Webspirs Pascal Biomed

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Search History* #14 children (5743 records)Searches and records below from: Pascal BioMed Part 2 (1996)* #13 children (4406 records)Searches and records below from: Pascal BioMed Part 1 (1996)* #12 children (4558 records)Searches and records below from: Pascal BioMed Part 2 (1995)* #11 children (4281 records)Searches and records below from: Pascal BioMed Part 1 (1995)* #10 children (4572 records)Searches and records below from: Pascal BioMed Part 2 (1994)* #9 children (3800 records)Searches and records below from: Pascal BioMed Part 1 (1994)* #8 children (4115 records)Searches and records below from: Pascal Scitech 2000 Part 2

#7 science (70561 records)Searches and records below from: Pascal Scitech 2000 Part 1




#3 science (75373 records)

Searches and records below from: Pascal Scitech 1998 Part 1#2 science (58287 records)* #1 children (63 records)

Record 1 of 5743 in Pascal BioMed Part 1 (1997)

T1: Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in childrenPA: CHANG-M-H; CHEN-C-J; LAI-M-S; HSU-H-M; WU-T-C; KONG-M-S; LIANG-D-C; SHAU-W-Y; CHEN-D-SCA: Taiwan-Childhood-Hepatoma-Study-Group, TaiwanAF: Department of Pediatrics, College of Medicine, National Taiwan University,

Taipei, Taiwan; Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Health, Executive Yuan,Taipei, Taiwan; Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan; Department of Pediatrics, Chang-Gung Children's Hospital, Linkou, Taoyuan,Taiwan; Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Hepatitis Research Center, College of Medicine, National Taiwan University, Taipei,TaiwanSO: The-New-England-journal-of-medicine. 1997; 336 (26) : 1855-1859IS: 0028-4793PY: 1997CP: United-StatesLA: EnglishBL: Analytic

LT: SerialAB: Background A nationwide hepatitis B vaccination program was implemented inTaiwan in July 1984. To assess the effect of the program on the development of hepatocellular carcinoma, we studied the incidence of this cancer in children inTaiwan from 1981 to 1994. Methods We collected data on liver cancer in childrenfrom Taiwan's National Cancer Registry, which receives reports from each of thecountry's 142 hospitals with more than 50 beds. Data on childhood liver cancer were also obtained from Taiwan's 17 major medical centers. To prevent the inclusion of cases of hepatoblastoma, the primary analysis was confined to liver cancers in children six years of age or older. Data were also obtained on mortality fr


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003). At base line, the mean (SD) hemoglobin A1c value was higher in the group with highly disordered eating behavior(11.11.2 percent) than in the groups whose eating behavior was moderately disordered 18.91.7 percent) or nondisordered 18.71.6 percent, P


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ed sampling equations, which used one, four, or five concentration time points,accurately estimated CsA AUC when compared with an actual 7-to 9-point curve. Anequation that used a single concentration time point at 5 hours was unbiased and provided the best precision in calculating a 12-hour interval AUC. This equation had a mean absolute percentage error of 5.8% (95% confidence interval, 3.3 to8.3). Equations using four or five concentration time points were found to provide estimates of AUC for a 24-hour interval AUC, with less than 10% error. Thesefindings suggest that limited sampling models using as few as one to four concentration time points provide accurate estimations of CsA AUC in pediatric patients. The use of these limited sampling models provides the clinical advantage oflower blood sampling requirements and reduced costs associated with the monitoring of cyclosporine.AI: ABNR: 17 ref.DEE: Ciclosporin-; Immunosuppressive-agent; Pharmacokinetics-; Area-under-the-curve; Samplings-; Homotransplantation-; Kidney-; Child-; Oral-administration; Chemotherapy-; Treatment-; Surveillance-; Limited-sampling; Therapeutic-drug-monitoringDEF: Ciclosporine-; Immunodepresseur-; Pharmacocinetique-; Aire-sous-la-courbe;Prelevement-; Homotransplantation-; Rein-; Enfant-; Voie-orale; Chimiotherapie-; Traitement-; Surveillance-; Prelevement-limite; Suivi-therapeutique-medicamenteuxDES: Ciclosporina-; Inmunodepresor-; Farmacocinetica-; Area-debajo-de-la-curva;Toma-de-muestra; Homotrasplante-; Rinon-; Nino-; Via-oral; Quimioterapia-; Trat

amiento-; Vigilancia-IDE: Human-; Transplantation-; Surgery-; Kidney-disease; Urinary-system-diseaseIDF: Homme-; Transplantation-; Chirurgie-; Rein-pathologie; Appareil-urinaire-pathologieIDS: Hombre-; Trasplantacion-; Cirugia-; Rinon-patologia; Aparato-urinario-patologiaJN: Therapeutic-drug-monitoringCD: TDMODVLOC: INIST, Shelf number 18087, INIST No. 354000044957020050AN: 970351867SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: The influence of dosage, age, and comedication on steady state plasma lamotrigine concentrations in epileptic children : A prospective study with preliminary assessment of correlations with clinical responsePA: BARTOLI-A; GUERRINI-R; BELMONTE-A; ALESSANDRI-M-G; GATTI-G; PERUCCA-EAF: Clinical Pharmacology Unit, University of Pavia, Pavia, Italy; Institute ofChild Neurology and Psychiatry, University of Pisa and IRCCS Stella Maris Foundation, Pisa, ItalySO: Therapeutic-drug-monitoring. 1997; 19 (3) : 252-260IS: 0163-4356PY: 1997CP: United-States

LA: EnglishBL: AnalyticLT: SerialAB: The effects of age, dosage, and type of comedication on plasma lamotrigine(LTG) concentrations and the relationship between plasma drug levels and clinical response were evaluated in a prospective study of 45 patients, aged 3 to 38 years, with epilepsy uncontrolled by conventional anticonvulsant therapy. Six of the 45 patients were on single-drug therapy, and 39 were on two to five concurrently administered antiepileptic drugs when LTG was added. Thirteen patients wereassessed at three or more LTG dosage levels. Within individuals, steady state pl


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asma LTG concentrations increased linearly with increasing daily dosage over theexamined dose range (25 to 575 mg/day or 0.75 to 21 mg/kg.day). Among patientsalso receiving enzyme-inducing agents, such as carbamazepine, barbiturates, or phenytoin, plasma LTG concentrations normalized to a 1 mg/kg daily dose were lower in children aged 3 to 6 years (0.30 0.17 g/ml; n = 6)than in the older children (0.43 0.18 g/ml; n = 12) and adolescents/adults (0.68 0.26 g/ml; n = 10). In patients treated with valproate, the age dependency of plasma LTG was less evident, possibly because of a smaller sample size and the confounding effect of comedication. Within any given age group, dose-normalized LTG concentrations were about five-fold higher in patients comedicated with valproic acid than in those comedicated with enzyme inducers. Twenty patients showed a favorable response (with a >=40% reduction in seizure frequency compared with the pre-LTG period) and continued on long-term treatment. Plasma drug concentrations in these apparent responders were highly variable and did not differ significantly from those observed innonresponders (6.6 5.2 versus 4.8 3.3g/ml). These findings show that plasma LTG concentrations exhibit a wide interindividual variability under the influence of age and type of comedication, but they are predictably related to dosage within individual patients. Although there was no apparent relationship between drug levels and clinical response in this difficult-to-treat population, further studies on the potential value of monitoring plasma LTG concentrations are indicated.AI: ABNR: 31 ref.

DEE: Lamotrigine-; Anticonvulsant-; Chemotherapy-; Epilepsy-; Treatment-; Posology-; Age-; Adult-; Child-; Drug-interaction; Pharmacokinetics-; Activity-concentration-relationDEF: Lamotrigine-; Anticonvulsivant-; Chimiotherapie-; Epilepsie-; Traitement-;Posologie-; Age-; Adulte-; Enfant-; Interaction-medicamenteuse; Pharmacocinetique-; Relation-concentration-activiteDES: Lamotrigina-; Anticonvulsivante-; Quimioterapia-; Epilepsia-; Tratamiento-; Posologia-; Edad-; Adulto-; Nino-; Interaccion-medicamentosa; Farmacocinetica-; Relacion-concentracion-actividadIDE: Human-; Nervous-system-diseases; Central-nervous-system-disease; Cerebral-disorderIDF: Homme-; Systeme-nerveux-pathologie; Systeme-nerveux-central-pathologie; Encephale-pathologie

IDS: Hombre-; Sistema-nervioso-patologia; Sistema-nervosio-central-patologia; Encefalo-patologiaJN: Therapeutic-drug-monitoringCD: TDMODVLOC: INIST, Shelf number 18087, INIST No. 354000044957020010AN: 970351862SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Traitement des cancers differencies de la thyroide de l' enfant : Etude d'une serie de 130 cas suivis a l' Institut Gustave-Roussy. Les cancers differenci

es de la thyroideTT: Treatment of differentiated thyroid cancer in children. A series of 130 cases at the Gustave-Roussy Institute. Differentiated thyroid cancerPA: TRAVAGLI-J-P; DE-VATHAIRE-F; CAILLOU-B; SCHLUMBERGER-MSO: Annales-d'endocrinologie. 1997; 58 (3) : 254-256IS: 0003-4266PY: 1997CP: FranceLA: FrenchBL: Analytic


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LT: SerialNR: 16 ref.JN: Annales-d'endocrinologieCD: ANENAGLOC: INIST, Shelf number 822, INIST No. 354000061726630160AN: 970351851SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian childrenPA: MUHE-L; LULSEGED-S; MASON-K-E; SIMOES-E-A-FAF: Department or Pediatrics and Child Health, Faculty of Medicine, Addis AbabaUniversity, Addis Ababa, Ethiopia; Division of Child Health and Development, World Health Organization, Geneva, Switzerland; Department of Pediatrics, Divisionof Infectious Diseases, University of Colorado Health Sciences Center and Children's Hospital, Denver, Colorado, United StatesSO: Lancet-British-edition. 1997; 349 (9068) : 1801-1804FTXT: ScienceDirect (tm) http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=SilverLinker&_urlversion=4&_method=citationSearch&_volkey=0140%2d6736%23349%231801%239068&_version=1&md5=03866172ae62b69ceda7812d660f750a ScienceDirect (China) http://elsevier.lib.tsinghua.edu.cn/science?_ob=GatewayURL&_origin=SilverL

inker&_urlversion=4&_method=citationSearch&_volkey=0140%2d6736%23349%231801%239068&_version=1&md5=03866172ae62b69ceda7812d660f750a ScienceDirect (Taiwan) http://sdos.ejournal.ascc.net/science?_ob=GatewayURL&_origin=SilverLinker&_urlversion=4&_method=citationSearch&_volkey=0140%2d6736%23349%231801%239068&_version=1&md5=03866172ae62b69ceda7812d660f750aIS: 0140-6736PY: 1997CP: United-KingdomLA: EnglishBL: AnalyticLT: SerialAB: Background Pneumonia is the most important cause of morbidity and mortalityin children aged under 5 years worldwide. Studies in developing countries have

