17
Important information: All information regarding limitation of liability and potential conflicts of interest can be found at the end of the report Redeye, Mäster Samuelsgatan 42, 10tr, Box 7141, 103 87 Stockholm. Tel. +46 8-545 013 30, E-post: [email protected] Update Equity Research 26 March 2019 KEY STATS Ticker VITR.ST Market Mid cap Share Price (SEK) 205.0 Market Cap (MSEK) 22253 Net Debt 19E (MSEK) -787 Free Float 58 % Avg. daily volume (‘000) 0 BEAR BASE BULL 100.0 160.0 200.0 KEY FINANCIALS (SEKm) 2017 2018 2019E 2020E 2021E 2022E Net sales 1046 1151 1418 1604 1762 1929 EBITDA 408 479 626 717 851 934 EBIT 341 394 512 587 716 797 EPS (adj.) 2.4 2.9 3.7 4.2 5.2 5.8 EV/Sales 12.6 13.5 15.2 13.2 11.8 10.6 EV/EBITDA 32.3 32.4 34.3 29.6 24.5 21.8 EV/EBIT 38.6 39.4 42.0 36.1 29.1 25.6 P/E 51.3 51.5 55.4 48.3 39.2 35.2 ANALYSTS Arvid Necander [email protected] Mathias Spinnars [email protected] 10 8 9 8,5 5 0 50 100 150 200 250 OMXS 30 Vitrolife Illuminated Path to Growth A Strong End to 2018 Sales amounted to SEK 320 million in Q4´18, corresponding to a growth of 12% in local currency. In the whole year of 2018, media sales grew by about 6% in local currency, which indicates that the weak performance in Q1’18 was of temporary nature and that Vitrolife has maintained its market share. The gross margin came in at 67% (64%) in Q4 and the EBITDA reached an impressive SEK 135 million, corresponding to an EBITDA margin of 42% (38%). The net margin was 27% (25%) during the quarter. With two consecutive quarters of strong growth and profitability, we see that the worries following the somewhat sluggish development in H1’18 are blown away. Going forward, we see that strong growth opportunities still remain across the business units. High Growth Potential in Product Portfolio, But Market Wants More Having included the sales from the new genomics business unit in our estimates and reviewed the IVF market landscape, we unmask a high growth potential. We forecast a gradual ramp up of sales in genomics in 2019, reaching full effect in the last quarter of the year. In total, we forecast sales of SEK 143 million in the business unit in 2019, corresponding to about 10% of net sales. Although our forecast expects a strong contribution from genomics in 2019 and 2020, we believe that expectations are too high. Further, we argue that time-lapse will see decreasing sales growth in Europe, where the company has reached a high penetration for time-lapse systems. While we believe that some of the impact will be offset by strong performance in the USA, we expect that broader adaption is further away in China, making it challenging for the company to deliver the growth required to support the current valuation. Strong Momentum for VITR.ST - Our Model Indicates No Upside An active news flow, filled with significant catalysts for the share, has given the Vitrolife share strong momentum in the last 12 months. We argue that the share currently is trading beyond its intrinsic value and reflects overly optimistic expectations for growth. Our model gives a fair value (base case) of SEK 160 (110) per share, indicating no upside at current levels. Our bull and bear case are SEK 200 and 100 per share, respectively. Vitrolife Sector: Life Science REDEYE RATING VITR.ST VERSUS OMXS30 FAIR VALUE RANGE Financial Strength Profitability Profit Outlook Management Ownership

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Page 1: Vitrolife - Amazon S3...Mar 26, 2019  · of innovation in IVF and foresee increased usage as genetic mapping continues to develop. The continued innovation within PGT is also expected

Important information: All information regarding limitation of liability and potential conflicts of interest can be found at the end of the report Redeye, Mäster Samuelsgatan 42, 10tr, Box 7141, 103 87 Stockholm. Tel. +46 8-545 013 30, E-post: [email protected]

Update

Equity Research 26 March 2019

KEY STATS

Ticker VITR.ST Market Mid cap

Share Price (SEK) 205.0 Market Cap (MSEK) 22253 Net Debt 19E (MSEK) -787 Free Float 58 %

Avg. daily volume (‘000) 0

BEAR BASE BULL 100.0

160.0

200.0

KEY FINANCIALS (SEKm)

2017 2018 2019E 2020E 2021E 2022E Net sales 1046 1151 1418 1604 1762 1929 EBITDA 408 479 626 717 851 934 EBIT 341 394 512 587 716 797

EPS (adj.)

2017 2018 2019E 2020E 2021E 2022E EPS (adj.) 2.4 2.9 3.7 4.2 5.2 5.8 EV/Sales 12.6 13.5 15.2 13.2 11.8 10.6 EV/EBITDA 32.3 32.4 34.3 29.6 24.5 21.8 EV/EBIT 38.6 39.4 42.0 36.1 29.1 25.6 P/E 51.3 51.5 55.4 48.3 39.2 35.2

ANALYSTS

Arvid Necander [email protected] Mathias Spinnars [email protected]

108

9 8,5

5

0

50

100

150

200

250

OMXS 30 Vitrolife

Illuminated Path to Growth

A Strong End to 2018

Sales amounted to SEK 320 million in Q4´18, corresponding to a growth of 12% in local

currency. In the whole year of 2018, media sales grew by about 6% in local currency, which

indicates that the weak performance in Q1’18 was of temporary nature and that Vitrolife has

maintained its market share. The gross margin came in at 67% (64%) in Q4 and the EBITDA

reached an impressive SEK 135 million, corresponding to an EBITDA margin of 42% (38%).

