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Ospedale Evangelico Villa Betania Fondazione Evangelica Betania U.O.S. di Anatomia ed Istologia Patologica Responsabile: dott.ssa Rosa Giannatiempo. U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1. Le molecole di adesione intercellulare negli aborti spontanei: studio immunoistochimico - PowerPoint PPT Presentation
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Ospedale Evangelico Villa BetaniaFondazione Evangelica BetaniaU.O.S. di Anatomia ed Istologia PatologicaResponsabile: dott.ssa Rosa Giannatiempo
Le molecole di adesione intercellulare negli aborti spontanei: studio immunoistochimicoM.PostiglioneA.MaglioneA.RussoA.NicastroD.OppressoreA.PintoC.TrombettaR.Giannatiempo
Early placental development is associated with complex regulatory mechanisms, and molecular pathways involved during placental development are critical for pregnancy progression. Background
ObjectiveWe examined the role of adhesion molecules in the mechanism of spontaneous abortions.
STUDY DESIGN 2008:MaterialsI Trimestre35II Trimestre30III Trimestre20hhh
STUDY DESIGN 2008:Methods
DiluitionSourcePretreatmentCloneCD 311:10DAKODGJC70ACD 441:50DAKOMWDF1485E-CadherinPred.VentanaMWECH6
CD31Term placentaU.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1
CD31-II Tr.CD31-II Tr.CD31-III Tr.CD31-III Tr.U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1
CD44TermplacentaU.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1
Results:CD44 A down-regulation of CD44 was observed in decidual (D) cells.
CD44-I Tr.CD44-I Tr.CD44-I Tr.U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1
CD44-II Tr.CD44-II Tr.CD44-III Tr.CD44-III Tr.U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1
E-CadherinTermplacentaU.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1U.O.S.Anatomia Patologica-Ospedale F.Betania-ASL NA1
Decreased MVD in CTs in spontaneous abortion cases can suggest that MVD is critical in uteroplacental adequacy. Moreover,a down-regulation of E-cadherin could be responsible for impaired CTs differentiation and loss of the pregnancy. Furthermore, decreased CD44 expression in D cells may be cause of impairing stroma-villous connections.Their analysis in spontaneous abortions will provide useful information for clarifying the physiopathology of spontaneous abortions. Conclusions
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