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FACULTY OF HEALTH Matthew Jose MBBS, FRACP, PhD, FASN, AFRACMA Royal Hobart Hospital Update in Peritoneal dialysis

Update in Peritoneal dialysis - ANZSN ASM · FACULTY OF HEALTH Matthew Jose MBBS, FRACP, PhD, FASN, AFRACMA Royal Hobart Hospital Update in Peritoneal dialysis

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FACULTY OF HEALTH

Matthew JoseMBBS, FRACP, PhD, FASN, AFRACMA

Royal Hobart Hospital

Update in Peritoneal dialysis

I pay my respects to the traditional owners of

this land, the Larrakia people, and to their elders

past, present and emerging.

2FACULTY OF HEALTH

Conflicts of Interest

– Member International Society of Peritoneal Dialysis (ISPD)

– Chairperson, PD working group of AKTN

(Australasian Kidney Trials Network)

– Chairperson, ANZDATA Steering Committee

(Australia and New Zealand Dialysis and Transplant Registry)

– No commercial conflicts of interest

FACULTY OF HEALTH 3

ANZDATA Working Groups:

Advanced trainee membership 2017

HD – Emily See

PD – Jenny Chen

Transplant – Eric Au

Paediatrics – Jean Koh

PROMs – Nicole Lioufas

Indigenous – no nomination

Learning Objectives

– Know the recent publications on PD

– Recognise clinical practice variation

– Recognise variation in clinical outcomes

– Know the current resources available to assist

optimising PD outcomes for both patients and

staff

FACULTY OF HEALTH 5

Peritoneal Dialysis in Australia

and New Zealand:

Current practice and outcomes

FACULTY OF HEALTH 6

0

20

40

60

80

100

Pe

rce

nt

QLD NSW/ACT VIC TAS SA NT WA NZ

2016 ANZDATA Annual Report, Figure 2.6

at end of 2015

Dialysis Modality by State

PD Home HD Other HD

ANZDATA 2016 Annual report

Number of Patients=2514

0

5

10

15

20

25

Pe

rce

nt

0-14 15-24 25-34 35-44 45-54 55-64 65-74 75-84 85+

2016 ANZDATA Annual Report, Figure 5.4

Australia 2015

Age (%) of current peritoneal dialysis patients

0.00

0.25

0.50

0.75

1.00

Pa

tie

nt S

urv

iva

l

0 1 2 3 4 5Years

Age

<40 (1255)

40-59 (2655)

60-74 (3090)

=75 (1441)

2016 ANZDATA Annual Report, Figure 5.11

2004 - 2015Censored for transplant - Australia

Patient survival - peritoneal dialysis at 90 days

0.00

0.25

0.50

0.75

1.00

Te

chn

iqu

e S

urv

iva

l

0 1 2 3 4 5Years

Age

<40 (1255)

40-59 (2655)

60-74 (3090)

=75 (1441)

2016 ANZDATA Annual Report, Figure 5.14

2004 - 2015Censored for transplant - Australia

Technique survival - peritoneal dialysis at 90 days

0

50

100

150

200

250

Nu

mb

er

of P

atien

ts

0 1 2 3 4 5 6 7 8 9 =10Years on PD

2016 ANZDATA Annual Report, Figure 5.1

Prevalent PD patients Australia 31 Dec 2015

Time on peritoneal dialysis

Proportion of PD patients in unit

Darwin 2006

13

“Eminence-based” Medicine

V

Evidence-based Medicine

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PD pathway

14

Pt selection Catheter

insertion

PD training Novice PD Veteran PD

Clinical Governance

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15FACULTY OF HEALTH

16

http://academy.theisn.org

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17FACULTY OF HEALTH

PDI 2016;

PDI 2017; 37 (2): 141-154

Li et al Perit Dial Int 2016; 36 (5): 481-508

PDI 2017; 37(4): 362-374

PD pathway

22

Pt selection

Patient selection

23

Mr T.D

male

50yo

Rural location

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24

PD: Making it happen

25

Pt-targeted pre-dialysis education:

• Increases likelihood of choosing PD OR 2.2 (1.07-4.32)

• Increases likelihood of receiving PD OR3.50 (2.82-4.35)

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Devoe et al, AJKD 2016; 68(3): 422

PD pathway

26

Pt selection Catheter

insertion

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Preventing infections in PD: Screening for S.aureus

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Preventing infections in PD: what do we actually do?Screening for S.aureus

64% screen for S.aureus, but treatment length is variable

Campbell et al, PDI 2017; 37(2): 191FACULTY OF HEALTH

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Preventing infections in PD: what do we actually do?