The net margin was 27% (25%) during the quarter.

With two consecutive quarters of strong growth and profitability, we see that the worries

following the somewhat sluggish development in H1’18 are blown away. Going forward, we

see that strong growth opportunities still remain across the business units.

High Growth Potential in Product Portfolio, But Market Wants More

Having included the sales from the new genomics business unit in our estimates and

reviewed the IVF market landscape, we unmask a high growth potential. We forecast a

gradual ramp up of sales in genomics in 2019, reaching full effect in the last quarter of the

year. In total, we forecast sales of SEK 143 million in the business unit in 2019, corresponding

to about 10% of net sales.

Although our forecast expects a strong contribution from genomics in 2019 and 2020, we

believe that expectations are too high. Further, we argue that time-lapse will see decreasing

sales growth in Europe, where the company has reached a high penetration for time-lapse

systems. While we believe that some of the impact will be offset by strong performance in

the USA, we expect that broader adaption is further away in China, making it challenging for

the company to deliver the growth required to support the current valuation.

Strong Momentum for VITR.ST - Our Model Indicates No Upside

An active news flow, filled with significant catalysts for the share, has given the Vitrolife share

strong momentum in the last 12 months. We argue that the share currently is trading beyond

its intrinsic value and reflects overly optimistic expectations for growth. Our model gives a

fair value (base case) of SEK 160 (110) per share, indicating no upside at current levels. Our

bull and bear case are SEK 200 and 100 per share, respectively.

Vitrolife Sector: Life Science

REDEYE RATING

VITR.ST VERSUS OMXS30

FAIR VALUE RANGE

Finan

cial

Stren

gth

Profi

tabilit

y

Profi

t Outl

ook

Mana

geme

nt Ow

nersh

ip

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REDEYE Equity Research Vitrolife 26 March 2019

2

New Business Unit - Genomics In the Q4 report, Vitrolife reported that they are forming a new business unit (genomics), which

will incorporate Illumina’s IVF business for preimplantation genetic testing (PGT). The

integration was ongoing in Q4’18 and the company informed that they have invested in a new

distribution channel and recruited personnel. Further, Vitrolife reported that the first customer

deliveries of product were made in early 2019. We believe that it will take some time to transfer

the customers from Illumina and forecast a gradual sales impact from genomics during the

year. Our forecast expects that the business unit will be in full effect towards the end of 2019.

Prior to the Illumina partnership, we pointed PGT as a natural next step for Vitrolife in the search

for new technologies. We argue that technological development in PGT will be the main driver

of innovation in IVF and foresee increased usage as genetic mapping continues to develop.

The continued innovation within PGT is also expected to result in a continued high growth for

the market. The value of the global PGT market is expected to increase from about USD 340

million in 2017 to 540 million in 2022, corresponding to a CAGR of 10% (MarketsAndMarkets,

2018).

While continued technological advances and new applications are expected to be strong

drivers for the PGT market, we also see other factors supporting a high growth. Today, the

penetration of PGT is estimated to less than 10% and with an expected continued clinic

consolidation, we expect that more clinics will be able to offer PGT and thereby increase the

availability.

Figure 1. Forecasted Sales, Vitrolife Genomics

Source: Redeye Research

0,0

10,0

20,0

30,0

40,0

50,0

60,0

1Q19E 2Q19E 3Q19E 4Q19E

SE

Km

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REDEYE Equity Research Vitrolife 26 March 2019

3

While the European market is significantly larger in terms of the number of IVF cycles, we also

recognise that many European countries restrict or forbid the use of PGT. Therefore, we believe

that the American market likely will be the most important - at least in the short-term horizon.

We do, however, believe that regulation will loosen up in Europe as the technologies continue

to develop.

Figure 3. PGT Availability in Europe

Source: Vitrolife, 2018

Figure 2. PGT Market to Witness High Growth

Source: MarketsAndMarkets, 2018

0

100

200

300

400

500

600

2017 2022

US

Dm

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REDEYE Equity Research Vitrolife 26 March 2019

4

Further, we believe that the growth curve will differ for different types of PGT tests. PGT

encompasses both PGT for aneuploidies (PGT-A, previously referred to as PGS and CCS), PGT

for monogenic/single gene disorders (PGT-M, previously referred to as PGD). Additionally, new

applications such as PGT for chromosome structural rearrangements (PGT-SR) and

Preimplantation Genetic Testing for Polygenic disease (PGT-P) are evolving. In the

partnership’s current form, Vitrolife will be the distributor of Illumina’s PGT-A kit VeriSeq PGS

and PGT-M kit HumanKaryomap-12 in EMEA and Americas.

PGT-A Will Complement Time-Lapse When screening for sporadic chromosome abnormalities (aneuploidy), it is referred to as PGT-

A. Chromosomal abnormalities can impact the chance of successful embryo implantation and

result in miscarriage or chromosomal syndrome like downs syndrome. The test is performed

through an embryo biopsy, where a few cells are tested to enable the selection of an embryo

without abnormalities.

