Vol. 12 No. l/2

CYTOKINES

CONTENTS

Editorial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Gail A. Rock

Editorial Review: Cytokines-a Barely Believable Story . . . . . . . . . . . . . . . . . . . . 3 Terry I. Ham blin

Growth and Differentiation Factors for Hemopoietic Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Mona Hansson, Gunilla Kling

Erythropoietin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Peter I. Williamson

Therapeutic Applications of the Myeloid Haemopoietic Growth Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Finella Brito-Babapulle

Interleukin-2 and Lymphokine Activated Killer Cells . . . . . . . . . . . . . . . . . . . . 35 Terry I. Ham blin

Regulation of the B Cell Response by Cytokines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Andrew J. T. George

Interferons in Haemato-oncology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 D. W. Galvani

Tumour Necrosis Factor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 Alison /ones

INTERNATIONAL FORUM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 Tetsuzo Agishi

HEMAPHERESIS LISTENING POST: Use of Peripheral Stem Cells in Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 Irena Sniecinski

NOTICE TO REVIEWERS OF MANUSCRIPTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81

TO OUR READERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82

UPCOMING EVENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83

Report from the European Society for Haemapheresis . . . . . . . . . . . . . . . . . . . . 85 C. Coffe, U. E. Nydegger

SUBMITTED PAPERS

Are Oral Contraceptives Removed during Plasmapheresis? . . . . . . . . . . . 87 Scott F. Ford, Ingrid S. Sketris, Iohn Verrier Jones

Evaluation of the Organon Teknika Plasmapur System with New Software and Two Types of Filter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 H. W. Eijkhout, P. Van Driessche, J. H. Schade, C. E. Hack, H. I. C. De Wit

III

In Vitro Evaluation of a New Dual Screen Microaggregate Filter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 Paula A. Napychank, Wilda McDonough, Toby L. Simon, Edward L. Snyder

NEW PATENTS: New Patents and Published Patent Applications for the United States and Over 30 Other Countries . . . . . . . . . . . . . . . . . . . . . . . i

Vol. 12 No. 3

UNRELATED BONE MARROW TRANSPLANTATION

CONTENTS

Editorial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 Gail A. Rock

Editorial Review: Bone Marrow Transplantation Using Unrelated Bone Marrow Donors-a Technology in Evolution . . . . . . . . . . . . . . . . . . . . . . . . . 111 Noel A. Buskard

The Use of Unrelated Bone Marrow Transplantation in the Treatment of Chronic Myelogenous Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Patrick G. Beatty

Unrelated Donor Marrow Transplantation for Severe Aplastic Anaemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 M. R. Howard

Unrelated Donor Bone Marrow Transplantation for Correction of Lethal Congenital Immunodeficiencies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135 A. H. Filipovich

Tissue Typing Considerations in the Use of Unrelated Bone Marrow Donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 Machteld Oudshoom, Aad van Leeuwen, /on 1. van Rood

Bone Marrow Transplants for Patients With Acute Leukemia and Myelodysplastic Syndrome Using Unrelated Donors . . . . . . . . . . . . . . . . . . . . . . 151 H. A. Messner

Collection and Transportation of Human Bone Marrow Cells From Unrelated Donors ..,...........,......,,.,,.,........,................................ 155 F. B. Petersen, Pamela Weinberg, I. A. Hansen, E. D. Thomas

LETTER TO THE EDITOR: Viral Safety of Coagulation Factor Concentrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..*...................................................... 161 A. Fartugia

CURRENT TRENDS: PREPARATION OF PLATELET CONCENTRATES

zfdyu$m and Utilization of Leukocyte Poor Apheresis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163

Kenneth C. Anderson, Barbara C. Gorgone, Elizabeth Wahlers, Jane Cook, Barbara Barrett, Janet Andersen

IV

The Preparation of Platelet Concentrates by the Light-Spin/ Hard-Spin Technique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171 Walter H. Dzik

SUBMITTED PAPERS

Continuous Plow Cell Separator Use for Bone Marrow PmCe88illS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 P. I<. Baker, E. G. H. Rhodes, J. K. M. Duguid

Long-term Plasmapheresis in the Treatment of HOmOZygOu8

Familial Hypercholesterolemia in Two Chinese Patients . . . . . . . . . . . . . . . 189 Christina Wang, Kee Lam Wong, Chun Ho Cheng, Tai Kwong Chan, Wing Tat Liu, Hsiang /u Lin

TheIapeUtiC I&ukaphenX& . . . . . . . . . . . ..*................................................. 193 Milan Radovic, Bela Balint, Ljubomir Milenkovic, Ljerka Tiska- Rudman, fovan Taseski

Intensive Plasmapheresis as an Alternative Therapy for Intractable Pruritu8 of Primary Biliary Cirrhosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 Abraham I. Kohan, Iorge A. Findor, Estela Brush Igartua, Nestor Villaravid

NEW PATENTS: New Patents and Published Patent Application8 for the United States and Over 30 Other Countries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . i

UPCOMING EVENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v

Vol. 12 No. 4

PEDIATRIC TRANSFUSION

CONTENTS

Editorial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201 Gail A. Rock

Editorial Review: Pediatric Transfusion . . . . . . . . . . . . . . . . . . ..*...................... 203 Naomi L. C. Luban

