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undifferentiated schizo
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COLLEGE OF NURSING
Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 1
Nursing Management of Patient with
Undifferentiated Schizophrenia
Dela Cruz, Victor Jr S.
BSN3Y3-9B
Our Lady of Fatima University
Valenzuela City
Ma’am Rosario Fernando
Clinical Instructor
COLLEGE OF NURSING
Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 2
Nursing Management of Patient with Undifferentiated Schizophrenia
Introduction
R.A, 34 years old, male from Concessionaires area, PNPA. Patient is the
5th siblings, 2nd year college level when he became mentally ill 12 years prior
to admission. He had regular check-up at this center on January 27, 2003.
Given drugs of monthly Levozepromazine. His last check-up was on March
17, 2008 and has subsequent check-up care of Trece Martines.
Schizophrenia (from the Greek roots skhizein ("to split") and phrēn
("mind") is a severe mental illness characterized by a variety of symptoms
including but not limited to loss of contact with reality. Schizophrenia is not
characterized by a changing in personality; it is characterized by a
deteriorating personality. Simply stated, schizophrenia is one of the most
profoundly disabling illnesses, mental of physical that the nurse will ever
encounter (Keltner,2007). There are 5 subtypes of schizophrenia naming;
paranoid, disorganized, catatonic, undifferentiated, and residual.
Schizophrenia undifferentiated is the type of schizophrenia wherein
characteristic symptoms (delusions, hallucinations, disorganized
speech, grossly disorganized or catatonic behavior, and negative
symptoms) are present, but criteria for paranoid, catatonic,
or disorganized subtypes are not met.
COLLEGE OF NURSING
Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 3
Schizophrenia is not a terribly common disease but it can be a
serious and chronicone. Worldwide about 1 percent of the population
is diagnosed with schizophrenia. About 1.5 million people will be
diagnosed with schizophrenia this year around the world. Ninety-five percent
(95%) suffer a lifetime; thirty-three percent (33%) of all homeless Americans
suffer from schizophrenia; fifty percent (50%) experience serious
side effects from medications; and ten percent (10%) kill themselves
(Keltner, 2007).
According the study of cureresearch.com done 697,543 out of
86,241,697 of Filipinos or approximately 0.8% are suffering from
schizophrenia. 5 schizophrenia ranks among the top 10 causes of
disability in developed countries worldwide. Schizophrenia is a
disease that typically begins in early adulthood; between the ages of
15 and 25. Men tend to get develop schizophrenia slightly earlier
than women; whereas most males become ill between 16 and 25
years old, most females develop symptoms several years later, and the
incidence in women is noticeably higher in women after age 30. The average
age of onset is 18 in men and 25 in women. Schizophrenia onset is quite rare
for people under 10 years of age, or over 40 years of age.
COLLEGE OF NURSING
Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 4
Anatomy and Physiology
The nervous system is an intricate, highly organized network of
billions of neurons and neuroglia. The structures that make up the
nervous system include the brain, cranial nerves, spinal nerves, ganglia,
enteric plexuses and sensory receptors. The two main subdivisions of the
nervous system are the central nervous system and the peripheral nervous
system.
The central nervous system consists of the brain and spinal cord. The
brain is the center for registering sensations, correlating them with one
another and with stored information, making decisions and taking
actions. It also is the center for the intellect, emotions, behavior, and
memory. The major parts of the brain include: the brain stem, cerebellum,
diencephalon, and cerebrum. The spinal cord is connected to a section of
the brain called the brainstem and runs through the spinal canal.
Cranial nerves exit the brainstem. Nerve roots exit the spinal cord to both
sides of the body. The spinal cord carries signals (messages) back and
forth between the brain and the peripheral nerves.
COLLEGE OF NURSING
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NURSING MANAGEMENT 5
The brain stem is continuous with the spinal cord and consists
of the medulla oblongata, pons, and midbrain. The medulla oblongata
forms the inferior part of the brain stem. The medulla contains the cardiac,
respiratory, vomiting and vasomotor centers and deals with
breathing, heart rate and blood pressure. The pons is a bridge that
connects parts of the brain with one another. The midbrain extends from
the pons to the diencephalon. The midbrain is a short section of the
brainstem between the diencephalon and the pons.
