Dr.  Muhammad  Sadiq  

Up  and  Coming  Techniques  in  Medical  Physics  Translated  into  Clinical  Prac<ce  

   Ac<veNeedle  Technology  

 By  

Outline  

•  Unmet  Clinical  Need      •  Solu<on    -­‐  Ac<veNeedle  Technology  

•  Compe<tor  Analysis    •  Success  to  date  

•  Summary  

Unmet  Clinical  Need  

         Ultrasound    (US)  guidance  is  a  primary  technique  for  a  range  of  needle  based  procedures:    

Source:  www.nibib.nih.gov/science-­‐educa<on     Source:  www.sportsandpain.co.nz     Source:  www.sparrow.org/HealthLibrary    

Source:  www.nysora.com    

An  unmet  clinical  need:  To  improve  accuracy  and  safety  by  reducing  needle  placement  errors  

Unmet  Clinical  Need  

   Needle  

An  Example  of  Poor  Needle  Tip  Visibility  Source:    Emerg  Med.  2009  Nov;  37  (4):403-­‐8  

An  Example  of  Needle    Tip  Deflec<on  Source:  www.bdml.stanford.edu    

1  in  10  pa<ents  report  nerve  damage  

2  in  10  pa<ents  undergo  repeat  biopsy  

Addi<onal  clinical  <me  costs  over  $1200/hr  

Needle  placement  errors  costs  over  $1Bn  p.a.    

Source:  www.sparrow.org/HealthLibrary    

Unmet  Clinical  Need  

Primary  Market  Research:  Results  of  the  na<onwide  survey  conducted  with  the  help  of  the  collabora<ng  clinician  

Solu<on  -­‐  Prototype  

     A  “needle  actua<ng”  device  for  US-­‐guided  needle  procedures  (WO  2014140556  A1,  2014)  

           Poten<al  Clinical  Benefits  

Pre-­‐clinical  Prototype   Needle  Actua<ng  Device  in  Opera<on  

Increased  Visibility:  Especially  at  angles  steeper  than  45˚  

Reduced  Deflec<on:  Especially  at  depths  deeper  than  3  cm  

Reduced  Pain/Trauma:  Beaer  penetra<on  through  <ssue  interfaces  

Solu<on  –  Demonstra<on  

Solu<on  –  Demonstra<on  

Effect  of  Ac<va<on  on  Needle  Penetra<on  Force  

Effect  of  Ac<va<on  on  Needle  Tip  Deflec<on  

Ex-­‐vivo  Animal  Tissue  Model  

Phantom  Model  

Compe<tor  Analysis  

Compe<tor  Analysis  –  Ac<veNeedle’s  Technology  Vs  Exis<ng  Technologies  

80%  surveyed  clinicians  would  use  the  Ac<veNeedle’s  Product  

CLINICAL  IMPACT   ECONOMIC  IMPACT  PATIENT  IMPACT  

Team  

Dr.  Muhammad  Sadiq  Founder  &  Director  

Dr.  Graeme  McLeod  Co-­‐founder  &  Clinical  

•  RSE  Enterprise  Fellow  funded  by  Scohsh  Enterprise  •  PhD  in  Biomedical  Engineering  •  BEng  (Hons.)  in  Mechanical  Engineering  

•  Consultant  &  Honorary  Reader  in  Anaesthesia  •  MBChB  PGCert  MedEd  MRCGP  FRCA  FFPMRCA  MD  •  Innova<on  in  Anaesthesia  Award,  2012  

Expert  Advisors  

Dr.  Sarah  Vinnicombe  Clinical  Advisor  

•  Consultant  &  Honorary  Reader  in  Radiology  •  Director  of  Breast  Screening,  Central  and  East  London  •  Raised  Research  Funding  of  £1.6M  

Prof.  Sandy  Cochran  Scien<fic  Advisor  

•  Head  of  Division  DIT,  University  of  Dundee  •  Deputy  Director,  IMSaT,  University  of  Dundee  •  Raised  Research  Funding  of  £11M  

Prof.  George  Corner  Quality  Assurance  

•  Head  of  Instrumenta<on,  Ninewells  Hospital  &  School  •  Consultant  Medical  Physicist,  NHS  Tayside  •  Quality  Controller  and  Lead  Auditor,  WSHB  

Trac<on  &  Success  to  Date  

2015Venture Programme

Developing YourResearch Idea

For research staff and postgraduate researchers

Programme and Competition with prize money of up to £5,000

http://www.dundee.ac.uk/opd/otheropportunities/venture/

Organisationaland Professional

Development

Joint  Winner  of  EPSRC  funded  Venture  Compe<<on,  2012  

Selected  among  the  60  projects  for  showcase  at  the  Parliament,  2013  

Best  Novel  Idea  Award,  2013  

Runner-­‐up  at  the  EU’s  leading  Business  Compe<<on  –  OneStart,  2014  

2nd  Prize  at  the  Scotland’s  leading  Business  Compe<<on  –  Converge  Challenge,  2014  

Awarded  the  Pres<gious  SE  Funded  RSE  Enterprise  Fellowship,  2014