suggested an association between nutritional rickets and pneumonia. Since both nutritional rickets and pneumonia are common in Ethiopia, we did a case-control study to determine the role of nutritional rickets in the development of pneumonia. Methods Cases were children younger than 5 years admitted to the Ethic-Swedish Children's Hospital during a 5-year period with a diagnosis of pnuemonia (n=521), but data were incomplete for 21 of these and they were not included. Controls (n=500) were matched for admission within 3 months of cases and age within 3 months and had no evidence of pneumonia. Nutritional, demographic, and clinical and radiographic data for rickets and pneumonia were collected. Matched odd ratios and logistic regression were used to test the significance of the associationof rickets and pneumonia. Findings Rickets was present in 210 of 500 cases compared with 20 of 500 controls (odds ratio 22.11). There were significant differences between cases and controls for family size, birth order, crowding, and months

of exclusive breastfeeding (p


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DEE: Pneumonia-; Rickets-; Vitamin-D; Calcium-; Risk-factor; Ethiopia-; Case-control-study; Child-; Nutritional-statusDEF: Pneumonie-; Rachitisme-; Vitamine-D; Calcium-; Facteur-risque; Ethiopie-;Etude-cas-temoin; Enfant-; Etat-nutritionnelDES: Neumonia-; Raquitismo-; Vitamina-D; Calcio-; Factor-riesgo; Etiopia-; Estudio-caso-control; Nino-; Estado-nutricionalIDE: Africa-; Human-; Respiratory-disease; Lung-disease; Diseases-of-the-osteoarticular-system; Bone-disease; Nutrition-disorder; Vitamin-deficiency; Inorganic-element; Vitamin-IDF: Afrique-; Homme-; Appareil-respiratoire-pathologie; Poumon-pathologie; Systeme-osteoarticulaire-pathologie; Osteopathie-; Trouble-nutrition; Carence-vitaminique; Element-mineral; Vitamine-IDS: Africa-; Hombre-; Aparato-respiratorio-patologia; Pulmon-patologia; Sistema-osteoarticular-patologia; Osteopatia-; Trastorno-nutricion; Carencia-vitaminica; Elemento-inorganico; Vitamina-JN: Lancet-British-editionCD: LANCAOLOC: INIST, Shelf number 5004, INIST No. 354000062022700110AN: 970351805SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Absence of GS gene mutations in childhood thyroid tumorsafter Chernobyl in contrast to sporadic adult thyroid neoplasiaPA: WALDMANN-V; RABES-H-MAF: Institute of Pathology, Ludwig Maximilians University of Munich, Thalkirchner Strasse 36, 80337 Munchen, GermanySO: Cancer-research-Baltimore. 1997; 57 (12) : 2358-2361IS: 0008-5472PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Heterotrimeric G proteins participate in the signal transduction cascade. A

dult thyroid tumors have been shown to harbor specific point mutations in codons201 and 227 of the GS subunit of the adenylate cyclase stimulator. This protein affects the GDP/GTP turnover and finally results in an enhanced activation of GS and thus adenylate cyclase. We attempted to findout if GS gene mutations were present in thyroid tumors of children from Belarus after the Chernobyl nuclear accident. Paraffin sections of 20thyroid tumors were used for PCR amplification by oligonucleotide intron primers flanking exons 8 and 9, encompassing codon 201 and 227, respectively. By direct sequencing of the 274-bp amplification product, we did not detect any mutations of the GS gene in codon 201 or 227. In contrast to thyroid neoplasia of adults, GS gene mutations do not play a role in the development of childhood thyroid tumors after the Chernobyl reactor accident.AI: AB

NR: 32 ref.DEE: Radioactive-contamination; Accident-; Belarus-; Malignant-tumor; Thyroid-gland; Point-mutation; G-protein; Cell-subpopulation; Adult-; Carcinogenesis-; Adenylate-cyclaseDEF: Radiocontamination-; Accident-; Belarus-; Tumeur-maligne; Thyroide-; Mutation-ponctuelle; Proteine-G; Sous-population-cellulaire; Adulte-; Carcinogenese-;Adenylate-cyclase; Tchernobyl-; Gene-GsDES: Radiocontaminacion-; Accidente-; Bielorusia-; Tumor-maligno; Tiroides-; Mutacion-puntual; Proteina-G; Subpoblacion-celular; Adulto-; Carcinogenesis-; Adenylate-cyclase


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IDE: Eastern-Europe; Europe-; Human-; Phosphorus-oxygen-lyases; Lyases-; Enzyme-; Endocrinopathy-; Thyroid-diseasesIDF: Europe-Est; Europe-; Homme-; Phosphorus-oxygen-lyases; Lyases-; Enzyme-; Endocrinopathie-; Thyroide-pathologieIDS: Europa-del-Este; Europa-; Hombre-; Phosphorus-oxygen-lyases; Lyases-; Enzima-; Endocrinopatia-; Tiroides-patologiaJN: Cancer-research-BaltimoreCD: CNREA8LOC: INIST, Shelf number 5088, INIST No. 354000061859050090AN: 970351782SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Blunt intestinal injury in children : Diagnostic and therapeutic considerations. DiscussionPA: KURKCHUBASCHE-A-G; FENDYA-D-G; TRACY-T-F-JR; SILEN-M-L; WEBER-T-R; HOYT-D-B, comment; WISNER-D-H, comment; KARRER-F-M, comment; ALBERTY-R-E, commentAF: Division of Pediatric Surgery, Department of Surgery, St Louis University Health Sciences Center and Cardinal Glennon Children's Hospital, St Louis, Mo, United StatesCF: *Scientific Session of the Western Surgical Association, *104, *Portland, Ore United States, *1996-11-20

SO: Archives-of-surgery-Chicago-IL-1960. 1997; 132 (6) : 652-658IS: 0004-0010PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: Serial; *Conference-MeetingMT: article; commentsAB: Objectives: To identify computed tomographic (CT) findings in children whohave experienced blunt trauma and who have known intestinal injuries and to correlate these findings with the findings of the initial physical examination. Design: A retrospective review of children (aged


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surgery. Most injuries were treated with segmental resection or suture repair, but enterostomies were required in 2 patients. Complications (ie, the need for enterostomy and fascial dehiscence) were seen as a result of late or missed diagnosis, which could occur as late as 4 to 6 weeks after injury as intestinal obstruction due to stricture. Conclusions: The initial physical examination findings and CT evaluation can independently identify the presence of intestinal injury inapproximately 25% of cases. In the remainder of cases, the awareness of the more subtle findings of bowel injury on a CT scan can complement the physical examination findings and potentially lead to a more timely intervention for bowel injury.AI: ABNR: 20 ref.DEE: Gut-; Lesion-; Trauma-; Computerized-axial-tomography; Diagnosis-; Retrospective-; Blunt-body; Evaluation-; Child-; Treatment-DEF: Intestin-; Lesion-; Traumatisme-; Tomodensitometrie-; Diagnostic-; Retrospective-; Corps-emousse; Evaluation-; Enfant-; Traitement-DES: Intestino-; Lesion-; Traumatismo-; Tomodensitometria-; Diagnostico-; Retrospectiva-; Cuerpo-embotado; Evaluacion-; Nino-; Tratamiento-IDE: Human-; Digestive-diseases; Intestinal-disease; Radiodiagnosis-; Medical-imageryIDF: Homme-; Appareil-digestif-pathologie; Intestin-pathologie; Radiodiagnostic-; Imagerie-medicaleIDS: Hombre-; Aparato-digestivo-patologia; Intestino-patologia; Radiodiagnostico-; Imageneria-medical

JN: Archives-of-surgery-Chicago-IL-1960CD: ARSUAXLOC: INIST, Shelf number 2034, INIST No. 354000061859540130AN: 970351770SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Correlates of disablement in systemic onset juvenile chronic arthritis : Across sectional studyPA: VAN-DER-NET-J; KUIS-W; PRAKKEN-A-B-J; LUKKASSEN-I; SINNEMA-G; HUTTER-A-P; BRACKEL-H-J-L; DE-WILDE-E-J; HELDERS-P-J-M

AF: Department of Pediatric Physical Therapy of the University Hospital for Children and Youth "Wilhelmina Children's Hospital", Utrecht, Netherlands; Department of Pediatric Rheumatology of the University Hospital for Children and Youth "Wilhelmina Children's Hospital", Utrecht, Netherlands; School of Medicine of theUniversity of Utrecht, Netherlands; Department of Pediatric Psychology of the University Hospital for Children and Youth "Wilhelmina Children's Hospital", Utrecht, Netherlands; Department of Pediatric Cardiology of the University Hospitalfor Children and Youth "Wilhelmina Children's Hospital", Utrecht, Netherlands; Department of Pediatric Pulmonology of the University Hospital for Children and Youth "Wilhelmina Children's Hospital", Utrecht, Netherlands; Department of Psychology of the University of Leiden, NetherlandsSO: Scandinavian-journal-of-rheumatology. 1997; 26 (3) : 188-196IS: 0300-9742

PY: 1997CP: SwedenLA: EnglishBL: AnalyticLT: SerialAB: The impact of systemic onset JCA on functional outcome was studied in a multidimensional construct. Twenty-one patients were subjected to auxologic evaluation, a laboratory check, pulmonary and cardiac function tests, radiographic evaluation, joint count on tenderness, swelling and function, ADL, health assessment(CHAQ), and psychosocial evaluation. Six of 21 patients had active systemic dis


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ease. Restrictive pulmonary function was found in 8/17 patients, 1/21 had pericarditis. Joint impairment was moderate. Functional limitations were mild. Self-esteem was positive. Parental report on functional limitation correlated significantly with joint impairment. Performance of daily activities correlated stronglywith perceived competence. Active inflammatory disease did not correlate with joint impairment and functional limitation. Patients with systemic onset JCA develop mild functional limitations, which partially correlate with the more seriousimpairments. Pulmonary function disorders are a common impairment. Active inflammatory disease might influence functional outcome, but there is no evidence thatit influences joint impairment outcome.AI: ABNR: 36 ref.DEE: Juvenile-rheumatoid-arthritis; Functional-deficit; Respiratory-disease; Cardiovascular-disease; Prognosis-; Child-; Chronic-DEF: Arthrite-chronique-juvenile; Deficit-fonctionnel; Appareil-respiratoire-pathologie; Appareil-circulatoire-pathologie; Pronostic-; Enfant-; Chronique-DES: Artritis-cronica-juvenil; Deficiencia-funcional; Aparato-respiratorio-patologia; Aparato-circulatorio-patologia; Pronostico-; Nino-; Cronico-IDE: Human-; Diseases-of-the-osteoarticular-system; Inflammatory-joint-diseaseIDF: Homme-; Systeme-osteoarticulaire-pathologie; Rhumatisme-inflammatoireIDS: Hombre-; Sistema-osteoarticular-patologia; Reumatismo-inflamatorioJN: Scandinavian-journal-of-rheumatologyCD: SJRHATLOC: INIST, Shelf number 4382, INIST No. 354000061959610080