Posterior to the brain stem is the cerebellum. Traditionally, the
cerebellum has been known to control equilibrium and coordination and
contributes to the generation of muscle tone. It has more recently
COLLEGE OF NURSING
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NURSING MANAGEMENT 6
become evident, however, that the cerebellum plays more diverse
roles such as participating in some types of memory and exert in a
comples influence on musical and mathematical skills. Superior to the
brainstem is the diencephalon, which consists of the thalamus,
hypothalamus, and epithalamus. The thalamus acts a relay center for
all sensory impulses, except smell to the cerebral cortex. The
hypothalamus is involved in the acceleration or deceleration of the heart.
Impulses from the posterior hypothalamus produce a rise in arterial
blood pressure and increase of the heart rate. Impulses from the
anterior portion have the opposite effect. The hypothalamus is also
involved in body temperature regulation. If the arterial blood flowing
through the anterior portion of the hypothalamus is above normal level, the
hypothalamus initiates impulses that cause heat loss through sweating
and vasodilation of cutaneous vessels of the skin. A below-normal
blood temperature causes the hypothalamus to relay impulses that result in
heat production and retention through the initiation of shivering, the
contraction of cutaneous blood vessels. The hypothalamus is also
involved in the regulation of hunger and control of gastrointestinal
activity. Low levels of blood glucose, fatty acids and amino acids are
partially responsible for the sensation of hunger elicited from the
hypothalamus. When sufficient amounts of food have been ingested, the
hypothalamus inhibits the feeding center. It also regulates sleeping and
COLLEGE OF NURSING
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NURSING MANAGEMENT 7
wakefulness. A specialized sexual center in the hypothalamus responds to
sexual stimulation of the tactile receptors within the genital organs. Also,
the hypothalamus is associated with specific emotional responses,
such asanger, fear, pain and pleasure. The hypothalamus produces
neurosecretory chemicals that stimulate the anterior pituitary gland to
release various hormones. The epithalamus is the posterior portion of the
diencephalon.
Supported on the diencephalon and brain stem is the
cerebrum, which is the largest part of the brain. The cerebrum is the
largest part of the brain and controls voluntary actions, speech,
senses, thought, and memory. The surface of the cerebral cortex
has grooves or infoldings (called sulci), the largest of which are termed
fissures. Some fissures separate lobes.
The convolutions of the cortex give it a wormy appearance.
Each convolution is delimited by two sulci and is also called a gyrus
(gyri in plural). The cerebrum is divided into two halves, known as
the right and left hemispheres. A mass of fibers called the corpus
callosum links the hemispheres. The right hemisphere controls voluntary
limb movements on the left side of the body, and the left hemisphere
controls voluntary limb movements on the right side of the body.
Almost every person has one dominant hemisphere. Each hemisphere
is divided into four lobes, or areas, which are interconnected.
COLLEGE OF NURSING
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NURSING MANAGEMENT 8
The frontal lobes are located in the front of the brain and are
responsible for voluntary movement and vie their connections with other
lobes, participate in the execution of sequential tasks; speech output;
organizational skills; and certain aspects of behavior, mood, and memory.
The parietal lobes are located behind the frontal lobes and in front of the
occipital lobes. They process sensory information such as temperature, pain,
taste, and touch. In addition, the processing includes information about
numbers, attentiveness to the position of one’s body parts, the space around
one’s body, and one's relationship to this space. The temporal lobes are
located on each side of the brain. They process memory and auditory
(hearing) information and speech and language functions.
The occipital lobes are located at the back of the brain. They receive
and process visual information.
Neurotransmitters are chemicals which relay, amplify, and modulate
signals between a neuron and another cell. Some neurotransmitters are
commonly described as "excitatory" or "inhibitory". The only direct effect of
a neurotransmitter is to activate one or more types of receptors. Examples of
neurotransmitters are acetylcholine, dopamine, gamma-aminobutyric acid,
dopamine, glutamate, aspartate, and serotonin. The chemical compound
acetylcholine is a neurotransmitter in both the peripheral nervous system
(PNS) and central nervous system (CNS) in many organisms including
humans. In the peripheral nervous system, acetylcholine activates muscles,
COLLEGE OF NURSING
Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 9
and is a major neurotransmitter in the autonomic nervous system. In the
central nervous system, acetylcholine and the associated neurons form
a neurotransmitter system, the cholinergic system, which tends to
cause excitatory actions. Gamma-Aminobutyric acid (GABA) is the
chief inhibitory neurotransmitter in the mammalian central nervous system.
