vet.osu.edu/biosciences

BIOS    

The Department of Veterinary Biosciences is intentional about developing collaborations and partnerships that enhance our impact through the discovery, commercialization, and application of research and scholarship. Some key partners, their mission, and our interactions include: Center for Clinical & Translational Science (CCTS) is a “collaboration dedicated to turning the scientific discoveries of today into life-changing disease prevention strategies and the health diagnostics and treatments of tomorrow.” Funded by a multi-year NIH Clinical and Translational Science Award, the CCTS leverages expertise from across the University and partners with community health and education agencies, businesses, and regional institutional networks to support biomedical researchers. VBS Leadership Roles: Cheryl London – Program Director, Translational Therapeutics. VBS Members: Brad Bolon, Krista La Perle Comprehensive Cancer Center (CCC) is one of only 41 designated comprehensive cancer centers in the nation. “The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis and therapies – providing tomorrow’s standard of care today.” VBS Leadership Roles: Pat Green – Program Leadership; Krista La Perle – Director, Comparative Pathology & Mouse Phenotyping Shared Resource; Cheryl London – Director Veterinary Clinical Trials Office and Biospecimen Repository; VBS Members: Kathy Boris-Lawrie, Jim DeWille, Pat Green, Cheryl London, Larry Mathes, Stefan Niewiesk, Tracey Papenfuss, Tom Rosol, Li Wu Public Health Preparedness for Infectious Disease (PHPID) is a collection of researchers working to “improve global health and wellness by reducing the threats of infectious diseases through innovative interdisciplinary research, education and outreach.” VBS Faculty Hires: Jianrong Li, Li Wu; VBS Members: Kathy Boris-Lawrie, Prosper Boyaka, Ian Davis, Pat Green, Jianrong Li, Stefan Niewiesk, Mike Oglesbee, Tracey Papenfuss, Yasuko Rikihisa, Li Wu Center for Microbial Interface Biology (CMIB) is a multidisciplinary research center focused on microbe-host interactions that “facilitates synergistic interactions among investigators in the clinical and basic sciences from across the campus to promote and coordinate interdisciplinary research in the fields of infectious diseases and microbial pathogenesis.” VBS Members: Kathy Boris-Lawrie, Prosper Boyaka, Ian Davis, Pat Green, Jianrong Li, Stefan Niewiesk, Tracey Papenfuss, Yasuko Rikihisa, Li Wu

Strategic University Partnerships Drive Excellence

 

 

Logic will get you from A to B. Imagination will take you everywhere.

- Albert Einstein

 

The  National  Academy  of  Inventors  (NAI)  awarded  the  rank  of  Fellow  to  Dr.  Yasuko  Rikihisa,  Distinguished  University  Professor  of  Veterinary  Biosciences.  Only  researchers  who  “have  demonstrated  a  prolific  spirit  of  innovation  in  creating  or  facilitating  outstanding  inventions  and  innovations  that  have  made  a  tangible  impact  on  quality  of  life,  economic  development  and  the  welfare  of  society”  are  elected  to  the  rank  of  NAI  Fellow.  Dr.  Rikihisa  is  one  of  two  OSU  faculty  awarded  this  rank  this  year  and  joins  two  previous  OSU  Fellows.      

Dr.  Rikihisa’s  research  focuses  on  the  causative  agents  for  tick-­‐borne  disease  within  the  Ehrlichia,  Anaplasma,  Neoehrlichia,  Neorickettsia,  and  Aegyptianella  genera;  spanning  organisms  and  susceptible  host  species  including  deer,  mouse,  rat,  dog,  horse,  cat,  birds,  and  humans.  Her  work  has  supported  a  growing  patent  portfolio  (11  issued  US  and  3  issued  international  patents).  The  commercial  significance  of  her  research  and  patents  is  demonstrated  through  active  licenses  of  her  patent  portfolio  to  commercially  focused  companies.  Diagnostic  tests  for  tick-­‐borne  diseases  in  companion  animals  comprise  current  commercial  products  based  on  her  patents.  These  tests,  offered  in  the  domestic  and  international  marketplace,  have  become  the  highest  volume  diagnostic  tests  used  throughout  the  world  in  veterinary  medicine.  Additionally,  vaccine  products  from  Dr.  Rikihisa’s  patents  are  in  commercial  development  at  this  time.        

Commercialization  revenue  stemming  from  licenses  to  her  patents  places  the  College  of  Veterinary  Medicine  as  the  leading  revenue  generating  college  at  Ohio  State  for  6  straight  years.    

