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It’s been an incredibly productive year for the Centre of Research Excellence (CRE ACTIONS). As you are aware, we were a little behind the eight ball at the start of last year. The appointment of Cecilia Keiru has changed a lot. The management limb run by Cecilia and with recently being ably assisted by Lyn Munck has really allowed the collaboration to become much more productive. Numerous projects have been completed and others initiated. Over 34 PhDs have been adapted, 22 sites now have active CRE collaboration. We append a map to highlight the international progress of what’s going on within the group.
The Asia-Pacific ELSO (APELSO) was a high point of the CRE in the last couple of months. Kiran Shekar had suggested that our group should host the APELSO 2017 as a centre point of our two and a half year CRE. There was a huge amount of work and all credit to the management team – Marianne, Cecilia, Lyn and with Johnny Millar, Max Malfertheiner, Paul Jarrett, Kiran Shekar, Jacky Suen, Viktor von Bahr, all assisting MCI conference organizers put together what was as much an event as a conference. Including speakers, workshops and full registration there was almost 600 attendees. High points for me were: the patient interaction on stage, putting a swimming cap on the Health Minister, and the release of the first ever supplement of Critical Care Resuscitation Journal of 12 very high quality publications put together from almost all continents. A book that a number of us had been working on was also published – an 854 page magnum opus - with myself, Shaun Gregory and Michael Stevens all contributing and a huge number of our CRE collaborators involved in the 27 chapters inside it.
Volume 1, Issue 5 October 2017
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The APELSO really brought together almost all our teams as well as new attendees. It was wonderful at the one-day meeting prior to the main APELSO to see as many collaborators but equally during the 2-day meeting hearing the vast amount of working that is going on from within our group and creating new collaborations for the next year or two. Next year promises to just be as busy. At the CRE ACTIONS planning day, we discussed the potential of either submitting another NHMRC CRE next year but also building up to a CRC. We are actively seeking assistance of consultants who have put together successful CRCs in the past and we will be working over this in the next 6-12 months to determine what the best way forward is. We are heading over to the ECMONet third meeting in Rome at the start of February next year (someone has to do all the hard gigs) and month by month and particularly after the APELSO, the international global ECMO community sees very much the benefit that’s going on with this kind of collaboration. It’s been a truly outstanding year and congratulations to all of you for making it happen. As always, we couldn’t have done it without you. As most of you take a truly well-deserved break, I take this opportunity to wish you all a wonderful holiday season. And come back ready and re-charged for another bigger and better year for the ACTIONS CRE. Professor John F. Fraser MBChB, PhD, FRCP (Glas.), FFARCSI, FRCA, FCICM Director, Critical Care Research Group
IN THIS ISSUE: End-user engagement 3
Clinical Guideline - MCS 4
CRE Strategic Outlook 5
Asia-Pacific ELSO 2017 6
Big Wins 8
New Researcher Focus 9
OpenHeart Project 11
Opportunities 13
Acknowldegements 14
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ECMO and VAD Nurses Network | Inaugural meeting at The Critical Care Research Group, Prince Charles Hospital, Brisbane
The aims of the CRE ACTIONS consumer engagement network are to audit the existing level of consumer participation in research at the relevant sites and coordinate with consumer health councils and other pre-existing consumer entities. We will survey researchers and specialist staff for their questions and concerns, then workshop consumer participation with research teams. Recovered (ECMO/VAD) or cardiac transplant (post-VAD) patients, their families or carers will be approached. We will run a workshop on consumer participation for interested consumers and provide staff and researcher training in consumer engagement according to identified needs. First projects to be tested have been identified as:
• Consumer educational IT platform for increasing awareness and understanding of both VAD and ECMO
• Wearable VAD component re-design
• ECMO mobilisation – do patients feel safe?
• VAD interface relaying information in real time to VAD nurses
Participating institutions: • The Prince Charles Hospital • The Alfred • St Vincent’s Hospital • Royal Children’s Hospital • Fiona Stanley Hospital • NZ Heart & Lung Transplant
Service
With acknowledgement to the ECMO&VAD nurses network participating members for their contribution.
A key CRE objective is to improve the patient experience through consumer participation in our research. In mid-June this year, we established and hosted a 2-day meeting in Brisbane for the first ever collaborative network of ECMO and VAD coordinators from Sydney hospitals, The Alfred, Western Australia and across Queensland, as a means to access expertise on long term patient concerns, to help make improvements to the VAD-patient interface.
End-user Engagement in our Research It has been identified that fully engaged consumers are able to inform which research will have most impact on patients, what needs to be done next, and how best to undertake research (e.g. patient surveys).
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Clinical Guideline Development – MCS Within our Centre of Research Excellence program (CRE ACTIONS), we are tasked with coming up with NHMRC Clinical Practice Guideline on use of MAD therapy for the Australian healthcare setting (and adaptable internationally).
