The world leader in serving science

Darren Barrington-Light

Product Marketing Specialist

Informatics and Chromatography Software

Unlock the Value of Your Data

2

Today’s Laboratory Environment

Mobile

Technology

Electronic

Records

Compliance

SDMS

LIMS MES

ERP Management

Operations

Data Capture

Instruments

& Hardware

CDS LES MS Data

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Are you maximizing your ROI?

…or are your processes and technologies costing you money?

Management

Operations

Data Capture

Instruments

& Hardware

ERP

CDS LES SDMS

LIMS MES

Using multiple, disparate & siloed solutions?

Looking for information in multiple databases?

Not able to link raw data to samples?

Entering and transcribing data & info manually?

Spending time collating reports for regulatory agencies?

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Real World Pharmaceutical Laboratory Workload

As much as 40%

of time is spent

documenting

compliance for

regulated

customers.

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Your Complete Laboratory Process

Laboratory Execution

Data Acquisition and Processing

Product Specification

Instrument Calibration and Maintenance

Release Testing Product Release Data Archival and Retrieval

Your Laboratory is a Critical Component of Your Business Enterprise

Informatics drives your end-to-end laboratory process and connects your lab to your enterprise.

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Leading Provider of Scientific Software Solutions

Data into Knowledge

Determine/Design

Methods

Data Management and Integration across the Enterprise

Thermo Scientific™ SampleManager™ software

Thermo Scientific™ Chromeleon™ CDS software

Instrument Control

and Remote

Monitoring

Data Analysis Data Capture

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CDS

Streamline Chromatography

Workflows

Connects to 450 instrument

modules from 17 vendors

Simplifies data processing to

get it right the first time

Simplifies method execution

through eWorkflows™

LIMS

Get a complete picture of your laboratory data

from the original raw data to final results.

SDMS

Procedural ELN/LES

Simplify Process Execution

Drives users through a

stepwise process

No customizations needed to

deploy methods & SOPs

Connects to the general LIMS

capabilities to provide an

integration solution

Simplify Your Laboratory Operations

Complete Laboratory

Management

Sample, test & result

management

Management of lab personnel

& resources

Process optimization &

standardization

Visualize without Original

Application

Laboratory data archival,

retrieval and preservation

Support for >180 instrument

data formats

Vendor independent XML for

long term storage

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Thermo Scientific Chromeleon CDS: Unlock the Value of Your Laboratory

Chromeleon unifies chromatography and routine quantitative MS workflows

streamlining laboratory operations and boosting productivity.

Your Instruments

Your Processes

Your Data

Your Results

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Operational Simplicity delivers ease-of-use, saving time,

effort, and training costs

Suite of intelligent tools work together ensuring more

right-the-first time analyses, saving time and cost

True 24/7 laboratory uptime with outage protection for

maximum utilization of resources and faster return on

investment

Thermo Scientific Chromeleon CDS Software

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• One software platform for the whole lab

• Control over 450 different modules from 17 different

manufacturers including:

• Thermo Scientific (LC, IC, GC, MS, Sample Prep)

• Agilent (LC, GC)

• Waters (LC)

• Shimadzu (LC, GC)

• Varian (LC, GC)

• Perkin Elmer (LC, GC)

• Gilson (LC)

• CTC PAL (Sample Prep)

Reduced training

Reduced administration

Reduced infrastructure

Reducing Costs – Single Software Platform

SP

IC-MS

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Simplifying Lab Workflows – Mass Spectrometry

• >20 years CDS experience

• Gold standard CDS • Scalable enterprise architecture

• Unparalleled ease-of-use

• Strong quantitation functionality

• Comprehensive auditing and data

management

• >30 years of MS experience

• Leading-edge MS portfolio • Highest sensitivity and selectivity

• Unrivaled MS application expertise

Streamline chromatography and MS quantitation workflows in one software package

Use MS like any other routine detector

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Simplifying Lab Workflows – eWorkflows

eWorkflows contain:

• Instruments on which the analysis can be run

• All associated methods and files including reports and external documents like SOPs

Ensure your SOP is followed

Reduce errors and produce

reliable results faster

Fully customizable for any

application in any laboratory

Minimize amount of training

required

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Thermo Scientific AppsLab Library of Analytical Applications

AppsLab contains

eWorkflows that can be

downloaded and run directly

in Chromeleon CDS.

