Embed Size (px)
DESCRIPTION
VARIATION OF LEUKOCYTES IN DISEASE. Neutrophilia PMN> Neutropenia mild PMN
Citation preview
VARIATION OF LEUKOCYTES IN DISEASE
Neutrophilia PMN> Neutropenia mild PMN<1000-1500 moderate PMN< 500-1000 SEVER PMN< 500
EOSINOPHILA EOS> 700 OR > 200
BASOPHILIA BAS>150 OR >100
MONOCYTOSIS MON>950
LYMPHOCYTOSIS LYM> 4000LYMPHOCYTOPENIA LYM< 1500
DR F. MOKARIAN
LEUKOCYTOSIS>10000LEKOPENIA<4000
VARIATION OF LEUKOCYTES IN DISEASE
CAUSES OF NEUTROPHILIA
Acute infection Other inflammation : burn operation MI gout CVD HYPERSENCITYVITY Intoxication :Metabolic: DKA PERICARDITIS IN UREMIA ECLAMCIA Poisoning by chemical and drugsAcute hemorrhageAcute hemolysisMalignant neuplasmsPhysiologic neutropeniaMPDOthers: CIN HN Corton G CSF
DR F. MOKARIAN
VARIATION OF LEUKOCYTES IN DISEASE
CAUSES OF NEUTROPENIAPseudoneutropeniaAcquired neutDrugs And ChemicalsNeutritional Immune NeutFelty synNeut. Associated With Complement ActivationCongenital Or Chronic Neut
DR F. MOKARIAN
VARIATION OF LEUKOCYTES IN DISEASE
CAUSES OF :BASOPHILIA BASOPHILOPENIA MYXEDEMA HYPERTHYROIDISMULCERATIVE COLITIS OVULATIONCHRONIC SINISITIS PREGNANCYSMALLPPOX STRESSVARICELLANEPHROSISIDALUNG CACER CML PV MF HD HEMOLYTIC ANMIA
DR F. MOKARIAN
CAUSES OF EOSINOPHILAIAllergic disorder Skin disParasitic Infection Loeffler’s Syn PIE syn Tropical EosinophiliaCertain Infection Malignant disease of any type ( metastasis or necrosis )Hematological dis : HD CML PV PA SPLENECTOMY IRRADIATION INHERITED IDIOPATIC OTHERS: RA PAN SARCO POISEN
DR F. MOKARIAN
VARIATION OF LEUKOCYTES IN DISEASE
CAUSES OF MONOCYTOSIS •CERTAIN BACTERIAL INFECTION
TB SBE SYPHILIS BRUCELOSIS •DURING RECOVERY FROM ACUTE INFECTION AND FROM AGRANULOCYTOSIS •Protozoal And Ricketsial infextion Malaria typhose rocky moun. Spotted fever – kala azar •Hematologic malignancy : NHL HD AML MPD MM •Malignancy : ovary stomach breast•CVD : SLE RA •Granulomatous dis :Sarco Ulcerative colitis Regional enteritis •Tetracholoroetan poisening •Chronic high dose steroid therapy
DR F. MOKARIAN
VARIATION OF LEUKOCYTES IN
DISEASE
CAUSES OF LYMPHOCYTOSIS•Certain Acute Infection Pertosis - inf mono – hepatitis – acute infec. lymphosytosis •Certain chronic infection Brucellosis TB syphilis •Hematologic disorder ALL CLL HCL NHL NHL PCD•Relative lymphocytosis :
• exanthem inf . After the intial stage : mumps rubella• during convalesence from acute infection • thyrotoxicosis • most condition that associated with neutropenia
VARIATION OF LEUKOCYTES IN DISEASE
Causses of lymphocytopenia Acute infection Chronic Illness : CHF Pneumonia Pancreatic necrosis Active TB Uremia NHL HD CVD : SLE AID”SMALARIA STEROID IRRADIATION D
R F. MOKARIAN
VARIATION OF LEUKOCYTES IN DISEASE
Diseases most commonly giveng rise to a leukomoid blood picture INFECTION PNEUMONIA MENINGITIS DIFTERIA TB MYLOID LEUKEMIA VARICELLA IM INFEC. LYM , LYMPHOID LEUK
Intoxication : eclamsia , sever burns, mercury Malignant dis : bone met MM HD myelofibrosis Sever hemorrhage Acute hemolysis
DR F. MOKARIAN
VARIATION OF LEUKOCYTES IN DISEASE
LEKOMOID RECTION :• MYLOID LEUKOMOID REACTION LITTLE IMATURITY WITH LEFT SHIFT ( SIMULATE CML) TUMOR & INFECTION SIMULATING AML TB ALCOHOLISM MEGALOBLASTIC ANEMIA • LYMPHOID LEUKOMOID REACTION MATURE CELL PERTOSIS DERMATITIS HERPETIFORM VARICCELLA MELLANOMA BREAST CA TB MILLIARY
IMMATURE CELL IM HEPATITIS TB CM SYPHILIS
DR F. MOKARIAN