As we have previously pointed out, PGT screening will not be of value to all patients. Milán et

al. (2010) published results from a retrospective trial with 1848 patients and 2,253 IVF cycles,

showing that the effect of PGT-A on pregnancy outcome is highly dependent on maternal age,

indicating no benefit if advanced maternal age (35 and older) is not reached. A more recent

retrospective trial (where PGT-A testing was done with assays from Natera) conducted by

Simon et al., (2018) came to a different conclusion. The study included pregnancy outcomes

from 974 patients and 1,883 IVF cycles and showed that PGT-A does have a positive effect in

all maternal ages. When looking at the share of embryos transfers that resulted in clinical

pregnancies and live births, however, it is evident that the benefits of PGT-A does indeed

increase significantly with age.

Figure 4. Pre-implantation Genetic Testing

Source: Vitrolife, 2018

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5

We therefore argue that PGF will be used as a complement to time-lapse in order to enhance

the decision making mainly when IVF patients have reached advanced maternal age. Taking

this into account, we believe that PGT could be beneficial in about 25-30% of the IVF cycles

that are performed in the world. We therefore expect to see continued high market growth of

about 10% in the near to mid-term future, moving towards 5% at the end of our forecast period.

While the high market growth will leave space for several players, we recognise that Illumina

has been a dominant force in the market and that competition is increasing from players such

as Thermo Fisher, Agilent, PerkinElmer and Natera. We do, however, also believe that the IVF

has been far from the core business for the DNA sequencing giant, who is increasingly is

focusing on oncology. Taking this into account, we believe that Vitrolife will be able to deliver

above-market growth in the business in 2020-2021, which then will decrease gradually to about

6% at the end of our forecast period.

Figure 5. Success Rates by Age, PGT-A

Source: Simon et al., 2018

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6

PGT-M – A Revolution in Its Infancy PGT-M is used to reduce the risk of having a child with a known hereditary disorder. Through

genetic testing of an embryo biopsy, the method can discover diseases caused by mutations

in a single gene, such as cystic fibrosis or Huntington’s disease.

According to the US Centers for Disease Control and Prevention (CDC), about 150,000 babies

are born per year in the USA with birth defects. About 20% of them are congenital, which means

that they could be prevented with PGT-M. The method therefore has the potential of saving

many families from unnecessary suffering, as well as society from the high treatment costs

that the diseases often are associated with.

It is, of course, important to recognise that genetic mapping of human diseases is in its infancy

and that it will take a long time to uncover the clues of complex diseases that involve many

genes. With the investment that is going into biotech, it does, however, it is certain that we will

continue to see progress in the area. We therefore believe that the value of PGT-M will increase

over time and that that the use of the method will increase steadily, resulting in a high level of

sustainable growth, amounting to about 10% for a foreseeable future.

Proprietary Products Will Accelerate Growth and Boost Profitability Implementing PGT does require investment in new laboratory equipment and recruitment of

staff. Therefore, we argue that focus customers likely will be larger reference laboratories in

the first step. Vitrolife does, however, aim to develop fully kitted products, based Illumina

sequencing assays. We believe that the development mainly will focus on increasing the user

friendliness and making it easier to introduce PGT in the workflow for clinics.

With the introduction of these products, we believe that the potential customers will include

larger and mid-size laboratories as well, expanding the customer base significantly. Further, we

believe that gross margins for the proprietary products will be closer to the current company

average of about 65-70%. We do, however, expect that product development will take time and

forecast a launch in 2021.

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7

Significant Growth Potential Remain Across Business Units While genomics is expected to be the most significant growth driver in 2019 and 2020, we still

believe that significant growth potential remains in the more established business units. The

time-lapse business unit is expected to be a continued strong contributor in 2019 and 2020,

driven by increasing traction in the USA and China.

Media Sales in the media business unit showed strong performance in Q4 and amounted to SEK 156

(135) million. The result corresponded to a growth of 10% in local currency and the company

reported that growth was seen across all market regions. With three consecutive quarters of

stable growth and a growth of about 6% in 2018, we believe that Vitrolife has maintained its

market share and that the hiccup in China in first quarter of 2018 was of temporary nature.

We believe that growth opportunities still remain in pockets of the IVF media market, such as

the rapidly growing market for vitrification media. Going forward, we forecast high single digit

growth in the business unit and a gradual decrease to about 5% at the end of our forecast

period.

Disposables In the disposable devices business unit, sales increased by 32% in local currency and

amounted to amounted to SEK 49 (35) million in Q4. According to the company, growth was

seen across all products in the business unit. While we see the performance as impressive, we

believe that it likely was affected by factors of temporary nature. In the earnings call,

management pointed to the increased production capacity as one of the key factors behind

the result. Further, we recognise that order intake can vary significantly from quarter to quarter.

Management reported that the embryo transfer technology that was licensed from CrossBay

Medical in early 2018 will see a delay in the launch plan due to expanded product development.

In the earnings call, management guided for a 12-15 month delay (from the planned launch in

2020) due to findings from clinical testing during the year, where the company saw opportunity

for improvement. Our belief is that the new embryo transfer catheter will be used a niche

Figure 6. Sales per Business Unit

Source: Redeye Research

0

500

1000

1500

2000

2500

2014 2015 2016 2017 2018 2019E 2020E 2021E 2022E

SE

Km

Media Disposables Time-lapse ART equipment Genomics Freight revenue

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8

product, used in particularly difficult cases where the transfer has failed several times with

conventional catheters. We do, however, also believe that the high level of innovation will

warrant a significantly higher price than conventional catheters and forecast a gross margin of

about 70% for the product.

We forecast launch of the product in 2021, resulting in a small uptick in sales of disposables.

With the release of the product, as well as the increased marketing power through the

collaboration with GE Healthcare, we believe that Vitrolife will be able to gain market share in

the business unit. We forecast slightly above mid-single digit growth in the near to mid-term

horizon and reversion to about 5% at the end of our forecast period.