It plays a role in regulating neuronal excitability throughout the nervous
system. In humans, GABA is also directly responsible for the regulation of
muscle tone. Dopamine has many functions in the brain, including important
role in behavior and cognition, voluntary movement, motivation, punishment
and reward, inhibition of prolactin production (involved in lactation and
sexual gratification), sleep, mood, attention, working memory, and learning.
In the frontal lobes, dopamine controls the flow of information from other
areas of the brain. Dopamine disorders in this region of the brain can cause a
decline in neurocognitive functions, especially memory, attention, and
problem-solving. Reduced dopamine concentrations in the prefrontal cortex
are thought to contribute to attention deficit disorder. Dopamine is
commonly associated with the pleasure system of the brain, providing
feelings of enjoyment and reinforcement to motivate a person proactively to
perform certain activities. Dopamine is released (particularly in areas such as
the nucleus accumbens and prefrontal cortex) by naturally rewarding
experiences such as food, sex, drugs, and neutral stimuli that
become associated with them. Recent studies indicate that
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NURSING MANAGEMENT 10
aggression may also stimulate the release of dopamine in this way.
This theory is often discussed in terms of drugs such as cocaine,
nicotine, and amphetamines, which directly or indirectly lead to an
increase of dopamine in the mesolimbic reward pathway of the brain,
and in relation to neurobiological theories of chemical addiction (not
to be confused with psychological dependence), arguing that this
dopamine pathway is pathologically altered in addicted persons.
Projection neurons that produce dopamine are found in the diencephalon
and the brainstem. In the diencephalon, dopamine cell bodies give rise
to tuberopophysial dopamine projections, which inhibit the release of
prolactin and melanocyte-stimulating hormone from the anterior and
intermediate lobes of the pituitary, respectively, and the
incertohypothalamic projections, which connect the zona incerta in
the posterodorsal diencephalon with the anterior hypothalamus and
septal area. A third dopamine projection system arises from neurons
scattered along the ventricular system in the periaqueductal gray, the
dorsal motor of the nucleus of the vagus, and the nucleussoli tarius.
The preventricular system provides terminals in the gray matter
along the course of theventricles.Longer dopamine projection systems
arise from the substantia nigra and the ventral tegmentalarea (VTA) of the
midbrain. The former, the nigrostriatal dopamine system, is a particularly
important in the control of motor function. The function of the
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NURSING MANAGEMENT 11
VTA’s dopamine projections to the forebrain, called the mesolimbic and
mesocortical systems, has been linked to the complex group of disease we
refer to as schizophrenia. Sociability is also closely tied to dopamine
neurotransmission. Low D2 receptor-binding is found in people with social
anxiety. Traits common to negative schizophrenia (social withdrawal, apathy,
anhedonia) are thought to be related to a hypodopaminergic state in certain
areas of the brain. In instances of bipolar disorder, manic subjects can
become hypersocial, as well as hypersexual. This is credited to an increase in
dopamine, because mania can be reduced by dopamine-blocking anti-
psychotics. The locus ceruleus at the rostal end of the floor of the
fourth ventricle on each side marks the position of a nucleus with a
rich vascular supply and consisting of neurons containing
melanin pigment. The nucleus (also known as nucleus pigmentosus) is
partly in the pons and partly in the midbrain, lying dorsolateral to the
oral pontine reticular nucleus. The locus ceruleus is the largest of about a
dozen nuclei I the brainstem that produce catecholamines. Most
produce norepinephrine, but some of those in the medulla produce
epinephrine. A third catecholamine is dopamine, a transmitter used
by the large neurons of the substantia nigra and ventral tegmental
area, and by certain nuclei of the hypothalamus. Serotonin or 5-
Hydroxytryptamine (5-HT) is a monoamine neurotransmitter that is primarily
found in the gastrointestinal (GI) tract and central nervous system (CNS) of
COLLEGE OF NURSING
Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 12
humans and animals. Approximately 80 percent of the human body’s total
serotonin is located in the enterochromaffin cells in the gut, where it is used
to regulate intestinal movements. The remainder is synthesized in
serotonergic neurons in the CNS where it has various functions, including the
regulation of mood, appetite, sleep, muscle contraction, and some cognitive
functions including memory and learning. Modulation of serotonin at
synapses is a thought to be a major action of several classes of
pharmacological antidepressants. Serotonin secreted from the
enterochromaffin cells eventually finds its way out of tissues into the blood.
