URI SELIGSOHN, M - TAUProf. U. Seligsohn April 2013 URI SELIGSOHN, M.D PROFESSOR OF HEMATOLOGY CURRICULUM VITAE 6.2.1937 Born in Tel-Aviv, Israel 1954-1957 Military Service 1964-1991

Prof. U. Seligsohn April 2013

URI SELIGSOHN, M.D PROFESSOR OF HEMATOLOGY

CURRICULUM VITAE 6.2.1937 Born in Tel-Aviv, Israel 1954-1957 Military Service 1964-1991 Lt. Colonel Reserve Medical Corps, Israel Defense Forces EDUCATION 1957 - 1963 Medical School, Hebrew University and Hadassah, Jerusalem 1964 M.D. Thesis on “Circumstances and stresses preceding acute myocardial infarction”. ACADEMIC APPOINTMENTS 1970 Lecturer of Hematology, Tel-Aviv University 1973 Senior Lecturer of Hematology, Tel-Aviv University 1977 Associate Professor of Hematology 1982 Professor of Hematology

2002 to date Director, Amalia Biron Research Institute of Thrombosis and

Hemostasis, Tel-Aviv University CLINICAL EXPERIENCE 1963 - 1964 Internship at the Tel-Aviv Medical Center 1965 - 1967 Residency in Medicine, Sheba Medical Center, Tel-Hashomer 1967 - 1970 Residency and fellowship in Hematology, Sheba Medical Center

1972 - 1979 Staff member, Institute of hematology, Sheba Medical Center 1979 - 1993 Director, Institute of Hematology, Tel-Aviv Medical Center 1993 - 2002 Chairman, Department of Hematology, Sheba Medical Center 1993 –2005 Director of the Institute of Thrombosis and Hemostasis, Sheba Medical Center


EXPERIENCE IN ADMINISTRATION AND IN ORGANIZATION OF INTERNATIONAL SCIENTIFIC CONGRESSES

1972 - 1979 Deputy Director, Sheba Medical Center, Tel-Hashomer 1979 - 1983 Head of the Hematology Section, the Sackler Faculty of Medicine, Tel-Aviv University 1983 - 1993 Vice Dean, Sackler Faculty of Medicine and Director, School of Continuing Medical Education, Tel-Aviv University 1979 President of the XIIIth Congress of the World Federation of Hemophilia, Tel-Aviv 1982 Chairman, First International Workshop on Prevention in

Hemophilia, Neve Ilan 1986 President of the Joint Congress of the International Committee

on Thrombosis & Hemostasis and the Mediterranean League against Thrombosis, Jerusalem

1989 – 1995 Chairman, Israel Association of Thrombosis and Hemostasis 1995 President, Congress of the International Society on Thrombosis and Hemostasis, Jerusalem 2002 – 2005 Chairman of the Israel Society of Hematology and Blood

Transfusion. 2004 Chairman, International Educational and State of the Art Seminar

on Frontiers in Thrombosis and Haemostasis, Tel-Avivl TEACHING EXPERIENCE AND SABBATICALS 1966 - to date Teaching Hematology at Sackler Faculty of Medicine,

Tel-Aviv University 1970 - 1972 Visiting Assistant Professor of Medicine, University of Southern California, School of Medicine 1977 - 1978 Visiting Associate Professor of Medicine, University of California, San-Diego, U.S.A. 1987 Visiting Professor of Medicine, State University of New-York at Stony Brook 1988 Chairman, Advanced Course on Thrombosis, European

2


School of Hematology, Paris, France 1992 Visiting Professor, Scripps Research Institute, La Jolla, California 1994 Visiting Professor of the Royal Dutch Academy of Sciences 1996 Martin Rosenthal visiting Professor of Hematology, Mount- Sinai School of Medicine, N.Y. 1998 Visiting Professor, Mount Sinai School of Medicine, N.Y. 2002 Visiting Professor, Rockefeller University, N.Y. 2004 Visiting Professor, Rockefeller University, N.Y. 2009 Visiting Professor, Rockefeller University, N.Y 2011 Chairman, advanced course of thrombosis and Hemostasis, of ISTH and European School of Hematology, Cascais, Portugal INTERNATIONAL SCIENTIFIC ACTIVITIES Since 1978 Council of the Mediterranean League Against Thrombosis 1981-1986 Council member of the European Thrombosis Research Organization 1987 - 1992 Vice Chairman, Medical Advisory Board of the World Federation of hemophilia 1990 - 1994 World Federation of Hemophilia Committee on Laboratory Activities 1994 - 2000 Member, Council of the International Society on Thrombosis and Hemostasis (ISTH) 1993 - 2000 Member of the founding Board of the European Hematology Association 1998 - 2000 Member of the Subcommittee on Hemostasis of the American

Society of Hematology 2000 – 2002 Chairman of the Council of the International Society of Thrombosis and Hemostasis 2002 – 2010 Chairman, Education Committee of the Council of ISTH 2004 - 2010 Reelected member of the Council of ISTH

3


EDITORIAL BOARDS OF: 1980 - 1984 Thrombosis Research Since 1990 Blood Coagulation & Fibrinolysis 1997 - 2002 Thrombosis and Haemostasis Since 2003 Journal of Thrombosis and Hemostasis 2005 - 2008 Haematologica, the Hematology Journal Since 2009- Blood Cells, Molecules & Diseases GRANTS 1970-1972 National Institute of Health, U.S.A, Grants AM 14552

and OG 1272 (Subject: Dubin-Johnson syndrome in Israel)

1973 Chief Scientist of the Ministry of Health

(Subject: Fibrinogen metabolism) 1982 Chief Scientist of the Ministry of Health

(Subject: Cold-promoted activation of factor VII in blood bank conditions)

1987 Tel-Aviv University Research Authority: Basic Research Grant

(Subject: Genetic Aspects of Glanzmann Thrombasthenia) 1995-1998 Israel Science Foundation, Israel Academy of Sciences (Subject: Molecular Aspect of Glanzmann Thrombasthenia). POST-DOCTORAL RESEARCHERS 2002 – to date Michal Zucker, Ph.D 2003 – to date Ronit Mor-Cohen, Ph.D PH.D STUDENTS 1995 – 2000 Rivka Yatuv (graduated) 1996 - 2002 Yonit Amit 1997 - 2003 Ronit Mor-Cohen

4


2004 - 2009 Hagit Hauschner MASTER STUDENTS 1983 - 1985 Shlomo Berliner 2004 -2006 Nurit Lendner 2004 -2006 Avigal Lask 2007 -2010 Wissam Mansour M.D’s TRAINING IN BASIC SCIENCES 1973 - Ilan Nissel 1990 - Emilia Weiss 1974 - Nira Reichert 1992 - Muhamed Yunes 1976 - Raphael Shafir 1995 - Charli Stern 1978 - Tal Sigal 1999 - Avihai Segal 1981 - Irena Vigler 1999 - Yael Orion 1985 - Sara Rososhansky 2000 - Yifat Goldberg 1986 - Benjamin Brenner 2003 - Merav Leiba 1987 - Tami Kulka 2003 - Henit Yanay 1988 - Gali Avrahami 2004 - Ina Dubin 1989 - Ran Kornovski 2006 - Deborah Rubin-Asher AWARDS AND HONORS 1989 - Fellow of the Royal Society of Medicine, U.K 1991 - Incumbent of the Jose Henriques de Paiva Ferreira Chair of Research

in Thrombosis and Hemostasis, Tel Aviv University. 1991 - Ham-Wasserman lecture Award for Distinguished Research in

Hematology, American Society of Hematology. 1997 - Distinguished Career Award, International Society of Thrombosis and

Hemostasis 2001 – Member of the Israel Academy of Sciences and Humanities 2002 – Rufus Cole Lecture, Rockefeller University, N.Y. 2007 - Robert P. Grant Medal by the International Society of Thrombosis and Hemostasis

5


2009 - Commendation by ISTH in recognition of outstanding leadership and continuing commitment to the education and outreach initiatives

2010 - The Sheba Prize for life time achievements

6


Selected publications Books Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, , Prchal J, Editors. Williams Textbook of Hematology. Eighth Edition. McGraw–Hill, N.Y. 2010, pp 2439.

Articles 1. Seligsohn U, Shani M, Ramot B, Adam A, Sheba C. Dubin-Johnson

syndrome in Israel. II. Association with factor VII deficiency. Quart J Med 39:569-584, 1970.

2. Seligsohn U, Osterud B, Brown SF, Griffin JM, Rapaport SI. Activation of human factor VII in plasma and purified systems: Roles of activated factor IX, kallikrein and activated factor XII. J Clin Invest 64:1056-1065, 1979.

3. Seligsohn U, Zivelin A, Zwang E. Combined factor V and factor VIII among non-Ashkenazi Jews. N Engl J Med 307:1191-1195, 1982.

4. Seligsohn U, Berger A, Abend M, Rubin L, Attias D, Zivelin A, Rapaport SI. Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Engl J Med 310:559-562, 1984.

5. Newman PJ, Seligsohn U, Lyman S, Coller BS. The molecular genetic basis of Glanzmann’s thrombasthenia in the Iraqi-Jewish and Arab populations in Israel. Proc Natl Acad Sci (U.S.A.) 88:3160-3164, 1991.

6. Asakai R, Chung DW, Davie EW, Seligsohn U. Factor XI deficiency in Ashkenazi Jews in Israel. N Engl J Med 325:153-158, 1991.

7. Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C, Fowler B, Seligsohn U. Coexistence of hereditary homocysteinuria and factor V Leiden. Effect on Thrombosis. N Engl J Med 334:763-768, 1996.

8. Zivelin A, Griffin JH, Xu X, Pabinger I, Samama M, Conard J, Brenner B, Eldor A, Seligsohn U. A single genetic origin for a common Caucasian risk factor for venous thrombosis. Blood 89:397-402, 1997.

9. Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussali MJ, Hauri H-P, Ciavarella N, Kaufman RJ, Ginsbrug D. Mutations in the ER-Golgi intermediate compartment, protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell 93:61-70, 1998.

10. Salomon O, Steinberg DM, Koren-Morag N, Tanne D, Seligsohn U. Reduced incidence of ischemic stroke in patients with severe factor XI deficiency. Blood 111:4113-4117, 2008.

7


PUBLICATIONS – FULL LIST

Prof. Uri Seligsohn BOOKS 1. Seligsohn U., Rimon, A., Horoszowski H. Eds. Hemophilia. Castle

House Publications, London, 1981, pp. 245. 2. Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U. Eds. Williams

Hematology. Sixth Edition. McGraw-Hill, N.Y. 2001, pp 1941. 3. Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Kaushansky K, Prchal J,

Editors. Williams Textbook of Hematology. Seventh Edition. McGraw–Hill, N.Y. 2006, pp 2189.

4. Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, , Prchal J,

Editors. Williams Textbook of Hematology. Eighth Edition. McGraw–Hill, N.Y. 2010, pp 2439.

CHAPTERS IN BOOKS

1. Seligsohn U. Factor XI (PTA) Deficiency in Genetic Diseases Among Ashkenazi Jews. Goodman RM and Motulsky AG, Eds. Raven press, 1979, pp. 141-148.

2. Farine I, Horoszowski, H, Seligsohn U, Heim M. Laser Surgery In Hemophilic Patients in FF Palazzi Tratamiento Ortopedico de Las Lesiones Hemophilicas del Aparato Locomotor, 1980.

3. Horoszowski H, Heim M, Seligsohn U, Farine I. The Use of the Laser Scalpel in Orthopedic Surgery on Hemophilic Patients in Hemophilia, Seligsohn U, Horoszowski H, Rimon A, Eds. Castle House Publication, London, 1981, pp. 189-193.

4. Seligsohn U. Combined Factors V and VIII Deficiency in Factor VIII - von Willebrand Factor, Volume II. Seghachian MJ, Savidge GF, Eds. CRC Press, Inc., Boca Raton, USA, 1989, pp. 89-100.

5. Seligsohn U, Mibashan RS, Rodeck CH, Nicolaides KH, Millar DS, Coller BS. Prevention Program of Type I Glanzmann Thrombasthenia in Israel: Prenatal Diagnosis in Current Studies in Hematology and Blood Transfusion. Karger, Basel, Switzerland. 55:174-179, 1988.

6. Seligsohn U, Ben-Tal O. Hereditary tendencies of thrombosis and their frequency distribution in Hemorrhagies et thromboses en Pediatrie, Schlegel N, Beaufils F, Eds. Seminaires de l’Hopital Bretonneau. Reanimation urgences Pediatrique. Arnette Paris, 1988, pp. 215-219.

7. Asakai R, Chung DW, Davie EW, Seligsohn U. Heterogeneity of Factor XI Deficiency in Ashkenazi Jews in Genetic Diversity Among Jews. Bonne-Tamir B, Adam A, Eds. Oxford University Press 1992, pp. 150-153.

8


8. Seligsohn U, Peretz H, Newman PJ, Coller BS. Glanzmann Thrombasthenia in Israel: Clinical, Biochemical, and Molecular Genetic Characterization in Genetic Diversity Among Jews. Bonne-Tamir B, Adam A, Eds. Oxford University Press 1992, pp. 275-282.

9. Seligsohn U. Disseminated Intravascular Coagulation in Williams Hematology. Beutler E, Lichtman MA, Kipps TJ, Coller BS, Eds. Fifth Edition, McGraw-Hill, 1995, pp. 1497-1516.

10. Seligsohn U, Griffin JH. Contact Phase and Factor XI in The metabolic and Molecular Basis of Inherited Diseases. Scriver CR, Beaudet AL, Sly WS, Valle D, Eds. 7th Edition. McGraw-Hill, 1995, pp. 3289-3311.

11. Seligsohn U. Disseminated Intravascular Coagulation in Blood: Principles and practice of hematology. Handin RI, Lux SE, Stossel TP, Eds. JB Lippincott Company, Philadelphia 1995. pp. 1289-1317.

12. Seligsohn U, White G. Inherited Deficiencies of Coagulation Factors II, V, VII, XI and XIII, and the Combined Deficiencies of Factors V and VIII, and of the Vitamin K Dependent Factors in: Williams Hematology, 6th edition McGraw-Hill, N.Y. 2000, pp. 1617-1638.

13. Seligsohn U. Disseminated Intravascular Coagulation in Williams Hematology 6th edition McGraw-Hill, N.Y. 2000, pp. 1677-1695.

14. Seligsohn U, Coller BS. Classification, Clinical Manifestations and Evaluation of Disorders of Hemostasis in: Williams Hematology, 6th edition. McGraw-Hill, N.Y. 2000, pp. 1471-1477.

15. Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U. Approach to the Patient in Williams Hematology, 6th edition. McGraw-Hill, N.Y. 2000, pp. 3-8.

16. Seligsohn U. Factor XI deficiency. Textbook of Haemophilia. Lee C A, Berntorp EE, Hoots WK, Eds. Blackwell Publishing, Oxford 2005, pp. 321-327.

17. Seligsohn U, Kaushansky K. Classification, Clinical Manifestations and Evaluation of Disorders of Hemostasis. In Williams Hematology, 7th edition. McGraw-Hill, N.Y. 2006, pp. 1741-1747

18. Seligsohn U, Zivelin A, Inbal A. Inherited deficiencies of coagulation factors II, V, VII, X, XI, XIII, and the combined deficiencies of factor V and VIII and of the vitamin K-dependent factors. In: Williams Hematology, 7th edition. McGraw-Hill, N.Y. 2006, pp. 1887-1907.

19. Seligsohn U, Hoots K. Disseminated Intravascular Coagulation. In: Williams Hematology, 7th edition. McGraw-Hill, N.Y. 2006, pp. 1959-1979.

20. Seligsohn U, Griffin JH. Hereditary Thrombophilias. In: Williams Hematology, 7th edition. McGraw-Hill, N.Y. 2006, pp. 1981-2007.

21. Seligsohn U, Bolton-Maggs P. Factor XI deficiency. Lee CA, Berntorp EE, Hoots WK, Eds. In: Textbook of Hemophilia, 2nd edition. Wiley-Blackwell, NJ. 2010, pp. 355-361.

22. Seligsohn U, Kaushansky K. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis. In: Williams Hematology, 8th edition. McGraw-Hill, N.Y. 2010, pp. 1883-1889.

9


23. Seligsohn U, Zivelin A, Salomon O. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors. In: Williams Hematology, 8th edition. McGraw-Hill, N.Y. 2010, pp. 2031-2050.

24. Levi M, Seligsohn U. Disseminated Intravascular Coagulation. In: Williams Hematology, 8th edition. McGraw-Hill, N.Y. 2010, pp. 2101-2120.

25. Seligsohn U, Lubetsky A. Hereditary Thrombophilia. In: Williams Hematology, 8th edition. McGraw-Hill, N.Y. 2010, pp. 2121-2143.

ARTICLES

1. Zahavi J, Seligsohn U. Unusual course of infectious mononucleosis. JAMA 200:1181-1183, 1967.

2. Ben-Bassat I, Seligsohn U, Leiba H, Leef FF, Chaitchick S, Ramot B.

Sequestration studies with chromium-51 labelled red cells as criteria for splenectomy. Isr J Med Sci 3:832-837, 1967.

3. Seligsohn U, Ramot B. Chronic monocytic leukemia: A case with an eight year

survival. Isr J Med Sci 3:868-874, 1967. 4. Seligsohn U, Ramot B. Angiopathic hemolytic anemia: Report of five cases

and review of the literature. Harefuah 74:39-44, 1968. 5. Seligsohn U, Weber H, Yoran D, Horowitz A, Ramot B. Microangiopathic

hemolytic anemia and defibrination syndrome in metastatic carcinoma of the stomach. Isr J Med Sci 4:69-75, 1968.

6. Seligsohn U, Ramot B. Clinical and pathological aspects of the defibrination

syndrome and primary fibrinolysis. Harefuah 76:391-396, 1969. 7. Seligsohn U, Ramot B. Combined factor V and factor VIII deficiency. Report of

four cases. Brit J Haemat 16:475-486, 1969. 8. Seligsohn U, Shani M, Ramot B, Adam A, Sheba C. Hereditary deficiency of

blood clotting factor VII and Dubin-Johnson syndrome in an Israeli family. Isr J Med Sci 5:1060-1065, 1969.

9. Seligsohn U. Polycytemia, hypertension, prolonged fever, tumor in

epigastrium, and progressive heart failure. Harefuah 76:302-307, 1969. 10. Shani M, Seligsohn U. Familial hyperbilirubinemia. Harefuah 77:477-579,

1969. 11. Revach M, Kabili S, Zemer D, Seligsohn U. Massive sublingual hemorrhage

due to Coumadin causing suffocation. Harefuah 78:597-598, 1970. 12. Seligsohn U, Shani M, Ramot B. Gilbert syndrome and factor VII deficiency.

