WearMeSoC - Nano-Tera 2016

8/18/2019 WearMeSoC - Nano-Tera 2016

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Prof. Dr. Qiuting Huang, 26.04.2016

26.04.2016Qiuting Huang 1

WearMeSoC

Multi Functional Wearable Wireless Medical Monitoring Based on A Multi Channel Data

Acquisition and Communication Management System on a Chip


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IoT: The e!t "# Billion Connected De$ices


Transportation

%ealth& Fitness

'n$ironmental

'nergyManagement


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(ro)ing Interests in Wearable De$ices



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Challenges *pportunities

Aging Population

Growing need of the elderl

!ilent !uffering

"irele## $e%olution

Ad%ent of &2& and 'o(

!)artphone# and (a*let#

+ano le-troni-# 'ntegration Potentiall enefiting Health-are

Main *b+ecti$e/De%elop te-hnologie# e##ential to )iniaturie wirele## )onitoring, andde)on#trate it# effe-ti%ene## in real )edi-al u#e -a#e#

Source: Swiss Federal Statistical Office

#-alating &edi-al o#t#

But

ot# of Pro)i#e#

ot of Potential

!o)e Apppli-ation# Are lear

&ore (o e Di#-o%ered

"ill e 5rag)ented

+eed Platfor)

+eed &iniaturiation

+eed ow o#t

+eed PlugandPla

Indeed



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Auricall

A new de%i-e for a nonin%a#i%e, wirele##,-ontinuou# )onitoring of o?gen #aturation

and heart rate in patient# with heart failure

Hardware 8onept

9 !tandard8le*ele=troden

9 8G Beine A*leitung )it wei le=troden>

9 !auer#toff!Cttigung#)e##ung

!udano ', 5la))er A, Her)ann 5, !*urra (, 8ai#er P, Hirt A,Her)ann &, orti $, $u#-hit=a 5, Eund G, +oll G. 'nt ardiol.200F !ep 1612B1>/1413.

The eeds 1 A$ailable Components 3imit Miniaturi4ation/re 1 ano Tera 0esearch



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WearMeSoC *b+ecti$es

26.04.2016Qiuting Huang I

5igure 2 5un-tional :utline of "eara*le "irele## &onitor !:BPage I of the 2012 Propo#al>

atter

Antenna

$adio

&i-ro !D ard Holder

&e)or

Planned

!o

le-trodeonne-tor#

Part of !lide !hown in &a 2013 +( on%ention


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5ision: %ighly Integrated Wireless Med /lat6orm

Plug and Pla for lini-ian# and Patient#

26.04.2016Qiuting Huang F


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7ourney To)ards Miniaturi4ation and Wearability

26.04.2016Qiuting Huang


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Start o6 WearMeSoC& %andheld 5ersion

(oo )an -hip# #poil the *roth



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S2in Inter6ace to 'lectrode

11

9 Addre##ing "eara*ilit/9 D Drift and &otion Artefa-t#

9 A5 &u#t +ot !aturate9 Proper hoi-e of HP orner

9 &ain# 'nterferen-e9 o-ation Dependent



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Data A-Jui#ition hip with 'nterferen-e an-ellation

Data Acquisition ASIC:

&$$/

'np. ')pedan-e/ '$

+oi#e B1K100H>/

(olerated :ff#et/

101d

23@&L

0.F2MN$&!

O300)N

"ith #ignal re-on#tru-tion/

&a?. D$/

&a?. P"$/

10I.6d

@ )"



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|| 26.04.2016Qiuting Huang 13

'M(: %and (esture 0ecognitionBProf. enini, (H and ni%. ologna>

&G -ontrolled hand pro#the#i#

I2C

J T A G

SPIELECTRODES

CONNECTOR

JTAG/SWD

USB

BATTERY

IMU

PRESSURE

SENSOR

SDCARD

BLUETOOTH

MODULE

SENSORS

REGULATORMCU

REGULATOR

USART

SPI

ANALOG DIGITAL

CEREBROARM Cortex M4MCU

POWERMANAGEMENT

BLUETOOTH

REGULATOR

CEREBRO DIGITAL

REGULATOR

CEREBRO ANALOG

REGULATOR

5urther &iniaturiation De#ira*le

"ear&e!o A5


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/eripheral eural Inter6ace to 5isceral *rgans. 8nderstanding the 0egulation o6 Blood /ressure



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eed 6or Miniaturi4ation

0esearch /lat6orm 6or Bioelectronics

[email protected] Huang


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Integration 6or Miniaturi4ation



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ano.'lectronics /ro$ides the Tiniest o6 eural

Inter6ace

1I

3644

52

60

68

76

84

92

100

108

116

124

132

140

148

156

164

172

180

BP(mmHg

14 Test Cortec inWistar rat320g_1.5!soflu t"aneand 1.5#$%in O2_Cortec_&T' sti%ulation()*_3+_0.2%(_200us_20',_20s

2!57"00 2!57"20 2!57"40 2!58"00 2!58"20

C

0SAN

Time 9s,

A

B/))Hg

B%0

eat)in

100

120

140

160

180

200

220

240

260

280

300

320

340

360

380

400

420

440

460

480 H#$%&R$ Test Cortec inWistar rat320g_1.5!soflut "aneand 1.5#$%inO2_Cortec_&T' sti%ulation()*_3+_0.2%(_200us_20',_20s

2!57"00 2!57"20 2!57"40 2!58"00 2!58"20

!ti)ulating AD+B20#>



ourte# of Prof. !. a-our, P5

ourte# of Dr. Q. "ang, HN



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|| 26.04.2016Qiuting Huang 1F