Time-lapse Sales in the time-lapse business amounted to SEK 94 (79) million, corresponding to a growth

of 14% in local currency. The last three quarters appear to signal a slowdown and, with a high

penetration for time-lapse systems in Europe, we expect the development will continue in

market. We do, however, argue that significant growth opportunities still remain in the USA and

China, in a near to mid-term horizon.

Support for increased acceptance for time-lapse in the USA has been shown in the last two

quarters, where the company has reported strong growth in the market. Additionally, we expect

that the approval of the EmbryoScope+, which holds significantly higher capacity than the

already approved EmbryoScope, is better suited for the Chinese market and will improve the

prospects for growth. We do, however, believe that the short-term impact on sales will be

modest. Time-lapse was recently introduced in China and we believe that it, just as in Europe,

will take some time before the technology reaches broad adaption in IVF clinics. We therefore

model a modest contribution from the market until 2020, when is assumed to accelerate.

ART equipment Sales in the ART equipment decreased by 19% in local currency and amounted to SEK 15 (17)

million. Revenue was in line with what was seen in the previous quarter, causing us to believe

that the sales erosion has peaked. We forecast flat sales in 2019 and mid-single digit growth

in the following years.

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9

Financial forecasts In the last three quarters of 2018, Vitrolife enjoyed a significant currency tailwind. Further, we

recognise that margins will see increasing pressure during 2019 with roll out of the Illumina

portfolio. With Vitrolife acting as the distributor of Illumina’s products, margins will be

significantly lower than the company average. We forecast gross margins of about 45%,

resulting in an increasingly negative impact on the total gross margin in 2019. When taking this

into account, we believe that Vitrolife will have a hard time living up to the market’s expectations

for sales growth.

Table 1. Income Statement(SEKm) 1Q18 2Q18 3Q18 4Q18 1Q19 2Q19 3Q19 4Q19

Net sales 264,0 283,2 284,0 320,1 308,9 347,2 350,7 411,3

Cost of goods sold -92,5 -95,9 -96,2 -105,7 -104,7 -121,2 -125,6 -147,8

Gross income 171,5 187,3 187,9 214,4 204,2 226,0 225,1 263,5

Selling expenses -42,2 -46,6 -44,3 -51,5 -46,0 -51,0 -48,4 -56,8

Administrative expenses -25,4 -25,1 -21,7 -27,1 -26,3 -26,0 -22,8 -29,6

Research & development costs -18,5 -18,8 -15,3 -35,8 -22,6 -24,0 -20,0 -31,3

Other operating revenues & exp. 4,2 1,7 -2,5 1,7 -0,6 -0,6 -0,6 -0,6

EBIT 89,7 98,5 104,0 101,7 108,8 124,4 133,3 145,3

Financial income & expenses 4,9 1,9 -7,8 5,8 1,4 0,0 -2,0 2,0

Income after financial items 94,5 100,3 96,2 107,5 110,2 124,3 131,3 147,2

Income taxes -22,7 -20,8 -21,1 -23,3 -25,8 -25,1 -28,0 -31,2

Net income 71,8 79,6 75,1 84,1 84,4 99,2 103,3 116,1

Earnings per share 0,66 0,73 0,69 0,77 0,77 0,91 0,95 1,07

EBITDA 106,3 116,2 121,0 135,2 137,1 153,4 162,3 173,6

Sales grow th 8,2% -0,8% 15,5% 18,2% 17,0% 22,6% 23,5% 28,5%

Gross margin 65,0% 66,1% 66,1% 67,0% 66,1% 65,1% 64,2% 64,1%

EBIT margin 34,0% 34,8% 36,6% 31,8% 35,2% 35,8% 38,0% 35,3%

EBITDA margin 40,3% 41,0% 42,6% 42,2% 44,4% 44,2% 46,3% 42,2%

Source: Redeye Research

Table 2. Income Statement(SEKm) 2014 2015 2016 2017 2018 2019E 2020E 2021E

Net sales 511 722 856 1 046 1 151 1 418 1 604 1 762

Cost of goods sold -161 -238 -295 -365 -390 -499 -564 -559

Gross income 349 485 561 682 761 919 1 039 1 204

Selling expenses -112 -140 -156 -170 -185 -202 -225 -242

Administrative expenses -60 -80 -94 -99 -99 -105 -115 -122

Research & development costs -42 -56 -62 -69 -88 -98 -110 -121

Other operating revenues & exp. 8 17 -1 -2 5 -2 -3 -3

EBIT 143 226 249 341 394 512 587 716

Financial income & expenses 4 1 0 0 5 1 1 1

Income after financial items 147 227 249 341 399 513 588 717

Income taxes -37 -43 -58 -76 -88 -110 -126 -148

Net income 109 183 191 265 311 403 462 569

Earnings per share 1,1 1,7 1,8 2,4 2,9 3,7 4,2 5,2

EBITDA 167 279 303 408 479 626 717 851

Sales grow th 13% 41% 19% 22% 10% 23% 13% 9,9%

Gross margin 68% 67% 66% 65% 66% 65% 65% 68,3%

EBIT margin 28% 31% 29% 33% 34% 36% 37% 40,6%

EBITDA margin 33% 39% 35% 39% 42% 44% 45% 48,3%

Source: Redeye Research

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10

Valuation Vitrolife’s performance has been has certainly been impressive in the past 6 months, where the

company has seen both high growth and margin expansion. Further, the company has

announced new partnerships with GE Healthcare and Illumina and received new market

approvals. These factors, in combination with rumours of China abolishing the one child policy,

the entry to large cap and the approval of EmbryoScope+ in China, has sent the share to new

heights. In the past six months, the share is up by almost 60%.

