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Vomiting, Diarrhoea, Vomiting, Diarrhoea, Abdominal PainAbdominal Pain&&Fluid TherapyFluid Therapy
Department of PaediatricsCUHK
VomitingVomiting
TerminologyTerminology
vomiting– forceful ejection of gastric contents– often preceded by nausea and retching
possetting– gentle expulsion of gastric contents
with swallowed air (“wind”)regurgitation
– similar to possetting, but larger lossretching
– laboured rhythmic respiratory activity that precedes vomiting
Mechanism of vomitingMechanism of vomiting
Vomiting process
• patent upper GI tract
• retro-peristalsis
• lower esophageal sphincter
relaxation
• contraction of abdominal
muscles and diaphragm
Causes of VomitingCauses of Vomiting
infection/inflammation• gastroenteritis
• viral• bacterial• toxin
• immunological• cow-milk• coeliac• food allergy
• inflammatory• appendicitis• mesenteric adenitis
GI obstruction• pyloric stenosis• intussusception• volvulus• strangulated hernia• Hirschsprung• tumour• post-operative ilieus
CNS irritation• infection• raised ICP• drugs / poisons• metabolites
Incompetent LES• possetting• reflux• hiatus hernia
HistoryHistory
Onset• Present since birth ?• Present since weaning ?• Present since introduction of new food?• Sudden or gradual ?
Vomit• Size, frequency and timing to feed• Undigested food ? bile ? blood ? coffee-
ground ?
HistoryHistory
Associated symptoms• Stool:
• Diarrhoea ? • constipation ? • Smelly stool that is difficult to
flush ?
• Abdominal pain / Abdominal distension• Fever• Change in appetite / feeding habit• Weight loss ? or gain ?
HistoryHistory
Social history• Family members having vomiting /
dirrhoea• Recent traveling
ExaminationExamination
Full examination is necessary in all childrenGeneral examination
• Activity• Nutritional status• Weight and Height (and compare with
previous)• Temperature• Anaemia• Jaundice• Degree of dehydration• Cleft palate• Neurological status
ExaminationExamination
Abdomen: Inspection• Distension
• Constipation• Gastroenteritis• Obstruction / Ileus• Coeliac Disease
• Surgical Scar
ExaminationExamination
Abdomen: Palpation• Local tenderness• Generalized tenderness• Guarding and rebound tenderness
• Peritoneal irritation• Masses
• Organomegaly• Pyloric mass• Sausage shaped mass
• Hernial orifices• Genitalia
ExaminationExamination
Abdomen: Auscultation• Bowel sounds
• Normal• Hyperactive: irritation, obstruction• Diminished, absent: paralytic ileus
Abdomen: Rectal examination• Anal fissures• Sphincter• Faeces• Blood• Masses
InvestigationsInvestigations
Ordered according to index of suspicion• Examine stool for consistency, blood,
mucus, and steatorrhoea• Examine urine for RBC, WBC and organism
under microscope• Stool for bacterial culture and virus
isolation• Urine for culture• Blood for cell counts, U&Es, culture• Test feed for infant 2 to 10 weeks• AXR: Supine, Erect for intestinal obstruction• USG abdomen
Gastro-oesophageal refluxGastro-oesophageal reflux
Small, effortless vomits of semi-digested milk soon after feeding
Common in infants because of• immature lower oesophageal sphincter• short intra-abdominal length of
oesophagusUsually resolve by 1 year oldUsually mild but severe cases with
complications:• pulmonary aspiration• oesophagitis, peptic stricture• failure to thrive, feeding problems
Gastro-oesophageal refluxGastro-oesophageal reflux
Investigation– usually not required– 24-h oesophageal pH monitoring
• contrast study
Gastro-oesophageal refluxGastro-oesophageal reflux
management• often requiring no treatment• mild: positioning at 30° head-up prone
& thickening agent• drugs enhancing gastric emptying
• H2 antagonists
• fundoplication
Pyloric StenosisPyloric Stenosis
hypertrophy of pyloruspresented between 2 and 7 weeks of ageM:F = 4:1presentation
• large, non-bilious, projectile vomiting after each feed
• dehydration, weight loss
Pyloric StenosisPyloric Stenosis
visible peristalsis “olive”-shaped mass at
right upper quadrant
Pyloric StenosisPyloric Stenosis
Investigation• ultrasonography & contrast study
antrum
thickened pyloricmuscle
elongated pyloriccanal
Pyloric StenosisPyloric Stenosis
Management
• fluid resuscitation• electrolyte correction
• hypochloraemic alkalosis with hypokalaemia
• Ramstedt’s pyloromyotomy
Persistent & Chronic VomitingPersistent & Chronic Vomiting