(letter), Lancet 1:1938, 1970.

10


13. Seligsohn U, Peyser MR, Toaff R, Shani M, Ramot B. Severe hereditary factor

VII deficiency during pregnancy. Evidence for the absence of transplacental diffusion of factor VII. Thromb Diath Haemorrh 24:146-151, 1970.

14. Shani M, Seligsohn U, Gilon E, Sheba C, Adam A. Dubin-Johnson syndrome

in Israel. I. Clinical and genetic aspects in 101 cases. Quart J Med 39:549-567, 1970.

15. Seligsohn U, Shani M, Ramot B, Adam A, Sheba C. Dubin-Johnson syndrome

in Israel. II. Association with factor VII deficiency. Quart J Med 39:569-584, 1970.

16. Ben-Ezzer J, Remington C, Shani M, Seligsohn U, Sheba C, Szeinberg A.

Abnormal excretion of the isomers of urinary coproporphyrin by patients with Dubin-Johnson in Israel. Clin Sci 40:17-30, 1971.

17. Rosenthal T, Shapiro Y, Seligsohn U, Ramot B. Disseminated intravascular

coagulation in experimental heathstroke. Thromb Diath Haemorrh 26:417-425, 1971.

18. Shani M, Seligsohn U, Post CA, Adam A, Ramot B, Szeinberg A, Sheba C.

Dubin-Johnson syndrome in Iranian Jews. Pahlavi Med J 2:471-475, 1971. 19. Seligsohn U, Man AL. Massive bleeding due to primary fibrinolysis following

rhinoplasty. Harefuah 82:219-20, 1972. 20. Seligsohn U, Shani M, Ramot B, Adam A, Sheba C. Association of hereditary

factor VII deficiency and Dubin-Johnson syndrome. Birth Defects 8:133-138. Williams & Wilkins Co., Baltimore, 1973.

21. Seligsohn U, Rapaport SI, Zivelin A. Patterns of incorporation of

75-Se-methionine into fibrinogen and other plasma proteins in rabbits stimulated by different test conditions. Thromb Diath Haemorrh 29:76-86, 1973.

22. Seligsohn U, Alexander N, Rapaport SI. Fibrinogen synthesis in

adrenalectomized rabbits. Proc Soc Exp Biol Med 142:824-848, 1973. 23. Seligsohn U, Rapaport SI, Kuefler PR. Extra-adrenal effect of ACTH on

fibrinogen synthesis. Amer J Physiol 224:1172-1179, 1973. 24. Seligsohn U. Hemophilia and other clotting disorders. Isr J Med Sci 9:1338-

1340, 1973. 25. Reichert M, Seligsohn U, Ramot B. Thrombasthenia in Iraqi Jews. Isr J Med

Sci 9:1406, 1973. 26. Shani M, Seligsohn U, Adam A. The inheritance of Dubin-Johnson syndrome.

Isr J Med Sci 9:1427-1430, 1973.

11


27. Ben-Ezzer J, Shani M, Seligsohn U, Post CA, Adam A, Blonder J, Szeinberg

A. Dubin-Johnson syndrome: Abnormal excretion of the isomers of urinary coproporphyrin by clinically unaffected family members. Isr J Med Sci 9:1431-1436, 1973.

28. Seligsohn U, Rapaport SI, Shen SMC, Kuefler PR. Effect of corticosteroids

upon fibrinogen metabolism in rabbits. Thromb Diath Haemorrh 30:531-540, 1973.

29. Seligsohn U, Rapaport SI, Rostami HJ. Delayed incorporation of (75-Se)

selenomethionine into fibrinogen: Its effect upon kinetic studies of fibrinogen with (75-Se) selenomethionine in rabbits. Brit J Haemat 26:627-644, 1974.

30. Seligsohn U. The heterogeneity of hereditary disorders of blood coagulation.

Harefuah 87:24-26, 1974. 31. Shani M, Seligsohn U, Ben-Ezzer J. effect of phenobarbitol on liver function

in patients with Dubin-Johnson syndrome. Gastroenterology 67:303-308, 1974.

32. Seligsohn U, Klein B. The effect of leucocytic extraction fibrinogen synthesis

in rabbits. Thromb Res 7:17-24, 1975. 33. Cohen I, Glaser T, Seligsohn U. effects of ATP on bovine fibrinogen and

ristocetin induced platelet aggregation in Glanzmann’s thrombasthenia. Brit J Haemat 31:343-347, 1975.

34. Reichert N, Seligsohn U, Ramot B. Clinical and genetic aspects of

Glanzmann’s thrombasthenia. Report of 22 cases. Thromb Diath Haemorrh 34:806-820, 1975.

35. Meytes D, Seligsohn U, Ramot B. Multiple myeloma with terminal

erythroleukemia. Acta Haemat 55:358-362, 1976. 36. Seligsohn U, Zitman D, Mani A, Klibanski C. The Coexistence of factor XI

(PTA) deficiency and Gaucher’s disease. Isr J Med Sci 12:1448-1452, 1976. 37. Seligsohn U, Shani M. The Dubin-Johnson syndrome and pregnancy. Acta

Hepato Gastroenterol 24:167-169, 1977. 38. Fried D, Seligsohn U, Gottlieb A, Raviv U. Late onset of hemorrhagic disease

of the newborn. Harefuah 92:565-566, 1977. 39. Giddings JC, Seligsohn U, Bloom AL. Immunological studies in combined

factor V and factor VIII deficiency. Brit J Haemat 37:257-264, 1977. 40. Herscovici B, Seligsohn U, Weinstein I, Wolman M. Effects of prolonged

administration of high molecular Levan on hematological parameters in rabbits. Biochem Exp Biol 13:193-197, 1977.

12


41. Siegal T, Seligsohn U, Aghai E, Modan M. Clinical aspects of DIC in 118

cases. Thromb Haemost 39:122-134, 1978. 42. Sidi A, Seligsohn U, Jonas P, Mani A. Factor XI deficiency: Detection and

management during urological surgery. J Urology 119:528-530, 1978. 43. Seligsohn U. High frequency of factor XI (PTA) deficiency in Ashkenazi Jews.

Blood 51:1223-1228, 1978. 44. Seligsohn U, Osterud B, Rapaport SI. A coupled amidolytic assay for factor

VII: its use with a clotting assay to determine the activity state of factor VII. Blood 52:978-988, 1978.

45. Seligsohn U, Osterud B, Griffin JM, Rapaport SI. Evidence for the

participation of both activated factor XII and activated factor IX in cold promoted activation of factor VII. Thromb Res 13:1049-1056, 1978.

46. Seligsohn U, Zivelin A, Peretz C, Modan M. Detection of hemophilia A

carriers by replicate factor VIII activity and antigenicity determinations. Brit J Haemat 42:433-439, 1979.

47. Seligsohn U, Kasper C, Osterud B, Rapaport SI. Activated factor VII in factor

IX concentrate: Presence in different preparations and persistence in the circulation following infusion. Blood 53:828-837, 1979.

48. Seligsohn U, Osterud B, Brown SF, Griffin JM, Rapaport SI. Activation of

human factor VII in plasma and purified systems: Roles of activated factor IX, kallikrein and activated factor XII. J Clin Invest 64:1056-1065, 1979.

49. Horowitz I, Graubart J, Gal G, Roman Y, Seligsohn U. Ambulatory oral

surgery treatment in haemophilias. Harefuah 99:201-203, 1980. 50. Seligsohn U, Modan M. Definition of the population at risk of bleeding due to

factor XI deficiency in Ashkenazic Jews and the value of activated partial thromboplastin time in its detection. Isr J Med Sci 17:413-415, 1981.

51. Bar-Meir S, Baron J, Seligsohn U, Gottesfeld F, Levy R, Gilat T. qqm-Tc-

HIDA colecystography in Dubin-Johnson and Rotor’s syndromes. Radiology 142:743-746, 1982.

52. Heim M, Horoszowski H, Seligsohn U, Martinowitz U, Strauss S. Ilio-poas

hematoma - its detection and treatment with special reference to hemophilia. Arch Orthop Trauma Surgery 99:195-197, 1982.

53. Ochshorn M, Michalevicz R, Tchetchick M, Behar A, Seligsohn U. Angio-

immunoblastic lymphadenopathy: a case with a 17-year follow-up. Postgrad Med J 58:367-370, 1982.

13


54. Heim M, Horoszowski H, Martinowitz U, Seligsohn U, Engel J. Haemophilic hands - a three year follow-up study. The Hand 14:333-336, 1982.

55. Seligsohn U, Zivelin A, Zwang E. Combined factor V and factor VIII among

non-Ashkenazi Jews. New Engl J Med 307:1191-1195, 1982. 56. Seligsohn U, Zivelin A, Bar-Shani S. Cold promoted activation of factor VII: Is

it a problem under blood bank conditions. Haemostasis 13:186-191, 1983. 57. Seligsohn U, Zivelin A, Zwang E. Decreased factor VIII clotting antigen levels

in the combined factor V and VIII deficiency. Thromb Res 33:95-98, 1984. 58. Seligsohn U, Berger A, Abend M, Rubin L, Attias D, Zivelin A, Rapaport SI.

Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Engl J Med 310:559-562, 1984.

59. Berliner S, Lusky A, Zivelin A, Modan M, Seligsohn U. Hereditary factor XIII

deficiency: Report of four families and definition of the carrier state. Brit J Haematol 56:495-505, 1984.