DCF Valuation While we believe that the partnership will be key for continued sales growth and value creation,

we believe that the current share price discounts more than what can be met. Following a

review after the performance in the past quarter and including the sales from the new

genomics business unit, our fair value is increased to SEK 160 (110) per share.

Figure 7. Share Price Development and Catalysts, VITR.ST

Source: Nasdaq

0

200

400

600

800

1000

1200

100

120

140

160

180

200

2202018-0

8-0

1

2018-0

8-1

5

2018-0

8-2

9

2018-0

9-1

2

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9-2

6

2018-1

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9

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1-3

0

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2-1

3

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2-2

7

2019-0

3-1

3

Sh

are

s tr

ad

ed

(0

00

's)

SE

K / s

ha

re

Total volume Closing price

Q4 results

Embry oScope+approv ed in

China

Included in OMX Stockholm large

cap

Q3 resultsAnnounced

Illumina

partnership

Rumours of plans to

abolish

one-child

policy in China

Table 3. DCF Summary

SEKm Per share

DCF 2019-30 5 729 53

DCF 2031- 10 843 100

IBD 0 0

Cash & cash equivalents 491 5

Other -23 0

Summa 17 039 157

CAGR 2019-22 13,8%

CAGR 2019-30 9,2%

EBIT margin 2030 46,0%

EPS 2025 7,83

WACC 7,2%

Terminal grow th rate 2,0%

Number of shares FY1 (Mn) 108,6

Source: Redeye Research

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11

Multiple-based Valuation To illustrate the valuation of Vitrolife on a multiple basis, we have chosen intervals of multiples

for a slightly more mature company. We apply our estimates for 2023E and add the net cash

as well as paid dividends. To take the time value into account, the value is discounted to present

value.

Sensitivity Analysis An NPV valuation of a company is highly sensitive to the discount rate (WACC) an investor

uses. In order to capture the sensitivities, we have computed a table that shows the value

generated when applying different rates in our model.

Table 4. Discounted Multiple-based Valuation

Multiple Estimate 2023E Multiples Value per share

EV/S S 2 102 4,0x - 8,0x 77 - 133

EV/EBITDA EBITDA 1 022 15,0x - 25,0x 123 - 191

EV/EBIT EBIT 884 20,0x - 30,0x 139 - 197

P/E EPS 6 25,0x - 35,0x 122 - 168

Source: Redeye Research

Table 5. Sensitivity Analysis

WACC

5,2% 6,2% 7,2% 8,2% 9,2%

Equity value 28 983 21 566 17 039 14 001 11 829

Value per share 267 199 157 129 109

Källa: Redeye Research

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12

Investment Case Involuntary childlessness happens to about 10% of couples. The number is expected to increase as the maternal

age is rising steadily over the world. A large share of the couples can be helped through in-vitro fertilisation (IVF)

treatment, however, which has seen high technological advancement in recent years. This has led IVF to become a

huge industry and there are now clinics everywhere across the developed and developing world.

Strong Position in an Attractive Growth Market

Assuming an average sales value of SEK 2,000 per IVF cycle, the global market for disposable IVF products is

estimated to about SEK 4 billion. This would give Vitrolife a market share of about 20%, a number that is believed to

have increased significantly through the recent years.

We expect to see an overall market growth of 5-10% through our forecast period. Vitrolife has been able to grow

faster than the overall market, however, due to geographical expansion to growth markets, an expanded product

offering and successful acquisitions. Given the company’s strong product portfolio and high quality, proven by the

excellent track record, we believe that sales growth will exceed that of the overall IVF market for a foreseeable

future.

Sustainable Growth and High Profitability Ahead

Significant growth opportunities still remain across the business units, but expectations are high. A high continued

growth in the near-term relies on successful expansion of time-lapse to the USA and China. Market uptake for time-

lapse has so far been slow in the USA, where PGT technology has gotten a strong traction. Further, the company is

in an early commercialisation for time-lapse in China, where IVF is provided on a self-pay basis.

We do, however, recognise that the documentation of the technology’s benefits is growing and argue that time-

lapse will become complimentary to PGT in American clinics, although this will take time. We believe that the

scenario will be similar in China, although we expect it will take about two years for the technology to gain traction

among the Chinese IVF clinics.

With, what we believe to be reasonable assumptions, we expect profits to increase rapidly. If the company delivers

on our estimates, valuation multiples become significantly lower 2-3 years ahead. In our base case, we expect to

see an average sales growth (CAGR) of more than 10% until 2020, and an EBITDA margin higher than 40%. The EPS

is expected to be doubled by 2023.

Valuation Indicates High Expectations

Vitrolife’s performance has been has certainly been impressive in the past 12 months, where the company has seen

both high growth and margin expansion. Although many growth opportunities remain, we believe that the current

share price discounts more than what can be met. Our discounted cash flow (DCF) model gives a value of about

SEK 160 per share, indicating no upside from current levels.

Valuation

Bear Case 100.0 SEK Base Case 160.0 SEK Bull Case 200.0 SEK We model slower growth, amounting to 10% per year until 2021. The scenario is based on more sluggish development for time-lapse in the USA and China. We also account for a higher cost base, resulting in an EBITDA margin of 32% in 2021. In this scenario, our model indicates a value of SEK 100 per share.