There, it is actively taken up by blood platelets, which store it. When the
platelets bind toa clot, they disgorge serotonin, where it serves as
a vasoconstrictor and helps to regulate hemostasis and blood clotting.
Serotonin also is a growth factor for some types of cells, which may give it a
role in wound healing.
Psychopathology
The pathophysiology of schizophrenia has long remained a mystery
and still today, even with various hypotheses, remains somewhat uncertain:
there are too many variants; not enough consistency in findings; and,
despite research, a lack of documented proof.
COLLEGE OF NURSING
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NURSING MANAGEMENT 13
The most well-known and respected hypothesis with regards to the
pathophysiology of schizophrenia began in the 1990s and consisted primarily
of the notion there is a problem with the dopamine levels in the brain of
schizophrenics.
Dopamine is both a hormone and a neurotransmitter, which means
that it activates five different receptors in the brain, aptly named D1, D2, D3,
D4, and D5. That said, it may not be the only neurotransmitter involved in
the pathophysiology of schizophrenia. Glutamate and Serotonin have also
been implicated.
Contributing to this hypothesis is the fact that drugs administered to
aid dopaminergic activity bring on schizophrenic characteristics such as
psychosis, in a patient, whereas drugs administered to block them help
reduce, or eliminate symptoms of schizophrenia altogether.
Additional studies affecting the pathophysiology of schizophrenia
include suggestions that maternal factors such as infection, malnutrician,
location of birth, season of birth, and delivery, may play a significant part in
the formation and subsequent appearance of schizophrenia. Studies have
shown that the worldwide rate of births affected with schizophrenia is up to
8% higher when occurring in spring or winter, though no explanation for this
can be offered.
Another aspect of the pathophysiology of schizophrenia that has been
explored in relative detail is that of genetics, and their relation to the
COLLEGE OF NURSING
Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 14
likelihood of immediate relatives being born with the disease. Shockingly, it
has been found that 10% of all immediate family members of an infected
person will be struck down with the disease. This is specifically in relation to
parents, siblings, and children. With regards to twins or other multiple births,
the chances they will share the disease is 50%. Genetic reports suggest that
it is the X chromosome which determines whether or not a person is infected
with schizophrenia, specifically, chromosomes 1, 3, 5, and 11, however
further studies are needed in order to prove this theory.
Though there are many theories and hypotheses regarding the
pathophysiology of schizophrenia, there is, unfortunately, still no cure for the
disease. The best a sufferer can hope for nowadays is to benefit from
available medication which keeps the disease under control or in remission
for the duration of time for which it is taken.
History
R.A, 34 years old, male from Concessionaires area, PNPA admitted on
February 7,2012. Patient is the 5th siblings, 2nd year college level when he
became mentally ill 12 years prior to admission. He had regular check-up at
this center on January 27, 2003. Given drugs of monthly Levozepromazine.
His last check-up was on March 17, 2008 and has subsequent check-up care
of Trece Martines. Medication just conditioned to be manifested.
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NURSING MANAGEMENT 15
1 week prior to admission, patient became assaultive and distractive
infront of family.
2 days prior to admission, patient strambulated father and was
helpless to calls, restless and sleep hence brought to the center.
According to mother “nananakit”, “nanununtok”, “sina-sabal ang
tatay”, “naghuhubad” and “di-nakatulog”.
According to patient “check-up lang” and “hindi po totoo yun”.
Mental Status Exams
Name: R.A Diagnosis: Undifferentiated
Schizophrenia
Age: 34 Ward: Pavillion 6, Pay Ward 1-E
Appearance
34 year-old Filipino, male, 5’7 in height. At the time of examination, patient
was well groomed and dressed. He was not confined to bed. R.A was
cooperative throughout the interview. He maintained eye contact, except
during the times when recounting the history before he was admitted. Then,
he appeared depressed. His level of personal hygiene was fairly good. The
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NURSING MANAGEMENT 16
patient’s movements are organized and purposeful during the interview. He
moves in a normal pace and does not show any signs of over and under
activity. The patient’s facial expressions are very much appropriate to his
verbal responses during the interview. He was composed and receptive to
whatever the I ask him.