AN: 970351753SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: The anterior epitympanic recess: CT anatomy and pathologyPA: PETRUS-L-V; LO-W-W-MAF: Department of Radiology, Olive View-UCLA Medical Center, Sylmar, Calif, United States; Department of Radiology, St Vincent's Medical Center, Los Angeles, Calif, United StatesCF: *Annual meeting of the American Society of Head and Neck Radiology, *Los Angeles, Calif United States, *1996-04

SO: American-journal-of-neuroradiology. 1997; 18 (6) : 1109-1114IS: 0195-6108PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: Serial; *Conference-MeetingAB: PURPOSE: To describe the variation in size and shape of the anterior epitympanic recess and to discuss pathologic processes that affect this space. METHODS: Axial CT scans of the temporal bones of 31 adults and 19 children were reviewed retrospectively to ascertain the morphology and size of the anterior epitympanic recess. Selected confirmed disease processes involving this space were studied. RESULTS: The anterior epitympanic recess, which is consistently identified on

axial CT scans, is either single or multicelled. In our study, it was made up of a solitary cell in 61 of 100 ears. Side-to-side symmetry in shape was presentin 78 of 100 cases. The size of a solitary air cell ranged from 1.0 to 7.0 mm. CONCLUSIONS: The configuration of the anterior epitympanic recess is readily affected by a persistent stapedial artery, by facial nerve schwannomas, by hemangiomas of the facial nerve canal in the geniculate region, and by congenital and acquired cholesteatomas. Familiarity with the CT anatomy of this space facilitatesrecognition of these pathologic processes at an early stage.AI: ABNR: 21 ref.


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DEE: Computerized-axial-tomography; Temporal-bone; Ear-; Morphology-; Morphometry-; Ear-disease; Enumeration-; Anatomy-; Bibliographic-review; Diagnosis-; Child-; Adult-DEF: Tomodensitometrie-; Os-temporal; Oreille-; Morphologie-; Morphometrie-; Oreille-pathologie; Enumeration-; Anatomie-; Revue-bibliographique; Diagnostic-; Enfant-; Adulte-; Espace-epitympanique-anterieurDES: Tomodensitometria-; Hueso-temporal; Oido-; Morfologia-; Morfometria-; Oido-patologia; Enumeracion-; Anatomia-; Revista-bibliografica; Diagnostico-; Nino-;Adulto-IDE: Human-; Radiodiagnosis-; Medical-imagery; ENT-diseaseIDF: Homme-; Radiodiagnostic-; Imagerie-medicale; ORL-pathologieIDS: Hombre-; Radiodiagnostico-; Imageneria-medical; ORL-patologiaJN: American-journal-of-neuroradiologyCD: AAJNDLLOC: INIST, Shelf number 19668, INIST No. 354000061862340140AN: 970351647SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Le syndrome hemolytique et uremique de l' enfantTT: Haemolytic uraemic syndrome in childrenPA: BEAUNE-G; PERSONNE-I

AF: Laboratoire de biochimie, hopital Debrousse, 29, rue Soeur-Bouvier, 69322 Lyon, FranceSO: Lyon-pharmaceutique. 1997; 48 (4) : 197-199IS: 0024-7804PY: 1997CP: FranceLA: FrenchBL: AnalyticLT: SerialMT: case-report,-clinical-caseNR: 5 ref.DEE: Hemolytic-uremic-syndrome; Child-; Infant-; Case-study; Chemotherapy-; Treatment-; Renal-failure

DEF: Hemolyse-uremie; Enfant-; Nourrisson-; Etude-cas; Chimiotherapie-; Traitement-; Insuffisance-renaleDES: Hemolisis-uremica; Nino-; Lactante-; Estudio-caso; Quimioterapia-; Tratamiento-; Insuficiencia-renalIDE: Human-; Urinary-system-disease; Hemopathy-; Hemolytic-anemia; Kidney-diseaseIDF: Homme-; Appareil-urinaire-pathologie; Hemopathie-; Anemie-hemolytique; Rein-pathologieIDS: Hombre-; Aparato-urinario-patologia; Hemopatia-; Anemia-hemolitica; Rinon-patologiaJN: Lyon-pharmaceutiqueCD: LYPHADLOC: INIST, Shelf number 3666, INIST No. 354000062007790040



T1: Development of cardiovascular risk factors from ages 8 to 18 in Project HeartBeat ! : Study design and patterns of change in plasma total cholesterol concentrationPA: LABARTHE-D-R; NICHAMAN-M-Z; HARRIST-R-B; GRUNBAUM-J-A; DAI-S


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CA: Project-HeartBeat-!-Investigators, United StatesAF: The University of Texas-Houston Health Science Center, School of Public Health, United StatesSO: Circulation-New-York. 1997; 95 (12) : 2636-2642IS: 0009-7322PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialMT: short-communicationAB: Background Project HeartBeat! is a longitudinal study of the development ofcardiovascular risk factors as growth processes. Patterns of serial change, ortrajectories, from ages 8 to 18 years for plasma total cholesterol concentration(TC) and percent body fat illustrate the design and synthetic cohort approach of the study. Methods and Results Six hundred seventy-eight children (49,1% female, 20.1% black) entered the study at ages 8, 11, and 14 years and were followedup with examinations every 4 months for


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PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Objective: To study the utility and functional benefits of an implanted functional electrical stimulation (FES) system for hand grasp and release in adolescents with tetraplegia secondary to spinal cord injuries. Design: Intervention study with before-after trial measurement with each subject as his or her own control. Setting: Nonprofit pediatric orthopedic rehabilitation facility specializing in spinal cord injury. Participants: A convenience sample of five adolescentsbetween 16 and 18 years of age with C5 or C6 level tetraplegia at least I yearafter traumatic spinal cord injury. Key muscles for palmar and lateral grasp andrelease were excitable by electrical stimulation. Interventions: A multichannelstimulator/receiver and eight electrodes were surgically implanted to provide stimulated palmar and lateral grasp and release. In conjunction with implantationof the FES hand system, surgical reconstruction in the form of tendon transfers, tendon lengthenings and releases, and joint arthrodeses was performed to augment stimulated hand function. Rehabilitation of the tendon transfers and trainingin the use of the FES hand system were provided. Main Outcome Measures: Measurements of pinch and grasp force, the Grasp and Release Test (GRT), and an assessment of six activities of daily living (ADL) were administered before implantation of the FES hand system and at regular follow-up intervals. Results of the stimulated response of individual muscles and surgical reconstruction were evaluated

using standard and stimulated muscle testing techniques and standard assessmentof joint range of motion. All subjects completed follow-up testing. Results: Lateral and palmar forces were significantly greater than baseline forces (p = .043). Heavy objects on the GRT could only be manipulated with FES, and FES increased the level of independence in 25 of 30 ADL comparisons (5 subjects, 6 activities) as compared to baseline. After training. FES was preferred in 21 of 30 comparisons over the typical means of task completion. Of the 40 electrodes implanted, 37 continue to provide excellent stimulated responses and all of the implantedstimulators have functioned without problems. The surgical reconstruction procedures greatly enhanced FES hand function by either expanding the workspace in which to utilize FES (deltoid to triceps transfer), stabilizing the wrist (brachioradialis to wrist extensor transfer), or stabilizing joints (intrinsic tenodesistransfer, FPL split transfer). Conclusion: For five adolescents with tetraplegi

a, the combination of FES and surgical reconstruction provided active palmar andlateral grasp and release. Laboratory-based assessments demonstrated that the FES system increased pinch force, improved the manipulation of objects, and typically increased independence in six standard ADL as compared to pre-FES hand function. The study also showed that the five adolescents generally preferred FES for most of the ADL tested. Data on the benefits of the implanted FES hand systemoutside of the laboratory are needed to understand the full potential of FES.AI: ABNR: 47 ref.DEE: Trauma-; Spinal-cord; Complication-; Medullary-tetraplegia; Instrumentation-therapy; Galvanic-vestibular-test; Gripping-; Hand-; Result-; Adolescent-DEF: Traumatisme-; Moelle-epiniere; Complication-; Tetraplegie-medullaire; Traitement-instrumental; Stimulation-galvanique; Prehension-; Main-; Resultat-; Adol

escent-DES: Traumatismo-; Medula-espinal; Complicacion-; Tetraplejia-medular; Tratamiento-instrumental; Estimulacion-galvanica-vestibular; Prension-; Mano-; Resultado-; Adolescente-IDE: Human-; Nervous-system-diseases; Central-nervous-system-disease; Spinal-cord-disease; Neurological-disorder; Motor-system-disorderIDF: Homme-; Systeme-nerveux-pathologie; Systeme-nerveux-central-pathologie; Moelle-epiniere-pathologie; Trouble-neurologique; Trouble-moteurIDS: Hombre-; Sistema-nervioso-patologia; Sistema-nervosio-central-patologia; Medula-espinal-patologia; Trastorno-neurologico; Trastorno-motor


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JN: Archives-of-physical-medicine-and-rehabilitationCD: APMHAILOC: INIST, Shelf number 8199, INIST No. 354000061848330060AN: 970351516SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Comparison of Indirect calorimetry and thermodilution cardiac output measurement in childrenPA: CAPDEROU-A; DOUGUET-D; LOSAY-J; ZELTER-MAF: Hopital Marie-Lannelongue and Departement de Physiologie, Faculte de Medecine Pitie-Salpetriere, Paris, FranceSO: American-journal-of-respiratory-and-critical-care-medicine. 1997; 155 (6) :1930-1934IS: 1073-449XPY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: We validated experimentally the ability of hood indirect calorimetry to measure accurately Vo2. For this purpose we compared cardiac output calc

ulated from the Fick equation Q = Vo2/(Cao2 - CVo2), in which Vo2 was obtained by hood indirect calorimetry, to thermodilution cardiac output (Qth) measured simultaneously during cardiac catheterization in children (n = 16). Because Flco2 is a critical factor in hood Indirect calorimetry calculations, we also assessed the consequence of taking into account measured Flco2 rather than using the usual standard value of 0.0004.We found a good agreement between Q and Qth whether we used experimentally measured Flco2 in ambient air (Qth = 0.89 Q + 0.39,r = 0.941) or standard Flco2(Qth = 0.84 Q + 0.55, r = 0.930). However, Vco2 and R computed from standard Flco2 differed significantly (p < 0.001) from values derived from measured Flco2. This demonstrates that

indirect calorimetry allows reasonable estimates of Q, Vo2, Vco2, and R provided that the actual values of Flco2 are used.AI: ABNR: 22 ref.DEE: Measurement-method; Blood-flow; Heart-; Calorimetry-; Indirect-method; Thermodilution-; Exploration-; Comparative-study; Child-DEF: Methode-mesure; Debit-sanguin; Coeur-; Calorimetrie-; Methode-indirecte; Thermodilution-; Exploration-; Etude-comparative; Enfant-DES: Metodo-medida; Flujo-sanguineo; Corazon-; Calorimetria-; Metodo-indirecto;Termodilucion-; Exploracion-; Estudio-comparativo; Nino-IDE: Human-; Hemodynamics-; Circulatory-systemIDF: Homme-; Hemodynamique-; Appareil-circulatoire