We expect average an annual sales growth of 15% until 2021, when the EBITDA margin expands to 48%. This gives a fair value of about SEK 160 per share.

The average sales growth amounts to 25% until 2021. The scenario relies on faster-than-expected acceptance for time-lapse technology in the USA and China. The higher sales lifts the EBITDA margin to 46% in 2021. In this scenario, our model indicates a value of SEK 200 per share.

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Summary Redeye Rating The rating consists of five valuation keys, each constituting an overall assessment of several factors that are rated

on a scale of 0 to 2 points. The maximum score for a valuation key is 10 points.

Rating changes in the report Management: 10.0

Vitrolife is a company of high quality that has lived up to high set expectations. The CEO has experience from

similar positions at other listed medtech companies. The board and management have a number of successful

years behind them, growing Vitrolife into a key player in the sector.

Ownership: 8.0

We have a positive view of Bure's large ownership in Vitrolife and representation in the board of directors. The rating

is affected negatively by the limited ownership from the management and board of directors.

Profit Outlook: 9.0

The IVF market still has significant growth opportunities. Growth expected to be driven by increasing maternal age

and the introduction of new technology. The market is competitive, however, and cannot be characterized as

underdeveloped.

Profitability: 8.5

Vitrolife has managed to combine a high level of growth with high profitability consistently. Some of our profitability

measures demand a longer history, however, which affects the rating. If the current trend continues, further

upgrades will be warranted.

Financial Strength: 5.0

Vitrolife has a strong balance sheet considering the relatively stable business, but should not be seen as

overcapitalised either. As with many other smaller companies, the rating is affected negatively by the reliance on the

success of a few products the product portfolio.

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PROFITABILITY 2017 2018 2019E 2020E 2021E ROE 24% 23% 24% 22% 23% ROCE 30% 29% 30% 28% 29% ROIC 39% 47% 51% 53% 62% EBITDA margin 39% 42% 44% 45% 48% EBIT margin 33% 34% 36% 37% 41% Net margin 25% 27% 28% 29% 32%

Please comment on the changes in Rating factors……

INCOME STATEMENT 2017 2018 2019E 2020E 2021E Net sales 1,046 1,151 1,418 1,604 1,762 Total operating costs -638 -673 -792 -887 -911 EBITDA 408 479 626 717 851 Depreciation -26 -31 -33 -37 -37 Amortization -41 -54 -82 -93 -98 Impairment charges 0 0 0 0 0 EBIT 341 394 512 587 716 Share in profits 0 0 0 0 0 Net financial items 0 5 1 1 1 Exchange rate dif. 0 0 0 0 0 Pre-tax profit 341 399 513 588 717 Tax -76 -88 -110 -126 -148 Net earnings 264 310 402 461 567

BALANCE SHEET 2017 2018 2019E 2020E 2021E Assets Current assets Cash in banks 396 491 787 1,069 1,458 Receivables 153 185 226 253 275 Inventories 151 161 197 220 239 Other current assets 10 9 12 13 14 Current assets 710 847 1,221 1,555 1,987 Fixed assets Tangible assets 84 94 110 118 124 Associated comp. 4 6 6 6 6 Investments 5 18 22 25 27 Goodwill 409 422 422 422 422 Cap. exp. for dev. 0 0 0 0 0 O intangible rights 199 306 359 385 402 O non-current assets 0 0 0 0 0 Total fixed assets 701 846 918 956 980 Deferred tax assets 12 5 6 7 8 Total (assets) 1,422 1,697 2,146 2,518 2,975 Liabilities Current liabilities Short-term debt 0 0 0 0 0 Accounts payable 117 125 154 174 192 O current liabilities 0 0 0 0 0 Current liabilities 117 125 154 174 192 Long-term debt 0 0 0 0 0 O long-term liabilities 0 8 10 11 12 Convertibles 0 0 0 0 0 Total Liabilities 117 133 164 186 204 Deferred tax liab 69 57 70 79 87 Provisions 7 12 14 16 18 Shareholders' equity 1,226 1,493 1,894 2,235 2,664 Minority interest (BS) 3 3 3 3 3 Minority & equity 1,229 1,496 1,898 2,238 2,667 Total liab & SE 1,422 1,697 2,146 2,518 2,975

FREE CASH FLOW 2017 2018 2019E 2020E 2021E Net sales 1,046 1,151 1,418 1,604 1,762 Total operating costs -638 -673 -792 -887 -911 Depreciations total -67 -85 -115 -130 -135 EBIT 341 394 512 587 716 Taxes on EBIT 0 0 0 0 0 NOPLAT 341 394 512 587 716 Depreciation 67 85 115 130 135 Gross cash flow 408 479 626 717 851 Change in WC -12 -34 -49 -32 -25 Gross CAPEX -17 -227 -187 -168 -160 Free cash flow 380 217 390 518 666

CAPITAL STRUCTURE 2017 2018 2019E 2020E 2021E Equity ratio 86% 88% 88% 89% 90% Debt/equity ratio 0% 0% 0% 0% 0% Net debt -395 -491 -787 -1,069 -1,458 Capital employed 829 1,000 1,105 1,163 1,203 Capital turnover rate 0.7 0.7 0.7 0.6 0.6

GROWTH 2017 2018 2019E 2020E 2021E Sales growth 22% 10% 23% 13% 10% EPS growth (adj) 38% 17% 30% 15% 23%

