Excessive Sleepiness (ES) in Obstructive Sleep Apnea (OSA)

Consequences of ES Exist for OSA Patients

Doctors Agree: ES Can Persist Despite Airway Treatment

Excessive Sleepiness (ES) is considered to be the most common symptom of Obstructive Sleep Apnea (OSA).1 ES is associated with neurocognitive and functional impairment that can affect daily life.1

of healthcare professionals surveyed believe that ES can have serious, adverse consequences on OSA patients such as negatively impacting their QOL2

Emerging research suggests OSA may cause neuronal injury that may result in ES, which is associated with neurocognitive and functional impairment15,16

The survey revealed only 30% of healthcare professionals are very aware of the emerging scientific research showing brain alterations associated with ES in OSA that affect wakefulness as it relates to ES3

A recent SERMO survey conducted by Jazz Pharmaceuticals among pulmonologists, neurologists and psychiatrists treating patients with OSA reveals perceptions of ES prevalence among their patients and key differences in how healthcare professionals identify and evaluate ES.

98% ?

ES is common among patients who are being treated with airway therapy.4-6

Over 80% believe that patients with Obstructive Sleep Apnea can still experience symptoms of Excessive Sleepiness when airway treatment has been optimized.7

Wake Up Call

Impact on Quality of Life Brain Alterations Caused by OSA

US-OSA-00351

It’s Essential for Physicians to Initiate the Conversation with Patients

For more information please visit: ESandOSA.com

Research shows that patients often underreport their symptoms of ES to their healthcare professionals 1,4,12,13

of healthcare professionals surveyed indicated that they most often initiate the discussion of symptoms of ES with patients14

Pulmonologistsprefer to use the standard ESS when evaluating patients for ES9

Breakdown by Specialty

70%

Preferences Vary in How to Identify Symptoms & Evaluate for ES

82% 76% 54%

Survey findings reveal that using the Epworth Sleepiness Scale (ESS) and proactively asking an informal set of questions are the most widely used ways to assess Excessive Sleepiness among healthcare professionals.8

Psychiatriststend to evaluate their patients by proactively asking an informal set of questions about how tired they are10

Neurologiststake a more hybrid approach, combining the use of ESS and proactively asking an informal set of questions (68%)11

About the SurveyParticipants in the 10-question, self-administered online SERMO survey included a nationally-represented sample of 476 neurologists, pulmonologists, and psychiatrists. They were surveyed around key topics in Excessive Sleepiness and Obstructive Sleep Apnea. The study was conducted in March 2018 using SERMO’s RealTime platform. SERMO is one of the world’s most prominent social networks and largest pollsters for physicians.

References:1. American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2014.2. Data on File (SOL-2018-008). Palo Alto, CA: Jazz Pharmaceuticals, Inc.3. Data on File (SOL-2018-009). Palo Alto, CA: Jazz Pharmaceuticals, Inc.4. Weaver TE et al. Sleep. 2007;30(6):711-719.5. Jackson ML et al. J Clin Sleep Med. 2018;14(1):48-566. Soose RJ et al. World J Otorhinolaryngol Head Neck Surg. 2017; 3:79-84.7. Data on File (SOL-2018-007). Palo Alto, CA: Jazz Pharmaceuticals, Inc.8. Data on File (SOL-2018-011). Palo Alto, CA: Jazz Pharmaceuticals, Inc.

9.Data on File (SOL-2018-003). Palo Alto, CA: Jazz Pharmaceuticals, Inc.10. Data on File (SOL-2018-012). Palo Alto, CA: Jazz Pharmaceuticals, Inc.11. Data on File (SOL-2018-013). Palo Alto, CA: Jazz Pharmaceuticals, Inc.12. Young T et al. N Engl J Med. 1993;328(17):1230-1235.13. Guilleminault C, Brooks SN. Excessive daytime sleepiness: a challengefor the practicing neurologist. Brain. 2001;124(Pt 8):1482-1491.14. Data on File (SOL-2018-010). Palo Alto, CA: Jazz Pharmaceuticals, Inc.15. Joo EY et al. Sleep. 2010;33(2):235-24116. Lal C et al. Chest. 2012;141(6):1601-1610

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US-OSA-00352