Behavior
Behavior was passively cooperative during examination. The patient was
friendly and warm during the interview. He was sitting on chair calmly.
Speech
R.A articulated himself clearly. During the interview, he was pleasant and
cooperative and displayed a positive attitude. He went into details, the
circumstances surrounding his admission. He was able to maintain adequate
eye contact. His speech was coherent, spontaneous and appropriate with
normal rate, volume and rhythm. He described his mood as depressed.
Affect and mood
Patients affect was depressed and her range of mood reduced. He also
appeared anxious and irritable.
Thought
Patients thought stream was decreased. It was also disturbed and his speech
slowed down and content reduced significantly when mentioning past
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NURSING MANAGEMENT 17
unhappiness. He did not exhibit any formal thought disorders. She was able
to answer questions spontaneously and directly. She did not use any new or
created words. He did experience thought block when exploring sensitivities
in his past. No negative thought disorder was detected. Other than feeling of
guilt, R.A has no other positive symptoms, such as delusions, phobias or
compulsions. Suicidal ideation was not detected.
Perception
R.A exhibits normal perception. Symptoms such as illusions,
misinterpretations, depersonalization and passivity phenomena were not
elicited.
Cognition
His memory was intact for recent and remote events. He was able to answer
questions and recall his past without difficulties. I was able to establish
adequate rapport with him throughout the interview and he was able to
follow directions. He denied any ideation of worthlessness or hopelessness.
Insight and judgement
When questioned about his condition, R.A accepted the fact that he is ill and
requires treatment. He has cooperated with doctors and nurses and is
compliant with management.
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NURSING MANAGEMENT 18
Nursing Physical Assessment
R.A, 34 years old, was conscious, not in cardiorespiratory distress. With
a blood pressure of 120/80, respiratory rate of 22, temperature of 36.9 and
has respiratory rate of 110. Abdomen is flat, soft, NABS (Normal Active Bowel
Sounds), no masses and tenderness. Anicteric sclera pink palpebrable
conjunctiva, no symmetric chest expansion, no retractions, clear breath
sounds adynamic precordium. Has tachycardia, regular rhythm, no murmur.
Flat, soft, normoactive bowel sounds. Grossly normal extremities, no
cyanosis, no edema and has psychosocial problem.
Related Treatments
The patient was given Haloperidol 5mg. OD, it is classified as
Antipsychotics to alters the effects of dopamine in the CNS and also has
anticholinergic and alpha-adrenergic blocking activity and diminished signs
and symptoms of psychoses. It is indicated for organic psychoses, acute
psychotic symptoms; relieve hallucinations, delusions, disorganized thinking,
severe anxiety and seizures. Common side effects are: extrapyramidal
symptom such as muscle rigidity or spasm, shuffling gait, posture leaning
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NURSING MANAGEMENT 19
forward, drooling, masklike facial appearance, dysphagia, akathisia, tardive
dyskinesia, headache, seizures, tachycardia, arrhythmias, hypertension,
orthostatic hypertension. blurred vision, glaucoma, dry mouth, anorexia,
nausea, vomiting, constipation, diarrhea, weight gain, urinary frequency,
urine retention, impotence, enuresis, amenorrhea, gynecomastia, anemia,
leucopenia, agranulocytosis, rash, dermatitis, and photosensitivity. It is
contraindicated to seizure disorder glaucoma and elderly clients. Nursing
considerations are;Assess mental status prior to and periodically during
therapy. Monitor BP and pulse prior to and frequently during the period of
dosage adjustment. May cause QT interval changes on ECG. Observe patient
carefully when administering medication, to ensure that medication is
actually taken and not hoarded. Monitor I&O ratios and daily eight. Assess
patient for signs and symptoms of dehydration. Monitor for development of
neuroleptic malignant syndrome (fever, respiratory distress, tachycardia,
seizures, diaphoresis, hypertension or hypotension, pallor, tiredness, severe
muscle stiffness, loss of bladder control. Report symptoms immediately. May
also cause leukocytosis, elevated liver function tests, elevated CPK. Advise
patient to take medication as directed. Take missed doses as soon as
remembered, witih remaining doses evenly spaced throughout the day. May
require several weeks to obtain desired effects. Do not increase dose or
discontinue medication without consulting health care professional. Abrupt
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withdrawal may cause dizziness, nausea, vomiting, GI upset, trembling, or
uncontrolled movements of mouth, tongue or jaw.
