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Urea and Uric Acid Excretion/
Urine Composition
DaYea, Christina
Urea
Urea: By-product of amino acids catabolism Plasma concentration reflects the amount of
protein Urea enters the renal tubule by filtration 50% of urea is reabsorbed
Remainder is excreted in urine
Uric Acid
Uric Acid: Product of the metabolism of certain organic bases in nucleic acids Active transport reabsorbs the uric acid in
glomerular filtrate Small amount is secreted into the renal tubule
and is excreted in urine
Urine Composition Reflects the amounts of water and solutes
that the kidneys eliminate from the body
Retains in the internal environment to maintain homeostasis
Due to variations in dietary intake and physical activity, the composition may differ form time to time Water (95%), urea and uric acid Electrolytes, amino acids
Urine Composition Volume of urine
produced is usually between 0.6 and 2.5 liters per day Depends on fluid
intake, environmental temperature, relative humidity, emotional condition, respiratory rate, body temperature
Normal output is 50~60 milliliters per hour Less than 30 ml per
hour may indicate kidney failure
Review The urea enters the ______________ by filtration
___________ is a by-product of amino acid catabolism
____________ is a product of the metabolism of certain organic bases in nucleic acids
Urine is about 95% __________, and usually contains _______ and ___________ acid
Urine composition reflects the amounts of _____ and solutes that the _________ must eliminate from the body or retain in the _________ ___________ to maintain ________________.
renal tubule Urea
Uric Acid
wateruricurea
kidneys
water
internal environment homeostasis