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VIAȚA ȘI MIRACOLUL KINETOCORILOR SINTEZĂ DIN SANTAGUIDA S., MUSACCHIO A. (2009) THE LIFE AND MIRACLES OF KINETOCHORES.THE EMBO JOURNAL.28:2511–2531. ZAMFIR MARIA-ANCA

Viața Și Miracolul Kinetocorilor

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Viaa i miracolul KINETOCORILOR

Viaa i miracolul KINETOCORILORSintez din Santaguida S.,Musacchio a. (2009) The life and miracles of kinetochores.The EMBO Journal.28:25112531.Zamfir maria-anca

Prezentare general a funciei i organizrii KINETOCORILOR Kinetocor de la S. Cerevisiae: centromerul de 125 bp subdivizat n regiunile CDEI, CDEII, CDEIII

Cse4: ADN centromeric de aproximativ 125 bp mpachetat n stadiul de nucleozom

Localizarea proteinelor kinetocorului de-a lungul axului complexului kinetocor-microtubul la S.cerevisiae n metafaz i anafaza trzie

Organizarea centromerilor regionali i kinetocorilor: domeniul central al centromerului de la S.pombe conine 2 imr (innermost repeat) i un miez (core); comparaie S. Pombe i om

Kinetocori adiaceni obinui dintr-o celul aflat n metafaz prin ngheare rapid i substituire prin ngheare (McEwen i colab., 1998)

Kinetocor de la metazoare

D. melanogaster: localizarea proteinelor kinetocorului de-a lungul axului complexului kinetocor-microtubul (n metafaz)

Biorientare: ataare eronatSpecificarea epigenetic a centromerilor

Specificarea epigenetic a cromatinei centromerice

Ataarea kinetocorului de microtubul

Ataarea kinetocorului de microtubul BibliografieAllshire RC, Karpen GH (2008) Epigenetic regulation of centromeric chromatin: old dogs, new tricks? Nat Rev Genet 9: 923937.Black BE, Bassett EA (2008) The histone variant CENP-A and centromere specification. Curr Opin Cell Biol 20: 91100.Black BE, Brock MA, Bedard S, Woods VL, Cleveland DW (2007) An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci USA 104: 50085013.Cheeseman IM, Hori T, Fukagawa T, Desai A (2008) KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol Biol Cell 19: 587594.Cimini D, Moree B, Canman JC, Salmon ED (2003) Merotelickinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. J Cell Sci 116: 42134225.Cleveland DW, Mao Y, Sullivan KF (2003) Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112: 407421.Davis TN, Wordeman L (2007) Rings, bracelets, sleeves, and chevrons: new structures of kinetochore proteins. Trends Cell Biol 17: 377382.Kelly A, Funabiki H (2009) Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr Opin Cell Biol 21: 5158.Lampson MA, Renduchitala K, Khodjakov A, Kapoor TM (2004) Correcting improper chromosome-spindle attachments during cell division. Nat Cell Biol 6: 232237.Li X, Nicklas RB (1995) Mitotic forces control a cell-cycle checkpoint. Nature 373: 630632.Mandelkow EM, Mandelkow E, Milligan RA (1991) Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study. J Cell Biol 114: 977991.McAinsh AD, Tytell JD, Sorger PK (2003) Structure, function, and regulation of budding yeast kinetochores. Annu Rev Cell Dev Biol 19: 519539.

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