SciStream™ enables the import, aggregation, and arrangement of raw instrument data and metadata files into the

TIBCO Spotfire® Analytics and Visualization Platform. This allows scientists to quickly import various instrument data files from plate readers, high content screening readers, flow cytometers (*.fcs files) and quantitative pathology imaging systems along with their corresponding metadata or plate layouts. SciStream™ accommodates a variety of data and file formats in high volume, empowering scientists to gain novel insights during assay development, as well during large screening campaigns.

Unlock the Power ofDynamic Visualizationfor your Instrument Data

Upload Your Instrument Data into TIBCO Spotfire® with SciStream

Figure 1. SciStream example of importing a plate block.

PerkinElmer is the exclusive global distributor of the TIBCO Spotfire® platform for certain scientific and clinical R&D applications.

Attributes and Capabilities

SciStream™ enables the import, aggregation, and arrangement of raw instrument data and metadata files into the TIBCO Spotfire® Analytics and Visualization Platform.

• Allows creation, editing and saving of file formats

• Includes an interactive preview of the data file using color coding and visual cues to highlight the various headers, footers, columns, and data block areas defined in the file format layout settings

• Includes three levels of delimiter to appropriately separate text (primary, secondary, and filename)

• Extracts the required metadata and information from header and footer rows, columns or cells directly into columns in TIBCO Spotfire®

• Includes support for Excel and other text files with plate layout information (well content, compound information, dilution scheme, etc.)

• Supports batch import of multiple data files into a single table in TIBCO Spotfire®

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Benefits

SciStream™ software dramatically extends the import function in TIBCO Spotfire® to deliver data files from virtually any scientific instrument.

• Imports a wide variety of instrument data files directly into TIBCO Spotfire®:

■ Plate readers (e.g. EnVision, EnSpire, and more)

■ High Content Screening readers and software (e.g. Operetta, Opera, Columbus, and more)

■ Flow cytometer FCS files (Flow Cytometry Standard 3.0 and 3.1)

■ Quantitative Pathology Imaging Systems (Mantra/Vectra/inForm)

■ Other instruments and software that produce text-based files (tissue scanners, inForm software, EZReader, etc.)

■ Non-PerkinElmer platforms are supported

• Supports a vast variety of data formats and configurations of generic data import:

■ For virtually any plate reader, scanner or HCS reader

■ Single and multiple readout value for each well

■ Multiple plates and multiple time points in a single file (kinetic data – label-free, calcium flux, etc.)

■ Data in a block format

■ Data with file, plate, block headers and footers

Dedicated Import Functionalities for Specific Scientific Applications

• Flow cytometers

■ Supports FCS 3.0 and 3.1 data files

■ Automated compensation correction using embedded spillover table

■ Extract keyword values and other metadata (e.g. well location, date, sample name, etc.) from FCS file header section and file name

• PerkinElmer’s Quantitative Pathology Imaging Systems (Mantra/Vectra/inForm)

■ Detects and imports inForm output files (cell level data). All corresponding images or fields are automatically imported and displayed in TIBCO Spotfire® and overlaid with cell markings (masks) representing all the cells identified during image analysis

■ Filtering or marking on any TIBCO Spotfire® visualization (scatter plots, bar charts, histograms, etc.) will highlight or display the corresponding cell markings/masks on the corresponding image(s)

■ Supports other object/cell level images and data when X and Y coordinates are available (HCS and other imaging applications)

Figure 3. Quantitative pathology image analysis in TIBCO Spotfire®.

Figure 2. SciStream example.

Learn more about SciStream at www.perkinelmer.com/SciStream or call 1-800-315-7300