Where do Children Die?

New Horizons: 3 ‘H’s

• How can research be reshaped to work on the world’s most difficult and important problems? (relevance)

• How can research be reshaped to promote innovative science and breakthrough discoveries? (innovation)

• How can research be reshaped to maximize not only scientific output but also societal impact and impact on health policy? (impact)

Project title Funding Partner €

Etiology of pneumonia in children under 5y – a multi-centric pilot study

Sanofi Pasteur 270 000

Ethiology of Fevers : candidate biomarkers for differentiation between pneumonia and malaria fever in children

Institut Mérieux/NIH 145 000 

Viral and bacterial biodiversity in influenza Fundaçao Pesquisa Rio de Janeiro (FAPERJ)

76 000(in kind)

Hemorrhagic fevers: Crimean Congo Virus L'institut de recherche biomédicale des armées( IRBA)

25 000 

PneumoTone Agence de Médecine Préventive (AMP)

46 300(in kind)

LaCoRIS: Respiratory Infectious Disease Among Cohorts in Vientiane Province, Laos  

U.S. Naval Medical Research Unit Number 2, Phnom Penh (NAMRU-2

PP)

160 000

Global Influenza Hospital Surveillance Network (GIHSN) Sanofi Pasteur 192 000

Validation study of a typhoid test to measure disease burden Bill & Melinda Gattes Foundation 375 000

Current Funded Projects

Total: 1 264 300

Project title Consortium Funding Partner €

COMPARE: COllaborative Management system for Pathogen detection And Risk assessment in Europe

GABRIEL(partner) and

28 others

European Commission H2020

400 000(total project: 28 000 000)

Implementation of automated genotyping to strengthen research capacities for tuberculosis control in Bangladesh

GABRIEL, icddr,b

TRD: 2014 Impact Grants – Research

capacity strengthening

37 000

Strengthening the transversal capacity of health actors in the fight against tuberculosis (TB) and multidrug-resistant TB (TB-MDR) in Zaporozhye region, Ukraine  

GABRIEL /LPE

(coordinator)

5% Initiative - France Expertise

International

430 000

Pipeline (1/2)

Project title Dimension Funding Partner €

Co-infections modeling in pneumonia severity: in vivo, in vitro and in silico approaches (COMODE)

LPE, UCBL1, Novadiscovery

Agence National pour la Recherche

285 000

Multidisciplinary approach for biomarkers identification in respiratory viral/bacteria co-infection

LPE, UCBL1, ProfileXpert

Fondation pour la Recherche Médicale

340 000

Global Research Collaboration for Infectious Disease Preparedness (GloPID-R) Secretariat

FMx(coordinator)/

ISARIC

European Commission

H2020

3 900 00

Pipeline (2/2)

Total for FMx: 5 302 000 US$

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Lyon’s Core Lab Team

Rodolphe Mérieux LaboratoryAntananarivo, Madagascar

Rodolphe Mérieux LaboratoryAntananarivo, Madagascar

Quality Initiative

• Designed to help GABRIEL member laboratories meet ISO 15189 accreditation requirements

• Working group at Fondation Mérieux piloting project

• Four pilot sites selected: o Christophe Mérieux Infectiology Centre in Laos, o Charles Mérieux Infectiology Centre in Mali, o Rodolphe Mérieux Laboratory at the GHESKIO Centre in Haitio Molecular Biology and Genetics Department National University of

Asunción in Paraguay

Quality Initiative

• Achievementso Assessment of the 4 selected laboratories and identification of

necessary improvements o Action plan to assist laboratories in meeting international quality

standardso “Self-assessment” questionnaire for all GABRIEL members

Gathering information on their current Quality Assurance Management Developed with Fiocruz, Brazil