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Serrated polypsColorectal carcinogenesis and clinical implicationsIJspeert, J.E.G.
Publication date2017Document VersionOther versionLicenseOther
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Citation for published version (APA):IJspeert, J. E. G. (2017). Serrated polyps: Colorectal carcinogenesis and clinical implications.
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507009-L-os-IJspeert507009-L-os-IJspeert507009-L-os-IJspeert507009-L-os-IJspeert Processed on: 12-12-2016Processed on: 12-12-2016Processed on: 12-12-2016Processed on: 12-12-2016
Joep IJspeert
UITNODIGING
Voor het bijwonen van deopenbare verdediging van het
proefschrift
SERRATED POLYPScolorectal carcinogenesis and
clinical implications
door
Joep IJspeert
op vrijdag 27 januari 2017om 14.00 uur
in de Agnietenkapel van deUniversiteit van Amsterdam,
Oudezijds Voorburgwal 229-231te Amsterdam
Paranimfen
Taco [email protected]
Joep IJspeert
Alexanderkade 1-II1018 CH Amsterdam
0621392201
S E R R AT E D P O LY P Scolorectal carcinogenesis and
clinical implications
SER
RA
TE
D P
OLY
PS colorectal carcinogenesis and clinical im
plications Joep IJspeert
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SERRATED POLYPScolorectal carcinogenesis and clinical implications
Joep IJspeert
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ISBN: 978-94-028-0452-2
Cover: Mathiole
Lay-out: Ilse Stronks, persoonlijkproefschrift.nl
Printed: Ipskamp Printing
The printing of this thesis was financially supported by: the Academic Medical Centre Amsterdam,
Stichting Wetenschap en Onderzoek Interne Geneeskunde OLVG, Nederlandse Vereniging voor
Gastroenterologie, Zambon Nederland B.V., Yakult Nederland B.V., Olympus Nederland B.V., Dr. Falk
Pharma Benelux B.V., ChipSoft, US Endoscopy, Norgine, PENTAX Nederland B.V.
Financial friends of this thesis: Jet Gerards, Peter IJspeert, Ron van der Heijden, Taco Zwart
Copyright © 2016 Joep Evert Godfried IJspeert. All rights are reserved. No part of this thesis may be
reproduced or transmitted in any form or by any means without the prior permission in writing of
the author
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SERRATED POLYPScolorectal carcinogenesis and clinical implications
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 27 januari 2017, te 14.00 uur
door
Joep Evert Godfried IJspeert
geboren te Groningen
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Promotiecommissie
Promotores prof. dr. E. Dekker Universiteit van Amsterdam
prof. dr. P. Fockens Universiteit van Amsterdam
Overige leden dr. F. Balaguer Prunés University of Barcelona
prof. dr. W.A. Bemelman Universiteit van Amsterdam
prof. dr. J.C.H. Hardwick Universiteit Leiden
prof. dr. A.A.M. Masclee Universiteit Maastricht
prof. dr. J.P. Medema Universiteit van Amsterdam
prof. dr. C.J.M. van Noesel Universiteit van Amsterdam
Faculteit der Geneeskunde
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TAbLE Of cOnTEnTS
General introduction and outline of this thesis 9
Chapter 1 Serrated neoplasia—role in colorectal carcinogenesis and clinical
implications
Nature Reviews Gastroenterology and Hepatology 2015
15
Chapter 2 Clinical, histological and molecular features of sessile serrated polyps
caught in the act of malignant progression
35
Chapter 3 Detection rate of serrated polyps and serrated polyposis syndrome in
colorectal cancer screening cohorts; A European overview
Gut 2016
51
Chapter 4 Prevalence, distribution and risk of sessile serrated adenomas/polyps in
a centre with a high adenoma detection rate and experienced
gastrointestinal pathologists
Endoscopy 2016
67
Chapter 5 CT-colonography versus colonoscopy for detection of high-risk sessile
serrated polyps
American Journal of Gastroenterology 2016
83
Chapter 6 Smoking status informs about the risk of advanced serrated polyps in a
screening population
Endoscopy International Open 2015
97
Chapter 7 The proximal serrated polyp detection rate is an easy to measure proxy
for the detection rate of clinically relevant serrated polyps
Gastrointestinal Endoscopy 2015
111
Chapter 8 Optical diagnosis of sessile serrated polyps: bottleneck for the optical
diagnosis paradigm?
Journal of Clinical Gastroenterology 2016
125
Chapter 9 Development and validation of the WASP-classification system for optical
diagnosis of adenomas, hyperplastic polyps and sessile serrated polyps
Gut 2015
141
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Chapter 10 Implementation of an e-learning improves the consistency in the
histopathological diagnosis of sessile serrated lesions within a
nationwide population screening program
Submitted
157
Chapter 11 Serrated polyposis syndrome; a silent killer when undetected
Endoscopy 2015
171
Chapter 12 Clinical risk factors of colorectal cancer in patients with serrated
polyposis syndrome: a multicentre cohort analysis
Gut 2015
177
Chapter 13 Thesis summary and future prospects 193
Appendix Nederlandse samenvatting voor niet-ingewijden
Contributing authors
List of publications
PhD portfolio
About the author
Dankwoord
Stellingen
205
213
217
220
223
227