Dr. Yasuko Rikihisa 2014 National Academy of Inventors Fellow

 

The  mission  of  the  National  Academy  of  Inventors  is  to  honor  academic  invention;  recognize  and  encourage  inventors;  enhance  the  visibility  of  university  and  non-­‐profit  research  institute  technology  and  innovation;  encourage  the  disclosure  of  intellectual  property;  educate  and  mentor  innovative  students;  and  translate  the  inventions  of  its  members  to  benefit  society.  

Innovation: a departmental value

 

 

 

Dr.  Mike  Oglesbee  has  been  named  as  one  of  six  2014  inductees  in  the  American  Association  for  the  Advancement  of  Science  (AAAS).  The  AAAS,  the  world’s  largest  federation  of  scientists,  works  to  advance  science,  engineering,  and  innovation,  throughout  the  world  for  the  benefit  of  all  people.  Members  of  the  AAAS  are  elevated  to  the  rank  of  Fellow  for  their  efforts  in  advancing  science  or  its  applications.  Since  2004,  eight  faculty  have  been  recognized  as  AAAS  Fellows  during  their  appointment  in  the  college,  all  within  Veterinary  Biosciences.      

Dr.  Oglesbee’s  recognition  was  based  upon  distinguished  contributions  to  our  understanding  of  how  cellular  heat  shock  proteins  determine  the  outcome  of  virus  infection.  Studies  showed  that  these  cellular  proteins  associate  with  the  virus’  genetic  information  to  enhance  immune  responses  to  the  virus,  resulting  in  clearance  of  infection  from  organs  such  as  brain.  Findings  suggest  a  protective  role  for  fever,  a  potent  stimulus  for  the  induction  of  heat  shock  proteins,  and  the  mechanism  has  potential  relevance  to  a  broad  number  of  viruses.        

A tradition of excellence in discovery and scholarship  

   

Dr.  Oglesbee’s  laboratory  has  demonstrated  that  heat  shock  proteins  associate  with  and  bind  to  the  virus’  genetic  material.  Viral  nucleocapsid  is  pictured  above  schematically  (blue  and  red)  and  by  electron  microscopy  (in  the  background).

Dr. Michael Oglesbee - 2014 Class of AAAS Fellows

Research is creating new knowledge. - Neil Armstrong

AAAS Fellows College of Veterinary Medicine

2004 Lawrence Mathes 2004 Thomas Rosol

2005 Michael Lairmore 2005 Yasuko Rikihisa 2006 Charles Capen 2006 Patrick Green

2007 Kathy Boris-Lawrie 2014 Michael Oglesbee

 

 

In the news Dr. Tom Rosol awarded fellow status in IATP The role of the International Academy of Toxicologic Pathology (IATP) is to: • Establish standards of excellence in education, training and

experience essential for competency in toxicologic pathology. • Support the education of scientists and other members of society

with evolving, relevant knowledge important to the health of society. • Advise governmental policy leaders on issues of toxicology and pathology. • Develop expert opinions on issues relevant to product safety.

IATP promotes these educational standards by recognizing and accrediting toxicologic pathologists through a peer-review application process to ensure the competence and experience of professional practitioners whose work affects the public welfare throughout the world.

Dr. Ian Davis featured in Columbus Dispatch article Flu vaccines fighting a moving target

In an interview regarding strategies to fight influenza, Dr. Davis describes the challenge of developing a universal flu vaccine due to the variation seen in the viral coat proteins as well as highlight current work in his laboratory directed to studying medical treatments for those infected with the flu virus. For the full story, visit http://www.dispatch.com/content/stories/local/2014/11/30/your-health/1-fighting-a-moving-target.html

Ongoing work in the Davis lab focuses on: • The pathogenesis of acute viral diseases of the lung • Modulation of lung fluid balance by viral pathogens • Effects of viral infection on respiratory epithelial cell function and signaling • Effects of viral infection on pulmonary mechanics • The role of metabokines in innate immune responses to pulmonary viral infection

Theories without data are like daydreams. - Jonathan Rottenberg

 

 

Spotlights: Discovery and Scholarship

My model … is The Beatles. They were four guys who kept each other's kind of negative tendencies in check. They balanced each other and the total was greater than the sum of the parts. Great things in business are never done by one person, they're done by a team of people. - Steve Jobs

New  grants!      