60. Seligsohn U, Zivelin A, Zwang E, Bar-Shani S. Factor VII in plasma of women

taking oral contraceptives. Lack of cold activation under blood bank conditions. Transfusion 24:171-172, 1984.

61. Solomon A, Rahmani R, Seligsohn U, Ben-Artzi F. Multiple myeloma: Early

vertebral involvement assessed by computerized tomography. Skeletal Radiol 11:258-261, 1984.

62. Levine PH, Brackmann HH, Seligsohn U. A proposed system of classification

of hemophilia centers for the World federation of Hemophilia (W.F.H.). Scand J Haematol Suppl 40, 33:459-460, 1984.

63. Melamed I, Djaldetti M, Joshua H, Seligsohn U. Association of the hemophilia

A carrier state and hemorrhagic thrombocytopathy with dilatation of the platelet membrane complex. Acta Hemat 71:381-387, 1984.

64. Seligsohn U, Rososhansky S. A Glanzmann’s thrombasthenia cluster among

Iraqi Jews in Israel. Thromb Haemost 52:230-231, 1984. 65. Zikk D, Shanon E, Seligsohn U, Himelfarb MZ. Parotid gland hemorrhage as

a complication of coumarin compound ingestion. Arch Otorhinolaryngol 241:243-246, 1985.

66. Seligsohn U, Mibashan RS, Rodeck CH, Nicolaides KH, Miller DS, Coller BS.

Prenatal diagnosis of Glanzmann’s thrombasthenia (Research Letter). Lancet II:1419, 1985.

67. Mibashan RS, Millar DS, Rodeck CH, Nicolaides KH, Berger A, Seligsohn U.

Prenatal diagnosis of hereditary protein C deficiency (Letter). New Engl J Med 313:607, 1985.

14


68. Saito H, Ratnoff OD, Bouma BN, Seligsohn U. Failure to detect variant

(CRM+) plasma thromboplastin antecedent (factor XI) molecules in hereditary plasma thromboplastin antecedent deficiency: A study of 125 patients of several ethnic backgrounds. J Lab Clin Med 106:718-722, 1985.

69. Agam G, Luria R, Shohat O, Dvilansky A, Seligsohn U, Livne A. Lysine

binding to activated human platelets and its similarity to fibrinogen finding. Biochim Biophys Acta 847:293-300, 1985.

70. Rubinstein ZL, Seligsohn U, Modan M, Shani M. Hepatic computerized

tomography in the Dubin-Johnson syndrome: Increased liver density as a diagnostic aid. Computerized Radiol 9:315-318, 1985.

71. Sahar E, Michalevicz R, Broudo I, Seligsohn U. Quantitation by flow

cytometry of anthracycline drug uptake by peripheral blood and bone marrow cells in human leukemias. Exp Hematol 14:119-125, 1986.

72. Berliner S, Seligsohn U, Zivelin A, Zwang E. A relatively high frequency of

sever (type III) von Willebrand’s disease in Israel. Brit J Haematol 62:535-543, 1986.

73. Coller BS, Seligsohn U, Zivelin A, Zwang E, Lusky A, Modan M. Immunologic

and biochemical characterization of homozygous and heterozygous Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations of Israel: comparison of techniques for carrier detection. Brit J Haematol 62:723-735, 1986.

74. Coller BS, Peerschke EI, Seligsohn U, Scudder IE, Nurden AT, Rosa JP.

Studies on the binding of an alloimmune and two murine monoclonal antibodies to the platelet glycoprotein IIb/IIIb complex receptor. J Lab Clin Med 107:384-392, 1986.

75. Tishler M, Abramov AL, Seligsohn U, Kahn Y. Purpura fulminans in an adult.

Isr J Med Sci 22:820-822, 1986. 76. Berliner S, Fuchs J, Seligsohn U, Kariv N, Hazaz B, Rotenberg Z,

Weinberger I, Agmon J, Pinkhas J, Aronson M. Possible role of fibrinogen in the aggregation white blood cells. Thromb Hemost 58:749-752, 1987.

77. Soberay AH, Herzberg MC, Rudney JD, Nieuwenhuis HK, Sixma JJ,

Seligsohn U. Responses of platelets to strains of streptococcus sanguis: findings in healthy subjects, Bernard-Soulier, Glanzmann’s, and collagen-unresponsive patients. Thromb Hemost 57:222-225, 1987.

78. Brenner B, Seligsohn U. Primary hypercoagulable states. Harefuah 112:177-

180, 1987.

15


79. Weiss P, Soff GA, Halkin H, Seligsohn U. Decline of proteins C and S and factors II, VII, IX and X during the initiation of warfarin therapy. Thromb Res 45:783-790, 1987.

80. Coller BS, Seligsohn U, Little PA. Type I Glanzmann thrombasthenia patients

from the Iraqi-Jewish and Arab pupulations in Israel can be differentiated by platelet glycoprotien IIIa immunoblot analysis. Blood 69:1696-1703, 1987.

81. Brenner B, Shapira A, Bahari C, Heimovich L, Seligsohn U. Hereditary

protein C deficiency during pregnancy. Am J Obstet Gynecol 157:1160-1161, 1987.

82. Brenner B, Seligsohn U, Hochberg S. Normal response of factor VIII and von

Willebrand factor to 1-Deamino-8D-Arginine vasopressin in nephrogenic diabetes insipidus. J Clin Endocrinol Metab 67:191-193, 1988.

83. Russell ME, Seligsohn U, Coller BS, Ginsberg MH, Skoglund P, Quertermous

T. Structural integrity of the glycoprotein IIb and IIIa genes in Glanzmann thrombasthenia patients from Israel. Blood 72:1833-1836, 1988.

84. Seligsohn U. Disseminated intravascular coagulation. Dilemas regarding its

pathogenesis, diagnosis and treatment. Revista Iberoamericana Thromb Hemost 1:7-11, 1988.

85. Seligsohn U, Mibashan RS, Rodeck CH, Nicolaides KH, Millar DS, Coller BS.

Prevention program of type I glanzmann thrombasthenia in Israel: Prenatal diagnosis. Curr Stud Hematol Blood Transf 55:174-179, 1988.

86. Seligsohn U, Coller BS, Zivelin A, Plow EF, Ginsberg M. Immunoblot analysis

of platelet glycoprotein IIb in patients with Glanzmann thrombasthenia in Israel. Brit J Haematol 72:415-423, 1989.

87. Barabsh GI, Hod H, Rath S, Miller HI, Roth A, Har-Zahav Y, Modan M,

Rotstein Z, Butler A, Zivelin A, Charnilass J, Laniado S, Rabinowitz B, Seligsohn U. Intermittent, dose-related reperfusion-reocclusion cycles during infusion of recombinant tissue plasminogen activator in patients with myocardial infarction. Amer J Cardiol 64:225-228, 1989.

88. Ben-Tal O, Zivelin A, Seligsohn U. The relative frequency of hereditary

thrombotic disorders among 107 patients with thrombophilia in Israel. Thromb Haemost 61:50-54, 1989.

89. Brenner B, Zwang E, Bronstein M, Seligsohn U. von Willebrand factor

multimer patterns in pregnancy-induced hypertension. Thromb Haemost 62:715-717, 1989.

90. Barbash GI, Hod H, Roth A, Miller HI, Rath S, Har-Zahav Y, Modan M, Zivelin

A, Laniado S, Seligsohn U. Correlation of baseline plasminogen activator inhibitor activity with patency of the infarct artery after thrombolytic therapy in acute myocardial infarction. Amer J Cardiol 64:1231-1235, 1989.

16


91. Brenner B, Tavori S, Zivelin A, Keller CB, Suttie JW, Tatarsky I, Seligsohn U.

Hereditary deficiency of all vitamin K-dependent procoagulants and anticoagulants. Brit J Haematol 75:537-542, 1990.

92. Rahmani R, Rozen P, Papo J, Lellin A, Seligsohn U. Association of von

Willebrand’s disease with plasma cell dyscrasia and gastrointestinal angiodysplasia. Isr J Med Sci 26:504-509, 1990.

93. Barbash GI, Roth A, Hod H, Miller HI, Rath S, Har-Zahav Y, Modan M,

Seligsohn U, Battler A, Kaplinsky E, Rabinowitz B, Laniado S. Rapid resolution of ST elevation and prediction of clinical outcome in patients undergoing thrombolysis with alteplase (recombinant tissue-type plasminogen activator): results of the Israeli Study of Early Intervention in Myocardial Infarction Brit Heart J 64:241-247, 1990.

94. Barbash GI, Roth A, Hod H, Miller HI, Modan M, Rath S, Har-Zahav Y,

Shachar A, Basan S, Battler A, Rabinowitz B, Kaplinsky E, Seligsohn U, Laniado S. Improved survival but not left ventricular function with early and prehospital treatment with tissue plasminogen activator in acute myocardial infarction. Am J Cardiol 66:261-266, 1990.

95. Barbash G, Hod H, Roth A, Faibel HE, Mandel Y, Miller HI, Rah S, Har-Zahav

Y, Rabinowitz B, Seligsohn U, Pelled P, Schlesinger Z, Laniado S, Kaplinsky E. Repeat infusions of recombinant tissue-type plasminogen activator in patients with acute myocardial infarction and early recurrent myocardial ischemia. J Amer Coll Cardiol 16:779-783, 1990.

96. Coller BS, Cheresh DA, Asch E, Seligsohn U. Platelet vitronectin receptor

expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel. Blood 77:75-83, 1991.

