THERAPY WORKSHEET

Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color

Are the results of this single preventive or therapeutic trial valid?

Was the assignment of patients to treatments randomised?

Was the randomisation list concealed?Ya. Pada bagian Methods khususnya dijelaskan pada Study Procedures bahwa pasien dikelompokkan secara acak.

Was follow-up of patients sufficiently long and complete?Ya. Pada penelitian ini pasien diikuti selama 12 minggu.

Were all patients analysed in the groups to which they were randomised?Ya. Semua pasien dianalisis dalam kelompok mereka diacak.

Were patients and clinicians kept blind to treatment?Ya. Pada bagian Methods khususnya di Study Procedures dijelaskan bahwa pasien dan dokter tidak mengetahui obat yang digunakan (double-blind).

Were the groups treated equally, apart from the experimental treatment?Ya. Kelompok kontrol dan percobaan diterapi dengan memberikan topikal selama 12 minggu.

Were the groups similar at the start of the trial?Ya. Kelompok dalam penelitian tetap sama mulai dari awal penelitian.

Are the valid results of this randomised trial important?

Pengobatan selama 12 minggu dengan klindamisin fosfat 1.2% dan tretinoin 0.025% pada lesi inflamasiRelative risk reduction (RRR)Absolute risk reduction (ARR)Number needed to treat (NNT)

CEREERCER EER

CERCER-EER1/ARR

11,36 %6,56 %42,25 %4,8 %20

Pengobatan selama 12 minggu dengan klindamisin fosfat 1.2% dan tretinoin 0.025% pada lesi non-inflamasiRelative risk reduction (RRR)Absolute risk reduction (ARR)Number needed to treat (NNT)

CEREERCER EER

CERCER-EER1/ARR

40,08 %22,60 %43,61 %17,48 %5

Can you apply this valid, important evidence about therapy in caring for your patient?

Do these results apply to your patient?

Is your patient so different from those in the study that its results cannot apply?Tidak. Penderita acne vulgaris di Indonesia sering ditemui dan tidak berbeda dengan partisipan dalam penelitian ini.

Is the treatment feasible in your setting?Ya. Bisa karena formula ini sudah ada di pasaran.

What are your patients potential benefits and harms from the therapy?

NNT pada lesi inflamasi

NNT pada lesi non-inflamasi20 5

Are your patients values and preferences satisfied by the regimen and its consequences?

Do your patient and you have a clear assessment of their values and preferences?Tentu saja pasien menginginkan pengobatan yang aman, murah dan mudah.

Are they met by this regimen and its consequences?Bisa dilakukan