DATA PER SHARE 2017 2018 2019E 2020E 2021E EPS 2.43 2.85 3.70 4.24 5.23 EPS adj 2.43 2.85 3.70 4.24 5.23 Dividend 0.74 0.00 1.11 1.27 1.57 Net debt -3.64 -4.52 -7.25 -9.85 -13.44 Total shares 108.55 108.55 108.55 108.55 108.55

VALUATION 2017 2018 2019E 2020E 2021E EV 13,160.7 15,501.4 21,504.3 21,216.3 20,822.0 P/E 51.3 51.5 55.4 48.3 39.2 P/E diluted 51.3 51.5 55.4 48.3 39.2 P/Sales 12.9 13.9 15.7 13.9 12.6 EV/Sales 12.6 13.5 15.2 13.2 11.8 EV/EBITDA 32.3 32.4 34.3 29.6 24.5 EV/EBIT 38.6 39.4 42.0 36.1 29.1 P/BV 11.0 10.7 11.7 10.0 8.4

SHARE INFORMATION Reuters code VITR.ST List Mid cap Share price 205.0 Total shares, million 108.6 Market Cap, MSEK 22252.9 MANAGEMENT & BOARD CEO Thomas Axelsson CFO Mikael Engblom IR Chairman Carsten Browall FINANCIAL INFORMATION ANALYSTS Redeye AB Arvid Necander Mäster Samuelsgatan 42, 10tr [email protected] 111 57 Stockholm Mathias Spinnars [email protected]

SHARE PERFORMANCE GROWTH/YEAR 16/18E 1 month 7.3 % Net sales 16.4 % 3 month 40.8 % Operating profit adj 22.5 % 12 month 72.9 % EPS, just 23.4 % Since start of the year 39.5 % Equity 24.3 %

SHAREHOLDER STRUCTURE % CAPITAL VOTES William Demant Invest A/S 22.6 % 22.6 % Bure Equity 20.8 % 20.8 % State Street Bank And Trust co 10.1 % 10.1 % Capital Group 4.6 % 4.6 % Morgan Stanley Investment Management 3.5 % 3.5 % Lannebo Fonder 3.2 % 3.2 % The Bank of New York Mellon SA/NV 2.2 % 2.2 % Eccenovo AB 2.1 % 2.1 % Norges Bank 2.0 % 2.0 % (Gc) BNP Paribas Sec Services Paris 1.6 % 1.6 %

DCF VALUATION CASH FLOW, MSEK WACC (%) 7.2 % NPV FCF (2018-2020) 1072 NPV FCF (2021-2027) 3554 NPV FCF (2028-) 11938 Non-operating assets 452 Interest-bearing debt 0 Fair value estimate MSEK 17017 Assumptions 2017-2023 (%) Average sales growth 9.7 % Fair value e. per share, SEK 156.8 EBIT margin 40.4 % Share price, SEK 205.0

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Redeye Rating and Background Definitions The aim of a Redeye Rating is to help investors identify high-quality companies with attractive valuation.

Company Qualities

The aim of Company Qualities is to provide a well-structured and clear profile of a company’s qualities (or operating

risk) – its chances of surviving and its potential for achieving long-term stable profit growth.

We categorize a company’s qualities on a ten-point scale based on five valuation keys; 1 – Management, 2 –

Ownership, 3 – Profit Outlook, 4 – Profitability and 5 – Financial Strength.

Each valuation key is assessed based a number of quantitative and qualitative key factors that are weighted

differently according to how important they are deemed to be. Each key factor is allocated a number of points

based on its rating. The assessment of each valuation key is based on the total number of points for these

individual factors. The rating scale ranges from 0 to +10 points.

The overall rating for each valuation key is indicated by the size of the bar shown in the chart. The relative size of the

bars therefore reflects the rating distribution between the different valuation keys.

Management

Our Management rating represents an assessment of the ability of the board of directors and management to

manage the company in the best interests of the shareholders. A good board and management can make a

mediocre business concept profitable, while a poor board and management can even lead a strong company into

crisis. The factors used to assess a company’s management are: 1 – Execution, 2 – Capital allocation, 3 –

Communication, 4 – Experience, 5 – Leadership and 6 – Integrity.

Ownership

Our Ownership rating represents an assessment of the ownership exercised for longer-term value creation. Owner

commitment and expertise are key to a company’s stability and the board’s ability to take action. Companies with a

dispersed ownership structure without a clear controlling shareholder have historically performed worse than the

market index over time. The factors used to assess Ownership are: 1 – Ownership structure, 2 – Owner

commitment, 3 – Institutional ownership, 4 – Abuse of power, 5 – Reputation, and 6 – Financial sustainability.

Profit Outlook

Our Profit Outlook rating represents an assessment of a company’s potential to achieve long-term stable profit

growth. Over the long-term, the share price roughly mirrors the company’s earnings trend. A company that does not

grow may be a good short-term investment, but is usually unwise in the long term. The factors used to assess Profit

Outlook are: 1 – Business model, 2 – Sale potential, 3 – Market growth, 4 – Market position, and 5 –

Competitiveness.

Profitability

Our Profitability rating represents an assessment of how effective a company has historically utilised its capital to

generate profit. Companies cannot survive if they are not profitable. The assessment of how profitable a company

has been is based on a number of key ratios and criteria over a period of up to the past five years: 1 – Return on

total assets (ROA), 2 – Return on equity (ROE), 3 – Net profit margin, 4 – Free cash flow, and 5 – Operating profit

margin or EBIT.