Platelets in Newborns: Physiology and Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 M. Andrew

Normal and Disordered Coagulation in the Neonate . . . . . . . . . . . . . . . . . . . . . . 231 Gordon L. Bray

The Role of Granulocyte Transfusions as Adjuvant Therapy in the Treatment of Neonatal Sepsis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 Mitchell S. Cairo

Detection, Correction and Ultimate Prevention of Anemias in the Preterm Infant . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 C. A. 1. Wardrop, I. G. Jones, B. M. Holland

LETTER TO THE EDITOR: Intravenous IgG to Prevent Stillbirth in Rhesus Incompatibility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271 Entique Rewald

V

HEMAPHERESIS LISTENING POST The Problem of Vascular Access for Hemaphersis . . . . . . ..*...*...*...*.*.*. 273 David Ciavarella

Optimal Venous Access . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 274 W. Ioh B. Hodgson, Selcuk Mercan

CURRENT TRENDS: EVOLVING CONCEPTS IN TRANSFUSION MEDICINE Transfusion-associated Graft-versus-host Disease: Who is at Risk? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 Kenneth C. Anderson

SUBMITTED PAPERS

Post-transfusion Graft-versus-host Disease Occurring in Non-immunosuppressed Patients in Japan ,..,....,..,........................*. 281 Koki Takahashi, Takeo Juji, Hiroshi Miyazaki

Automated Platelet-rich Plasma Collection: A Survey of 5 Years’ Experience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..*..................... 291 N. A. Anderson, D. H. Pamphilon, N. P. Tandy, 1. Saunders, A. Wilkes, I. D. Fraser

Studies on Quantitative Levels of Complement Activation Induced by Immobilized and Soluble Forms of Protein A: ReIevance to Extracorporeal Immunoadsorption . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Hiroshi Sato, Yutaka Yamagata, Teruhisa Kidaka

New “Leap-Frog” Technique for Autologous Blood Donation . . . . . . . . 307 Tetsunori Tasaki, Hitoshi Ohto, Rikiya Abe, Masahiro Ogata

Urokinase Infusion Restores Function of Thrombotically occluded Inferior Vena Cava Apheresis Catheters Refractory to Bolus Urokinase Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311 William D. Haire, Robert P. Lieberman, Kim Schmit-Pokorny, Anne Kessinger

UPCOMING EVENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . i

VI

Author Index

Abe, R., 307 Agishi, T., 75 Andersen, J., 163 Anderson, K. C., 163,277 Anderson, N. A., 291 Andrew, M., 207

Baker, P. K., 183 Balint, B., 193 Barrett, B., 163 Beattv. P. G.. 119 Bray, ‘G. L., 23 1 Brito-Babapulle, F., 25 Buskard, N. A., 111

Haire, W. D., 311 Hamblin, T. J., 3,3.5 Hansen, J. A., 155 Hansson, M., 5 Hodgson, W. J. B, 274 Holland, B. M., 2.57 Howard, M. R., 123

Igartua, E. B., 197

Jones, A., 67 Jones, J. G., 257 Jones, J. V., 87 Juji, T., 281

Cairo, M. S., 247 Chan, T. K., 189 Cheng, C. H., 189 Ciavarella, D., 273 Coffe, C., 85 Cook, J., 163

De Wit, H. J. C., 91 Duguid, J. K. M., 183 Dzik, W. H., 171

Eijkhout, H. W., 91

Farrugia, A., 161 Filipovich, A. H., 135 Findor, J. A., 197 Ford, S. F., 87 Fraser, I. D., 291

Galvani, D. W., 59 George, A. J. T., 43 Gorgone, B. C., 163

Hack, C. E., 91

Kessinger, A., 3 11 Kidaka. T.. 299 Kling, G., 5 Kohan, A. I., 197

van Leeuwen, A., 143 Lieberman, R. P., 3 11 Lin, H. J., 189 Liu, W. T., 189 Luban, N. L. C., 203

McDonough, W., 101 Mercan, S., 274 Messner, H. A., 151 Milenkovic, L., 193 Miyazaki, H., 281

Napychank, P. A., 101 Nydegger, U. E., 85

Ogata, M., 307 Ohto, H., 307 Oudshoom, M., 143

Pamphilon, D. H., 291 Petersen, F. B., 155

Radovic, M., 193 Rewald, E., 271 Rhodes, E. G. H., 183 Rock, G. A., 1, 109,201 van Rood, J. J., 143

Sato, H., 299 Saunders, J., 291 Schade, J. H., 91 Schmit-Pokomy, K., 3 11 Simon, T. L., 101 Sketris, I. S., 87 Sniecinski, I., 77 Snyder, E. L., 101

Takahashi, K.. 281 Tandy, N. P., 291 Tasaki. T.. 307 Taseski, J.: 193 Thomas, E. D., 155 Tiska-Rudman, L., 193

Van Driessche, P., 9 1 Villaravid, N., 197

Wahlers, E., 163 Wang, C., 189 Warchop, C. A. J., 257 Weinbern. P.. 155 Wilkes, x., 291 Williamson, P. J., 15 Wong, K. L., 189

Yamagata, Y., 299