97. Newman PJ, Seligsohn U, Lyman S, Coller BS. The molecular genetic basis

of Glanzmann’s thrombasthenia in the Iraqi-Jewish and Arab populations in Israel. Proc Natl Acad Sci (U.S.A.) 88:3160-3164, 1991.

98. Asakai R, Chung DW, Davie EW, Seligsohn U. Factor XI deficiency in

Ashkenazi Jews in Israel. N Engl J Med 325:153-158, 1991. 99. Peretz H, Seligsohn U, Zwang E, Coller BS, Newman PJ. Detection of the

Glanzmann’s thrombasthenia mutations in Arab and Iraqi-Jewish patients by polymerase chain reaction and restriction analysis of blood or urine samples. Thromb Haemost 66:500-504, 1991.

100. Coller BS, Seligsohn U, West SM, Scudder LE, Norton KJ. Platelet fibrinogen

and vitronectin in Glanzmann thrombasthenia: Evidence consistent with specific roles for GPIIb/IIIa and V3 integrins in platelet protein trafficking. Blood 78:2603-2610, 1991.

17


101. Inbal A, Kornbrot N, Zivelin A, Shaklai M, Seligsohn U. The inheritance of type I and type II von Willebrand’s disease in Israel: Linkage analysis, carrier detection and prenatal diagnosis using three intragenic restriction fragment length polymorphisms. Blood Coagul Fibrinol 3:167-177, 1992.

102. Inbal A, Seligsohn U, Kornbrot N, Brenner B, Harrison P, Randi A,

Rabinowitz I, Sadler JE. Characterization of three mutations causing von Willebrand disease type IIA in five unrelated families. Thromb Haemost 67:618-622, 1992.

103. Berliner S, Horowitz I, Martinowitz U, Brenner B, Seligsohn U. Dental

surgery in patients with severe factor XI deficiency without plasma replacement. Blood Coagul Fibrinol 3:465-468, 1992.

104. Lubetsky A, Seligsohn U, Ezra D, Halkin H. The effect of the plasma levels

of proteins C and S on the prediction of warfarin maintenance dose requirements. Clin Pharmacol Ther 52:42-49, 1992.

105. Seligsohn U. Factor XI deficiency. Thromb Haemost 70:68-71, 1993. 106. Seligsohn U, Peretz H. Molecular genetics aspects of factor XI deficiency

and Glanzmann thrombasthenia. Haemostasis 24:81-85, 1994. 107. Peretz H, Usher S, Martinovitz U, Seligsohn U. Factor VIII gene

rearrangement in hemophilia a carrier detection: A word of caution. (Letter). Blood 84:1351-1352, 1994.

108. Pittman DD, Tomkinson KN, Michnik D, Seligsohn U, Kaufman RJ. Post

translational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity. Biochemistry (Washington) 33:6952-6959, 1994.

109. Coller BS, Seligsohn U, Peretz H, Newman PJ. Glanzmann

Thrombasthenia: New insights from an historical perspective. Semin Hematol 31:301-311, 1994.

110. Peretz H, Rosenberg N, Usher S, Graff E, Newman PJ, Coller BS,

Seligsohn U. Glanzmann’s thrombasthenia associated with deletion-insertion and alternative splicing in the Glycoprotein IIb gene. Blood 85:414-420, 1995.

111. Shpilberg O, Peretz H, Zivelin A, Yatuv R, Chetrit A, Kulka T, Stern C, Weiss

E, Seligsohn U. One of the two common mutations causing factor XI deficiency in Ashkenazi Jews (Type II) is also prevalent in Iraqi Jews, who represent the ancient gene pool of Jews. Blood 85:429-432, 1995.

112. Zycowitz Z, Seligsohn U, Zivelin A, Eldor A. Resistance to activated protein

C. A novel cause of thrombosis. Harefuah 129:1-5, 1995.

18


113. Peake I, Seligsohn U, Gitel S, Kitchen S, Zivelin A. The laboratory diagnosis of haemophilia: Recommendations by the Laboratory Activities Committee of the World Federation of Hemophilia. Haemophilia 1:159-164, 1995.

114. Maymon R, Seligsohn U, Fainaru M. International post-graduate training

program in Medicine: Survey of 13 training courses 1988-1994. Harefuah 129:185-188.

115. Verlander PC, Kaporis A, Liu Q, Zhang Q, Seligsohn U, Auerbach AD.

Carrier frequency of the IVS + 4 A T mutation of the Fanconi anemia gene FAC in the Ashkenazi Jewish population. Blood 86:4043-4048, 1995.

116. Dardik R, Peretz H, Usher S, Seligsohn U, Martinowitz U. Current strategy

for genetic analysis of haemophilia A families. Haemophilia 2:11-17, 1996. 117. Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C, Fowler B,

Seligsohn U. Coexistence of hereditary homocysteinuria and factor V Leiden. Effect on Thrombosis. N Engl J Med 334:763-768, 1996.

118. Seligsohn U, Rosenberg N. Glanzmann thrombasthenia: Clinical and

molecular characterization. Revista Iberoamericana Thromb Hemost 9 (suppl 1):18-21, 1996.

119. Peretz H, Zivelin A, Usher S, Seligsohn U. A 14-bp deletion (codon 554 del

AAGgtaacagagtg) at exon 14/intron N junction of the coagulation factor XI gene disrupts splicing and causes severe factor XI deficiency. Hum Mut 8:77-78, 1996.

120. Brenner B, Zivelin A, Lanir N, Greengard JS, Griffin JH, Seligsohn U.

Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis. Blood 88: 877-880, 1996.

121. Tamary H, Fromovic Y, Shalmon L, Reich Z, Dym O, Lanir N, Brenner B, Paz

M, Luder AS, Blau O, Korostishevsky M, Zaizov R, Seligsohn U. Ala244Val is common, probably ancient mutation causing factor VII deficiency in Moroccan and Iranian Jews. Thromb Haemost 76:283-291, 1996.

122. Schulman S, Langevitz P, Livneh A, Martinowitz U, Seligsohn U, Varon D.

Cyclosporine therapy for acquired factor VIII inhibitor in a patient with systemic lupus erythematosus. Thromb Haemost 76:344-346, 1996.

123. Lane DE, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V,

Chandy M, Dahlback B, Ginter EK, Miletitch JP, Rosendaal FR, Seligsohn U. Inherited thrombophilia: Part 1. Thromb Haemost 76:651-662, 1996.

19


124. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, Chandy M, Dahlback B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inherited thrombophilia: Part 2. Thromb Haemost 76:824-834, 1996.

125. Seitz R, Duckert F, Lopaciuk S, Muszbek L, Rodeghiero F, Seligsohn U.

Study Group. ETRO working party on factor XIII questionnaire on congenital factor XIII deficiency in Europe: Status and perspectives. Sem Thromb Hemost 22:415-418, 1996.

126. Zivelin A, Griffin JH, Xu X, Pabinger I, Samama M, Conard J, Brenner B,

Eldor A, Seligsohn U. A single genetic origin for a common Caucasian risk factor for venous thrombosis. Blood 89:397-402, 1997.

127. Inbal A, Bank A, Zivelin D, Varon R, Dardik R, Shapiro R, Roshenthal E,

Shenkman B, Gitel S, Seligsohn U. Acquired von Willebrand disease in a patient with angiodysplasia resulting from immune-mediated clearance of von Willebrand factor. Br J Haematol 96:179-182, 1997.

128. Nichols WC, Seligsohn U, Zivelin A, Terry VH, Arnold ND, Siemieniak DR,

Kaufman J, Ginsburg D. Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping. J Clin Invest 99:596-601, 1997.

129. Rosenberg N, Yatuv R, Orion Y, Zivelin A, Dardik R, Peretz H, Seligsohn U.

Glanzmann thrombasthenia caused by an 11.2-kb deletion in the glycoprotein IIIa (3) is a second mutation in Iraqi Jews that stemmed from a distinct founder. Blood 89:3654-3662, 1997.

130. Seligsohn U, Zivelin A. Thrombophilia as a multigenic disorder.

Thromb Haemost 78:297-301, 1997. 131. Inbal A, Yee VC, Kornbrot N, Zivelin A, Brenner B, Seligsohn U. Factor XIII

deficiency due to a Leu600Pro mutation in the factor XIII subunit-a gene in three unrelated Palestinian Arab families. Thromb Haemost 77:1062-1067, 1997.

132. Inbal A, Kenet G, Zivelin A, Yermiyahu T, Bronstein T, Sheinfeld T, Tamari H,

Gitel S, Eshel G, Duchemin J, Aiach M, Seligsohn U. Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protien S deficiency. Thromb Haemost 77:1086-1089, 1997.

133. Zivelin A, Rosenberg N, Peretz H, Amit Y, Kornbrot N, Seligsohn U.

Improved method for genotyping apolipoprotein e polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes. Clin Chem 43:1657-1659, 1997.

134. Peretz H, Mulai A, Usher S, Zivelin A, Segal A, Weisman Z, Mittelman M,

Lupo H, Lanir N, Brenner B, Shpilberg O, Seligsohn U. The two common

20


mutations causing factor XI deficiency in Jews stem from distinct founders: One of Ancient Middle-Eastern origin and another of more recent European origin. Blood, 90:2654-2659, 1997.

135. Brenner B, Laor A, Lupo H, Zivelin A, Lanir N, Seligsohn U. Bleeding

predictors in factor-XI-deficient patients. Blood Coagul Fibrinol 8:511-515, 1997.