Financial Strength

Our Financial Strength rating represents an assessment of a company’s ability to pay in the short and long term.

The core of a company’s financial strength is its balance sheet and cash flow. Even the greatest potential is of no

benefit unless the balance sheet can cope with funding growth. The assessment of a company’s financial strength

is based on a number of key ratios and criteria: 1 – Times-interest-coverage ratio, 2 – Debt-to-equity ratio, 3 – Quick

ratio, 4 – Current ratio, 5 – Sales turnover, 6 – Capital needs, 7 – Cyclicality, and 8 – Forthcoming binary events.

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Redeye Equity Research team

Management Björn Fahlén

[email protected]

Håkan Östling

[email protected]

Technology Team Jonas Amnesten

[email protected]

Henrik Alveskog

[email protected]

Dennis Berggren

[email protected]

Havan Hanna

[email protected]

Kristoffer Lindström

[email protected]

Fredrik Nilsson

[email protected]

Tomas Otterbeck

[email protected]

Eddie Palmgren

[email protected]

Viktor Westman

[email protected]

Editorial Jim Andersson

[email protected]

Eddie Palmgren

[email protected]

Ludvig Svensson

[email protected]

Life Science Team Anders Hedlund

[email protected]

Arvid Necander

[email protected]

Klas Palin

[email protected]

Mathias Spinnars

[email protected]

Erik Nordström (Trainee)

[email protected]

Jakob Svensson (Trainee)

[email protected]

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Disclaimer Important information Redeye AB ("Redeye" or "the Company") is a specialist financial advisory boutique that focuses on small and mid-cap growth companies in the Nordic region. We focus on the technology and life science sectors. We provide services within Corporate Broking, Corporate Finance, equity research and investor relations. Our strengths are our award-winning research department, experienced advisers, a unique investor network, and the powerful distribution channel redeye.se. Redeye was founded in 1999 and since 2007 has been subject to the supervision of the Swedish Financial Supervisory Authority. Redeye is licensed to; receive and transmit orders in financial instruments, provide investment advice to clients regarding financial instruments, prepare and disseminate financial analyses/recommendations for trading in financial instruments, execute orders in financial instruments on behalf of clients, place financial instruments without position taking, provide corporate advice and services within mergers and acquisition, provide services in conjunction with the provision of guarantees regarding financial instruments and to operate as a Certified Advisory business (ancillary authorization). Limitation of liability This document was prepared for information purposes for general distribution and is not intended to be advisory. The information contained in this analysis is based on sources deemed reliable by Redeye. However, Redeye cannot guarantee the accuracy of the information. The forward-looking information in the analysis is based on subjective assessments about the future, which constitutes a factor of uncertainty. Redeye cannot guarantee that forecasts and forward-looking statements will materialize. Investors shall conduct all investment decisions independently. This analysis is intended to be one of a number of tools that can be used in making an investment decision. All investors are therefore encouraged to supplement this information with additional relevant data and to consult a financial advisor prior to an investment decision. Accordingly, Redeye accepts no liability for any loss or damage resulting from the use of this analysis. Potential conflict of interest Redeye’s research department is regulated by operational and administrative rules established to avoid conflicts of interest and to ensure the objectivity and independence of its analysts. The following applies:

For companies that are the subject of Redeye’s research analysis, the applicable rules include those established by the Swedish Financial Supervisory Authority pertaining to investment recommendations and the handling of conflicts of interest. Furthermore, Redeye employees are not allowed to trade in financial instruments of the company in question, effective from 30 days before its covered company comes with financial reports, such as quarterly reports, year-end reports, or the like, to the date Redeye publishes its analysis plus two trading days after this date.

An analyst may not engage in corporate finance transactions without the express approval of management, and may not receive any remuneration directly linked to such transactions.

Redeye may carry out an analysis upon commission or in exchange for payment from the company that is the subject of the analysis, or from an underwriting institution in conjunction with a merger and acquisition (M&A) deal, new share issue or a public listing. Readers of these reports should assume that Redeye may have received or will receive remuneration from the company/companies cited in the report for the performance of financial advisory services. Such remuneration is of a predetermined amount and is not dependent on the content of the analysis.

Redeye’s research coverage Redeye’s research analyses consist of case-based analyses, which imply that the frequency of the analytical reports may vary over time. Unless otherwise expressly stated in the report, the analysis is updated when considered necessary by the research department, for example in the event of significant changes in market conditions or events related to the issuer/the financial instrument. Recommendation structure Redeye does not issue any investment recommendations for fundamental analysis. However, Redeye has developed a proprietary analysis and rating model, Redeye Rating, in which each company is analyzed and evaluated. This analysis aims to provide an independent assessment of the company in question, its opportunities, risks, etc. The purpose is to provide an objective and professional set of data for owners and investors to use in their decision-making. Redeye Rating (2019-03-26)

Duplication and distribution This document may not be duplicated, reproduced or copied for purposes other than personal use. The document may not be distributed to physical or legal entities that are citizens of or domiciled in any country in which such distribution is prohibited according to applicable laws or other regulations. Copyright Redeye AB.

Rating Management Ownership Profit outlook Profitability Financial Strength

7,5p - 10,0p 49 46 20 11 20

3,5p - 7,0p 91 89 121 42 56

0,0p - 3,0p 14 19 13 101 78

Company N 154 154 154 154 154

CONFLICT OF INTERESTS

Arvid Necander : No Mathias Spinnars: No