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Understanding and Using INCB Opioid Understanding and Using INCB Opioid Consumption Statistics: Consumption Statistics:
Including Morphine EquivalenceIncluding Morphine Equivalence
8 August 20128 August 2012
Martha Maurer, MSW, MPH, PhDMartha Maurer, MSW, MPH, PhD
Pain & Policy Studies GroupPain & Policy Studies GroupWorld Health Organization Collaborating CenterWorld Health Organization Collaborating Center
for Policy and Communications in Cancer Carefor Policy and Communications in Cancer Care
University of Wisconsin Carbone Comprehensive Cancer CenterUniversity of Wisconsin Carbone Comprehensive Cancer Center
The Single Convention establishes two mechanisms:
(1) statistical returns system for narcotic drugs, and
(2) estimates system for narcotic drug requirements.
UN Single ConventionArticle 1, paragraph 2
For the purposes of this Convention a drug shall be regarded as “consumed” when it has been supplied to any person or enterprise for retail distribution, medical use or scientific research; and “consumption” shall be construed accordingly.
UN Single ConventionArticle 20, paragraph 1
The parties shall furnish to the Board…statistical returns on forms supplied by it in respect of the following matters: …(c) consumption of drugs.
Who is responsible?
PPSG Collaboration with INCB
- INCB publishes consumption statistics annually
- Public INCB reports do not include reported amounts that are less than 500 g
- PPSG has a long-term relationship with INCB
- PPSG receives complete annual raw data, including amounts less than 500 g, for the most recent year
Uses of Consumption Statistics
-Identification of the opioids that are available (i.e., manufacture or import authorization) in a country
-An indicator of a country’s current and historical ability to treat moderate to severe pain
-A tool to evaluate the efforts to improve opioid availability (i.e., following removal of a barrier.)
Limitations of Consumption Statistics
- Some countries may not annually report or may report incorrect statistics
- Not able to distinguish between different clinical uses, e.g., methadone to treat pain vs. addiction (dependence syndrome)
- Not able to distinguish between types of pain being treated, e.g., acute vs. chronic
- Consumption for single drugs offers only a partial view of a country’s ability to manage pain
Global Consumption of Morphine, 2010
**Austria’s consumption includes use of morphine for substitution therapySources: International Narcotics Control Board; World Health Organization population dataBy: Pain & Policy Studies Group, University of Wisconsin/WHO Collaborating Center, 2012
mg/capita
152 countries
Global Mean
5.9912
Disparity in Consumption: High vs. Low- and Middle-income countries (LMIC)
2010 Morphine Consumption (kg)
High Income (90%)
LMIC (10%)
0
10
20
30
40
50
60
EURO mean, 12.4285 mg/capita Global mean, 5.9912 mg/capita
**Austria122.5037
Kyrgyzstan0.1048
Ukraine0.6418
Albania0.9429
**Austria includes data for substitution therapySources: International Narcotics Control Board; World Health Organization population dataBy: Pain & Policy Studies Group, University of Wisconsin/WHO Collaborating Center, 2012
mg/capita
WHO Regional Office for Europe (EURO)2010 Morphine Consumption
0.0
0.5
1.0
1.5
SEARO mean, 0.1350 mg/capita Global mean, 5.9912 mg/capita
Bhutan3.9738
Sri Lanka0.3872
India0.0913
Bangladesh0.0502
Sources: International Narcotics Control Board; World Health Organization population dataBy: Pain & Policy Studies Group, University of Wisconsin/WHO Collaborating Center, 2012
mg/capita
WHO Regional Office for Southeast Asia (SEARO)2010 Morphine Consumption
Morphine Equivalence (ME) statistic – a more complete picture
PPSG developed a morphine equivalence (ME) statistic for each principal opioid used to treat severe pain:
• Fentanyl• Hydromorphone• Methadone• Morphine• Oxycodone• Pethidine
Allows for a comparison of the consumption of morphine to the equianalgesic consumption of other medications
Total ME statistic represents in one metric the aggregate consumption of these principal opioid analgesics used for severe pain
Pain & Policy Studies GroupUniversity of WisconsinCarbone Cancer Center
WHO Collaborating Center
Data sources:Consumption data - International Narcotics Control Board;Population – United Nations World Population Prospects, 2010 Revision;ME conversion factors – WHOCC Centre for Drug Statistics Methodology
Global Consumption in Morphine Equivalence (ME)1980-2010, mg/person
2009 Opioid Consumption in Morphine Equivalence2009 Opioid Consumption in Morphine Equivalence
http://www.painpolicy.wisc.edu/
Opioid Consumption Motion Chart http://www.painpolicy.wisc.edu/
PPSG’s Country Profileshttp://www.painpolicy.wisc.edu/internat/countryprofiles.htm
PPSG’s Country Profiles
Conclusions
• INCB data are an important source of data about opioid availability around the world
• Prior to 1986 morphine consumption alone was a reasonable indicator of total opioid consumption
• Subsequently morphine consumption alone less valid indicator
• Morphine Equivalence statistics allow for equianalgesic comparison across drugs
• Total morphine equivalence statistic represents aggregate consumption of all principle opioids used for severe pain