136. Bar-Sade RB, Theodor L, Gak E, Kruglikova A, Hirsch-Yechezkel G, Modan

B, Kuperstein G, Seligsohn U, Rechavi G, Friedman E. Could the 185delAG BRCA1 mutation be an ancient Jewish mutation? Eur J Hum Genet 5:413-416, 1997.

137. Rosenberg N, Dardik R, Rosenthal E, Zivelin A, Seligsohn U. Mutations in

the IIB and 3 genes that cause Glanzmann thrombasthenia can be distinguished by a simple procedure using transformed B-lymphocytes. Thromb Haemost 79:244-248, 1998.

138. Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA,

Moussali MJ, Hauri H-P, Ciavarella N, Kaufman RJ, Ginsbrug D. Mutations in the ER-Golgi intermediate compartment, protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell 93:61-70, 1998.

139. Yatuv R, Rosenberg N, Dardik R, Brenner B, Seligsohn U. Glanzmann

thrombasthenia in two Iraqi-Jewish siblings is caused by a novel splice junction mutation in the glycoprotein IIb. Blood Coagul Fibrinol 9:285-288, 1998.

140. Kaplinsky C, Kenet G, Seligsohn U, Rechavi G. Association between

hyperflexibility of the thumb and an unexplained bleeding tendency: is it a rule of thumb? Brit J Haematol 101:260-263, 1998.

141. French DL, Coller BS, Usher S, Berkowitz R, Eng C, Seligsohn U. Prenatal

diagnosis of Glanzmann thrombasthenia using the polymorphic markers BRCA1 and THRA1 on chromosome 17. Brit J Haematol 102:582-587, 1998.

142. Zivelin A, Rosenberg N, Faier S, Kornbrot N, Peretz H, Mannhalter C,

Horellou MH, Seligsohn U. A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene. Blood 92:1119-1124, 1998.

143. Ginsburg D, Nichols WC, Zivelin A, Kaufman RJ, Seligsohn U. Combined

factors V and VIII deficiency – the solution. Haemophilia 4:677-682, 1998. 144. Salomon O, Moisseiev J, Rosenberg N, Vidne O, Yassur I, Zivelin A, Treister

G, Steinberg DM, Seligsohn U. Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion. Blood Coagul Fibrinol 9:617-622, 1998.

21


145. Salomon O, Steinberg DM, Zivelin A, Gitel S, Dardik R, Rosenberg N, Berliner S, Inbal A, Many A, Lubetsky A, Varon D, Martinowitz U, Seligsohn U. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism. Prevalence and risk assessment. Arterioscl Thromb Vasc Biol 19:511-518, 1999.

146. Inbal A, Freimark D, Modan B, Chetrit A, Matetsky S, Rosenberg N, Dardik

R, Baron Z, Seligsohn U. Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. Blood 93:2186 -2190, 1999.

147. Nichols WC, Terry VH, Wheatly MA, Yang A, Zivelin A, Ciavarella N,

Stefanile C, Matsushita T, Saito H, de Bosch NB, Ruiz-Saez A, Torres A, Thompson AR, Feinstein DI, White GC, Negrier C, Vinciguerra C, Aktan M, Kaufman RJ, Ginsburg D, Seligsohn U. ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families. Blood 93:2261-2266, 1999.

148. Beguin S, Kumar R, Keularts I, Seligsohn U, Coller BS, Hemker HC. Fibrin-

dependent platelet procoagulant activity requires GPIb receptors and von Willebrand Factor. Blood 93:564-570, 1999.

149. Zivelin A, Gitel S, Griffin JH, Xu X, Fernandez JA, Martinowitz U, Cohen Y,

Halkin H, Seligsohn U, Inbal A. Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C. Blood 94: 895-901, 1999.

150. Goldstein DB, Reich DE, Bradman N, Usher S, Seligsohn U, Peretz H. Age

estimates of two common mutations causing factor XI deficiency: Recent genetic drift is not necessary for elevated disease incidence among Ashkenazi Jews. Am J Hum Genet 64:1071-1075, 1999.

151. Salomon O, Huna-Baron R, Kurtz S, Steinberg DM, Moisseiev J, Rosenberg

N, Yassur I, Vidne O, Zivelin A, Gitel S, Davidson J, Ravid B, Seligsohn U. Analysis of prothrombic and vascular risk factors in patients with nonarteric anterior ischemic optic neuropathy. Ophthalmology 106:739-742, 1999.

152. Salomon O, Huna-Baron R, Steinberg DM, Kurtz S, Seligsohn U. Role of

aspirin in reducing the frequency of second eye involvement in patients with non-arteric anterior ischaemic optic neuropathy. Eye 13:357-359, 1999.

153. Salomon O, Apter S, Shaham D, Hiller N, Bar-Ziv J, Itzchak Y, Gitel S,

Rosenberg N, Strauss S, Kaufman N, Seligsohn U. Risk factors associated with postpartum ovarian vein thrombosis. Thromb Haemost 82:1015-1019, 1999.

154. Thornton MA, Poncz M, Korostishevsky M, Yakobson E, Usher S, Seligsohn

U, Peretz H. The human platelet IIb gene is not closely linked to its integrin partner 3. Blood 94:2039-2047, 1999.

22


155. Oddoux C, Guillen-Navarro E, Ditivoli C, Dieave E, Cilio MR, Clayton CM, Nelson H, Sarafoglou H, Sarafoglou K, McCain N, Peretz H, Seligsohn U, Luzzatto L, Nafa K, Nardi M, Karpatkin M, Aksentijevich I, Kastner D, Axelrod F, Ostrer H. Mendelian diseases among Roman Jews: implications for the origins of disease alleles. J Clin Endocrinol Metab 84:4405-4409, 1999.

156. French DL, Seligsohn U. Platelet glycoprotein IIb/IIIa receptors and

Glanzmann’s thrombasthenia. Arterioscler Thromb Vasc Biol 20:607-610, 2000.

157. Schneiderman J, Morag B, Gerniak A, Rimon U, Varon D, Seligsohn U,

Shotan A, Adar R. Abciximab in carotid stenting for postsurgical carotid restenosis: Intermediate results. J Endovasc Ther 7:263-272, 2000.

158. Tamary H, Fromovich-Amit Y, Shalmon L, Zaizov R, Yaniv I, Klar A, Peretz

H, Brenner B, Lanir N, Zivelin A, Seligsohn U. Molecular characterization of four novel mutations causing factor VII deficiency. Hematology J 1:382-389, 2000.

159. Salomon O, Rosenberg N, Zivelin A, Steinberg DM, Kornbrot N, Dardik R,

Seligsohn U. Methionine synthase A2756G and metylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism. Hematology J 2:38-41,2001.

160. Keularts I, Zivelin A, Seligsohn U, Hemker HC, Beguin S. The role of factor

XI in thrombin generation induced by low concentrations of tissue factor. Thromb Haemost 85:1060-1065, 2001.

161. Seligsohn U, Lubetsky A. Genetic susceptibilities to venous thrombosis. N

Engl J Med 344:1222-1231, 2001. (Review). 162. Shahar A, Feiglin L, Shahar DR, Levy S, Seligsohn U. High prevalence and

impact of subnormal serum vitamin B12 levels in Israeli elders admitted to a geriatric hospital. The Journal of Nutrition, Health & Aging 5:124-127, 2001.

163. Yatuv R, Rosenberg N, Zivelin A, Peretz H, Dardik R, Trakhtenbrot L,

Seligsohn U. Identification of a region in glycoprotein IIIa involved in subunit association with glycoprotein IIb: further lessons from Iraqi-Jewish Glanzmann thrombasthenia. Blood 98:1063-1069, 2001.

164. Mor-Cohen R, Zivelin A, Rosenberg N, Shani M, Muallem S, Seligsohn U.

Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. J Biol Chem 276: 36923-36930, 2001.

165. Salomon O, Huna-Baron R, Moisseiev J, Rosenberg N, Rubovitz A,

Steinberg DM, Davidson J, Sela BA, Seligsohn U. Thrombophilia as a cause for central and branch retinal artery occlusion in patients without an apparent embolic source. Eye 15:511-514, 2001.

23


166. Streifler JY, Rosenberg N, Chetrit A, Eskaraev R, Sela BA, Dardik R, Zivelin

A, Ravid B, Davidson J, Seligsohn U, Inbal A. Cerebrovascular events in patients with significant stenosis of the carotid artery are associated with hyperhomocysteinemia and platelet antigen-1 (Leu33Pro) polymorphism. Stroke 32:2753-2758, 2001.

167. Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E,

Seligsohn U. The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in Whites, Japanese, and Africans. Am J Hum Genet70:758-762, 2002.

168. Shpilberg O, Rabi I, Schiller K, Walden R, Harats D, Tyrrell KS, Coller B,

Seligsohn U. Patients with Glanzmann thrombasthenia lacking platelet glycoprotein IIb3 (GPIIb/IIIa) and V3 receptors are not protected from atherosclerosis. Circulation 105:1044-1048, 2002.

169. Zivelin A, Bauduer F, Ducout L, Peretz H, Rosenberg N, Yatuv R, Seligsohn

U. Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene. Blood 99:2448-2454, 2002.

170. Goldberg Y, Berliner S, Seligsohn U. Clinical and economical advantages of

anticoagulant treatment in specialized clinics. Harefuah Journal of the Israel Medical Association 141:830-832, 2002.

171. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG, The MTHFR

Studies Collaboration Group (Abbate R, Marcucci R, Samani NJ, Anderson JL, Zebrack JS, Ardissino D, Morlini FM, van Bockxmeer FM, Brownrig L, Chambers J, Kooner JS, Genest J, Rozen R, Ferrer-Antunes C, Palmeiro A, Fernandez-Arcas N, Reyes-Engel A, Folsom AR, Fowkes FGR, Lee AJ, Gemmati D, Scapoli GL, Girelli D, Corrocher R, Gulec S, Hopkins PN, Inbal A, Seligsohn U, Kluijtmans LAJ, Jukema JW, Kozich V, Janosikova B, Ma J, Stampfer MJ, Malinow MR, Ashfield-Watt PAL, Clark ZE, Meisel C, Stangl K, Graham IM, Morita H, Nagai R, Nakai K, Yamakawa-Kobayashi K, Hamaguchu H, Gaziano M, Schwartz SM, Siscovick DS, Silberberg JS, Szczeklik A, Domagala Teresa B, Tanis BC, Rosendaal FM, Thogersen AM, Nilsson TK, Todesco L, Litynsky P, Tokgozoglu SL, Tsai MY, Hanson NQ, Rimm FB, Verhoeff BJ, Trip MD. MTHFR 677CT polymorphism and risk of coronary heart disease. JAMA 288:2023-2031, 2002.

172. Seligsohn U. Glanzmann thrombasthenia: a model disease which paved the

way to powerful therapeutic agents. Pathophisiol Haemost Thromb 32:216-217, 2002.

173. Salomon O, Steinberg DM, Dardik R, Rosenberg N, Zivelin A, Tamarin I,

Ravid B, Berliner S, Seligsohn U. Inherited factor XI deficiency confers no protection against acute myocardial infarction. J Thromb Haemost 1:658-661, 2003.

24


174. Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EGD, Kaufman RJ, Ginsburg D. Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nature Gen 34:220-225, 2003.

175. Salomon O, Zivelin A, Livnat T, Dardik R, Loewenthal R, Avishai O,

Steinberg DM, Rosove MH, O'Connell N, Lee CA, Seligsohn U. Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency. Blood 101:4783-4788, 2003.

176. Rosenberg N, Yatuv R, Sobolev V, Peretz H, Zivelin A, Seligsohn U. Major

mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus. Blood 101:4808-4815, 2003.

177. Horton MA, Massey HM, Rosenberg N, Nicholls B, Seligsohn U.

Upregulation of osteoclast 21 integrin compensates for lack of v3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia. Br J Hematol 122:950-957, 2003.

178. Srivastava A, Usher S, Nelson EJ, Jayandharan G, Shaji RV, Chandy M,

Seligsohn U, Peretz H. Prenatal diagnosis of Glanzmann thrombasthenia. Natl Med J India 16:207-208, 2003.

179. Figlin E, Chetrit A, Shahar A, Shpilberg O, Zivelin A, Rosenberg N,

Brok-Simoni F, Gadoth N, Sela BA, Seligsohn U. High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel. Br J Haematol 123:696-701, 2003.

180. Salomon O, Rosenberg N, Steinberg DM, Huna-Baron R, Moisseiev J,

Dardik R, Goldan O, Kurtz S, Ifrah A, Seligsohn U. Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ib gene. Ophtalmology 111:184-188, 2004.

181. Bauduer F, Zivelin A, Ducout L, Shpringer E, Seligsohn U. The prevalence

of factor V G1691A but not of prothrombin G20210A and methylenetetrahydrofolate reductase C677T is remarkably low in French Basques. J Thromb Haemost 2:361-362, 2004. (Research Letter).

182. Segal A, Zivelin A, Rosenberg N, Ginsburg D, Shpilberg O, Seligsohn U. A

mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia. Blood Coagul Fibrinol 15:99-102, 2004.

183. Bolton-Maggs PHB, Peretz H, Butler R, Mountford R, Keeney S, Zacharski L,

Zivelin A, Seligsohn U. A common ancestral mutation (C128X) occurring in 11 non-Jewish families from the UK with factor XI deficiency. J Thromb Haemost 2:918-924, 2004.

25


184. Rosenberg R, Landau M, Luboshitz J, Rechavi G, Seligsohn U. A novel Phe171Cys mutation in integrin IIb causes Glanzmann thrombasthenia by abrogating IIb3 complex formation. J Thromb Haemost 2:1167-1175, 2004.

185. Sarvary A, Szucs S, Balogh I, Becsky A, Bardos H, Kavai M, Seligsohn U,

Egbring R, LOpaciuk S, Muszbek L, Adany R. Possible role of factor XIII subunit A in Fc and complement receptor-mediated phagocytosis. Cell Immunol 228:81-90, 2004.

186. Seligsohn U. A new mechanism for inherited factor XI deficiency. Blood

104:7-8, 2004. 187. Fromovich-Amit Y, Zivelin A, Rosenberg N, Tamary Hm Landau M,

Seligsohn U. Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients. J Thromb Haemost 2:1774-1781, 2004.

188. Vysokovsky A, Saxena R, Landau M, Zivelin A, Eskaraev R, Rosenberg N,

Seligsohn U, Inbal A. Seven novel mutations in the factor XIII A-subunit gene causing hereditary factor XIII deficiency in ten unrelated families. J Thromb Haemost 2:1790-1797, 2004.

189. Zivelin A, Ogawa T, Bulvik S, Landau M, Toomey JR, Lane J, Seligsohn U,

Gailani D. Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): A cross-reactive material positive variant defective in factor IX activation. J Thromb Haemost 2:1782-1789, 2004.

190. Salomon O, Seligsohn U. New observations on factor XI deficiency.

Haemophilia 10:184-187, 2004. 191. Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH, Livneh A,

Rosenberg N, Gelernter I, Gur H, Ehrenfeld M. Thrombophilic factors are not the leading cause of thrombosis in Behcet's disease. Ann Rheum Dis 63:1445-1449, 2004.

192. Salomon O, Seligsohn U, Steinberg D M, Zalel Y, Lerner A, Rosenberg N,

Pshithizki M, Oren M, Ravid B, Davidson J, Schiff E, Achiron R. The common prothrombotic factors in nulliparous women do not compromise blood flow in the feto-maternal circulation and are not associated with preeclampsia or intrauterine growth restriction. Am J Obstet Gynecol 191:2002-2009, 2004.

193. Mor-Cohen R, Zivelin A, Rosenberg N, Goldberg I, Seligsohn U. A novel

ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients. Hepatology Research 31:104-111, 2005.

194. Salomon O, Steinberg DM, Tamarin I, Zivelin A, Seligsohn U. Plasma

replacement therapy during labor is not mandatory for women with severe factor XI deficiency. Blood Coagul Fibrinol 16:37-41, 2005.

26


195. Goldberg Y, Meytes D, Shabtai E, Shinron O, Shainberg B, Seligsohn U, Berliner S. Monitoring oral anticoagulant therapy by telephone communication. Blood Coagul Fibrinol 16:227-230, 2005.

196. Fromovich-Amit Y, Zivelin A, Rosenberg N, Landau M, Rosa J-P, Seligsohn

U. Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation. Blood Coagul Fibrinol 16:369-374, 2005.

197. Rosenberg N, Hauschner H, Peretz H, Mor-Cohen R, Landau M, Shenkman

B, Kenet G, Coller BS, Awidi AA, Seligsohn U. A 13-bp deletion in IIb gene is a founder mutation that predominates in Palestinian-Arab patients with Glanzmann thrombasthenia. J Thromb Haemost 3:2764-2772, 2005.

198. Livnat T, Zivelin A, Martinowitz U, Salomon O, Seligsohn U. Prerequisites

for recombinant factor VIIa-induced thrombin generation in plasmas deficient in factors VIII, IX or XI. J Thromb Haemost 4:192-200, 2006.

199. Salomon O, Zivelin A, Livnat T, Seligsohn U. Inhibitors to factor XI in patients

with severe factor XI deficiency. Seminars in Hematol 43:S10-12, 2006. 200. Gadoth N, Figlin E, Chetrit A, Sela B-A, Seligsohn U. The neurology of

cobalamin deficiency in an elderly population in Israel. J Neurol 253:45-50, 2006.

201. Vysokovsky A, Rosenberg N, Dardik R, Seligsohn U, Inbal A. Effect of four

missense mutations in the factor XIII A-subunit gene on protein stability: studies with recombinant proteins. Blood Coagul Fibrinol 17:125-30, 2006.

202. Peretz H, Rosenberg N, Landau M, Usher S, Remington E, Mor-Cohen R,

French DL, Mitchell BW, Chandy M, Coller BS, Srivastava A, Seligsohn U. Molecular Diversity of Glanzmann Thrombasthenia in Southern India: New insights into mRNA splicing and structure-function correlations of IIb3 integrin. Human Mutat 27:359-369, 2006.

203. Seligsohn U, Ginsburg D. Deciphering the mystery of combined factor V

and factor VIII deficiency. J Thromb Haemost 4:927-931, 2006.

204. Peyvandi F, Kaufman RJ, Seligsohn U, Salomon O, Bolton-Maggs PHB, Spreafico M, Menegatti M, Palla R, Siboni S, Mannucci PM. Rare Bleeding disorders. Haemophilia 12:137-142, 2006.

