment Involvement of patients, carers and the public in:
prioritisation of questions development of study methodology and outcomes maintaining an overview of the portfolio and identifying gaps study overview and management dissemination of results
Links with funding bodies, NICE, James Lind Alliance Links with international groups to enable questions in rarer
conditions to be answered
UK Clinical Research Network (UKCRN)
CSGs in cancer Bladder Cancer Clinical Studies Group Brain Tumour Clinical Studies Group Breast Cancer Clinical Studies Group Colorectal Cancer Clinical Studies Group Complementary Therapies Clinical Studies Development Group Consumer Liaison Group Gynaecological Cancer Clinical Studies Group Haematological Oncology Clinical Studies Group Head and Neck Cancer Clinical Studies Group Lung Cancer Clinical Studies Group Lymphoma Clinical Studies Group Melanoma Clinical Studies Group Palliative Care Clinical Studies Development Group Primary Care Clinical Studies Development Group Prostate Cancer Clinical Studies Group Psychosocial Oncology Clinical Studies Development Group Renal Cancer Clinical Studies Group Radiotherapy Clinical Studies Group Sarcoma Clinical Studies Group Testis Cancer Clinical Studies Group Upper GI Cancer Clinical Studies Group
UK Clinical Research Network (UKCRN)
CSGs in cancer Bladder Cancer Clinical Studies Group Brain Tumour Clinical Studies Group Breast Cancer Clinical Studies Group Colorectal Cancer Clinical Studies Group Complementary Therapies Clinical Studies Development Group Consumer Liaison Group Gynaecological Cancer Clinical Studies Group Haematological Oncology Clinical Studies Group Head and Neck Cancer Clinical Studies Group Lung Cancer Clinical Studies Group Lymphoma Clinical Studies Group Melanoma Clinical Studies Group Palliative Care Clinical Studies Development Group Primary Care Clinical Studies Development Group Prostate Cancer Clinical Studies Group Psychosocial Oncology Clinical Studies Development Group Renal Cancer Clinical Studies Group Radiotherapy Clinical Studies Group Sarcoma Clinical Studies Group Testis Cancer Clinical Studies Group Upper GI Cancer Clinical Studies Group
UK Clinical Research Network (UKCRN)
LLCG-14Gem/ carbo ± thalidomide
Ming Lee/ Karen [email protected] nationally
GEM HospitalisationGem/ cisp vs Gem/ carbo
Nick Thatcher / Linda Ashcroftlinda.ashcroft@christie-
tr.nwest.nhs.ukLimited centre accrual
GRINRT vs RT + Gemcitabine
Allan Pr [email protected]
Open nationally
SOCCARSequential vs Concur rent
CTRTJoe Maguire/ Car l J ackson
[email protected] to open soon
INCHCHART vs CT + CHART
Matthew Hatton/ Adrian Hodson
[email protected] to open soon
Stage I/ III diseaseFit for radical chemo-radiotherapy, centre
able to do CHART?
Stage III diseaseFit for radical
chemo-radiotherapy?
Stage I/ II diseaseUnfit for surgery?
NCRI Lung Cancer Studies Group –Approved studies - Mar 04for more details see http://www.ncrn.org.uk/Portfolio
TOPICALBSC ± Tarceva
Ming Lee/ Blair [email protected]
Due to open soon
Fit for resection & chemotherapy?
LU22Surgery vs CT + Surgery
Ian Smith/ Adr ian Hodson [email protected] nationally
Mesothelioma
Fit for radical resection?
MS01ASC vs ASC + navelbine vs ASC + MVP
Mar tin Muers/ Adr ian [email protected]
Open nationally
MARSCT/ RT vs CT/ surgery/ RT
Tom Treasure/Mark [email protected]
Feasibility phase open soon
MesoVATSTalc pleurodesis vs VATS cytoreductive pleurectomy
Andy Ritchie/ Clare [email protected]
[email protected] centre accrual
In development
BTOG 2 - carboplatin vs cisplatin 50 vs cispatin 80 - [email protected] NOAH - 2x2 design - docetaxel vs gemcitabine / cisplatin vs carboplatin -p.j .woll@sheffi eld.ac.uk Brain metastases - steroids ± whole brain radiotherapy - [email protected] SCLC - chemotherapy ± statins - [email protected] NSCLC - adjuvant chemotherapy vs neo-adjuvant chemotherapy - [email protected] Wedge resection - wedge resection vs radical radiotherapy [email protected] Spinal cord compression - single dose vs multiple dose radiotherapy - [email protected] Lung cancer - low molecular weight heparin - [email protected]
Epidemiology studies
Early Lung Cancer Study - molecular biomarkers in ear ly lung cancer detection - [email protected] Liverpool Lung Project - [email protected] - Genetic Lung Cancer Predisposition Study - [email protected] MALCS - mesothelioma and lung cancer control study - [email protected]
LLCG-12Cisplatin + etoposide ± thalidomide
Ming Lee/ Karen [email protected] nationally
Fit for chemotherapy?
Small cell lung cancer
Non-small cell lung cancer
Yes
Yes
Advanced DiseaseFit for
chemotherapy?
Advanced DiseaseUnfit for
chemotherapy?
Yes
Yes
Yes
Requir ing treatment for pleural effusion?
Fit for chemotherapy?
YesYesYes
YesYes
Palliative treatmentRIB - Single dose RT vs Ibandronate for localised metastatic bone pain - Peter Hoskin/ Or la Cummins - [email protected]
SC20 - Single vs multiple fractions for re-irradiation of painful bone metastases - Peter Hoskin/ Or la Cummins - [email protected] .ac.uk
Yes
YesYes
YesYes
Flow chart by Richard Stephens - email: [email protected]
UK Clinical Research Network (UKCRN)
Involvement of patients and the public
UKCRN Patient and Public Liaison Lead – Marianne Miles
Topic Research Network Leads Development of common standards and approaches to
involving consumers in UKCRN activities Membership of Clinical Studies Groups Establishment of Consumer Research Panels Provision of training and support
UKCRC – increasing public awareness of research
UK Clinical Research Network (UKCRN)
Summary
UKCRN will provide infrastructure to support clinical research that answers current uncertainties in healthcare
Links with James Lind Alliance important Development of Clinical Studies Groups provide
another forum to identify questions Links with patients and the public are fundamental Exciting times ahead!