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Vaccine Supply Update – UNICEF’s role at global level. UNICEF Supply Division GMMM Geneva, Switzerland 15-17 March 2011. The procurement of vaccines and related supplies is UNICEF's largest procurement activity, conducted on behalf of 80 – 100 countries annually. 2.53 billion doses. - PowerPoint PPT Presentation
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UNICEF Supply DivisionGMMM Geneva, Switzerland15-17 March 2011
Vaccine Supply Update –UNICEF’s role at global level
The procurement of vaccines and related supplies is UNICEF's largest procurement activity, conducted on behalf of 80 – 100 countries annually
Source: 2010 vaccine database, UNICEF
Immunization SuppliesVaccinesBCG , DTP, TT/Td/DT, Measles containing, OPV, HepB, YF, DTP-HepB, DTP-HepB/Hib, DTP/Hib, Hib, MR, Meningitis, MMR, IPV, Pneumo, etc.
Safe Injection equipment
Cold Chain Equipment
Immunization Supplies: US$ 750m 2.53 billion doses 1,769 shipments2010:
Countries UNICEF procures on behalf of
All Vaccines
Part of the Vaccines
$0
$100
$200
$300
$400
$500
$600
$700
$800
$900
1978
1979
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2010
UNICEF SD Annual procurement value of vaccines, in million USD
UNICEF annual vaccine procurement has increased five fold since 2000 - supporting UNICEF Programmes and on behalf of Partners, Global Programmes, Governments and NGO’s
Campaigns, GAVI,
Price Increases
The arrows indicate the main programme drivers for the increased procurement value.
Source UNICEF Supply Division
Scaling up of campaigns, new
vaccine introduction, boosting routine
coverage, price increases
P o l i o
UNICEF vaccine procurement values on behalf of governments and partners are increasing
$0
$100,000,000
$200,000,000
$300,000,000
$400,000,000
$500,000,000
$600,000,000
$700,000,000
$800,000,000
$900,000,000
1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
PROG PS
GAVI 48%
Procurement Services 33%
UNICE F Programme 19%
GAVI falls under procurement services but is highlighted separately to show the overall portion of GAVI funded procurementSource UNICEF Supply Division
Major vaccine group volumes by year (2005-2010), in doses
OPV has been # 1 in terms of the procurement volume.
Procurement volume in 2010• OPV: 1,885 million doses• Measles: 169 million doses• TT: 130 million doses• BCG: 106 million doses• DTP-HepB/Hib: 98 million doses• Yellow Fever: 35 million doses• Meningitis: 23 million doses
0
500,000,000
1,000,000,000
1,500,000,000
2,000,000,000
2,500,000,000
3,000,000,000
3,500,000,000
2005 2006 2007 2008 2009 2010
Procurement Volume in dose
BCG DTP-HepB/Hib MEASLES MENING OPV TT YF Others
Source: UNICEF Supply Division
UNICEF’s procurement strategies are focused on achieving Vaccine Security, acknowledging the different forces in the individual markets
1. A healthy industry is vital to ensure uninterrupted and sustainable supply of vaccines
2. Procurement from multiple suppliers for each vaccine presentation3. Procurement from manufacturers in developing countries and industrialized
countries4. Paying a price that is affordable to Governments and Donors and a price that
reasonably covers manufacturers minimum requirements5. UNICEF should provide manufacturers with accurate and long-term forecasts;
Manufactures should provide UNICEF with accurate and long-term production plans
6. As a public buyer, providing grants to manufacturers is not the most effective method of obtaining capacity increases
7. The option to quote tiered pricing should be given to manufacturers.
The Vaccine Procurement Principles, implemented following the supply crisis in the traditional vaccine markets, are valid for all vaccine markets
to ensure a healthy market
Within Supply, UNICEF activities are focused on 2 core areas to enhance access and delivery
Market Shaping:Interacting with
Industry; Establishing the required supply
Agreements;VaccineSecurity
Market Shaping: SupportingPartners,
Strategic Demand Forecasting & Financing forNew Vaccine Introduction
Vaccine Industry Market Shaping - Global Availability
Supply Chain Performance Enhancement
Supply Chain Performance EnhancementSupporting Local Delivery
Cou
ntrie
s
Market Shaping within a changing landscape
Increasing complexity within procurement as new products become available
Competition with Industrialised countries for production allocation
Demand reacting to changes and developments in immunization programmes, vaccine development and Donor support
Country preferences on presentation and formulation
Requires balancing with financial sustainability
Need for increased flexibility on tendering strategies, maintaining long time horizons and providing for market flexibility
AnnualForecasting
OrderPlacement
Supplier Airport
Monitoring &Reporting
Central Cold Chain Storage
District/RegionalCold Chain Storage
HealthCentre
Immunisation
DataAnalysis
UNICEF Supply Division’s main roles in the immunization supply chain. Effective forecasting and planning requires supply and logistics be fully integrated into programme planning.