CNS: raised intracranial pressure• early morning vomiting• headache worsen on lying down
Appendicitis• uncommon before 3 years old• atypical presentation in retrocaecal and
pelvic appendices
Persistent & Chronic VomitingPersistent & Chronic Vomiting
Cyclical vomiting• psychogenic, with stressful factors• of school age• prodromal symptoms: pale, withdrawn• associated with migraine
Anorexia or bulimia nervosa– adolescent– deranged body image– weight-fear– induced vomiting
DiarrhoeaDiarrhoea
Clinical manifestationsClinical manifestations
Diarrhoea: increase in frequency (> 3 times) and change in character of stool (volume and liquidity)
Lead to rapid dehydration and progressive acidosis
Acute - within 2 weeks
Chronic or persistent - beyond 2 weeks
WHO: 2.6 episodes/child/year, global mortality 3.3 million/year
Acute gastroenteritisAcute gastroenteritis
Morbidity in developed world, yet mortality in developing world
Complicated in developed world with secondary lactase deficiency
Complicated in developing world with recurrent episodes and malnutrition, like deficiency of zinc, vitamin A etc,
Especially affecting children < 2 years
Infective causes of diarrhoea Infective causes of diarrhoea and vomitingand vomitingViruses BacteriaRotavirus Enteroinvasive E. coliAdenovirus Camphylobacter jejuniCoronavirus Salmonella sp.Astrovirus Shigella sp.Calcivirus Vibrio choleraParvovirus Yersinia enterocoliticaEchovirus
Protozoa Bacterial toxinsGiardia lamblia Enterotoxic E. coliCrytosporidium Staphylococcus aureusEntamoeba histolytica Bacillus cereusMalaria Clostridium difficile
HistoryHistory
Onset• Sudden or gradual ?
Stool• Volume, frequency and timing to feed• Loose, watery, rice watery• Blood, mucus, steatorrhoea
HistoryHistory
Associated symptoms• Vomiting• Abdominal pain / Abdominal distension• Fever• Change in appetite / feeding habit• Weight loss ?
Social history• Family members having vomiting /
dirrhoea• Recent traveling
ExaminationExamination
Full examination is necessary in all childrenGeneral examination most important
• Activity• Nutritional status• Weight and Height (and compare with
previous)• Temperature• Anaemia• Jaundice• Degree of dehydration
ExaminationExamination
Abdomen: Inspection• Distension
• Constipation (with overflow diarrhoea)
• Gastroenteritis
Abdomen: Palpation• Local tenderness• Generalized tenderness• Guarding and rebound tenderness
• Peritoneal irritation
ExaminationExamination
Abdomen: Auscultation• Bowel sounds
• Normal• Hyperactive: irritation, obstruction• Diminished, absent: paralytic ileus
Abdomen: Rectal examination• Anal fissures• Sphincter• Faeces• Blood• Masses
InvestigationsInvestigations
Ordered according to index of suspicion• Examine stool for consistency, blood,
mucus, and steatorrhoea• Examine urine for RBC, WBC and
organism under microscope• Stool for bacterial culture and virus
isolation• Urine for culture• Blood for cell counts, U&Es, culture
Mild Moderate Severe
Body weight 5% 6-9% 10%
General Appearance
Thirsty, Alert Thirsty, restless or lethargic
Drowsy, cold, sweating
Tears Present Absent Absent
Anterior Fontanelle
Normal Sunken Very sunken
Eyes Normal Sunken Very sunken
Tissue Turgor Normal Absent Absent
Mucous Membranes
Moist Dry Very Dry
Pulse Normal Rapid Rapid, weak, may be
impalpable
Urine flow Normal Reduced, concentrated
Oliguria
Blood pressure Normal Normal or low Low, may be unrecordable
Fluid deficit 50ml/kg 60-90ml/kg 100ml/kg
TreatmentTreatment
Rehydration fluid and electrolytes (po/iv)glucose-electrolyte solutionNutritional treatment - continuation of breast
feeding (lactadherin), or formula feedingAntidiarrhoeal drugsNew agent: mucoprotective agents such as
dioctahedral smectite, or probiotic bacteria such as killed lactobacillus acidophilus
AAP Practice Parameter 1996AAP Practice Parameter 1996
ORS is the preferred treatment for fluid and electrolyte losses caused by diarrhoea in children who have mild to moderate dehydration
Use of cola, fruit juice and sports beverages is not recommended– Inappropriate electrolyte content– Too much carbohydrate
ORSORS
Commercially available ORS contain 45-50mmol/l of sodium– Best suitable for maintenance– Can also be used in mild to moderate
dehydrated otherwise healthy children– Taste better than the saltier solution
WHO recommended ORS– High sodium content 90mmol/l– Suitable for secretory diarrhoea eg.