Risperidone is an atypical antipsychotic drug that is used for treating
schizophrenia, bipolar mania and autism. Atypical antipsychotics differ from
typical antipsychotics due to the lesser degree of extrapyramidal
(movement) side effects and constipation. Risperdal Consta is an injectable,
long-acting form of risperidone. The exact mechanism of action of
risperidone is not known, but, like other anti-psychotics, it is believed that
risperidone affects the way the brain works by interfering with
communication among the brain's nerves. Nerves communicate with each
other by making and releasing chemicals called neurotransmitters. The
neurotransmitters travel to other nearby nerves where they attach to
receptors on the nerves. The attachment of the neurotransmitters either
stimulates or inhibits the function of the nearby nerves. Risperidone blocks
several of the receptors on nerves including dopamine type 2, serotonin type
2, and alpha 2 adrenergic receptors. It is believed that many psychotic
illnesses are caused by abnormal communication among nerves in the brain
and that by altering communication through neurotransmitters, risperidone
can alter the psychotic state. Risperidone was approved by the FDA in
December, 1993. Risperidone is used to treat schizophrenia, bipolar mania
[as a sole therapy or combination therapy with lithium (Eskalith, Lithobid)
or valproate (Depakene, Depacon) and for the treatment of irritability
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associated with autistic disorder in children and adolescents. Clinical studies
involving small numbers of patients have shown some benefit in using
risperidone for stuttering and Tourette syndrome (non FDA-approved uses).
Another non-FDA approved use of risperidone is forobsessive-compulsive
disorders. Risperidone can be administered once or twice daily. Initial dosing
is generally 2 mg/day. Dose increases can occur in increments of 1-2
mg/day, as tolerated, to a recommended dose of 4-8 mg/day. In children,
risperidone should be initiated at 0.5 mg once daily, and can be increased in
increments of 0.5 or 1 mg/day, as tolerated, to a recommended dose of 2.5
mg/day. Risperidone can be given with or without meals. The recommended
dose of Risperdal Consta is 25 mg injected into the deltoid or gluteal muscle
every two weeks. Patients who have never received risperidone are started
on oral risperidone in order to evaluate tolerability. Patients then may be
transitioned to Risperdal Consta if oral risperidone is tolerated. Risperidone
may interfere with elimination by the kidneys of clozapine (Clozaril), a
different type of antipsychotic medication, causing increased levels of
clozapine in the blood. This could increase the risk of side effects with
clozapine.
Biperiden hydrochloride is a prescription medication that belongs to a
class of drugs called anticholinergics. Biperiden HCl is a weak peripheral
anticholinergic agent. It has, therefore, some antisecretory, antispasmodic
and mydriatic effects. In addition, Biperiden possesses nicotinolytic activity.
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Parkinsonism is thought to result from an imbalance between the excitatory
(cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum.
The mechanism of action of centrally active anticholinergic drugs such as
Biperiden is considered to relate to competitive antagonism of acetylcholine
at cholinergic receptors in the corpus striatum, which then restores the
balance. The parenteral form of Biperiden is an effective and reliable agent
for the treatment of acute episodes of extrapyramidal disturbances
sometimes seen during treatment with neuroleptic agents. Akathisia,
akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis,
and profuse sweating are markedly reduced or eliminated. With parenteral
Biperiden, these drug-induced disturbances are rapidly brought under
control. Subsequently, this can usually be maintained with oral doses which
may be given with tranquilizer therapy in psychotic and other conditions
requiring an uninterrupted therapeutic program. Only limited
pharmacokinetic studies of biperiden in humans are available. The serum
concentration at 1 to 1.5 hours following a single, 4 mg oral dose was 4-5
ng/mL. Plasma levels (0.1-0.2 ng/mL) could be determined up to 48 hours
after dosing. Six hours after an oral dose of 250 mg/kg in rats, 87% of the
drug had been absorbed. The metabolism of Biperiden is also incompletely
understood, but does involve hydroxylation. In normal volunteers a single 10
mg intravenous dose of biperiden seemed to cause a transient rise in plasma
cortisol and prolactin. No change in GH, LH, FSH, or TSH levels were seen.
