WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Pilot WP 6.4 Genomics & colon cancer

WP 6.4 Genomics & colon cancer

9th Consortie Meeing Rome September 2006

Pilot WP 6.4

Genomics & colon cancer



4 genetic dept.

4 laboratories

50 surg.dept.

>20 gyn.dept.

HNPCC-registerToday:

Paper based

Future Aims:Interoperability

Communication

Further IT-support

Web-reporting of data



HNPCC-registerToday:

Paper based

Future Aims:Interoperability

Communication

Further IT-support

Web-reporting of data



Danish Health Data

Network

Web Server

Laboratory / Surgery Dep. / Genetic Dep.

Web Service Provider

Front endHNPCC

DB

HTML Web Service Not part of InfoBioMed

Web Page Client Web Service Client

Vali-dation



Invited departmentsGenetic

Department

Århus

Odense

Vejle

Hvidovre

SurgicalDepartment

Herning

Ålborg

Odense Hvidovre

ÅrhusLaboratory

Ålborg

Copenhagen

Hvidovre

Århus

100% functioning IP-addresses







Herning

Ålborg

Odense

GeneticDepartment

SurgicalDepartment

Laboratory

Ålborg

Copenhagen

Århus

VejleHvidovre

Odense

ÅrhusÅrhus

HvidovreHvidovre







Herning

Ålborg

Odense

GeneticDepartment

SurgicalDepartment

Laboratory

Ålborg

Copenhagen

Århus

VejleHvidovre

Odense

ÅrhusÅrhus

HvidovreHvidovre

II:1

Max Bergren



Herning

Ålborg

Odense

GeneticDepartment

SurgicalDepartment

Laboratory

Ålborg

Copenhagen

Århus

VejleHvidovre

Odense

ÅrhusÅrhus

HvidovreHvidovre







Herning

Ålborg

Odense

Laboratory

Ålborg

Copenhagen

Århus

VejleHvidovre

Odense

ÅrhusÅrhus

HvidovreHvidovre

MLH1, exon4,

c.350C>T, p.T117M

GeneticDepartment

SurgicalDepartment



HHUD – evaluation



International HL7 Interoperability Conference IHIC 2006

August 24-25, 2006, Cologne, Germany

http://www.hl7.org/





FORTHFamily Information HL7v3 model



FORTHIndividual Information

HL7v3 model



Example: CDA for Surveillance messages



Summary

• HL7 interoperability can eliminate heterogeneity and speed-up reporting of laboratories, surgery, and genetic counseling departments to the Danish HNPCC registry.

• In the long run it can also facilitate cooperation among HNPCC registries in Europe.

• We have experimented with the HL7 v3 tools, Family History Model of the Clinical Genomics SIG and CDA release 2 to facilitate information exchange and promote interoperability.



Conclusions

HL7 v3 tools are useful but require a long time of work. Interoperability of the result is limited.

• Family History topic is the most promising solution in the long term.– collaboration with the Clinical Genomics SIG is

envisioned to share understanding and reach consensus.• CDA release 2 currently provides early feedback and max

flexibility among the solutions we investigated. • Implementation guides should be developed and shared with

the community for the CDA and the Family History model.– they are the key to interoperability!

2005 2006

WEB

XML/HL7

S t r u c t u r i n g E u r o p e a n B i o m e d i c a l I n f o r m a t i c s t o S u p p o r t I n d i v i d u a l i s e d H e a l t h c a r e

I S T - 5 0 7 5 8 5

w w w . i n f o b i o m e d . o r g

P r e - a n a l y s i s

C u r r e n t S t a t u s f o r E x c h a n g e o f D a t a o n H N P C C - f a m i l i e s

W P 6 . 4 – G e n o m i c s a n d c o l o n c a n c e r

I n t e r n a l d o c u m e n t v 0 . 2 F i n a l

S t r u c t u r i n g E u r o p e a n B i o m e d i c a l I n f o r m a t i c s t o S u p p o r t I n d i v i d u a l i s e d H e a l t h c a r e

I S T - 5 0 7 5 8 5

w w w . i n f o b i o m e d . o r g

P r e - a n a l y s i s

C u r r e n t S t a t u s f o r E x c h a n g e o f D a t a o n H N P C C - f a m i l i e s

W P 6 . 4 – G e n o m i c s a n d c o l o n c a n c e r

I n t e r n a l d o c u m e n t v 0 . 2 F i n a l

SNP2005Leicester

SNP2005Leicester

FORTH

UPM

Internet

Web Server

Laboratory / Surgery Dep. / Genetic Dep.

Web Service Provider

Front endHNPCC

DB

HTML / HTTP Web Service / HTTP Web Service / HTTP

Web Page Client Web Service Client

ImplementationImplementationFUNEN

HNPCC

2007

HHUD

EvaluationEvaluation

Custodix

Aveiro

ISCIII

http://www.enchantedlearning.com/europe/greece/

http://www.enchantedlearning.com/europe/greece/



Specific output WP 6.4

• Current status data exchange HNPCC

• 4 XML standards on clinical content

• Design of XML documents

• WEB service client

• Implementation & evaluation of WEB-client

• Ethical, legal and security issues

• Early HL7 and CDA experience

• Dissemination experience



Experience ??

Documents

WP 6.4 Genomics & colon cancer 9 th Consortie Meeing Rome September 2006 Pilot WP 6.4 Genomics & colon cancer