• Celecoxib  derivative:  Host  cell-­‐directed  inhibitors  of  intracellular  pathogens.  PI:  John  Gunn,  Co-­‐I:  Larry  Schlesinger,  Prosper  Boyaka.  University  of  North  Carolina-­‐Chapel  Hill    

• ATCC  adaptation  of  PEDv  and  sequencing.  PI:  Jianrong  Li.  4-­‐Stear  Animal  Health  

• Role  of  PRMT5  in  HTLV-­‐1  transformation  and  disease.  PI:  Patrick  Green.  National  Institute  of  Allergy  and  Infectious  Disease,  R21  

Publication  spotlight:  A  model  of  Sjögren’s  syndrome    

Sjörgen’s  syndrome  is    common  autoimmune  disorder  of  people  that  affects  the  salivary  and  lacrimal  glands.  Dr.  Brad  Bolon  was  part  of  an  investigative  team  that  developed  a  humanized  mouse  model  of  Sjörgen’s  syndrome  to  study  the  T  cell  pathogenesis  of  the  disease  as  well  as  test  experimental  therapeutics  for  potential  use  against  the  disease  in  people.    

 

Clinical  Immunology          http://www.ncbi.nlm.nih.gov/pubmed/25451161  

Research  Spotlight:    Mechanisms Underlying HIV-1 Restriction in Myeloid Cells    

 

Dr.  Li  Wu  was  invited  to  present  at  the  Ohio  Virology  Association,  on  the  current  work  of  his  laboratory.  Dr.  Wu’s  research  focuses  on  the  interaction  between  dendritic  cells  and  HIV.  His  research  has  found  that  dendritic  cells  disseminate  HIV  and  are  critical  for  viral  transmission  but  also  restrict  HIV  and  help  enhance  HIV’s  evasion  of  the  host  immune  response.    Recent  studies  in  his  lab  have  focused  on  the  role  of  SAMHD1,  a  dNTPase  that  is  highly  expressed  in  myeloid  lineage  cells  and  CD4  T  cells  and  restricts  HIV-­‐1  infection  in  non-­‐cycling  myeloid  cells.  

 

 

Sharing new knowledge Young NA, Wu LC, Bruss M, Kaffenberger BH, Hampton J, Bolon B, Jarjour WN. A chimeric human-mouse model of Sjögren's syndrome. Clin Immunol http://www.ncbi.nlm.nih.gov/pubmed/25451161 Morrison JP, Sharma AK, Rao D, Pardo ID, Garman RH, Kaufmann W, Bolon B. STP 2014 Continuing Education Course #3: Fundamentals of Translational Neuroscience in Toxicologic Pathology: Optimizing the Value of Animal Data for Human Risk Assessment. Toxicol Pathol http://www.ncbi.nlm.nih.gov/pubmed/25398755 Dissinger N, Shkriabai N, Hess S, Al-Saleem J, Kvaratskhelia M, Green PL. Identification and Characterization of HTLV-1 HBZ Post-Translational Modifications. PLoS One http://www.ncbi.nlm.nih.gov/pubmed/25389759 Muir WW, Del Rio CL, Ueyama Y, Youngblood BL, George RS, Rausch CW, Lau BS, Hamlin RL. Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs. Crit Care Res Pract http://www.ncbi.nlm.nih.gov/pubmed/25405028 Moore SA, Oglesbee MJ. Spinal Cord Ependymal Responses to Naturally Occurring Traumatic Spinal Cord Injury in Dogs. Vet Pathol http://www.ncbi.nlm.nih.gov/pubmed/25445323 Hinds CA, Niehaus AJ, Premanandan C, Rajala-Schultz PJ, Rings DM, Lakritz J. Characterization of the contributions of Hp-MMP 9 to the serum acute phase protein response of lipopolysaccharide challenged calves. BMC Vet Res http://www.ncbi.nlm.nih.gov/pubmed/25358728 Cheng Z, Lin M, Rikihisa Y. Ehrlichia chaffeensis Proliferation Begins with NtrY/NtrX and PutA/GlnA Upregulation and CtrA Degradation Induced by Proline and Glutamine Uptake. MBio http://www.ncbi.nlm.nih.gov/pubmed/25425236 Harasawa R, Fujita H, Kadosaka T, Ando S, Rikihisa Y. Proposal for 'Candidatus Mycoplasma haemomuris subsp. musculi' in mice, and 'Candidatus Mycoplasma haemomuris subsp. ratti' in rats. Int J Syst Evol Microbiol http://www.ncbi.nlm.nih.gov/pubmed/25406232 Elmore SA, Cora MC, Gruebbel MM, Hayes SA, Hoane JS, Koizumi H, Peters R, Rosol TJ, Singh BP, Szabo KA. Proceedings of the 2014 National Toxicology Program Satellite Symposium. Toxicol Pathol http://www.ncbi.nlm.nih.gov/pubmed/25385331 Ishihara A, Weisbrode SE, Bertone AL. Autologous implantation of BMP2-expressing dermal fibroblasts to improve bone mineral density and architecture in rabbit long bones. J Orthop Res http://www.ncbi.nlm.nih.gov/pubmed/25418909

The difficulty lies not so much in developing new ideas as in escaping from old ones. - John Maynard Keynes

 

 

Ohio State at ACVP & ASVCP 2014

If your actions inspire others to dream more, learn more, do more and become more, you are a leader.