Thermo Scientific™ AppsLab Library of Analytical

Applications is a central repository for all of the

analytical methods created by Thermo Fisher scientists.

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Simplifying Lab Workflows – eWorkflows

1. Select

eWorkflow

2. Select

Instrument

3. Click

Launch

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Simplifying Lab Workflows – eWorkflows

4. Input number of

samples

5. Input position of first

sample Optional

6. Click Finish

Sequence preview

Sampler rack view

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Simplifying Lab Workflows – eWorkflows

Sequence created in 6

clicks with correct:

Name

Location

Methods

Report

Structure

Custom Variables

Plus:

SOP attached

Can run immediately

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• Cobra is an algorithm that:

• Finds peak start/end times accurately and consistently

• Accurately determines “true” underlying baseline

• Often requires no further parameters to reach integration goal

• Cobra Wizard provides:

• Fast, guided way to determine initial detection parameters

• Just 5 steps to achieve integration goal

Simplifying Lab Workflows – Integration

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Simplifying Lab Workflows – Integration

Parameter-less first pass Cobra integration

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Simplifying Lab Workflows – Integration

1. Start Cobra Wizard

4. Select the narrowest peak

5. Select the smallest peak

2. Define the integration range

3. Set the baseline noise range

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Simplifying Lab Workflows – Integration

Parameters added to component table…

… and your integration could be done!

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Simplifying Lab Workflows – Integration

• SmartPeaks – unique tool for easily reaching your integration goals for unresolved peaks

• Great example of Operational Simplicity

• Process is clear and understandable – requires no training

• Only a few steps

• Correctly integrates all unresolved peaks in seconds

1. Activate SmartPeaks

Wizard

2. Select Area of Interest

3. Select the Integration you Want

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Simplifying Lab Workflows – Integration

• Parameters added to component table

• Changes apply to ALL chromatograms in sequence

Your integration is done!

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Translating Operational Simplicity into Lab Productivity

• Significant productivity gains reported by range of customers from different industries

• In addition, productivity gains have been verified by direct competitor comparison

• Head to head comparison of the same tasks (prescribed by customer) in each CDS

Boosting Lab Productivity – Competitor Comparison

<50%

Windows

<50%

Mouse Clicks

>50%

Faster

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Boosting Lab Productivity – Competitor Comparison

Create & Save Instrument Method

2 Create Folder & Set

Access Control

1

Create Sequence

3 Assign Instrument

Method

4

Monitor Baseline

5

Start Sequence

6

Create & Save

Processing Method

2 Start

Sample Set

1 Set Initial Integration

Parameters

3

Enter Peak Names

4 Create 3 Calibration

Levels

5 Apply the Method Set

& Reprocess Data

7 Create Default

Report & Print Results

8

Create Method Set

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Create & Save Instrument Method

2 Create Project & Set

Access Control

1 Create Method

Set

3 Create

Sample Set

4 Assign

Instrument Method

5

Start Sequence

7 Monitor Baseline

6

Create & Save

Processing Method

2 Start

Sequence

1 Set Initial Integration

Parameters

3

Enter Peak Names

4 Create 3 Calibration

Levels

5 Create Default

Report & Print Results

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WORKFLOW STEPS FOR SEQUENCE CREATION & RUN

WORKFLOW STEPS FOR DATA PROCESSING

55% Fewer Windows

51% Fewer Mouse Clicks

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▼

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▼

▼

▼

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▼

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5min

Faster

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CDS

Streamline Chromatography

Workflows

Connects to 450 instrument

modules from 17 vendors

Simplifies data processing to

get it right the first time

Simplifies method execution

through eWorkflows™

LIMS

Get a complete picture of your laboratory data

from the original raw data to final results.