Cholera
ORS Therapy in mild to ORS Therapy in mild to moderate dehydrationmoderate dehydration
50-100ml/kg ORS to be given over a 4-hour period
Replacement of stool (10ml/kg for each stool) and vomitus will require adding appropriate amounts of solution to the total
Administering in small but frequent amounts– 10 ml every two minutes = 500 ml over 4
hours
Labour intensive, time consuming
Intravenous fluid therapyIntravenous fluid therapy
Although oral rehydration is encouraged, clinician must be prepared to administer IV fluids who do not respond to oral regimen
Severely dehydrated or who are in a state of shock must receive immediate and aggressive intravenous fluid therapy
Daily fluid requirementDaily fluid requirement
Fluid First 10 kg 100 ml/kg/daySecond 10 kg 50
ml/kg/dayAfter first 20 kg 20 ml/kg/day
Fluid requirement increases by 10% per degree Celcius rise in body temperature
Sodium 3 mmol/kg/dayPotassium 2 mmol/kg/day
Daily fluid requirementDaily fluid requirement
Example for a 25-kg boy• Daily fluid requriement
• First 10kg = 100 x 10 = 1000 ml
• Second 10kg = 50 x 10 = 500 ml• After 20 kg = 20 x 5 = 100
ml• Total = 1000 + 500 +
100 = 1600ml
• Daily Na requirement = 75 mmol• Daily K requirement = 50 mmol
Phase I: Treat shock(0 - 30 minutes)
Phase II: Initial Rehydration(½ - 8 hours)
Phase III: Continued Replacement(8 - 24 hours)
20ml/kg 0.9% NaCl
Reassess
Improved
No Change
Measure plasma electrolytes
Calculate fluid deficit and maintenance
Review plasma electrolytes and fluid status
Initial replacement with saline-dextrose solution
Half the calculated fluid deficit and maintenance
Replacement with saline-dextrose solution
Half the calculated fluid deficit and maintenance
Hypertonic dehydrationHypertonic dehydration
Difficult to assess degree of dehydration, unless the child in clinically shock (>10% dehydration)
The plan – replace total fluid deficit slowly over 48
hours– To lower serum sodium slowly:
10mmol/L/day
Rapid correction may cause cerebral oedema
Antibiotics in special Antibiotics in special circumstancecircumstance
Salmonella GE in infantShigella with trimethoprim-sulfamethoxazoleCampylobacter with erythromycinCholera with tetracyclineAmoebic dysentery - giardiasis
(metronidazole)NB: drug resistance, promote carrier state,
worsen the course of diarrhoea
RefeedingRefeeding
Children who have diarrhoea and are not dehydrated should continue to be fed regular diet
Children who require rehydration should be fed regular diet as soon as they have been rehydrated
Early feeding of regular diet does not worsen the course or symptoms of mild diarrhoea and may reduce the duration of diarrhoea modestly
RefeedingRefeeding
Avoid fatty foods and foods high in simple sugars
Rice, wheat, potatoes, bread and cereals (complex carbohydrate), lean meats, yogurt, fruits and vegetables are usually well tolerated
Most children who have diarrhoea will tolerate full-strength milk
Lactose-free formula may be used if secondary lactase deficiency is suspected
Antidiarrhoeal compoundsAntidiarrhoeal compounds
Decrease stool water and electrolyte lossesChange toward more formed stoolRelieve discomfortFalse sense of securityDelaying more effective therapyGenerally not recommended
Drugs that alter intestinal Drugs that alter intestinal motilitymotility
LoperamideDecreases transit velocity Increases the ability of gut to maintain fluidReduces stool losses, shortens the course of