IDS: Hombre-; Hemodinamica-; Aparato-circulatorioJN: American-journal-of-respiratory-and-critical-care-medicineLOC: INIST, Shelf number 2013, INIST No. 354000061859700180AN: 970351408SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Airway hyperresponsiveness and cough-receptor sensitivity in children with


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recurrent coughPA: CHANG-A-B; PHELAN-P-D; SAWYER-S-M; ROBERTSON-C-FAF: Departments of Thoracic Medicine and Paediatrics, University of Melbourne,Melbourne, Australia; Centre for Adolescent Health, Royal Children's Hospital, Melbourne, AustraliaSO: American-journal-of-respiratory-and-critical-care-medicine. 1997; 155 (6) :1935-1939IS: 1073-449XPY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: In children, recurrent cough is a common presenting symptom that may represent asthma. We tested the hypotheses that children with recurrent cough have increased cough-receptor sensitivity (CRS) or airway hyperresponsiveness (AHR). Skin prick testing, the capsaicin CRS test, and hypertonic saline (HS) challenge were performed in 44 children (median age: 8.9 yr) with recurrent dry cough (>= 2episodes of cough, each lasting >= 2 wk, within a period of 12 mo) and 44 controls. Measures of CRS were the concentration of capsaicin required to stimulate >=2 coughs (Cth) and >= 5 coughs (C5). During the coughing period, Cth (mean log:0.62 [95% Cl: 0.43 to 0.81]) and C5 (mean log: 1.15 [95% Cl: 0.86 to 1.44]) ofthe subjects without AHR were significantly lower (p = 0.0026, 0.027, respectively) than Cth (mean log: 1.27 [95% Cl: 0.88 to 1.66]) and C5 (mean log: 1.79 [95%

Cl: 1.21 to 2.37]) of the subjects with AHR and those of the controls (p = 0.0002 and 0.0001). During the cough-free period, there was no difference in CRS among the groups. In subjects who demonstrated AHR, the provocation dose causing a>= 15% fall in FEV1 (PD1S) during the cough period was significantly lower (p = 0.005) than that during the cough-free period.We conclude that AHR or increased CRS is present during the coughing phase in children with recurrent cough.AI: ABNR: 28 ref.DEE: Cough-; Recurrent-; Hypersensitivity-; Receiver-; Hyperreactivity-; Bronchus-; Etiology-; Exploration-; Child-DEF: Toux-; Recidivant-; Hypersensibilite-; Recepteur-; Hyperreactivite-; Bronche-; Etiologie-; Exploration-; Enfant-; Trouble-respiratoire

DES: Tos-; Recidivante-; Hipersensibilidad-; Receptor-; Hiperreactividad-; Bronquio-; Etiologia-; Exploracion-; Nino-IDE: Human-; ENT-disease; Respiratory-disease; Obstructive-pulmonary-disease; Bronchus-diseaseIDF: Homme-; ORL-pathologie; Appareil-respiratoire-pathologie; Bronchopneumopathie-obstructive; Bronche-pathologieIDS: Hombre-; ORL-patologia; Aparato-respiratorio-patologia; Broncopneumopatia-obstructiva; Bronquio-patologiaJN: American-journal-of-respiratory-and-critical-care-medicineLOC: INIST, Shelf number 2013, INIST No. 354000061859700190AN: 970351407SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Exercise ability in survivors of severe bronchopulmonary dysplasiaPA: JACOB-S-V; LANDS-L-C; COATES-A-L; DAVIS-G-M; MACNEISH-C-F; HORNBY-L; RILEY-S-P; OUTERBRIDGE-E-WAF: Divisions of Respiratory Medicine and of Newborn Medicine, McGill University Montreal Children's Hospital-Research Institute, Montreal, Quebec, CanadaSO: American-journal-of-respiratory-and-critical-care-medicine. 1997; 155 (6) :1925-1929


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IS: 1073-449XPY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: There is limited information concerning the exercise performance of long-term survivors of bronchopulmonary dysplasia (BPD), and much of what is availablepertains to those with relatively mild disease. The present study was undertakento describe exercise responses in patients with a history of severe BPD, defined as those patients with a clinical and radiographic diagnosis of BPD who required supplemental oxygen at least until they were 44 wk postconceptual age and whowere discharged home on oxygen. Fifteen children with a history of severe BPD were matched for gestational age with 15 children who had previously had respiratory distress syndrome but who did not develop BPD (Prem). These Prem control children were subsequently compared with 13 healthy control children born at term (Control) who were of similar postnatal age. Participants underwent pulmonary function testing, progressive exercise testing on a cycle ergometer, and a steady-state exercise test with cardiac output determined by CO2-rebreathing.Despite the patients with BPD having a lower FEV1 than those in thePrem group, who had lower values than the Control group (BPD, 64 21%; Prem, 85 11%; Control, 95 8%), the exercise capacity did not differ between the BPD and the Prem and between the Prem and the Control groups (BPD, 84 15%; Prem, 81 17%; Control, 91 12%). However, the BPDpatients used a greater percentage of their ventilatory reserve (VEmax/40 FEV1: BPD, 93 20%; Prem, 67 12%;Control, 59 13%). Of the four patients with BPD who had significant oxygen desaturation with exercise, three had the lowest values for FEV1 Cardiac output was appropriate for oxygen consumption in most patients.AI: ABNR: 28 ref.DEE: Hyaline-membrane; Dysplasia-; Bronchopulmonary-; Complication-; Maximal-expiratory-volume-per-second; Diffusing-capacity; Carbon-dioxide; Rebreathing-; Capacity-; Physical-exercise; Exploration-; Long-term; Child-DEF: Membrane-hyaline; Dysplasie-; Bronchopulmonaire-; Complication-; VEMS-; Ca

pacite-diffusion; Carbone-dioxyde; Rerespiration-; Capacite-; Exercice-physique;Exploration-; Long-terme; Enfant-DES: Membrana-hialina; Displasia-; Broncopulmonar-; Complicacion-; Volumen-expiratorio-maximo-por-segundo; Capacidad-difusion; Carbono-dioxido; Rerrespiracion-; Capacidad-; Ejercicio-fisico; Exploracion-; Largo-plazo; Nino-IDE: Human-; Respiratory-disease; Respiratory-distress; Premature-; Respiratory-intensive-care; Lung-volume; Gas-exchangeIDF: Homme-; Appareil-respiratoire-pathologie; Detresse-respiratoire; Premature-; Reanimation-respiratoire; Volume-pulmonaire; Echange-gazeuxIDS: Hombre-; Aparato-respiratorio-patologia; Trastorno-respiratorio; Prematuro-; Reanimacion-respiratoria; Volumen-pulmonar; Intercambio-gaseosoJN: American-journal-of-respiratory-and-critical-care-medicineLOC: INIST, Shelf number 2013, INIST No. 354000061859700170



T1: Absence of health insurance is associated with decreased life expectancy inpatients with cystic fibrosisPA: CURTIS-J-R; BURKE-W; KASSNER-A-W; AITKEN-M-LAF: Divisions of Pulmonary and Critical Care Medicine and General Internal Medi


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cine, Department of Medicine, University of Washington, Seattle, United States;Internal Medicine Associates of Auburn, Auburn, Washington, United StatesSO: American-journal-of-respiratory-and-critical-care-medicine. 1997; 155 (6) :1921-1924IS: 1073-449XPY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Life expectancy for individuals with cystic fibrosis (CF) has increased dramatically in the last 30 yr, but it is unclear whether the improved survival hasapplied equally to individuals with different health insurance status. We developed a retrospective inception cohort of all 189 patients with CF born 1/1/55 to12/31/70 who had at least one hospitalization at a university referral center.The median survival for patients with CF who were without health insurance was 6.1 yr compared with 20.5 yr for those with Medicaid and 20.5 yr for those with private insurance. Using multivariate Cox regression, health insurance and increased socioeconomic status were independently associated with longer survival. Theadjusted relative risk of death was greater for the absence of health insurancethan for factors previously shown to predict mortality in individuals with CF (female sex and presentation with meconium ileus). In summary, the absence of health insurance was associated with increased mortality rate in children with CF and was a stronger predictor of mortality than variables previously shown to be a

ssociated with mortality for CF. If increasing numbers of children with CF losehealth insurance coverage, our results suggest that their life expectancy will decrease dramatically.AI: ABNR: 35 ref.DEE: Cystic-fibrosis; Health-insurance; Socioeconomic-status; Survival-; Statistical-study; Relation-; Regression-analysis; Multivariate-analysis; Child-DEF: Mucoviscidose-; Assurance-maladie; Statut-socioeconomique; Survie-; Etude-statistique; Relation-; Analyse-regression; Analyse-multivariable; Enfant-DES: Mucoviscidosis-; Seguro-enfermedad; Estatuto-socioeconomico; Sobrevivencia-; Estudio-estadistico; Relacion-; Analisis-regresion; Analisis-multivariable; Nino-IDE: Human-; Respiratory-disease; Digestive-diseases; Pancreatic-disease; Genet

ic-disease; Metabolic-diseasesIDF: Homme-; Appareil-respiratoire-pathologie; Appareil-digestif-pathologie; Pancreas-pathologie; Maladie-hereditaire; Metabolisme-pathologieIDS: Hombre-; Aparato-respiratorio-patologia; Aparato-digestivo-patologia; Pancreas-patologia; Enfermedad-hereditaria; Metabolismo-patologiaJN: American-journal-of-respiratory-and-critical-care-medicineLOC: INIST, Shelf number 2013, INIST No. 354000061859700160AN: 970351403SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Sensitization to Aspergillus fumigatus and lung function in children with cystic fibrosisPA: WOJNAROWSKI-C; EICHLER-I; GARTNER-C; GOTZ-M; RENNER-S; KOLLER-D-Y; FRISCHER-TAF: University Children's Hospital and the Children's Department, Wilhelminenspital, Vienna, AustriaSO: American-journal-of-respiratory-and-critical-care-medicine. 1997; 155 (6) :1902-1907IS: 1073-449XPY: 1997