Antibiotics at the time of catheter insertion

Mostly cephalosporin at time of surgeryCampbell et al, PDI 2017; 37(2): 191FACULTY OF HEALTH

Insertion of PD Catheters: Who & How?

Surgeon? Nephrologist?

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Shanmugalingam et al, PDI 2017; 37(4): 434

Insertion of PD Catheters: Who & How: Liverpool group

140 of 171 (82%) successful

171 of 217 (79%)

percutaneous

Shanmugalingam et al, PDI 2017; 37(4): 434

Insertion of PD Catheters: Who & How: Liverpool group

How often should you flush the catheter: actual practice

34Y.Cho et al, Periton. Dial Int 2017 in pressFACULTY OF HEALTH

When can you start PD?Royal Brisbane & Rockhampton

– RCT, n=122 Catheter leak

– Week 1 28.2%

– Week 2 9.5%

– Week 4 2.4% P=0.001 (ITT)

Ranganathan et al, PDI 2017; 37 (4): 420

Urgent start PD (within 2 weeks): Higher leakage & catheter migration

See et al, PDI 2017; 37(4): 414

Single centre, matched case control study (not RCT)

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Urgent start PD (within 2 weeks):but overall outcomes no different

See et al, PDI 2017; 37(4): 414FACULTY OF HEALTH

PD pathway

38

Pt selection Catheter

insertion

PD training

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Factors the impact on PD success

39FACULTY OF HEALTH

Jose et al, Nephrology 2011

23.7%

26.3%

13.2%

15.8%

21.1%

On average, how many hours does your unit spend on training a new PD nurse to become

competent in training PD patients?

<15 hours

15-39 hours

40-69 hours

70-99 hours

100+ hours

Boudville et al, Nephrology 2017 (in press)

14.3%

54.3%

17.1%

14.3%

What is the average duration of patient training prior to PD initiation at home?

2-3 days per patient

4-5 days per patient

6-7 days per patient

>7 days per patient

Boudville et al, Nephrology 2017 (in press)

PD training practices by PDOPPS country164 facilities Australia Canada Japan UK US

Number of facilities 14 20 26 32 68

When training occurs

Prior to PD catheter insertion 7% 5% 62% 3% 3%

1 week after PD catheter insertion 0% 30% 27% 9% 19%

2-3 weeks after PD catheter insertion 64% 65% 0% 72% 63%

Other 29% 0% 12% 16% 15%

Training location

Facility only 43% 84% 100% 31% 53%

Combination of home and facility 57% 16% 0% 50% 47%

Home only 0% 0% 0% 19% 0%

Duration of training, days

2-3 15% 22% 39% 39% 14%

4-5 69% 56% 17% 52% 29%

6-7 8% 17% 13% 10% 30%

>7 8% 6% 30% 0% 27%

Figueiredo et al. ASN oral abstract (2016)

PD training practices by PDOPPS country

Australia Canada Japan UK US

Number of facilities 14 20 26 32 68

Final training assessment

Procedure demonstration 93% 100% 100% 100% 100%

Written test 29% 30% 8% 9% 87%

Oral test 50% 40% 24% 34% 69%

Other 7% 5% 0% 3% 10%

Number of nurses training one patient

One nurse 64% 95% 28% 81% 97%

Several nurses 36% 5% 72% 19% 3%

Figueiredo et al. ASN oral abstract (2016)

44

INSERT FACULTY NAME IN FOOTER 45

Education

level

Hours of

Training

Centre size Timing of

Training

Figueiredo et al, PDI 2016

Figueiredo et al, PDI 2016

A Targeted Education ApproaCH toimprove Peritoneal Dialysis outcomes

The HOME Network &

AKTN PD Working Group

PD pathway

49

Pt selection Catheter

insertion

PD training Novice PD

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Patient perspectiveson prevention and treatment of peritonitis

Campbell et al, PDI 2016; 36(6): 631

Exit site care

2017

Worth reading…......

Preventing infections in PD: what do we actually do?