diarrhoeaAssociates with serious adverse effect
– Lethargy, ileus, respiratory depression and coma
– Death has been reported
Drugs that alter secretionDrugs that alter secretion
Bismuth compounds, eg. Bismuth subsalicylate
Inhibit intestinal secretionModest beneficial effectsDose of every 4 hours for 5 daysTheoretical risk of Reye syndrome from
salicylate absorption
Drugs that absorb fluid and Drugs that absorb fluid and toxinstoxins
Kaolin-pectin, fiber, activated charcoal, attapulgite
Adsorb bacterial toxinsBind waterSerious toxic effects are not a concernEvidence of their efficacy has been
contradictory
Agents that alter intestinal Agents that alter intestinal microfloramicroflora
Patients with diarrhoea undergo reduction fecal flora, which leads to increased water losses
Lactobacillus sp.– Alter the bacterial colonization of the gut
therapeuticallyToxic effects are not a concernHowever efficacy of lactobacillus-compounds
in treating diarrhoea yet to be demonstrated
Treatment outcome/evaluationTreatment outcome/evaluation
hospitalization or notextent of investigationeffectiveness of rehydration (IV <=> PO)use of antimicrobials relief of symptoms - frequency of stools,
duration of diarrhoea, weight gainprevention strategy
• Public health measures - sanitation• Food preparation and storage• Promotion of breast feeding
Chronic DiarrhoeaChronic Diarrhoea
Birth to 6mo InfectionSecondary lactose deficiency
Persisting diarrhoeaCow’s milk intoleranceOther food intoleranceCystic fibrosisIn-born errorsAntuoimmune
enteropathySurgery
Chronic DiarrhoeaChronic Diarrhoea
6mo to 1yr InfectionCoeliac diseaseGiardia lambliaSurgery
1+ years Post-infectionCoeliac diseaseGiardia lamblia
10+ years Inflammatory bowel disease
Chronic diarrhoeaChronic diarrhoea
Postinfectious diarrhoea - persistence of diarrhoea and failure to gain weight more than 7 days after admission
Due to disaccharide intolerance(brush-border damage), cow milk protein hypersensitivity(b-lactoglobulin), persistent infection
Managed by soy-base formula, lactose-free formula, or semielemental diet
Chronic nonspecific diarrhoeaChronic nonspecific diarrhoea
“Toddler” diarrhoeaaffecting children 6 months to 2 yearsself-limitingpass 4 - 10 loose stool per daymay be intermittent, explosiveMay contain undigested foodNegative stool culture and reducing
substancesgrowth and development normal
Acute abdominal pain:Acute abdominal pain:“Does the child require “Does the child require emergency surgery?”emergency surgery?”
Signs of peritonism, appendicitis– Fever, localized tenderness, guarding,
rebound tenderness, absent bowel sounds– The younger the child the more vague the
signsSigns of obstruction
– Vomiting, abdominal distension, high pitch bowel sounds, empty rectum
Gastrointestinal bleeding– Haematemesis, bloody stool, “Current-
jelly” stool, malaena
Require early surgical referral
Abdominal cause but does not require immediate surgical referral
Systemic cause
AppendicitisPeritonitisIntussusceptionVolvulusStrangulated herniaTraumaGI Bleeding
GastroenteritisInfantile colicIngestionConstipationPeptic ulcerPancreatitis / mumpsCholecystitis / cholangitisUrinary tract infectionNephrotic syndromeHepatitisDysmenorrhoea
Any febrile illness but especially ENT infectionLower lobe pneumoniaAbdominal migraineDiabetic ketoacidosisSexual abusePorphyriaLead poisoningHenoch Scholein purpura