The Guideline Development committee got together for an inaugural meeting in October 2017 to set the ball rolling. A road map was established at this meeting and at the moment, the key priority for this committee is to identify a limited number of key clinical issues around which quality guidelines can be developed and delivered. Towards fulfilling NHMRC requirement:
I. Governance and Stakeholder involvement
II. Scope and purpose III. Evidence review IV. Guideline recommendations V. Guideline structure and style
VI. Public consultation VII. Dissemination and
implementation
Appreciation to the core team John Fraser – Committee Chair Vin Pellegrino Aiden Burrell James Winearls Chris Joyce Kiran Shekar Paul Bannon Priya Nair David Pearson Lynette Munck Cecilia Keiru
Our objective is to see there is uptake of these guidelines by practitioners and support the changes in clinical practice brought about by this implementation. We have therefore purposed to make the development process as inclusive as possible by incorporating all CRE nodes (Brisbane, Melbourne and Sydney) and have put together a preliminary multi-disciplinary (medics, nursing, allied health) committee matching this criteria.
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CRE Strategic Outlook Beyond the NHMRC CRE: What next?
The NHMRC Centre of Research Excellence (CRE ACTIONS) program, now in its third year of implementation, has made great strides and grown into an international tree of outstanding research fruits and potentials. With only two years to the end of this grant, we have already started to reflect on possible options for sustainability - to carry on the great work we are collectively doing, to advance the science and clinical application of mechanical circulatory support.
International Centre of Research Excellence (CRE ACTIONS) | Innovators and leaders in MCS
To this end, CRE Chief Investigators, Associate Investigators, Post-docs, students and collaborators held a strategic review meeting on October 12, 2017. A key part of this meeting focused on defining the future of ACTIONS CRE and looking beyond our current NHMRC funding.
CRE ACTIONS Strategic Priorities
CRE ACTIONS Performance Measures
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John Fraser and his CCRG team that made it happen at APELSO | A hallmark moment with Robert Bartlett
APELSO 2017 Conference Highlights Professor John Fraser and his Critical Care Research Group team hosted the Asia-Pacific ELSO (APELSO) Conference on October 12-14, 2017 at the Gold Coast. This was the first time that the event has been held in Australia, and was extremely successful with a strong international presence and high quality presentations. Over 400 delegates from around the Asia Pacific region, Europe and America attended.
The conference, on the theme of ECMO...and Beyond (The Future of Mechanical Circulatory Support), was a highly interactive meeting that provided an excellent opportunity for adult and pediatric Extracorporeal Membrane Oxygenation (ECMO) specialists, along with intensive care medicine specialists, scientists, allied health professionals and nurses to come together and learn from key opinion leaders and highly-respected speakers, attend simulation workshops, and build relationships and networks with each other.
Inaugural Opening Session
Hon Cameron Dick, Minister for Health | Key address to delegates at APELSO
Patient Story| ECMO journey by Kate Phillips (centre) and Skye McLean (right) | Survival has got to be worthwhile
Father of ECMO | Robert Bartlett credited with developing the lifesaving heart-lung technology
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Research partnership with colleagues from Estonia | Critical Care Research Group (CCRG)
Sanne Pedersen (right) hosting collaborators from Korea and Japan | CCRG Animal Lab Tour
Representing Korea University Medical Centre & Shibaura Institute of Technology, Japan | CCRG Labs Tour
ECMO ex-vivo circuit presentation by Viktor von Bahr (Sweden) | CCRG Labs Tour
CCRG biology research monthly team meeting
CCRG members at the EKKA 2017 | Strawberry scoopers in support of research
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Critical Care and Resuscitation Journal, dedicated entirely to Mechanical Circulatory Support issues| Launched at APELSO 2017
The Mechanical Circulatory and Respiratory Support (MCRS) textbook is one of the largest global collaborations for a single project in the field of MCRS. Editor royalties are being donated directly back to respective scientific societies to support young researchers in completing collaborative research between institutes around the globe. Grab your copy on booktopia: https://www.booktopia.com.au/mechanical-circulatory-and-respiratory-support-john-fraser/prod9780128104910.html?source=pla&gclid=EAIaIQobChMIs_2-hbWI1wIVFAoqCh2ydQcCEAQYAiABEgIqqPD_BwE
Critical Care and Resuscitation (CC&R) is the official scientific journal of the College of Intensive Care Medicine (CICM). The journal is a quarterly publication (ISSN 1441-2772) with original articles of scientific and clinical interest in the specialties of Critical care, Intensive Care, Anaesthesia, Emergency Medicine and related disciplines. The CC&R Journal currently has an impact factor of 3.3, placing it in 8th position in world critical care journals and in first position in the world outside the USA and Europe. The Journal is received by all fellows and trainees, along with an increasing number of subscribers from around the world. College of Intensive Care Medicine of Australia and New Zealand
Big Wins!