205. Zivelin A, Mor-Cohen R, Kovalsky V, Kornbrot N, Conard J, Peyvandi F,

Kyrle PA, Bertina R, Peyvandi F, Emmerich J, Seligsohn U. Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24,000 years ago. Blood 107:4666-4668, 2006.

206. Salomon O, Steinberg DM, Seligsohn U. Variable bleeding manifestations

characterize different types of surgery in patients with severe factor XI

27


deficiency enabling parsimonious use of replacement therapy. Haemophilia 12:490-493, 2006.

207. Nelson EJR, Nair SC, Peretz H, Coller BS, Seligsohn U, Chandy M,

Srivastava A. Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients. J Thromb Haemost 4:1730-1737, 2006.

208. Shenkman B, Budde U, Angerhaus D, Lubetsky A, Savion N, Seligsohn U,

Varon D. ADAMTS-13 regulates platelet adhesion under flow. A new method for differentiation between inherited and acquired thrombotic thrombocytopenic purpura. Thromb Haemost. 96:160-166, 2006.

209. Mor-Cohen R, Zivelin A, Fromovich-Amit Y, Kovalski V, Rosenberg N,

Seligsohn U. Age estimates of ancestral mutations causing factor VII deficiency and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with ancient Jewish migrations. Blood Coagul Fibrinol 18:139-144, 2006.

210. Rosenberg N, Lalezari S, Landau M, Shenkman B, Seligsohn U, Izrali S.

Trp207Gly in platelet glycoprotein Ib is a novel mutation which disrupts the connection between the leucine-rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome. J Thromb Haemost 5:378-386, 2007.

211. Shalev V, Rogowski O, shimron O, Sheinberg B, Shapira I, Seligsohn U,

Berliner S, Misgav M. The interval between prothrombin time tests and the quality of oral anticoagulants treatment in patients with chronic atrial fibriliation. Thromb Res 120:201-206, 2007.

212. Seligsohn U. Factor XI in Haemostasis and thrombosis: Past, present and

future. Thromb Haemost. 98:84-89,2007.

213. Zucker M, Zivelin A, Landau M, Salomon O, Kenet G, Bauduer F, Samama M, Conard J, Denninger MH, Hani AS, Berruyer M, Feinstein D, Seligsohn U. Characterization of seven novel mutations causing factor XI deficiency. Haematological. 92(10):1375-1380, 2007.

214. Mor-Cohen R, Rosenberg N, Peretz H, Landau M, Coller BS, Awidi A,

Seligsohn U. Disulfide bond disruption by a β3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active αIIbβ3. Thromb Haemost. 98:1257-1265, 2007.

215. Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-

Linares A, Groop L, Saetta AA, Korkolopoulou P, Seligsohn U, Waliszewska A, Schirmer C, Ardlie K, Ramos A, Nemesh J, Arbeitman L, Goldstein D, Reich D, Hirschhorn JN. Discerning the ancestry of European Americans in genetic association studies. PLoS (Public Library of Sciences) Genetics. 4(1) e236, 9-17, January 2008.

28


216. Zucker M, Zivelin A, Teitel J, Seligsohn U. Induction of an inhibitor antibody

to factor XI in a patient with severe inherited factor XI deficiency by Rh immune globulin. Blood. 111:1306-1308, 2008.

217. Zadra G, Asselta R, Tenchini ML, Castaman G, Seligsohn U, Mannucci PM,

Duga S. Simultaneous genotyping of coagulation factor XI type II and type III mutations by multi real-time PCR in healthy Italian individuals and in FXI-deficient patients. Haemotologica. 93:715-721, 2008.

218. Salomon O, Steinberg DM, Koren-Morag N, Tanne D, Seligsohn U. Reduced

incidence of ischemic stroke in patients with severe factor XI deficiency. Blood 111:4113-4117, 2008.

219. Livnat T, Martinowitz U, Zivelin A, Seligsohn U. Effects of factor VIII inhibitor

bypassing activity (FEIBA), recombinant factor VIIa or both on thrombin generation in normal and haemophilia A plasma. Haemophilia, 14:782-786,2008

220. Mor-Cohen R, Rosenberg N, Landau M, Lahav J, Seligsohn U. Specific

cysteines in β3 are involved in disulfide bond exchange-dependent and-independent activation of αIIbβ3. J Biol Chem. 283:19235-19244, 2008.

221. Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan MU, Avci Z,

Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham EGD, Seligsohn U, Peyvandi F, Ginsburg D. Genotype-Phenotype correlation in combined deficiency of factor V and factor VIII. Blood. 111:5592-5600, 2008.

222. Seligsohn, U. Factor XI deficiency in humans. State of the Art. . J Thromb

Haemost, 7 (Suppl. 1):84-87, 2009. 223. Zucker M, Zivelin A, Landau M, Rosenberg N, Seligsohn U. Three residues at

the interface of factor XI monomers augment covalent dimerization of FXI. J Thromb Haemost. 7:970-975, 2009.

224. Pauzner R, Greinacher A, Selleng K, Althaus K, Shenkman B, Seligsohn U.

False positive tests for heparin induced thrombocytopenia in patients with antiphospholipid antibodies and systemic lupus erythematosus. J Thromb Haemost, 7:1070-1074, 2009.

225. Livnat T, Tamarin I, Mor Y, Winckler H, Horowitz Z, Korianski Y, Bar-Zakay B,

Seligsohn U, Salomon O. Recombinant activated factor VII and tranexamic acid are hemostatically effective during major surgery in factor XI deficient patients with an inhibitor antibodies. Thromb Haemost. 102:487-492, 2009.

226. Salomon O, Katz B-Z, Dardik R, Livnat T, Steinberg DM, Achiron R,

Seligsohn U. Plasma levels of microparticles at 24 weeks of gestation do not predict subsequent pregnancy complications. Fertility and Sterility, 92:682-687, 2009.

29


227. Dardik R, Livnat T, Seligsohn u. Variable effects of alpha v suppression on VEGFR-2 expression in endothelial cells of different vascular beds. Thromb Haemost. 102:975-982, 2009.

228. Fabian ID, Sachs D, Moisseiev J, Alhalel A, Grinbaum A, Seligsohn U,

Salomon O. Cataract Extraction without prophylactic treatment in patients with severe factor XI deficiency. Am J Ophthalmol. 148:920-924, 2009.

229. Rubin-Asher D, Zeilig G, Ratner A, Asher I, Zivelin A, Seligsohn U, Lubetsky

A. Risk factors for failure of heparin thromboprophylaxis in patients with acute traumatic spinal cord injury. Thromb Res. 125: 501-504, 2010.

230. Hauschner H, Landau M, Seligsohn U, Rosenberg N. A unique interaction

between αIIb and β3 in the head region is essential for outside-in signaling-related functions of αIIbβ3 integrin. Blood. 115(22):4542-4550, 2010.

231. Seligsohn U. Inherited bleeding disorders common in Jews. Harefuah (J Isr

Med Assoc) 149(5): 298-303, 2010. 232. Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J,

Seligsohn U, Carrier M, Salomon O, Greer IA. The association of factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: A systematic review and meta-analysis of prospective cohort studies. PLoS Medicine 7(6) e1000292:1-12, 2010.

233. Seligsohn U. Factor XI deficiency. Hematology Education 4:69-73, 2010. 234. Mansour W, Einav Y, Hauschner H, Koren A, Seligsohn U, Rosenberg N.

An Asn2Asp Glanzmann thrombasthenia-causing mutation in αIIb β-propeller blade-1 disrupts a calcium binding site in blade-6. J Thromb Haemost, 9:192-200, 2011.

235. Salomon O, Steinberg DM, Zucker M, Varon D, Zivelin A, Seligsohn U.

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis. Thromb Haemost. 105:269-273, 2011.

236. Zucker M, Rosenberg N, Peretz H, Green D, Bauduer F, Zivelin A, Seligsohn

U. Point mutations regardd as missense mutations cause splicing defects in the factor XI gene. J Thromb Haemost. 9:1977-1984,2011.

237. Hauschner H, Mor-Cohen R, Seligsohn U, Rosenberg N. A mutation in the

β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIbβ3 to an active state. J Thromb Haemost. 10:289-297, 2012.

238. Mor-Cohen R, Rosenberg N, Einav Y, Zelzion E, Landau M, Mansour W,

Averbukh Y, Seligsohn U. Unique disulfide bonds in the epidermal growth factor (EGF) domains of β3 affect the structure and function of αIIbβ3 and αvβ3

integrins in a different manner. J Biol Chem 287:8879-8891, 2012.

30


31

239. Seligsohn U. Treatment of inherited platelet disorders. Haemophilia. 18(Suppl. 4):161-165, 2012.

240. Nurden AT, Freson K, Seligsohn U. Inherited platelet disorders.

Haemophilia. 18(Suppl. 4):154-160, 2012. 241. Fiore M, Nurden AT, Nurden P, Seligsohn U. Clinical utility gene card for:

Glanzmann thrombasthenia. Eur J Hum Genet. 20(10):1102, 2012. 242. Peretz H, Salomon O, Mor-Cohen R, Usher S, Zucker M, Zivelin A, Seligsohn

U. Type I mutation in the F11 gene is a third ancestral mutation which causes factor XI deficiency in Ashkenazi Jews. J Thromb Haemost. In press.

Documents

URI SELIGSOHN, M - TAUProf. U. Seligsohn April 2013 URI SELIGSOHN, M.D PROFESSOR OF HEMATOLOGY CURRICULUM VITAE 6.2.1937 Born in Tel-Aviv, Israel 1954-1957 Military Service 1964-1991