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CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Colonization with Aspergillus fumigatus (Af) constitutes a common finding in children with cystic fibrosis (CF). The relationship between sensitization toAf and lung functon (LF) was studied in 118 patients with CF (61 girls and 57 boys; mean age: 14.3 yr; SD: 7 yr). Mean follow up was 2.2 yr. On average, 8.1 (SD: 4.8) LF tests were performed per patient. Measurement of total IgE and specific IgE antibodies to Af, and a skin prick test (SPT) for Af, were done once a year. Thirty-one children (26%) were sensitized to Af. On average, LF parameters were not significantly different in Af-sensitized children than in nonsensitized children. Linear regression analyses were performed, using the repeated measuresdesign. With adjustment for gender, age, height, and weight, sensitization to Afwas associated with lower values of FEV1 ( = -0.209; p < 0.05)and FEF25-75 ( = -0.356; p < 0.01). Analysis of different subgroups of sensitization demonstratedthe effect on LF only in Af-sensitized patients with elevated total IgE levels,and not in Af-sensitized patients with normal IgE levels. Furthermore, there wasevidence for a more rapid decline in LF for Af-sensitized patients with elevated total IgE levels than in those with normal IgE levels. We conclude that sensitization to Af in the presence of increased IgE values is associated with lower LF values in children with CF.AI: AB

NR: 24 ref.DEE: Cystic-fibrosis; Aspergillus-fumigatus; Superinfection-; Sensitization-; Lung-volume; Follow-up-study; Complication-; Exploration-; Relation-; Child-DEF: Mucoviscidose-; Aspergillus-fumigatus; Surinfection-; Sensibilisation-; Volume-pulmonaire; Etude-longitudinale; Complication-; Exploration-; Relation-; Enfant-DES: Mucoviscidosis-; Aspergillus-fumigatus; Superinfeccion-; Sensibilizacion-;Volumen-pulmonar; Estudio-longitudinal; Complicacion-; Exploracion-; Relacion-;Nino-IDE: Fungi-Imperfecti; Fungi-; Thallophyta-; Human-; Respiratory-disease; Digestive-diseases; Pancreatic-disease; Genetic-disease; Metabolic-diseases; Mycosis-; Infection-; Allergy-; Immunopathology-IDF: Fungi-Imperfecti; Fungi-; Thallophyta-; Homme-; Appareil-respiratoire-path

ologie; Appareil-digestif-pathologie; Pancreas-pathologie; Maladie-hereditaire;Metabolisme-pathologie; Mycose-; Infection-; Allergie-; Immunopathologie-IDS: Fungi-Imperfecti; Fungi-; Thallophyta-; Hombre-; Aparato-respiratorio-patologia; Aparato-digestivo-patologia; Pancreas-patologia; Enfermedad-hereditaria;Metabolismo-patologia; Micosis-; Infeccion-; Alergia-; Inmunopatologia-JN: American-journal-of-respiratory-and-critical-care-medicineLOC: INIST, Shelf number 2013, INIST No. 354000061859700130AN: 970351397SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Scintigraphic evaluation of obstructing primary megaureter with Tc-99m MAG3PA: ERBAS-B; ROYAL-S-A; JOSEPH-DAF: Department of Radiology, University of Alabama at Birmingham, The Children's Hospital of Alabama, Birmingham, Alabama, United States; Department of Surgery, University of Alabama at Birmingham, The Children's Hospital of Alabama, Birmingham, Alabama, United StatesSO: Clinical-nuclear-medicine. 1997; 22 (6) : 355-358IS: 0363-9762PY: 1997CP: United-States


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LA: EnglishBL: AnalyticLT: SerialAB: Two children with the antenatal diagnosis of hydronephrosis secondary to aprimary obstructed megaureter are presented. Both children were treated nonoperatively. They were observed with serial diuretic scintigrams using Tc-99m MAG3 and renal sonography. Throughout, the children have been asymptomatic. During a 3-year follow-up period, the diuretic renogram documented resolution of obstruction in one child and stable renal function with improved drainage in the other.AI: ABNR: 11 ref.DEE: Megaureter-; Case-study; Child-; Hydronephrosis-; Diagnosis-; Renal-function; Scintigraphy-; Technetium-; Evaluation-DEF: Megauretere-; Etude-cas; Enfant-; Hydronephrose-; Diagnostic-; Fonction-renale; Scintigraphie-; Technetium-; Evaluation-DES: Megaureter-; Estudio-caso; Nino-; Hidronefrosis-; Diagnostico-; Funcion-renal; Centelleografia-; Tecnecio-; Evaluacion-IDE: Human-; Urinary-system-disease; Urinary-tract-disease; Ureteral-disease; Kidney-disease; Radionuclide-study; Medical-imageryIDF: Homme-; Appareil-urinaire-pathologie; Voie-urinaire-pathologie; Uretere-pathologie; Rein-pathologie; Exploration-radioisotopique; Imagerie-medicaleIDS: Hombre-; Aparato-urinario-patologia; Via-urinaria-patologia; Ureter-patologia; Rinon-patologia; Exploracion-radioisotopica; Imageneria-medicalJN: Clinical-nuclear-medicine

CD: CNMEDKLOC: INIST, Shelf number 16903, INIST No. 354000061849990010AN: 970351376SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Educational video game for juvenile diabetes : results of a controlled trial. Application of information technology in clinical diabetes care. Part 2. Models and educationPA: BROWN-S-J; LIEBERMAN-D-A; GEMENY-B-A; FAN-Y-C; WILSON-D-M; PASTA-D-J; LEHMANN-Eldon-D, ed

AF: Raya Systems Inc., 2570 W. El Camino Real, Suite 520, Mountain View, CA 94040, Canada; Stanford University Medical Center, California, United States; DMA Corporation, California, United States; Academic Department of Radiology, St. Bartholomew's Hospital, London, EC1A 7BE, United KingdomSO: Medical-informatics-1985. 1997; 22 (1) : 77-89IS: 0959-8316PY: 1997CP: United-KingdomLA: EnglishBL: AnalyticLT: SerialAB: Packy & Marlon, an interactive video game designed to improve self-care among children and adolescents with diabetes, was evaluated in a six-mo

nth randomized controlled trial. In the game, players take the role of animatedcharacters who manage their diabetes by monitoring blood glucose, taking insulininjections, and choosing foods, while setting out to save a diabetes summer camp from marauding rats and mice who have stolen the diabetes supplies. Study participants were patients aged 8 to 16 from two separate diabetes clinics. Each participant received a Super Nintendo video game system at an initial clinic visit and was randomly assigned to receive either Packy & Marlon (treatment group, N= 31) or an entertainment video game containing no diabetes-related content (control group, N = 28). Participants were interviewed and a parent filledout a questionnaire at baseline, three months, and six months. The findings in


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sults are presented, and the postoperative growth and deformation of the cervical spine were determined radiographically. Objectives. To investigate in a relatively long-term follow-up study whether occipitocervical fusion affects the growth of the cervical spine and induces spinal deformation. of Background Data. It has been reported that children who have undergone C1-C2 posterior fusion are likely to develop abnormal curvature or deformation of the cervical spine as a result of a disturbance of growth of the fused vertebrae. There have been no studies, however, to confirm that these changes occur after occipitocervical fusion inchildren. Methods. The subjects were one boy and seven-girls who had undergone occipitocervical posterior fusion during childhood. The average age at the time of surgery was 8.3 years, and the average follow-up period was 5.9 years. The folloWing were-assessed radiographically: redislocation of the atlas, bone union, changes in the curvature of the cervical spine, the height and width of the vertebral bodies, and the anteroposterior diameter of the spinal canal. Results. Solid bone union was achieved in all pa tients with maintenance of the reduced position at the time of surgery. None of the patients exhibited abnormal curvature ofthe cervical spine. The rate of increase in height of the C2 vertebral body wassignificanfly less than that of vertebral bodies below C3. The rate of increasein width of the vertebral body and the anteroposterior diameter of the spinal canal of the C2 verteoral body and vertebral bodies below C3 did not differ significantly. Conclusions. Occipitocervical fusIon with a rectangular rod is usefulfor treating atlantoaxial dislocation in children and yields excellent results because of the firm internal fixation it achieves. This surgery induced no apparent postoperative spinal deformations.

AI: ABNR: 20 ref.DEE: Fracture-; Atlantoaxial-; Treatment-; Arthrodesis-; Occipitocervical-; Association-; Laminectomy-; Atlas-; Technique-; Result-; Child-DEF: Fracture-; Atloidoaxoidien-; Traitement-; Arthrodese-; Occipitocervical-;Association-; Laminectomie-; Atlas-; Technique-; Resultat-; Enfant-DES: Fractura-; Atlantoaxial-; Tratamiento-; Artrodesis-; Occipitocervical-; Asociacion-; Laminectomia-; Atlas-; Tecnica-; Resultado-; Nino-IDE: Human-; Diseases-of-the-osteoarticular-system; Trauma-; Spine-disease; Surgery-IDF: Homme-; Systeme-osteoarticulaire-pathologie; Traumatisme-; Rachis-pathologie; Chirurgie-IDS: Hombre-; Sistema-osteoarticular-patologia; Traumatismo-; Raquis-patologia;

Cirugia-JN: Spine-Philadelphia-PA-1976CD: SPINDDLOC: INIST, Shelf number 18922, INIST No. 354000065703530060AN: 970351317SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Human granulocyte colony-stimulating factor after induction chemotherapy inchildren with acute lymphoblastic leukemiaPA: PUI-C-H; BOYETT-J-M; HUGHES-W-T; RIVERA-G-K; HANCOCK-M-L; SANDLUND-J-T; SYN

OLD-T; RELLING-M-V; RIBEIRO-R-C; CRIST-W-M; EVANS-W-EAF: St. Jude Children's Research Hospital, Memphis, United States; University of Tennessee, College of Medicine, Memphis, United States; University of Tenessee, College of Pharmacy, Memphis, United StatesSO: The-New-England-journal-of-medicine. 1997; 336 (25) : 1781-1787IS: 0028-4793PY: 1997CP: United-StatesLA: EnglishBL: Analytic