SDMS

Procedural ELN/LES

Simplify Process Execution

Drives users through a

stepwise process

No customizations needed to

deploy methods & SOPs

Connects to the general LIMS

capabilities to provide an

integration solution

Simplify Your Laboratory Operations

Complete Laboratory

Management

Sample, test & result

management

Management of lab personnel

& resources

Process optimization &

standardization

Visualize without Original

Application

Laboratory data archival,

retrieval and preservation

Support for >180 instrument

data formats

Vendor independent XML for

long term storage

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Thermo Scientific SampleManager: Unlock the Value of Your Laboratory

More than a LIMS – SampleManager manages the entire laboratory, ensuring

adherence to processes, maintaining data integrity and facilitating complete

regulatory compliance.

LIMS

SDMS

LES

Stability

SQC

Your Laboratory

Your Processes

Your Data

Your Environment

Mobile, Web

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Thermo Scientific SampleManager LES – Procedural ELN

Execute lab work anytime, anywhere.

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Perform Key Tasks from a Native Tablet App

Tasks available to the user

are shown in a fly-out

menu, in user’s language

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Result Entry

User alerts on

success or failure

of saving results or

limit violations

Supported Result

Types:

• Numeric

• Text

• Calculated

• DateTime

• Interval

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Lab Method Execution

Method execution starts by

presenting an introductory

summary and prerequisites

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Lab Method Execution

Instrument data can be read

directly into the App

During execution, for each step

instructions are shown, along with

prompts to capture step data

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Thermo Scientific SampleManager LIMS

A simplified native web user interface that

guides your lab through their day-to-day work

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Workflows Guide Users Through the Lab Process

Automate your laboratory decisions and improve your ability to

respond to the needs of your business.

Graphically define your lab process in

the system

Build the lab process without customizations

now and in the future

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Operator Training

Training is verified for instruments and lab testing

before it can be executed.

Training records are held against

the operator and maintained

against the analysis

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Instrument Management

Simplify your instrument management with instrument

calibration and maintenance.

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Stock Management

Stock levels can be monitored.

New orders can be placed and tracked.

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Prediction of Samples According to Schedule

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Statistical Quality Control

Get insight into your data in real time.

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Advanced Search and Data Mining

Dashboards provide a quick view of anything from stocks,

to sample delivery, or trends at a particular location.

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Chromeleon - SampleManager Link This link gives users ability to: • Drive an end to end process through the

Procedural ELN (LES)

• See real time information like instrument status & queue in LIMS

• Select samples in LIMS & use eWorkflows to create sequence

• Pull LIMS samples into existing sequence from Chromeleon

• Show Chromeleon results directly in LIMS

Reducing Costs – Seamless Data Flow

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Thermo Scientific™ SampleManager™ SDMS provides secure, future-proofed

data archival and management.

Data Visualization

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Reducing Costs – Leverage Existing Infrastructure

Thermo Scientific™ Integration Manager™ provides bi-directional interfaces

between CDS, LIMS, instruments and enterprise systems.

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End-to-End Integrated Laboratory Process

Result

Entry Test Assignment

Stock Management

Audit Settings System Configuration Settings E-signatures

Common Explorer Folders e.g. Instrument Management, EM, Stock Management

Stability SQC RM (T-Card)

OOS and Investigations (Incidents)

Environmental Monitoring

APR

Lot Login Sample/Job Login

Retains

Sample

Receipt

Approve

Sample

Results

Approve Lot

CoA

Approve Meta

Data Review

Instrument

Management Dashboards

Laboratory Methods/SOPs Summary Reports (Lot, Job, Sample, Batch)

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Your Project is a Partnership

Methodology Technology Services

• Assess current workflow

• Identify data exchange points

• Identify inefficiencies

• Simplify the process

• A complete lab solution:

Procedural Execution, CDS,

SDMS, & LIMS

• Integration tools to connect

with other vendor technology

• Requirements analysis

• Process harmonization

• Deliver results

• Ongoing support

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Unlock the Value

of Your

Laboratory