5i$oSoC $;#: Biomedical Data Acquisition SoCBin -olla*oration with Prof. . enini>


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'$olution To)ards Miniature



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Match Bo! Si4ed Demonstrator:'lectrocardiograph and /ulsed *!imetry )ith Wireless Connecti$ity



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Match Bo! Si4ed Demonstrator 6or 'C(



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'# a nonin%a#i%e )ea#ure)ent )ethod for *loodo?gen #aturation B!p:2> and heart *eat# per)inute BP&>

'# widel u#ed in patient )onitoring in/

anae#the#ia

inten#i%e -are #tation#

a)*ulant -are

'ntere#t in weara*le o?i)eter#/ ongter) )onitoring

&onitoring in #tre## te#t#

&edi-al re#ear-h, e.g., in pneu)olog

State-of-the-Art:

Left: Nonin Onyx for ambulant use checking– not monitoring

bot: Masimo Rad5v for stationary use incl.

monitoring

2 '

$( )S*( )S

$( IR*( IR

+

,-

.%

/

/

/

Integrated Circuit 6or /ulse *!imetry

26.04.2016Qiuting Huang22


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Integrated Systems 3aboratory Power -on#u)ption

#uall, LED + 50mA

A)*ient ight Add# an off#et wrong re#ult #in-e

$m.#1& i# un-orrelated to LED.

&otion

$e#ult# in )otion of the %enou# *lood lower than a-tual #aturation i# )ea#ured

Pul#atile #ignal and )otion artifa-t arediffi-ult to #eparate Bunderdeter)ined##te)>

)S

)S

IR

' '

$ 3 ,

' ' 3 IR

'$$

,- ,-

IR

$

, ',,

IR

,

Wearability Challenges

/

/

/

still

vertical

movement

horizontal

movement

arm swinging

Oscillating

finger

Raw signals perturbed by different kinds of motion.

A)*ient ight

A)plifier :ff#et



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Integrated Circuit 6or Sp*"


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Match Bo! Si4ed Demo Board 1 Sp*"

26.04.2016Qiuting Huang 2@

9 "irele## onne-tion to (a*let9 #er 'nterfa-e oth forDe%i-e !et p and $e#ultDi#pla

9 !a)e G' for ?G and !p:2


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Match Bo! Si4ed Demo 6or Sp*" 1 < Wa$elengths



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|| 26.04.2016Qiuting Huang 2I

Sp*" Implant 6or Chronic Study o6 %ypertension

-o))on-arotid arter

photodiode

1 :nline, http/www.*iolog-orner.-o)wor=#heet#ratR-ir-ulator.ht)l ,

06.03.2016

http://www.biologycorner.com/worksheets/rat_circulatory.htmlhttp://www.biologycorner.com/worksheets/rat_circulatory.html


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/lethysmography )hile Stimulating AD

$aw Pleth#)ograph# '$

N!

atheter referen-e/ lood Pre##ure P&

&ea#ured light inten#itie#,i.e. in%er#e of the a*#orption

re#pirator pul#epre##ure %ariation#BPPN>

ffe-t of AD+#ti)ulation

!hort ter) pre##ure %ariation# -an *e o*#er%ed in the pleth#)ographi-#ignal# Ba-tuall how pleth#)ograph wor=#>/5luid Pre##ure arter dilation light a*#orption4 4



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e!t Steps



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5i$oSoc $";#: Multi.Sensor SoCBin -olla*oration with Prof. . enini>

PMU

act!e"e#"or"

COTS

R$

D di#pla !D -ard ')age #en#or &e)or

gro#-ope a--elero)eter ther)o)eter )i-rophone ...%e%cate% a#a&o' rea%o(t

F -hannel *iopotentialwith -ontinuou# lead i)pedan-e

)a""!e "e#"or"

)*oto%o%erea%o(t

3 -hannel#

te+)erat(rerea%o(t

2 -hannel

L D O "

co#,'(rato#a#% %ata BUS

SAR ADCre-onfigura*le

@to14 *it

MU- CL.

UARTSPI "&a!e

SPI +a"ter J TAG/ GPIO"

SAR ADCre-onfigura*le

@to14 *it

A&'ort*+cADC12*it

M(&t0c*a##e&dri%er, *lo-=er,#ti)ulator

core 1 core L2 +e+or332 = !$A&

4!oSoC !251

BoI+)e%a#ce

core 2 core 6


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Conclusions


9 High ?pe-tation# in 'o( Ad%an-e#, Al#o for Health9 (i)e i# ripe in ter)# of !)artphone#, onne-ti%it and !o

9 'ntegration '# atal#t to !u--e##

9 &iniaturiation, Power, Ner#atilit, "eara*ilit

9 &at-h o? and !)aller !ied De)on#trator#

9 Dri%en * "eara*le ?G, !p:2 and ioele-troni- ')plant

9 na*led * &ed &onitor !o and other '#

9 onfident in a A-hie%ing the A)*itiou# (arget# "e !et :ur#el%e#

Documents

WearMeSoC - Nano-Tera 2016