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Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when
injected intramuscularly (1.0 mL) into the sacrospinalis muscles and
intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved
abdominal skin. Should be taken with food. Overdosage may result in dilated
and sluggish pupils; warm, dry skin; facial flushing; decreased secretions of
the mouth, pharynx, nose, and bronchi; foul-smelling breath; elevated
temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds,
and urinary retention. Neuropsychiatric signs include delirium, disorientation,
anxiety, hallucinations, illusions, confusion, incoherence, agitation, loss of
memory, paranoia, combativeness, and seizures. May progress to stupor,
coma, paralysis, and cardiac and respiratory arrest and death. Treatment is
sympotomatic and supportive. Contraindicated to Closed-angle glaucoma or
narrow angle between iris and cornea; prostatic hyperplasia; myasthenia
gravis except to reduce adverse muscarinic effects of an anticholinergic;
hypersensitivity; bowel obstruction; megacolon.
Another drug given is Diphenhydramine 50 mg HS, an antihistamine
used for treating allergic reactions. Histamine is released by the body during
several types of allergic reactions and--to a lesser extent--during some viral
infections, such as the common cold. When histamine binds to its receptors
on cells, it stimulates changes within the cells that lead to sneezing, itching,
and increased mucus production. Antihistamines compete with histamine for
cell receptors; however, when they bind to the receptors they do not
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stimulate the cells. In addition, they prevent histamine from binding and
stimulating the cells. Diphenhydramine also blocks the action of
acetylcholine (anticholinergic effect) and is used as a sedative because it
causes drowsiness. The FDA originally approved diphenhydramine in 1946.
Diphenhydramine is used for the relief of nasal and non-nasal symptoms of
various allergic conditions such as seasonal allergic rhinitis. It is also used to
alleviate cold symptoms and chronic urticaria(hives). Although
antihistamines are the preferred class of drugs in allergic rhinitis, they only
reduce symptoms by 40%-60%. Diphenhydramine also is used for allergic
reactions involving the eyes (allergic conjunctivitis), to prevent or treat
active motion sickness, and for mild cases of Parkinsonism, including drug-
induced Parkinsonism. The last two uses (motion sickness and Parkinsonism)
are based on the anticholinergic effects of diphenhydramine, and not its
antihistamine effects. Diphenhydramine is also used for treating insomnia.
Diphenhydramine has its maximal effect about one hour after it is taken.
When used to combat insomnia, it is prescribed at bedtime. Patients over the
age of 60 years are especially sensitive to the sedating and anticholinergic
effects of diphenhydramine, and the dose should be reduced. Doses vary
depending on formulation. A common regimen for treating adult allergic
reaction is 25-50 mg every 4-6 hours not to exceed 300 mg daily.
Diphenhydramine adds to (exaggerates) the sedating effects of alcohol and
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NURSING MANAGEMENT 25
other drugs than can cause sedation such as the benzodiazepine class of
anti-anxiety drugs.
Recommendation
To the patient:
He is advised to take part in complying with the treatment; the
medication and therapeutic regimen designed for his rehabilitation. He
should realize the importance of complying with his medication and the
benefits this practice would bring to the improvement of his well-being.
To the patient’s family:
The patient’s family plays an important role in the patient’s mental
illness and recovery. The family should make themselves physically present
so that the patient would feel their support and concern. They are
encouraged to continue interacting with the patient so that ideas of violence
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Our Lady of Fatima UniversityResearch and Development Center
NURSING MANAGEMENT 26
towards self and others will be diverted. In addition, it is of prime importance
that they are orientedand educated regarding the patient’s mental illness so
that they will understand him even better and assist him in his daily
activities.
References
mentalhelp.net
cureresearch.com
World Health Organization, www.who.int
schizophrenia.com
http://nursingcrib.com/pathophysiology/pathophysiology-of-schizophrenia/
medicinenet.com
http://wiki.medpedia.com
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NURSING MANAGEMENT 27
http://www.mims.com