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LT: SerialAB: Background Recombinant human granulocyte colony-stimulating factor (G-CSF,or filgrastim) hastens the recovery from neutropenia after intensive chemotherapy, but its role in the management of childhood leukemia is unclear. Methods We randomly assigned 164 patients with acute lymphoblastic leukemia (age range, 2 months to 17 years) to receive placebo or G-CSF (10 g per kilogram of body weight per day subcutaneously), beginning one day after the completion of remission-induction therapy and continuing until the neutrophil count was greater than orequal to 1000 per cubic millimeter for two days. The clinical and laboratory effects of this therapy were documented for 21 days. The area under the plasma G-CSF concentration-time curve was measured on days 1 and 7 in both groups. ResultsResponses to the growth factor could be assessed in 148 patients (73 in the G-CSF group and 75 in the placebo group). G-CSF treatment did not significantly lower the rate of hospitalization for febrile neutropenia (58 percent in the G-CSFgroup vs. 68 percent in the placebo group; relative risk, 0.85; 95 percent confidence interval, 0.59 to 1.16), increase the likelihood of event-free survival atthree years (83 percent in both groups), or decrease the number of severe infections (five in the G-CSF group vs. six in the placebo group). Patients treated with G-CSF had shorter median hospital stays (6 days vs. 10 days, P=0.011) and fewer documented infections (12 vs. 27, P=0.009). The median total costs of supportive care were similar in the G-CSF and placebo groups ($8,768 and $8,616, respectively). Among patients who did not have febrile neutropenia during the first week of G-CSF or placebo injections, higher systemic exposure to the growth factor on day 7 was significantly related to a lower probability of subsequent hospit

alization (P=0.049). Conclusions G-CSF treatment had some clinical benefit in children who received induction chemotherapy for acute lymphoblastic leukemia, butit did not reduce the rate of hospitalization for febrile neutropenia, prolongsurvival, or reduce the cost of supportive care.AI: ABNR: 57 ref.DEE: Acute-lymphocytic-leukemia; Chemotherapy-; Association-; Granulocyte-macrophage-colony-stimulating-factor; Predictive-factor; Randomization-; Neutropenia-; Prevention-; Child-; Acute-DEF: Leucemie-lymphoblastique; Chimiotherapie-; Association-; Facteur-stimulant-colonie-granulocyte-macrophage; Facteur-predictif; Randomisation-; Neutropenie-; Prevention-; Enfant-; Aigu-DES: Leucemia-linfoblastica; Quimioterapia-; Asociacion-; Factor-estimulante-co

lonia-granulocito-macrofago; Factor-predictivo; Aleatorizacion-; Neutropenia-; Prevencion-; Nino-; Agudo-IDE: Human-; Malignant-hemopathy; Lymphoproliferative-syndrome; Cytokine-; Polypeptide-; Hemopathy-; Leukopenia-IDF: Homme-; Hemopathie-maligne; Lymphoproliferatif-syndrome; Cytokine-; Polypeptide-; Hemopathie-; Leucopenie-IDS: Hombre-; Hemopatia-maligna; Linfoproliferativo-sindrome; Citoquina-; Polipeptido-; Hemopatia-; Leucopenia-JN: The-New-England-journal-of-medicineCD: NEJMAGLOC: INIST, Shelf number 6013, INIST No. 354000061907310030AN: 970351283SI: INIST

CR: 1997 INIST-CNRS. All rights reserved.


T1: Homelessness : Care, prevention, and public policyPA: PLUMB-J-DAF: Thomas Jefferson University, Philadelphia, Pennsylvania, United StatesSO: Annals-of-internal-medicine. 1997; 126 (12) : 973-975IS: 0003-4819PY: 1997


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CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Homeless men, women, and children make up a growing population that is vulnerable to preventable disease, progressive morbidity, and premature death. Homelessness and poverty are inextricably linked, and subgroups of persons who live in poverty have a particularly high risk for becoming homeless. Providing effective primary care for homeless persons is a formidable task because of many internal and external barriers to care. Targeted care strategies and new approaches toprimary care are required to lower these barriers. Effective disease preventionin the homeless requires effective programs and policies to prevent homelessness. It is imperative that health professionals, the societies to which they belong, and academic health systems reaffirm their social responsibility, commit to changing public policies that perpetuate homelessness, and assist in the development and provision of primary health care services for persons who are homeless or on the brink of homelessness.AI: ABNR: 26 ref.DEE: Homeless-; Medical-screening; Epidemiology-; Managed-care; Prevention-; Policy-; Physician-patient-relation; Transmission-protocol; Human-DEF: Sans-domicile-fixe; Depistage-; Epidemiologie-; Soin-integre; Prevention-;Politique-; Relation-medecin-malade; Protocole-transmission; Homme-DES: Sin-domicilio-fijo; Descubrimiento-; Epidemiologia-; Cuidado-integrado; Pr

evencion-; Politica-; Relacion-medico-paciente; Protocolo-transmision; Hombre-IDE: Public-health; Health-policy; Public-health-organization; Ethics-IDF: Sante-publique; Politique-sanitaire; Organisation-sante; Ethique-IDS: Salud-publica; Politica-sanitaria; Organizacion-salud; Etica-JN: Annals-of-internal-medicineCD: AIMEASLOC: INIST, Shelf number 2014, INIST No. 354000061906400070AN: 970351262SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Insulin algorithms in the self-management of insulin-dependent diabetes : the interactive 'Apple Juice' program. Application of information technology in clinical diabetes care. Part 1. Databases, algorithms and decision supportPA: WILLIAMS-A-G; LEHMANN-Eldon-D, edAF: Diabetes Consulting International, Inc., 128 SW 84 Th. Lane, Coral Springs,Florida 33071, United States; Academic Department of Radiology, St. Bartholomew's Hospital, London, EC1A 7BE, United KingdomSO: Medical-informatics-1985. 1996; 21 (4) : 327-344IS: 0959-8316PY: 1996CP: United-KingdomLA: EnglishBL: Analytic

LT: SerialAB: The 'Apple Juice' program is an interactive diabetes self-management program which runs on a lap-top Macintosh Powerbook 100 computer. The dose-by-dose insulin advisory program was initially designed for children with insulin-dependent(type 1) diabetes mellitus. It utilizes several different insulin algorithms, measurement formulae, and compensation factors for meals, activity, medication and the dawn phenomenon. It was developed to assist the individual with diabetes and/or care providers, in determining specific insulin dosage recommendations throughout a 24 h period. Information technology functions include, but are not limited to automated record keeping, data recall, event reminders, data trend/patte


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rn analyses and education. This paper highlights issues, observations and recommendations surrounding the use of the current version of the software, along witha detailed description of the insulin algorithms and measurement formulae applied successfully with the author's daughter over a six year period.AI: ABNR: 17 ref.DEE: Insulin-dependent-diabetes; Child-; Computer-program; Interactive-system;Chemotherapy-; Insulin-; Treatment-planning; Assay-; Information-system; Limitation-; System-architecture; Computer-aidDEF: Diabete-insulinodependant; Enfant-; Programme-ordinateur; Systeme-conversationnel; Chimiotherapie-; Insuline-; Plan-traitement; Dosage-; Systeme-information; Limitation-; Architecture-systeme; Assistance-ordinateur; Autogestion-DES: Diabetes-insulinodependiente; Nino-; Programa-computador; Sistema-conversacional; Quimioterapia-; Insulina-; Plan-tratamiento; Dosificacion-; Sistema-informacion; Limitacion-; Arquitectura-sistema; Asistencia-ordenadorIDE: Human-; Biomedical-data-processing; Endocrinopathy-; Immunopathology-; Autoimmune-disease; Pancreatic-hormone; Protein-hormone; Hypoglycemic-agentIDF: Homme-; Informatique-biomedicale; Endocrinopathie-; Immunopathologie-; Maladie-autoimmune; Hormone-pancreatique; Hormone-proteine; Hypoglycemiant-IDS: Hombre-; Informatica-biomedical; Endocrinopatia-; Inmunopatologia-; Enfermedad-autoinmune; Hormona-pancreatica; Hormona-proteina; Hipoglicemiante-JN: Medical-informatics-1985CD: MINFDZLOC: INIST, Shelf number 17530, INIST No. 354000065727060060



T1: Malaria-related beliefs and behaviour in southern Ghana : implications fortreatment, prevention and controlPA: AHORLU-C-K; DUNYO-S-K; AFARI-E-A; KORAM-K-A; NKRUMAH-F-KAF: Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, GhanaSO: TM-and-IH-Tropical-medicine-and-international-health. 1997; 2 (5) : 488-498FTXT: EBSCO Online http://www.ebsco.com/online/direct.asp?ArticleID=JQK3AHDT4D1

70NRF2813IS: 1360-2276PY: 1997CP: United-KingdomLA: EnglishBL: AnalyticLT: SerialAB: A research infrastructure was established in two ecological zones in southern Ghana to study the variables of malaria transmission and provide informationto support the country's Malaria Action Plan (MAP) launched in 1992. Residents'beliefs and practices about causes, recognition, treatment and prevention of malaria were explored in two ecological zones in southern Ghana using epidemiological and social research methods. In both communities females constituted more tha

n 80% of caretakers of children 1-9 years and the illiteracy rate was high. Fever and malaria, which are locally called Asra or Atridi, were found to representthe same thing and are used interchangeably. Caretakers were well informed aboutthe major symptoms of malaria, which correspond to the current clinical case definition of malaria. Knowledge about malaria transmission is, however, shroudedin many misconceptions. Though the human dwellings in the study communities conferred no real protection against mosquitoes, bednet usage was low while residents combatted the nuisance of mosquitoes with insecticide sprays, burning of coilsand herbs, which they largely considered as temporary measures. Home treatmentof malaria combining herbs and over-the-counter drugs and inadequate doses of ch


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loroquine was widespread. There is a need for a strong educational component tobe incorporated into the MAP to correct misconceptions about malaria transmission, appropriate treatment and protection of households. Malaria control policiesshould recognize the role of home treatment and drug shops in the management ofmalaria and incorporate them into existing control strategies.AI: ABNR: 1 p.1/4DEE: Malaria-; Belief-; Behavior-; Ghana-; Human-; Transmission-; Treatment-; Prevention-DEF: Paludisme-; Croyance-; Comportement-; Ghana-; Homme-; Transmission-; Traitement-; Prevention-DES: Paludismo-; Creencia-; Conducta-; Ghana-; Hombre-; Transmision-; Tratamiento-; Prevencion-IDE: Protozoal-disease; Parasitosis-; Infection-; Africa-; Public-healthIDF: Protozoose-; Parasitose-; Infection-; Afrique-; Sante-publiqueIDS: Protozoosis-; Parasitosis-; Infeccion-; Africa-; Salud-publicaJN: TM-and-IH-Tropical-medicine-and-international-healthLOC: INIST, Shelf number 26295, INIST No. 354000061957630110AN: 970351243SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Lymphocyte subset changes between 3 and 15 months of age in infants born toHIV-seropositive women in South AfricaPA: MOODLEY-D; BOBAT-R-A; COOVADIA-H-M; DOORASAMY-T; MUNSAMY-S; GOUWS-EAF: Department of Paediatrics and Child Health, University of Natal, Durban, South Africa; Department of Haematology, University of Natal, Durban, South Africa; MRC Centre for Epidemiological Research, Medical Research Council, Durban, South AfricaSO: TM-and-IH-Tropical-medicine-and-international-health. 1997; 2 (5) : 415-421FTXT: EBSCO Online http://www.ebsco.com/online/direct.asp?ArticleID=946MVBKDWMTJ5X52D345IS: 1360-2276PY: 1997CP: United-Kingdom

