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Poster Presentations: P2 P491
Jefferson’s sample, which were highly educated white participants already
enrolled in longitudinal research. No significant differences were found be-
tween the two groups regarding allocation of resources for research and at-
titudes towards positive outcomes of medical research, indicating
a generally favorable attitude towards research. Our results highlight the im-
portance of developing educational and social opportunities that foster rela-
tionships, decrease mistrust and address safety concerns.
Question BU data 1 MSSM data
1 I have a positive view about medical
research in general.
4.7 6 0.6
3.9 6 1.12 Medical researchers can be trusted to
protect the interest of people who take part
in their research studies.
4.0 6 0.9
3.5 6 1.13 We all have some responsibility to help
others by volunteering in research.
4.3 6 0.7
3.6 6 1.14 Society needs to devote more resources to
medical research.
4.2 6 0.9
4.1 6 1.25 Participating in medical research is
generally safe.
4.2 6 0.6
3.4 6 1.16 If I volunteer for medical research, I know
my personal information will be kept
private and confidential.
4.3 6 0.6
3.8 6 1.27 Medical research will find cures for many
major diseases during my lifetime.
3.9 6 0.9
3.9 6 1.21Jefferson, et al Clinical Research Participation among Aging Adults En-
rolled in an Alzheimer’s Disease Center Research Registry J Alzheimers
Dis. 2011 January 1; 23(3): 443–452.
P2-357 SELFAND PROXY RATINGS OF
PATIENT-REPORTED OUTCOMES: IMPACT OF
COGNITIVE STATUS
laili Soleimani1, Sabrina Lopez2, Angelica De La Fuente2, Gloria Benson2,
Judy Creighton2, Helene Geramain2, Cleopatra McGovern2,
Xiaodong Luo2, Mary Sano2, Judith Neugroschl2, 1Alzheimer’s Disease
Research Center, New York, New York, United States; 2Icahn School of
Medicine at Mount Sinai, New York, New York, United States.
Contact e-mail: [email protected]
Background: The use of patient reported outcomes (PROs) has been en-
couraged as an efficacy outcome by the FDA. This is challenging in cog-
nitive disorders, as insight may be impaired. In Alzheimer’s disease (AD),
proxy reports are often used to confirm symptoms. However, proxy reports
for the patient perspective are not well understood. The PROCOG is
a PRO measuring patient perspective on function: complex ADL’s, perfor-
mance and interpersonal functioning. This cross-sectional analysis at-
tempts to determine if self and proxy reports are comparable across
disease severity. Methods: 115 research participants whowere normal con-
trols (N¼32), amnestic MCI (n¼31) or had AD (n¼52) and their study part-
ners were recruited. The 55 item PROCOG developed by Frank et al, uses
a five point likert scale and higher scores reflect greater impairment. Partic-
ipants completed the scale themselves; Study partners completed the scale
as they thought their participant would. Group differences were examined;
Paired t-tests were used to compare participant and partner scores and
a "difference score" was calculated to describe the size and direction of
the difference. Results: Participant scores (Control: 43.966 29.61 aMCI:
64.356 37.75, AD: 49.766 36.64) demonstrated that those with aMCI re-
ported more impairment than controls (p¼0.001), but those with AD did
not. The Study Partner PROCOG scores reflected the severity of the cogni-
tive impairment at all stages (Control: 25.376 27.77, aMCI: 53.196 24.45
and AD: 98.466 45.59; P<0.01 for all comparisons). For difference scores
for aMCI there was no difference between partner and participant; but for
both AD and controls the differences were significant, with partner reporting
greater impairment in AD and less in controls. Conclusions: aMCI may be
point in which symptoms are apparent to informant and subject, a change
from either normal cognition who may perceive difficulties, and AD where
insight is impaired. In terms of PROCOG as an outcome measure, while
proxy responses of PROs may be comparable to participants among those
with aMCI, they do not reflect responses in those with more impairment
or those with no impairment. Novel approaches to determine how to use
proxy ratings for PRO are needed for studies that include a range of disease
severity.
P2-358 WITHDRAWN
P2-359 GOING NEW WAYS IN DEMENTIA CARE WITH
DELPHI-MV: AN INNOVATIVE CONCEPT OF
COLLABORATIVE DEMENTIA CARE
MANAGEMENT IN GERMANY
Tilly Eichler1, Jochen Ren�e Thyrian2, Adina Dreier3,Wolfgang Hoffmann2, 1German Centre for Neurodegenerative Diseases
(DZNE), Greifswald, Germany; 2German Center for Neurodegenerative
Diseases (DZNE), Greifswald, Germany; 3University of Greifswald,
Greifswald, Germany. Contact e-mail: [email protected]
Background: There is a growing demand for comprehensive care for per-
sons with dementia (PwD) and their caregivers. However, there are just
a few evidence-based models of care that are deliverable in routine care
and fit the specific circumstances of regional health care systems.Methods:
With DelpHi-MV (Dementia: life and person centred help in Mecklenburg -
Western Pomerania), a GP-based cluster-randomised controlled interven-
tion trial, we want to implement and evaluate an innovative concept of
collaborative dementia care management in Germany. DelpHi-Intervention
aims to provide "optimum care" to PwD living at home and their caregivers
by integrating multi-professional andmulti-modal strategies to optimise and
individualise treatment of dementia within the framework of the established
health care and social service systems. Based on German guidelines for ev-
idence-based diagnoses and treatment of dementia a comprehensive set of
95 intervention modules - the "DelpHi-Standard" - was defined. Each inter-
vention module consists of predefined trigger condition(s), a subsequent in-
tervention task as well as at least one criterion for completion of this task.
The intervention is conducted by Dementia Care Managers (DCM) - nurses
with dementia-specific training - at the people’s homes. It starts with a com-
prehensive assessment of the PwD and their caregivers, resulting in an indi-
vidual list with recommended intervention tasks. After discussion and
finalisation of this list in an interdisciplinary case conference the DCM sum-
marizes the results in a GP- information letter. GP and DCM determine the
further intervention strategy in collaboration. In the following half year the
DCM conducts her assigned intervention tasks. Completion of each task is
monitored during intervention visits and at follow-up assessment after one
year. Results: Enrolment into the study started January 2012, at January
2013 N¼251 PwDwere included. Construction of the DelpHi-Standard, im-
plementation of the intervention and descriptive data for intervention and
control patients will be presented. We expect at least moderate clinical ef-
fects of DelpHi-Intervention, i.e. statistically significant differences be-
tween control and intervention group across primary outcomes (quality of
life, behavioral and psychological symptoms of dementia, pharmacother-
apy, caregiver burden). Conclusions: Results can provide evidence for the
effectiveness of DelpHi-Intervention, paving the way for implementing
this concept into routine care.
P2-360 LONGITUDINAL COGNITIVE TRAINING IN
PEOPLE WITH MILD COGNITIVE IMPAIRMENT
Magda Tsolaki1, Eleni Poptsi2, Fotini Kounti2, Agogiatou Christina2,
Bakoglidou Evaggelia3, Soumpourou Aikaterini2, Zafeiropoulos Stavros2,
Georgia Batsila2, Evdokia Nikolaidou2, Vasiloglou Maria2, Ouzouni Fani2,
Markou Nefeli4, Zafeiropoulou Myrto2, 1Aristotle University of
Thessaloniki, Thessaloniki, Greece; 2Alzheimer Hellas, Thessaloniki,
Greece; 3Alzheimer Hellas, Thessaloniki, Greece; 4Alzheimer Hellas,
Thessaloniki, Greece. Contact e-mail: [email protected]
