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Weathering the Storm: How to Establish and Sustain an Independent Research
Career in an Era of Limited Funds
Lawrence J. Prograis, Jr., M.D Senior Scientist, Special Programs and Bioethics Division of Allergy, Immunology and Transplantation National Institute of Allergy and Infectious [email protected]
Workshop Outline
■NIH Extramural Program: Key Players, Funding Mechanisms (Alison Augustine, NIAID)
■Overview of CSR Peer Review (Tina McIntyre, CSR
■Peer Review Details (David Winter, CSR)
■Panel Discussion (Charlie Li, NIAID)
Understanding & Navigating the NIH
NIH Extramural Program
Alison Deckhut Augustine, Ph.D.Basic Immunology Branch
Division of Allergy, Immunology and TransplantationNational Institute of Allergy and Infectious Diseases, NIH
NIH – 27 Institutes and Centers
Office of the Director
National Libraryof Medicine
Center for Scientific Review
FogartyInternational
Center
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National Instituteof Diabetes andDigestive and
Kidney Diseases
National Instituteof Dental andCraniofacial
Research
National Institute onDeafness and Other
CommunicationDisorders
National EyeInstitute
National Heart,Lung, and Blood
Institute
National Instituteon Alcohol Abuseand Alcoholism
National CancerInstitute
National Instituteon Drug Abuse
National Instituteof Environmental Health Sciences
National Instituteof Mental Health
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof Allergy and
Infectious Diseases
National Center on Minority Health and Health Disparities
National Instituteon Aging
National Instituteof Child Health
and HumanDevelopment
National HumanGenome Research
Institute
National Instituteof General
Medical Sciences
National Instituteof Nursing Research
National Centerfor Complementary
and AlternativeMedicine
National Institute of Biomedical Imaging and Bioengineering
no fundingauthority
National Center for Advancing
Translational Sciences
Different Missions, Responsibilities and Constituencies
National Instituteon Minority Health
and HealthDisparities
NIH Extramural Staff
■Program Officer (PO)
■Scientific Review Officer (SRO)
■Grants Management Specialist (GMS)
Program Officer
A science professional, usually Ph.D. or M.D., who:
■ Provides scientific stewardship and administration of grants & contracts awarded by NIH
■ Identifies areas of scientific priority and develops funding opportunities for extramural researchers
■ Advocate for investigators: Provides guidance on NIH extramural policy/procedures, research resources, and funding opportunities to extramural investigators
Scientific Review Officer
A science professional, usually Ph.D. or M.D., who:
Is based at an NIH Institute or Center (IC), or at the Center for Scientific Review (CSR)
Manages Study Sections and review panels for grants and contracts
Selects review panel members
Assigns reviewers to applications
Compiles application summary statements
Grants Management Specialist
Business/finance professional who:
Negotiates and awards all grants
Provides fiscal administration of grants
Is the government official on fiscal and policy issues and approvals
Extramural Scientist Career Path and NIH Funding Options
Ph.D. or M.D.
FacultyPosition
AwardTypes
CareerStage
GraduateStudent
IndependentInvestigator
T32 T32 F32 K22 K99or R00K’s
Postdoctoral Fellow
F31 R01 R21 P01R03R15
Transition awards
R00 – Independent phase of K99/R00 Pathway to Independence R01 – Research Project Grant (up to 5 years of support, renewable)R03 – Small Research Grant (up to 2 years of support, non-renewable)R15 – Academic Research Enhancement Award (AREA) (up to 3 years, renewable)R21 – Exploratory/Developmental Research Grant (up to 2 years of support, non-renewable)P01 – Program Project Grant (multi-project grant, up to 5 years of support, renewable)
Grant Writing 101: The Big Three
Can your research move your field forward?
Is the field important – will progress make a difference in human health?
Can you and your team conduct the work (expertise, resources)?
When will I get my grant funded?
(well, sometimes it just feels that way…)
2013 Application Success Rates
Grant Mechanism NIAID – New applications
NIAID – Renewal applications
R01 12.3% 29.9%
R03 20.3% N/A
R15 11.9% 62.5%
R21 16.6% N/A
P01 14.3% 42.9%
NIH Institute
2013 Success Rate – New R01
2013 Success rate – Renewal R01
NIAID 12.3% 29.9%NCI 13% 26.9%NIA 11.1% 29.1%NIAMS 14.9% 26.9%
NICHD 10.9% 20.5%NIGMS 14.8% 37%
Funding Opportunity Announcements and Concepts
Funding Opportunity Announcements (FOA): http://grants.nih.gov/grants/oer.htm http://www.niaid.nih.gov/researchfunding/ann/pages/default.aspx
■ RFA:■ Set-aside funds; One application receipt date■ Areas of scientific interest indicated, also includes areas not
supported■ Awards may have a budget cap
■ PA: 3 Types■ PA –No set-aside funds or special review. Reviewed in standing
CSR study sections(paid with IC “payline” funds)■ PAR – Special review (Special Emphasis Panel) convened, no set-
aside funds ■ PAS – Set-aside funds, may include review by a Special Emphasis
Panel
Current NIAID Concepts
Concepts = Potential Opportunities http://www.niaid.nih.gov/researchfunding/council/concepts/pages/default.aspx
■ Molecular Mechanisms of Combination Adjuvants (RFA)
■ Program Announcement for High-Priority Immunology Grants (PA)■ Provide for growth in the field of fundamental immunology■ Emphasize the continued and long-term interest of NIAID in
fundamental immunology, a major mission of NIAID among other NIH institutes and centers
A Little Help From Your Friends: Pre-review
■ NIH extramural staff:■ SRO – advice about appropriate study sections; submission
requirements■ PO - advice about research focus (before review), appropriate study
sections, discussion of review results and applicant responses
■ Colleagues: read your application, well in advance of the application due date
■ GRIP: Grant Review for Immunologists Program■ Matches new PIs with established PIs in same area■ Obtain expert advice on grant applicationhttp://www.aai.org/Education/GRIP/index.html
What to Do After Review Talk to your NIH Program Officer
Attends the Study Section (most cases) Provide insights to discussion (unofficial) and possible funding
options
Read the Summary Statement Official document providing scientific merit score and summarizing
reviewers comments First paragraph (Resume) is the official summary of the meeting
discussion
Strategize Next Steps Talk to your NIH program officer again, after both of you have read the summary statement Discuss with colleagues, mentors