LA: EnglishBL: AnalyticLT: SerialAB: The evolution of T-lymphocyte subsets during infancy in perinatally HIV-infected African babies has not been previously described. In a hospital-based cohort study, T-lymphocyte subset changes were investigated in 72 South African black children born to HIV seropositive mothers. Sixteen (22.2%) children were classified as infected and 56 (77.8%) as uninfected by 18 months of age. Four (25%) of the infected infants died before the age of 9 months from HIV-related disease.The CD4 and CD8 T-lymphocyte subsets, expressed in absolute numbers,as percentages, percentiles or as ratios, were clear indicators of HIV infection at all ages between 3 and 15 months. The most marked changes were a decreasedpercentage of CD4 cells and an increase in percentage of CD8 cells in the infect

ed group. In the 4 infected infants who died, CD8 count and CD4 :CD8ratio clearly predicted poor clinical outcome at 3 months. Taken together, bothCD4:CD8 ratio and CD4 percentage are reliable markers of HIV infection in an African paediatric population; however, a raised CD8 lymphocyte count rather than a CD4 count is a more specific prognostic markerof disease progression in HIV infected children.AI: ABNR: 15 ref.DEE: AIDS-; Seropositivity-; Human-immunodeficiency-virus; Mother-; T-Lymphocyte; Cell-subpopulation; Prognosis-; Biological-marker; Infant-; South-Africa


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DEF: Fracture-; Os-; Enfant-; Age-scolaire; Epidemiologie-; Produit-laitier; Calcium-Ion; Boisson-non-alcoolisee; Nutrition-; Consommation-alimentaire; Exercice-physique; Sante-publique; Grece-; Facteur-risqueDES: Fractura-; Hueso-; Nino-; Edad-escolar; Epidemiologia-; Producto-lacteo; Calcio-Ion; Bebida-no-alcoholica; Nutricion-; Consumo-alimenticio; Ejercicio-fisico; Salud-publica; Grecia-; Factor-riesgoIDE: Human-; Europe-; Diseases-of-the-osteoarticular-system; Trauma-IDF: Homme-; Europe-; Systeme-osteoarticulaire-pathologie; Traumatisme-IDS: Hombre-; Europa-; Sistema-osteoarticular-patologia; Traumatismo-JN: Scandinavian-journal-of-social-medicineCD: SJSMAFLOC: INIST, Shelf number 16842, INIST No. 354000061929010090AN: 970351173SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Detection of intravascular injection of regional anaesthetics in childrenPA: FISHER-Q-A; SHAFFNER-D-H; YASTER-MAF: Department of Anaesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287-5842, United StatesSO: Canadian-journal-of-anaesthesia. 1997; 44 (6) : 592-598IS: 0832-610X

PY: 1997CP: CanadaLA: EnglishBL: AnalyticLT: SerialAB: Objectif : La detection de l' injection intravasculaire d' anesthesique local pendant l' administration d' un bloc regional chez l' enfant par la tachycardie et l' hypertension peut donner lieu a des faux positifs et des faux negatifs.Cette etude evalue les changements de l' ECG comme indices d' injection intravasculaire d' anesthesiques locaux adrenalises pendant l' administration du bloc.Methodes : L' inventaire de toutes les anesthesies epidurales administrees a desenfants pendant une annee dans un hopital d' enseignement. L' anesthesie generale etait un critere d' exclusion. Une bande de rythme EEG enregistree pendant l

' injection de la dose test et examinee relativement aux changements de frequence, de rythme et de configuration de l' onde T. Resultats : Pendant la periode d'etude, 742 blocas epiduraux pediatriques ont ete administres, dont 644 anesthesies caudales (284 sans catheter), 97 lombaires et une epidurale thoracique avecsucces dans 97.7 % des patients. Une injection intravasculaire est survenue au cours de 42 (5.6%) anesthesies epidurales (3.8% par l' aiguille et 7.6 par le catheter) et a ete detectee par l' aspiration immediate de sang chez six patients et par une augmentation de la frequence cardiaque > 10 bpm chez 30. La frequencea diminue chez 5 patients suggerant une reponse barotropique. Cinq ont presentedes augmentations de frequence < 10 bpm en reaction possible aux stimuli nocifs.Sur 30 patients chez qui l' injection intravasculaire etait claire et chez quides bandes de rythme etaient disponibles, 25 (83%) presentaient une augmentationde l' amplitude de l' onde T > 25%, et 29 (97%) avaient des changements de l' o

nde T ou du rythme en reponse a l' injection d' epinephrine. Il n' y a pas eu defaux positifs. Conclusion : POur reduire les risques associes a l' anesthesieepidurale chez l' enfant, de l' epinephrine devrait etre ajoutee a la dose testd' anesthesique local et l' EEG devrait etre monitore en continu pour reveler les changements de frequence, du rythme et d' amplitude de l' onde T. L' anesthesique local doit etre administre dans l' espace epidural en petites doses repetees.AI: ABNR: 23 ref.DEE: Bupivacaine-; Local-anesthetic; Regional-anesthesia; Drug-combination; Epi


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nephrine-; Electrocardiography-; Complication-; Malposition-; Intravenous-administration; Extradural-administration; Child-; Catecholamine-; Pharmacologic-test;Anilide-; Test-doseDEF: Bupivacaine-; Anesthesique-local; Anesthesie-regionale; Association-medicamenteuse; Adrenaline-; Electrocardiographie-; Complication-; Malposition-; Voie-intraveineuse; Voie-extradurale; Enfant-; Catecholamine-; Epreuve-pharmacologique; Anilide-; Dose-testDES: Bupivacaina-; Anestesico-local; Anestesia-regional; Asociacion-medicamentosa; Adrenalina-; Electrocardiografia-; Complicacion-; Malposicion-; Via-intravenosa; Via-extradural; Nino-; Catecolamina-; Prueba-farmacologica; Anilido-IDE: Human-; Electrodiagnosis-IDF: Homme-; Electrodiagnostic-IDS: Hombre-; Electrodiagnostico-JN: Canadian-journal-of-anaesthesiaCD: CJOAEPLOC: INIST, Shelf number 1106, INIST No. 354000061564190040AN: 970350959SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: The stability of pain Coping Strategies in young children, adolescents, andadults with sickle cell disease over an 18-month period

PA: GIL-K-M; WILSON-J-J; EDENS-J-LAF: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States; Duke University Medical Center, Durham, North Carolina, United StatesSO: The-Clinical-journal-of-pain. 1997; 13 (2) : 110-115IS: 0749-8047PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Objective: The current study assessed stability of pain coping strategies over an 18-month period in adults, adolescents, and young children with sickle ce

ll disease. Design: Eighteen-month longitudinal study. Assessments of coping strategies were done at baseline, 9 months, and 18 months. Patients: A total of 141patients with sickle cell disease (SCD) presenting to adult and pediatric sickle cell clinics for regularly scheduled check-ups. Outcome Measures: Coping Strategy Questionnaire subscales (Coping Attempts, Negative Thinking, and Illness-Focused Strategies). Results: Pearson Product-Moment correlation coefficients comparing baseline and 18-month follow-up coping data were highly significant for Coping Attempts and Negative Thinking/Illness Focused Strategies for adults. For young children, the 18-month follow-up scores on Negative Thinking were significantly correlated with baseline scores, however, no other 18-month correlations were significant. The results from the adolescent subset of subjects indicated no significant correlations on any of the coping strategies from baseline to 18-month follow-up. Stability was also assessed using intraclass correlations, which in

corporates more than two test-retest values on the same subjects. These analysesconfirmed that coping strategies in adults were highly stable, whereas for children and adolescents, there was instability. ANOVAs indicated that adolescents scored significantly higher than young children on Negative Thinking and Illness-Focused Strategies at baseline and follow-up. Conclusions: As compared with thehighly stable coping evidenced in adults with SCD, coping in children and adolescents with SCD is more variable. Thus, interventions should target children early before maladaptive coping patterns become entrenched.AI: ABNR: 23 ref.


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DEE: Pain-; Coping-; Sickle-cell-anemia; Strategy-; Stability-; Child-; Adolescent-; Adult-DEF: Douleur-; Coping-; Anemie-hematie-falciforme; Strategie-; Stabilite-; Enfant-; Adolescent-; Adulte-DES: Dolor-; Coronacion-; Anemia-globulo-falciforme; Estrategia-; Estabilidad-;Nino-; Adolescente-; Adulto-IDE: Human-; Hemopathy-; Hemolytic-anemia; Hemoglobinopathy-; Genetic-diseaseIDF: Homme-; Hemopathie-; Anemie-hemolytique; Hemoglobinopathie-; Maladie-hereditaireIDS: Hombre-; Hemopatia-; Anemia-hemolitica; Hemoglobinopatia-; Enfermedad-hereditariaJN: The-Clinical-journal-of-painCD: CJPAEULOC: INIST, Shelf number 20743, INIST No. 354000061562860020AN: 970350948SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Free latissimus dorsi muscle transfer using an endoscopic techniquePA: BYUNG-CHAE-CHO; JUNG-HYUNG-LEE; RAMASASTRY-S-S; BONG-SOO-BAIKAF: Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Taegu, Korea, Republic of

SO: Annals-of-plastic-surgery. 1997; 38 (6) : 586-593IS: 0148-7043PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Endoscopic techniques in plastic surgery have involved aesthetic proceduressuch as facelift, breast augmentation, abdominoplasty, and placement of tissueexpanders. Recently, endoscopic harvest of the donor tissue for free flap transfer has included the omentum, jejunum, latissimus dorsi muscle, and rectus abdominis muscle. Ten patients with a soft-tissue defect in the lower extremity were successfully reconstructed from December 1994 to October 1995 with a free muscle

transfer after endoscopic harvest of the latissimus dorsi muscle. Nine patientswere male and 1 patient was female. A 5- to 6-cm incision was initially made along the posterior axillary line, allowing direct identification of the thoracodorsal vascular pedicle. The latissimus dorsi muscle was dissected posteriorly until the limits of open dissection were reached, and then the dissection was continued under endoscopic visualization. The largest harvested muscle was 15 x 25 cmin size. Follow-up ranged from 6 to 15 months. We believe that plastic surgeonscan take advantage of endoscopic techniques to obtain reliable and safe results,with smaller scars and reduced postoperative donor site morbidity such as painand wound-healing problems. This technique may prove particularly applicable towomen, children, and patients who are prone to hypertrophic scars.AI: ABNR: 25 ref.