All savvy textbook on Mechanical Circulatory Support | Launched at APELSO 2017
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Eleonore Bolle (CRE/ICETLAB PhD student) receives the Best Abstract Award | Congratulations! | APELSO 2017
Look out for…
CRE ACTIONS Masterclass series CRE provides an internal tutorial program aimed at addressing the missing pieces of research management. Here’s a sneak peak of some topics lined up for 2018:
• How to Write a Good Review Paper • Searching the Literature Databases • Managing Research Budgets • Being In The Driver’s Seat of Your
Own Career • Managing Research Teams • Health Consumer Engagement • Writing Ethics Applications • Managing your Intellectual
Property Lecture dates will be made available through CRE mailers and CCRG weekly updates.
New Researcher Capability, Mentoring & Career Development We value our research students as important contributors, and form a key part of our research. To this end, CRE has designed a survey targeted at students and supervisors in our research. The rationale for this survey is to inform good practice in the supervision of research higher degree (RHD) students, and to ensure the students are well supported and have opportunities to grow into tomorrow’s leaders. Outcome of this survey will also facilitate continuity in recruiting the best and brightest to our group, and with successful student outputs.
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Welcome to Country | APELSO 2017, Gold Coast
Robert Bartlett (centre) with Kate Phillips (right) and Skye McLean | Not just surviving but thriving
Monty Dayman (centre), Gold Coast firefighter shares his amazing ECMO story | APELSO 2017 Gala Dinner
ECMO & VAD nurses integrating with engineers| ICETLAB
10 years and counting | Margaret Passmore’s (extreme right) work anniversary
APELSO Gala Dinner 2017
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The ICETLAB is developing a novel low-cost ventricular assist device, called the OpenHeart, to support patients in low-income countries where traditional treatment options are not available. Costs will be reduced by refusing to protect intellectual property and by creating an open-sourced platform for our extensive network of collaborators to contribute towards device development using their facilities, expertise, and in their own time.
Cardiovascular diseases are attributed as the leading cause of death throughout the developed world. Of these, Heart Failure is the fastest growing cardiovascular disease, and affects more than 300,000 Australians. Treatment options for Heart Failure include, ideally, heart transplants (however only 4,500 transplants are performed across the globe each year), or more commonly, the use of Mechanical Circulatory Support (MCS). MCS iDevices are used for patients with advanced heart failure.
The OpenHeart Project aims to promote improved collaboration and research standardisation between researchers in the field of MCS through implementation of an open-source online research platform. It is especially geared towards PhD students and early career researchers. It leverages the existing expertise in the field of MCS to develop new and improved heart and blood pumps for use in developing countries. Griffith’s Professor Geoff Tansley (CRE Chief Investigator) from the School of Engineering, along with UQ’s Dr Jo Pauls (CRE/ICETLAB post-doc) are the lead researchers and instigators of this project. The solution developed was architected and project managed by eResearch Services, with rights and use statements created by the University Copyright Officer Antony Ley. Website development was undertaken by Griffith Work-Integrated Learning students under the guidance of Amanda Miotto from eResearch Services. The solution, which was developed using WordPress.org, Confluence and BitBucket, is totally cloud based and natively uses cloud platform functionality to ensure ongoing supportability of the product. For more information, check out the OpenHeart Project website. Retrieved from: https://griffithinsight.wordpress.com/2017/10/31/have-you-heard-of-the-openheart-project/
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CRE ACTIONS IN ACTION
Best New Investigator Award goes to Paul Jarrett | Congratulations! | TPCH Week
Best abstracts session | APELSO 2017
ICETLAB team represented at ISMCS 2017 | 5 presentations
CRE Brisbane and Melbourne nodes project update meeting | David McGiffin hosting the team
Alice Boone presenting at TPCH Week | CCRG research students successes
Matt Wells PhD confirmation | CCRG research students successes
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Opportunities
The Centre of Research Excellence for Advanced Cardio-respiratory Therapies Improving OrgaN Support (CRE ACTIONS) is a collaboration that is unique on a global level, connecting leaders and innovators in Ventricular Assist Device (VAD) and Extra Corporeal Membrane Oxygenation (ECMO) (clinicians, scientists, engineers) and patients to address the spectrum of key challenges associated with the clinical implementation of Mechanical Assist Device (MAD) technologies. CRE ACTIONS in collaboration with ECMONet is pleased to announce a full PhD Scholarship in Mechanical Circulatory Support. Application details, to be released soon on CRE ACTIONS web page https://medicine-program.uq.edu.au/clinical-schools/school-clinical-medicine/research/cre-actions and ECMONet website http://www.internationalecmonetwork.org/
Acknowledgements Big thank you to all our global collaborators! We couldn’t do it without you…
The Centre of Research Excellence in Advanced Cardio-respiratory Therapies Improving OrgaN Support (CRE ACTIONS) is funded by the National Health and Medical Research Council (1079421). The contents of the published material are solely the responsibility of The Critical Care Research Group (CCRG) and do not reflect the views of NHMRC.
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Acknowledgements
Contact us
Critical Care Research Group Level 3, Clinical Sciences Building
The Prince Charles Hospital Rode Road
Chermside QLD 4032 Ph: (07) 3139 6880
Contact email:
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