VUOS

VUOSCOMPANY PROFILE

PARTNER FOR COOPERATION

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22 VUOS – PARTNER FOR COOPERATION

Where you can find us

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VUOS ownership

AGROFERTHOLDING, a.s.

SYNTHESIA, a.s.

VUOS, a.s.

100% 100%

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History

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VUOS main businesses

2. Toxicology and Analytics

1. R&D and Production of Fine Chemicals

Employees

Sales in %

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The Certificates of VUOS

• ISO 9001:2008• Certificates of Good Laboratory

Practice

• Certificate of Accreditation for Certification of Products No. 229/2002 (EN 45011:1998)

• Certificate of Accreditation No. 230/2002 Testing Laboratory No. 1057 (EN ISO/IEC 17025:2005)

• Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory


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Strong Points

• Education structure of employees

• VUOS is located in area of long-lasting chemical tradition and complete infrastructure

• Cooperation with University of Pardubice

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R&D, up scaling

• Pharmaceutical intermediates

• Intermediates for microelectronics

• Custom syntheses of chemical specialities

• Dyes and pigments for special application

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R&D, up scaling


Wide range of quantitiesGrams – in laboratory

Kilograms – in kilolab

unitMetric tons – in VUOS production plant

Hundreds of MT –

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VUOS ’s key chemistry

VUOS ’s key technology


Adamantane derivatives

N-Heterocycles

API Building Blocks

PhosgenationHydrogenation

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VUOS ’s technology/manufactureexpertise includes:acetylationaldolisationamidationalkylationaminationamoxidationalkali fusionarylhydrazines synthesesazocouplingbenzoylationchiral synthesischlorinationchlorosulfonationcyclisationclaisen condensationdecarboxylation

dehydrohalogenationdiazotisationeliminationesterificationFriedel-Crafts reactionheterocyclic synthesishydrolysis reactionsneutralisationnitrationnitriles synthesesoxidation – catalytic/chemicaloxidation in liquid phaserearrangementreduction with hydrazine and sodium borohydridesulfonation

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Kilolab Unit

2x reactors, 250 and 650 l

2x High performance rectification columns

Laboratory phosgenation units from 1 to 30 litres

Phosgenation

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Kilolab Unit

3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200 ˚C, Hastelloy C clad1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel1x autoclave 1 000 l, 10 bar, 140 ˚C, stainless steel many autoclaves up to 10 l

Hydrogenation

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Kilolab Unit

1 x glass reactor 50 l cooled down to – 80 ˚C1x glasslined reactor for NaH reactions (250 l)3x glass reactors 100l for RLi, Grignard reactions

Low temperature, RLi, RMgX, NaH

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Kilolab Unit

20x glass reactors, 100 l each6x glass lined reactors (200–1 500 l)2x evaporators 50 l / h4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity

Multipurpose chemistry

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45x glass lined reactors, total vol. 70 000 l (500–5 000 l)13x stainless steel reactors, total vol. 22 000 l (1 000–3,000 l)8x High performance rectification columnssufficient filtration capacity (nutsches, centrifuges)computer controlled

Production Equipment


Production Unit

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Toxicology, Ecologyand Analytics

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REAC Hand other legislative provisionsComplete Offer of Services by VUOS

•CONSULTING•TESTING

– Physico – chemical tests– Toxicological tests– Ecotoxicological tests

•EXPERT WORKS•REGISTRATION

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Analytical techniques:•NMR Spectroscopy•Mass Spectrometry (LC/GC-MS)•ICP-AES•IR Spectroscopy•Chromatography (HPLC, GC)•UV-Vis


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Toxicology:In vivo and in vitro testing accordingto the OECD or EU methods:•Acute toxicity test•Skin and eye irritation•Sensibilisation•Repeated dose tests•Reproduction toxicity tests•Carcinogenicity•Mutagenicity

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Ecotoxicological testing:In vivo and in vitro testing accordingto the OECD or EU methods:•Aquatic toxicity•Biotic degradation – Ready biodegradability•Inherent biodegradability•Abiotic degradation

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ContactsGeneral Manager: Dr. Karel NovákPhone: +420 46 682 2550, fax: +420 46 682 2976e-mail: [email protected] Manager: Miloš Jesenský,Ph.D.Phone: +420 46 682 3300, fax: +420 46 682 2976e-mail: [email protected]&D: Alois Koloničný, Ph.D.Phone:+420 46 682 3156, fax: +420 46 682 3900e-mail: [email protected] and Analytics: Viktor Mejstřík, Ph.D.Phone:+420 46 682 3127, fax: +420 46 682 2975e-mail: [email protected] Engineering: Luboš VíšekPhone:+420 46 682 5790, fax: +420 46 682 3900e-mail:[email protected]

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Documents

VUOS