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Weight Management Gene Expression Science
Advances in Gene Expression Science Allow Scientists to Compare & Contrast
Expression Patterns of two Biological States
Biological State #1 Biological State #2 State
Comparison of Genetic Profiles of Adipose Tissue in Identical Twins
Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51.
Same DNA
Different Expression of Genes
Normal Weight Twin Overweight Twin
Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to:
• Fat Regulation (storage versus utilization)• Muscle Protein Synthesis
• Nu Skin owns patented technologies to study anti-aging interventions through gene expression science
• Deep understanding of gene expression science
Identified Gene Expression Pathways Linked toFat Storage and Fat Metabolism
FAT
ST
OR
AG
E
FAT
BU
RN
LifeGen pre-clinical study of Adipose, Gastrocnemius muslce, Hypothalamus
Ghrelin
LeptinInsulin
References:
Gene Expression relates to the Appetite Control Center of the Brain
• Appetite Control• Eating Behavior• Regulation of energy intake
1. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520.
2. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755.
3. De Silva, et al. Cell Metab. 2011;14:700-706.
4. Malik S, et al. Cell Metab. 2008;7:400-409.
5. Farooqi IS, et al. Science. 2007;317:1355
6. Suzuki K, et al. Experimental Diabetes Research. 2012:1-19.
7. Viquerie N, et al. Diabetologia. 2005;48(1):123-131.
8. Mager et al. European Journal of Endocrinology. 2008;158:
9. Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.
Formulations Based on:• Proprietary gene Expression Research• The latest and most robust nutritional science
Eating Plan Based on:Protein Science & Nutrition Science
• Supports metabolically-active lean muscle and inhibits fat storage1
Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.
• An eating plan designed to complement the supplements.
Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Typical Reduced Calorie Diet – 2000 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oods
Carbohydrates(260 g)
Proteins(90 g)
Fats(67 g)
Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Typical Reduced Calorie Diet – 2000 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oods
Carbohydrates(180 g)
– 1200 kcal
Fats(33 g)
Proteins(45 g)
Carbohydrates(260g)
Fats(67g)
Proteins(90g)
Eating Plan – 1200 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oodsProteins
(90 g)
Carbohydrates(260 g)
Fats(67 g)
Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Fat B
urning F
oods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oods
Carbohydrates(120 g)
Fats(40 g)
Eating Plan – 1200 kcal
Proteins(90 g)
Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn
FA
T S
TO
RIN
GF
AT
BU
RN
ING
Time in Metabolic Burn Zone = Only 3 hours/day
Adapted from: 1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2. Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
ZO
NE
S
Eating Protein with Each Meal Accelerates Metabolic Burn
FA
T S
TO
RIN
GF
AT
BU
RN
ING
Adapted from: 1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2. Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
Time in Metabolic Burn Zone = 9 hours/day
ZO
NE
S
Open Label Clinical Study
Participants Reported…- Lower levels of Hunger- Changes in body silhouette- Clothes fit better- Liked this program better than programs
they had tried previously
- 90 Days on ingredients-based program- 45 women and 21 men completed the study
Results of unpublished preliminary study 2013
ageLOC TR90 Summary• Healthy weight management and Body Shaping program.• Based on gene expression science, addresses key
factors related to weight management: - Healthy Metabolism, - Promotes Lean Muscle Maintenance - Appetite Control
• Studies on TR90 weight management program resulted in significant weight loss, fat loss and changes in gene expression.
17
SIGNS & SYMPTOMS
NutritionScience
Gene Expression
Science
Antioxidant Science
LIFEPAK—THE PERFECT COMPANION
• Nutritional foundation is important– LifePak® provides that foundation
• Ensure adequate nutrition during reduced calorie regimen
• Dietary antioxidants for added protection from oxidative stress
LifePak Off-sets Oxidative Stress During DietingAv
erag
e SC
S fo
r stu
dy
parti
cipa
nts
10,000
20,000
30,000
40,000
36,00030,00029,000
Baseline 6 Weeks 12 Weeks
• Participants took LifePak
• Scanner Scores increase an average of 6,000 per person
Data from My Victory Open-label Study 2007
AGELOC R2 – The Perfect Companion
• Maintain energy levels
• Assist with cell renewal and cleansing during lipolysis
TR90 SUPPORT TOOLS
Create and communicate your personal transformation through a compelling story and transformation number that is completely unique to your ageLOC TR90 experience.
WHAT’S YOUR TRANSFORMATION NUMBER? Ninety nine