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Welcome to Parasitic Diseases
Environmental Disturbance Leads To Emergence Or Establishment Of Infectious Agents
Irrigation
Fall 2006
ParasiteAny organism that takes metabolic advantage
of another organismVirusesRickettsiaebacteriaFungiProtozoa*Helminths*
Nematodes - round worms Cestodes - segmented flat wormsTrematodes - non-segmented flat worms
Arthropods* - six and eight-legged critters
* Covered in Parasitic Diseases
Helminths (Worms)Nematodes - non-segmented round worms
Cestodes - segmented flat worms
Trematodes - non-segmented flat worms
Nematodes - round wormsNematodes - round worms
1. All are eukaryotes -1. All are eukaryotes - Caenorhabitis elegansCaenorhabitis elegans is theis thebest known example and is free-living in soil.best known example and is free-living in soil.
2. Most nematodes are non-parasitic.2. Most nematodes are non-parasitic.
3. Almost 4 billion people harbor at least one3. Almost 4 billion people harbor at least one species of parasitic nematode. Many havespecies of parasitic nematode. Many have more than one.more than one.
GeohelminthsEnterobius vermicularis Enterobius vermicularis (Pinworm)(Pinworm)
Trichuris trichiura Trichuris trichiura (Whipworm)(Whipworm)
Ascaris lumbricoides Ascaris lumbricoides (Giant intestinal worm)(Giant intestinal worm)
Toxocara canis Toxocara canis and T. and T. cati cati (Visceral larva (Visceral larva migransmigrans))
HookwormsHookwormsAncylostoma duodenaleAncylostoma duodenaleNecator americanusNecator americanus
Strongyloides stercoralis Strongyloides stercoralis (Cochin China diarrhea)(Cochin China diarrhea)
Immunity and Parasitism
Parasiteantigen
Worm infections elicit Th2 protective immune responses.Protozoan infections elicit Th1 protective immune responses.
Heavy Infection of Enterobius vermicularis
Photo: Martin Weber, MD, Children’s Hospital; Hannover Medical School; Hannover, Germany
Drug of Choice:
Mebendazole
Mode of Action:De-polymerizes all species ofinvertebrate tubulins; not vertebratetubulins.
Prevention and Control:
Prevention is difficult amongchildren, especially those attendingday care facilities and lower grades inschool. We “out-grow”our pinworminfections once we reach puberty.
Pathogenesis:
Trichuris spp. secrete a pore-forming proteinthat may play a role in anemia and diarrhea.Adult worms do not feed directly on blood orother host tissues. Mechanism of anemia stillunknown.
Pathogenesis:
1. “Verminous” pneumonia, lung tissue damage due to migratory larvae.
2. Bowel obstruction - too many adult worms.
3. Parasite secretes trypsin inhibitor, prevents host fromdigesting proteins.
4. Aberrant migration of “irritated” adult worms to:a. Ampula of Vaterb. Common ductc. Liverd. Pharynxe. Peritoneum
Clinical Disease:
1. Light infections are asymptomatic as long as theadult worms do not migrate.
2. Heavy infection leads to:a. protein calorie malnutrition - “failure
to thrive” syndrome.b. bowel obstruction.c. aberrant migratory events.
Prevention and Control:Sanitary disposal of dog and cat feces
Not practical
Pooper-scooper
Potty-trained cat!