Management ofthe global forecasting Exercise -Forecast data from 2003-Provisional Plan-Forecasting accuracyreports
Data analysisfor effective supplyPlanning- Sharing Price informationVaccine/Device/Cold chain Procurement DB from 1997
Shipping management for on-time deliveryVaccine Arrival Report
OperationalFollow-ups Procurement &Technical guide
Capacity building for in-country logisticsCold chain weight & volume calculator
Contracts and suppliersmanagement
UNICEF procures Measles containing vaccines on behalf of 80-100 countries annually for Routine and Supplementary Immunization Activities
Source: Allocation Table Data UNICEF
VaccinesMeasles-10, MR-10, MMR-1, MMR-5, MMR-10
130,914,370 doses 2010:
Countries UNICEF procures on behalf of
All Vaccines
Part of the Vaccines
2009: 173,632,162 doses
Measles containing vaccine procurement through UNICEF largely driven by supplementary activities
Source: UNICEF SD Historical Procurement Database and 2011 Forecast
Measles containing vaccine procurement (2002-2010) and forecast (2011-2012), in doses
0
20,000,000
40,000,000
60,000,000
80,000,000
100,000,000
120,000,000
140,000,000
160,000,000
180,000,000
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
Measles Routine
Measles Supplementary
MMR-1 Routine
MMR-10 Routine
MMR-10 Supplementary
MMR-5 Routine
MR-10 Routine
MR-10 Supplementary
Supplier Market and 2011 WAP prices
Measles-10:4 vaccines WHO pre-qualified: 0.24 $ per dose (70% of the vaccine is sourced from 1 supplier) MMR-1:2 vaccines WHO pre-qualified: 1.85 $ per dose MMR-5:1 vaccine WHO pre-qualified: 0.90 $ per dose MMR-10:2 vaccines WHO pre-qualified: 1.183 $ per dose MR-10:2 vaccines WHO pre-qualified: 0.534 $ per dose
2004 2005 2006 2007 2008 2009 2010 2011 2012$0.0000
$0.0500
$0.1000
$0.1500
$0.2000
$0.2500
$0.3000
MEA-10 WAP per dose
Source: UNICEF Supply Division
Planning is Key:
• Production of a dose: 6 -24 months• Capacity Increase: 2-3 years• New Plant: 5-7 years • Lead time for supply 4-8 weeks + transit time• New regulatory requirements can cause interruptions• Approx. 65 countries require NRA registration• UNICEF requests 20 months shelf life for measles vaccine• Current awards (in doses) based on 2009 forecast• Additional increases in quantities to meet updated demand are possible
but require planning
Some facts about vaccine supply
Year 2010 2011 2012Vaccine Award Quantity Award Quantity Award QuantityMea 10 165,000,000 125,000,000 110,000,000
MR 10 1,700,000 3,700,000 2,700,000
MMR 1 500,000 250,000 250,000
MMR 5 3,100,000 3,100,000 3,400,000
MMR 10 1,700,000 1,800,000 1,800,000Source: UNICEF Supply Division
Some facts about vaccine supply
Planning is Key:
• Production of a dose: 6 -24 months• Capacity Increase: 2-3 years• New Plant: 5-7 years • Lead time for supply 4-8 weeks + transit time• New regulatory requirements can cause
interruptions• Approx. 65 countries require NRA registration• UNICEF requests 20 months shelf life for
measles vaccine• Current awards 2011-2012 (in doses) based on
2009 forecast• Additional increases in quantities to meet
updated demand are possible but require planning
Year 2010 2011 2012Vaccine Award Quantity Award Quantity Award QuantityMea 10 165,000,000 125,000,000 110,000,000
MR 10 1,700,000 3,700,000 2,700,000
MMR 1 500,000 250,000 250,000
MMR 5 3,100,000 3,100,000 3,400,000
MMR 10 1,700,000 1,800,000 1,800,000
Source: UNICEF Supply Division
• Barcelona
• Helsingborg• Helsinki
• Shanghai
• Mumbai
• Dubai
Overview of AD-syringes procurement, 1997-2011*
Sources: UNICEF SD Historical Devices Procurement Database, and September 2010 allocation tables
Current Long Term Arrangements for all devices are up for re-tendering in 2011
Procuring immunization supplies from the following areas:
Manufacturers of AD syringes
Manufacturers of Safety Boxes
Measles Campaigns are the Introduction Window for RUP syringes (5ml)
UNICEF SD delivered RUP syringes for Measles campaigns in: Peru Nigeria Burkina Faso Chad
Increased supplier base: There are at present 14 WHO PQS prequalified suppliers (compared to 6 prequalified in Dec 2007)
Two types of RUP syringes available: • Regular RUP syringes• RUP syringes with Sharps Injury Prevention feature (SIP) protecting from
needle stick injuries
16
Effective forecasting and planning requires supply and logistics be fully integrated into programme planning
Evaluate the capacity to receive and deliver:• Cold Chain and Logistics Capacity• Parallel products – integrated campaigns• Routine and Campaign activities• Modes of shipment• Lead times
Consider the whole supply
chain; it’s capacity and the context
Thank you!
More information: http://www.unicef.org/supply/index_immunization.html