DEE: Soft-tissue; Disease-; Deficiency-; Lower-limb; Leg-; Foot-; Latissimus-dorsi-muscle; Flap-surgery; Skin-; Plastic-surgery; Treatment-; Endoscopy-; Autograft-; Case-study; Human-DEF: Partie-molle; Maladie-; Deficit-; Membre-inferieur; Jambe-; Pied-; Muscle-grand-dorsal; Lambeau-; Peau-; Chirurgie-plastique; Traitement-; Endoscopie-; Autogreffe-; Etude-cas; Homme-DES: Parte-blanda; Enfermedad-; Deficiencia-; Miembro-inferior; Pierna-; Pie-;Musculo-dorsal-ancho; Colgajo-; Piel-; Cirugia-plastica; Tratamiento-; Endoscopia-; Autoinjerto-; Estudio-caso; Hombre-IDE: Skin-disease; Endoscopic-surgery; Graft-


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LT: SerialAB: Background. No comprehensive data on the clinical features and the prognosis of cerebral malaria in the South Pacific are available at present. We conducted a prospective study in children with cerebral malaria to assess the case fatality rate (CFR) in the region and to identify potential risk factors for death. Methods. We recruited 134 children admitted to the Madang General Hospital between April 1991 and October 1993 with a strictly defined diagnosis of cerebral malaria. Besides clinical examination, we collected a blood sample for parasitological, haematological and biochemical assessment. Results. The CFR was 11.9% and the prevalence of residual neurological sequelae at discharge was 1.5%. The proportion of children presenting with deep coma (12%) or hypoglycaemia (17%) was lower in our study than in African ones, where severe complications are more frequent. Also mortality associated with hypoglycaemia on admission was lower. Clinicalor laboratory conditions significantly associated with death were deep coma, malarial anaemia and hyperleucocytosis. Conclusions. All conditions associated with deep coma, such as shock, hypoglycaemia and acidosis, should be corrected. Also prompt administration of blood transfusions to patients with anaemia is likelyto reduce the occurrence of death in Papua New Guinean children with cerebral malaria.AI: ABNR: 33 ref.DEE: Cerebral-disorder; Malaria-; Epidemiology-; Mortality-; Prognosis-; Risk-factor; Child-; Public-health; Papua-New-GuineaDEF: Encephale-pathologie; Paludisme-; Epidemiologie-; Mortalite-; Pronostic-;

Facteur-risque; Enfant-; Sante-publique; Papouasie-Nouvelle-GuineeDES: Encefalo-patologia; Paludismo-; Epidemiologia-; Mortalidad-; Pronostico-;Factor-riesgo; Nino-; Salud-publica; Papuasia-Nueva-GuineaIDE: Protozoal-disease; Parasitosis-; Infection-; Human-; Melanesia-; Oceania-;Nervous-system-diseases; Central-nervous-system-diseaseIDF: Protozoose-; Parasitose-; Infection-; Homme-; Melanesie-; Oceanie-; Systeme-nerveux-pathologie; Systeme-nerveux-central-pathologieIDS: Protozoosis-; Parasitosis-; Infeccion-; Hombre-; Melanesia-; Oceania-; Sistema-nervioso-patologia; Sistema-nervosio-central-patologiaJN: International-journal-of-epidemiologyCD: IJEPBFLOC: INIST, Shelf number 16214, INIST No. 354000061873490270AN: 970350636

SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samplesPA: CS-SZABO-G; MELCHING-L-I; ROUGHLEY-P-J; GLANT-T-TAF: Rush Medical College at Rush - Presbyterian-St. Luke's Medical Center, Chicago, Illinois, United States; Shriners Hospital for Crippled Children, Montreal,Quebec, Canada; McGill University, Montreal, Quebec, CanadaSO: Arthritis-and-rheumatism. 1997; 40 (6) : 1037-1045IS: 0004-3591

PY: 1997CP: United-StatesLA: EnglishBL: AnalyticLT: SerialAB: Objective. To determine the steady-state messenger RNA (mRNA) levels and corresponding protein contents of major matrix components in osteoarthritic (OA) cartilage. Methods. Steady-state levels of gene-specific mRNA (relative to GAPDH)were measured by quantitative polymerase chain reaction (PCR), and the relativelevels of the corresponding proteins were determined by Western blotting. Resul


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ts. All mRNA levels and corresponding protein contents of aggrecan and versican(hyaluronanbinding large proteoglycans), decorin, biglycan, fibromodulin, and lumican (small proteoglycans), and link protein were higher in OA cartilage samples than in age-matched normal samples. The ratio of increase, however, was different for each component. The mRNA and protein levels of higlycan, decorin, and fibromodulin increased synchronously, whereas message for link protein and lumicanwere several-fold higher than expected by their measured protein contents. Versican was also detected in OA cartilage; however, the versican protein content was associated with a relatively low mRNA level. Conclusion. The expression of matrix components was increased in chondrocytes of OA cartilage, especially the expression of small proteoglycans, most likely due to the repair processes. A discoordinate gene expression accompanied with imbalanced accumulation of noncollagenous matrix components may contribute to the disorganization of the cartilage andthe development of OA processes.AI: ABNR: 62 ref.DEE: Osteoarthritis-; Polymerase-chain-reaction; Immunoblotting-assay; Proteoglycan-; Binding-protein; Messenger-RNA; Cartilage-; Extracellular-matrix; Pathogenesis-; Human-DEF: Arthrose-; Reaction-chaine-polymerase; Methode-immunoblotting; Proteoglycane-; Proteine-liaison; RNA-messager; Cartilage-; Matrice-extracellulaire; Pathogenie-; Homme-DES: Artrosis-; Reaccion-cadena-polimerasa; Proteoglicano-; Proteina-enlace; RNA-mensajero; Cartilago-; Matriz-extracelular; Patogenia-; Hombre-

IDE: Diseases-of-the-osteoarticular-system; Arthropathy-; Degenerative-disease;Molecular-biologyIDF: Systeme-osteoarticulaire-pathologie; Arthropathie-; Maladie-degenerative;Biologie-moleculaireIDS: Sistema-osteoarticular-patologia; Artropatia-; Enfermedad-degenerativa; Biologia-molecularJN: Arthritis-and-rheumatismCD: ARHEAWLOC: INIST, Shelf number 8711, INIST No. 354000061510140060AN: 970350520SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Acceptability and use of insecticide impregnated bednets in northern GhanaPA: BINKA-F-N; ADONGO-PAF: Navrongo Health Research Centre, Ministry of Health, Ghana; Swiss TropicalInstitute, Basel, SwitzerlandSO: TM-and-IH-Tropical-medicine-and-international-health. 1997; 2 (5) : 499-507FTXT: EBSCO Online http://www.ebsco.com/online/direct.asp?ArticleID=AFR0GA2TEUW99PA6D5N6IS: 1360-2276PY: 1997CP: United-KingdomLA: English

BL: AnalyticLT: SerialAB: A district-wide study was undertaken in a rural population of northern Ghana to identify factors influencing the acceptance and use of insecticide-impregnated bednets (IIBNs). A series of focus group discussions were conducted during 2years of implementation of IIBNs to gauge community reactions to the introduction of the nets and a structured questionnaire was administered to approximatelyzero randomly selected individuals. Although the IIBNs were accepted and used because they provided protection from mosquito bites, seasonal factors, patterns of use, and questions of cost were key factors likely to influence the disseminat


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ion and effectiveness of bednets. Use of the bednets was highly seasonal. Almostall recipients used their IIBNs in the rainy season (99%), corresponding to theperiod of high mosquito density and 20% used them in the dry seasons, the period of low mosquito density. Mothers with young children were more likely to washthe bednets frequently (because the children soiled the bednets with faeces andurine), resulting in no protection from the insecticide. Provision of wider bednets, or the provision of plastic sheets with the bednets or possible incorporation of the insecticide in washing soaps could improve protection for young children. The success of the promotion of IIBNs in malaria control programmes will depend on the cost of the package and the time of year that it is delivered. Financing mechanisms for individual and village groups are discussed. Social researcheffectively monitored the intervention in this study, and it should be includedas an important component of national malaria control programmes.AI: ABNR: 1 p.1/4DEE: Malaria-; Plasmodium-falciparum; Sanitary-control; Sanitary-program; Acceptance-; Use-; Impregnation-; Permethrin-; Human-; Ghana-; Health-education; Bednet-DEF: Paludisme-; Plasmodium-falciparum; Lutte-sanitaire; Programme-sanitaire; Acceptation-; Utilisation-; Impregnation-; Permethrine-; Homme-; Ghana-; Education-sante; Moustiquaire-DES: Paludismo-; Plasmodium-falciparum; Lucha-sanitaria; Programa-sanitario; Aceptacion-; Utilizacion-; Impregnacion-; Permetrina-; Hombre-; Ghana-; Educacion-sanitaria

IDE: Protozoal-disease; Parasitosis-; Infection-; Sporozoa-; Protozoa-; Africa-; Public-health; Insecticide-IDF: Protozoose-; Parasitose-; Infection-; Sporozoa-; Protozoa-; Afrique-; Sante-publique; Insecticide-IDS: Protozoosis-; Parasitosis-; Infeccion-; Sporozoa-; Protozoa-; Africa-; Salud-publica; Insecticida-JN: TM-and-IH-Tropical-medicine-and-international-healthLOC: INIST, Shelf number 26295, INIST No. 354000061957630120AN: 970350472SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Social support and the smoking behaviour of parents with preschool childrenPA: ERIKSEN-W; SANDVIK-L; BRUUSGAARD-DAF: Department of Community Medicine and General Practice, University of Oslo,Oslo, NorwaySO: Scandinavian-journal-of-social-medicine. 1997; 25 (2) : 93-99IS: 0300-8037PY: 1997CP: SwedenLA: EnglishBL: AnalyticLT: SerialAB: In a study of the relationship between social support and smoking behaviour

, 1046 parents coming with their children for well-child control at health centres in Oslo, Norway, completed a questionnaire. The prevalence of daily smoking increased with decreasing social support. However, this association did not remain significant when adjusting for demographic and household characteristics. Among smoking parents, indoor smoking at home was related to medium (OR =1.97; CI: 1.01-3.81) and low social support (OR = 2.35; CI: 1.19-4.63) when adjusting for demographic and household characteristics. Smoking parents smoked more cigarettesper day when they had low social support. However, this association was only seen in parents with several children. In this group, smoking 10 cigarettes per day or more was strongly related to medium (OR = 5.05; CI: 1.66-15.35) and low soc


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ial support (OR=7.81; CI: 2.44-25.01).AI: ABNR: 24 ref.DEE: Tobacco-smoking; Parent-; Social-support; Child-; Preschool-age; Passive-smoking; Epidemiology-; Social-environment; Norway-; Public-healthDEF: Tabagisme-; Parent-; Support-social; Enfant-; Age-prescolaire; Tabagisme-passif; Epidemiologie-; Environnement-social; Norvege-; Sante-publiqueDES: Tabaquismo-; Pariente-; Apoyo-social; Nino-; Edad-preescolar; Nicotinismo-pasivo; Epidemiologia-; Medio-ambiente-social; Noruega-; Salud-publicaIDE: Human-; Europe-IDF: Homme-; Europe-IDS: Hombre-; Europa-JN: Scandinavian-journal-of-social-medicineCD: SJSMAFLOC: INIST, Shelf number 16842, INIST No. 354000061929010060AN: 970350414SI: INISTCR: 1997 INIST-CNRS. All rights reserved.


T1: Malignant germ cell tumours in childhood. CommentaryPA: PINKERTON-C-R; PRITCHARD-J, commentAF: Children's Department, The Royal Marsden NHS Trust and Institute of Cancer

Research, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom; Department of Haematology and Oncology, Great Ormond Street Hospital for Children, NHS Trust, London WC1N 3JH, United KingdomSO: European-journal-of-cancer-1990.

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