Exit site care

Campbell et al, PDI 2017; 37(2): 191

Preventing infections in PD: what do we actually do?Antifungal prophylaxis

Campbell et al, PDI 2017; 37(2): 191

Preventing Peritonitis: Fluid choice

0

20

40

60

80

100

Pe

rce

nt

CAPD APD

NT

NS

W/A

CT

VIC

QL

D

SA

WA

TA

S

NZ

NT

NS

W/A

CT

VIC

QL

D

SA

WA

TA

S

NZ

Proportions not presented if <10 patients

2016 ANZDATA Annual Report, Figure 5.7

Prevalent patients December 2015

Icodextrin use by state and country

Yes

No

Icodextrin

2014

Li et al Perit Dial Int 2016; 36 (5): 481-508

PD pathway

60

Pt selection Catheter

insertion

PD training Novice PD Veteran PD

Clinical Governance

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Clinical Governance

Performance Indicators – HD & PD

Identified hospital report - Dialysis

Data 2009-2014

Dialysis hospital report, Jan 2016

KPIs and uptake of PD: Victoria

Toussaint et al, PDI 2017; 37(2): 198

KPI-3: Proportion of dialysis patients who are 35% dialyzing at

home, both incident and (incident and prevalent rates prevalent)

Clinical Practice Variation:Proportion of PD patients in unit

Clinical practice variation: Evidenced-basedEminence-basedExperience-based

– Local practice patterns differ in individual renal units

– Lack of high quality evidence for clinical nephrology practice

– Lack of clinical trials

66

“Albatross” model

Each renal unit doing

its’ own thing

Clinical practice variation: observational data

6

12

18

36

Pa

tie

nt-

mo

nth

s p

er

ep

iso

de

0

.5

1

1.5

2

Ep

iso

de

s p

er

ye

ar

(95

% C

I)

0 20 40 60Treating unit

Excludes units with <10 person-years PD over 2006-2015

2016 ANZDATA Annual Report, Figure 5.25

By treating unit, Australia 2006-2015

PD peritonitis rate

QLD

NSW

ACT

VIC

TAS

SA

NT

WA

12

15

18

20

24

30

Pa

tie

nt-

mo

nth

s p

er

ep

iso

de

.4

.5

.6

.7

.8

.9

Ep

iso

de

s p

er

ye

ar

(95

% C

I)

2016 ANZDATA Annual Report, Figure 5.23

By state, Australia 2006-2015

PD peritonitis rate

Facility peritonitis rates*

Perl et al. ASN oral abstract (2016)

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6A/NZ Canada Japan United Kingdom United States

Peritonitis rate (95% CI), events per patient year

Rank

*Restricted to facilities with at least 5 patient years of follow-up (n=79)

71

It’s your fault

Variation: We often blame the patient

72FACULTY OF HEALTH

A greater use of PD = less peritonitis

73Nadeau-Fredette et al, PDI 2016; 36: 509-518FACULTY OF HEALTH

Centre Variation in Peritonitis Rates

Htay H et al, Clin J Am Soc Nephrol 2017; 12(7): 1090

16% patient

34% centre

Unadjusted

Patient-adjusted

Facility-adjusted

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Centre Variation in Peritonitis Cure

.8.9

11

.11

.2

Odd

ra

tio

0 10 20 30 40 50Center rank

Unadjusted

Patient-adjusted

Facility-adjusted

9% patient

66% centre

Htay H et al, unpublishedFACULTY OF HEALTH

Centre Variation in Technique Failure

.6.8

11

.21

.41

.6

Haza

rd R

atio

0 10 20 30 40 50Center rank

28% patient

53% centre

Htay H et al, Clin J Am Soc Nephrol 2017; 12(7): 1090FACULTY OF HEALTH

Collaboration:

to create new knowledge

Individual unit practice Collaboration between units

“Albatross Model” “Duck model” (flying-V)

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78FACULTY OF HEALTH

18

20

24

30P

atie

nt-

mo

nth

s p

er

ep

iso

de

.3

.4

.5

.6

.7

Ep

iso

de

s p

er

ye

ar

(95

% C

I)

2005 2007 2009 2011 2013 2015

2016 ANZDATA Annual Report, Figure 5.22

Australia 2006-2015

PD peritonitis rate

PD pathway

81

Pt selection Catheter

insertion

PD training Novice PD Veteran PD

Clinical Governance

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82

A good outcome?

83

www.songinitiative.org

FACULTY OF HEALTH

Acknowledgements

• Professor David Johnson

• Professor Josephine Chow

• Professor Neil Boudville

• Dr Yeoungjee Cho

• PD Nursing staff

• many New Zealanders

84FACULTY OF HEALTH

Questions ?

[email protected]