- John Quincy Adams

 The  joint  annual  meeting  of  ACVP  and  ASVCP  provides  a  great  venue  for  faculty,  residents,  &  students  to  present  ongoing  and  new  scholarship  as  well  as  provide  national  and  international  representation  to  advance  the  profession.  Additionally,  Ohio  State  continues  to  host  an  Alumni  Reception  (this  year  held  in  the  Pulse  Loft  with  view  looking  up  pictured)  and  engages  in  many  informal  discussions  throughout  the  meeting  to  build  connections  with  colleagues.      

Roles  in  ACVP  /  ASVCP  • Immediate  Past  President,  ACVP:  Maxey  Wellman  • ACVP  Councilor:  Krista  La  Perle  • ASVCP  Young  Investigator  Award  Judge:  Judy  Radin  • ACVP  Young  Investigator  Award  Judge:  Brad  Bolon  • ACVP  Certifying  Exam  Board  and  ACVP  Budget  Summit  Advisory  Meeting:  Paul  Stromberg    

Student  presentations  and  awards  • ASVCP  Travel  Award:  Nina  Zitzer  • Alimentary  toxic  aleukia-­‐like  syndrome  in  3  horses  with  T-­‐2  mycotoxicosis.  Zitzer  NC,  Radin  

MJ,  Wellman  ML,  Liepman  R,  Burns  T,  Lanigan  LG,  Russell  DS  • Glomerular  lipidosis  in  dogs:  a  lesion  on  the  spectrum  of  focal  segmental  glomerulosclerosis.  

Kohnken  R,  Cianciolo  R  • WNT  signaling  in  prostate  cancer  bone  metastasis.  Simmons  J,  Dirksen  W,  Rosol  T    

Faculty  presentations  • Vasoactive  eicosanoids  in  greyhound  compared  to  non-­‐greyhound  dogs.  Radin  MJ,  Tucker  K,  

Rogers  LK,  Iazbik  MC,  Hoepf  T,  Couto  CG,  Kellogg  C.  • Recent  cases  of  idiopathic  cutaneous  and  renal  glomerular  vasculopathy  in  dogs  in  the  United  

Kingdom.  Hawkins  IK,  Walker  D,  Holm  L,  Cianciolo  R  • Specialty  services  for  the  evaluation  of  renal  biopsies.  Cianciolo,  R  • The  effect  of  respiratory  syncytial  virus  infection  on  eosinophil  levels  in  the  lung.  Green  G,  

Petroff  N,  Huey  D,  Heinonen  S,  Mejias  A,  La  Perle  K,  Niewiesk  S    

Programming  • Renal  Pathology  –  Best  Practices,  post-­‐meeting  workshop.  Chair:  Cianciolo,  R  • Standard  setting  for  diagnostic  flow  cytometry  and  antigen  receptor  PCR,  planning  workshop.  

Co-­‐chairs:  Bienzle  D,  Burkhard  MJ  

 

 

 

 

Disease may be defined as ‘A change produced in living things in consequence of which they are no longer in harmony with their environment’. – William Thomas Councilman

Celebrating New Alumni Diplomates!

 

Have something to contribute to BIOS Do you have an interesting update? Do you know of someone we should highlight?

Famke  Aeffner  DVM,  PhD,  DACVP  Anatomic  Pathology  

Lisa  Lanigan  DVM,  PhD,  DACVP  Anatomic  Pathology  

Kelly  Santangelo  DVM,  PhD,  DACVP  Clinical  Pathology  

 2014  Presenters  

 

Sharon  Dial  (April)  Melinda  Camus  (May)  Deanna  Schaefer  (June)  

Norm  Lowes  (July)  Robin  Allison  (August)  

Mark  Johnson  (September)  Dorothee  Bienzle  (October)  Ernst  Leidinger  (November)  Maxey  Wellman  (December)  

ASVCP  Online  Cytology  Rounds    

On  April  24,  2014,  92  people  from  8  different  countries  logged  on  to  their  computers  to  participate  in  the  first  official  ASVCP  online  cytology  rounds.      

Online  rounds  are  scheduled  monthly  with  a  different  presenter  each  time.  The  rounds,  organized  by  Dr.  Sharon  Dial,  are  formatted  as  an  informal  discussion  of  cases  that  range  from  classic  examples  of  disease  processes  to  conundrums  faced  by    pathologist  on  a  daily  basis.    

Pictured  at  left:  Drs.  Maxey  Wellman  and  Nicole  Kohart  demonstrate  cytology  findings  for  December’  ASVCP  Online  Rounds.