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W. SCOTT DUNBAR Associate Professor Room 517F Frank Forward Tel.: 604 822 4725 Fax: 604 822 5599 [email protected] o Biography o Research Interests o Selected Publications Biography Education BSc Geophysics (Honours), University of British Columbia, 1972 MSc Geophysics, University of Toronto, 1973 PhD Civil Engineering/Geophysics, Stanford University, 1977 The first twenty years of my career were spent in civil and geotechnical engineering consulting. Over that period I was involved in projects such as tailings dam and waste dump design, open pit and underground mine design, and water resources projects including hydroelectric dams. In addition to North America, these projects took me to Africa, South and Central America, and Europe. (Guatemala was a favorite.) In 1997 Dr Rick Lawrence, Department Head at the time, invited me to join the Department. Since I had always enjoyed teaching and research, it was not a difficult decision to apply for the position. I was at a point in my career when I was ready for the change. Although my background is civil/geotechnical, I am interested in what a mine is going to look like in the year 2050 or even 2100. Can we go on extracting minerals the way we have been or should we be looking at alternatives? What alternatives? Some ideas are discussed in my Research Interests but I believe we should look way “outside the box” since otherwise mining engineering will not advance. I teach Mine Design to undergraduate students and Mine Economics to both undergraduate and graduate students. I also teach a graduate course in the use of decision analysis and simulation in engineering. In addition to my responsibilities with Mining Engineering I was the founding director of Integrated Engineering, a new interdisciplinary engineering degree with heavy emphasis on

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Page 1: WSD Web page - UBC Miningmining.ubc.ca/files/2013/03/Scott-Dunbar.pdfSelected Publications Curtis SB, Hewitt J, MacGillivray RTA, Dunbar WS, 2009. Biomining with bacteriophage: Selectivity

 

W. SCOTT DUNBAR  

Associate Professor  

Room 517F Frank Forward Tel.: 604 822 4725 Fax: 604 822 5599 [email protected] 

 o Biography o Research Interests o Selected Publications  BiographyEducation

BSc Geophysics (Honours), University of British Columbia, 1972 MSc Geophysics, University of Toronto, 1973 PhD Civil Engineering/Geophysics, Stanford University, 1977  The first twenty years of my career were spent in civil and geotechnical engineering consulting. Over that period I was involved  in projects such as tailings dam and waste dump design, open pit and underground mine design, and water resources projects  including hydroelectric dams. In addition to North America, these projects took me to Africa, South and Central America, and Europe. (Guatemala was a favorite.)  In 1997 Dr Rick Lawrence, Department Head at  the  time,  invited me  to  join  the Department. Since I had always enjoyed teaching and research, it was not a difficult decision to apply for the position. I was at a point in my career when I was ready for the change.   Although my background  is civil/geotechnical,  I am  interested  in what a mine  is going to  look like in the year 2050 or even 2100. Can we go on extracting minerals the way we have been or should  we  be  looking  at  alternatives? What  alternatives?  Some  ideas  are  discussed  in my Research Interests but I believe we should  look way “outside the box” since otherwise mining engineering will not advance.  I  teach Mine Design  to undergraduate  students and Mine Economics  to both undergraduate and  graduate  students.  I  also  teach  a  graduate  course  in  the  use  of  decision  analysis  and simulation in engineering.  In  addition  to  my  responsibilities  with  Mining  Engineering  I  was  the  founding  director  of Integrated  Engineering,  a  new  inter‐disciplinary  engineering  degree with  heavy  emphasis  on 

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design (see www.igen.ubc.ca). The program has been quite successful and has graduated about 120 students all of whom are employed in different industries.  The  counter‐balance  for  a  busy work  schedule  is  sports  (cycling,  cross‐country  and  downhill skiing),  re‐modeling  and  re‐landscaping  an  old  house with  the  help  of my wife,  Petra,  and spending time with two sons, one young daughter, and two grown daughters. I also like to read and travel.   Music? I am an unabashed blues aficionado. There was a blues singer named Scott Dunbar from Lake Mary  in Mississippi who played a  raw and basic  style.  Looked nothing  like me.  I wish  I could have met him before he died in 1994 (See http://sundayblues.org/archives/215)    

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ResearchInterestsNature  likes  to keep numbers  in control. So what keeps bacteria  from  replicating  to produce excessive numbers? The answer: bacteriophage (or simply phage). The sole purpose of phage is to replicate by infecting bacteria; they are harmless to humans, animals, and plants. There are several species of phage and each infects a limited range of species of bacteria.   Phage are  the most numerous biological entity  in  the biosphere. They are widely distributed and exist wherever there are bacterial hosts. It  is estimated that phage  infect half the world’s bacteria every ten days.   What has this got to do with mining? Read on.   The common feature of phage is a protein coating (a capsid) which surrounds genetic material such as DNA or RNA. There are enough genes in the genetic material to encode the information to make the phage capsid, but the phage does not have a metabolic system to generate energy or the genetic precursors required for reproduction. (For this reason phage are not considered to be alive.) The purpose of infection is to insert the genetic material and use the machinery of the host cell to synthesize proteins and reproduce.  Shown below  is a cartoon of  the M13 phage particle which  infects  the E coli bacterium. The particle  consists  of  DNA  surrounded  by  different  protein  coatings,  labelled  Px. M13  is  very small. By way of comparison, the diameter of a human hair  is about 20‐180 microns, at  least four orders of magnitude larger than the diameter of M13.  

  Without  compromising  the  ability  of  the  particle  to  infect  E  coli,  short  peptide  sequences (foreign sequences) can be  fused  to some of  the protein coatings of  the particle. Libraries of phage with about one billion different foreign sequences can be constructed.  In collaboration with  the Centre  for Blood Research at UBC, such  libraries have been used  to  identify  foreign protein sequences on M13 that bind to minerals of economic interest such as chalcopyrite and sphalerite.  We  tagged  the  binding  phage  particles  with  a  fluorescent  antibody  and  then introduced the tagged phage (millions of them) to a mixture of silica and sphalerite particles 45‐75 microns  in size. The  fluorescence  image at about 200× magnification  is shown below. The 

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dark  parfluoresce 

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Page 5: WSD Web page - UBC Miningmining.ubc.ca/files/2013/03/Scott-Dunbar.pdfSelected Publications Curtis SB, Hewitt J, MacGillivray RTA, Dunbar WS, 2009. Biomining with bacteriophage: Selectivity

SelectedPublicationsCurtis  SB,  Hewitt  J,  MacGillivray  RTA,  Dunbar  WS,  2009.  Biomining  with  bacteriophage: 

Selectivity  of  displayed  peptides  for  naturally  occurring  sphalerite  and  chalcopyrite. Biotechnology and Bioengineering 102:644–650. 

 Curtis  SB,  MacGillivray  RTA,  Dunbar  WS,  2011.  Effects  of  bacteriophage  on  the  surface 

properties of chalcopyrite (CuFeS2), and phage‐induced flocculation of chalcopyrite, glacial till, and oil sands tailings. Biotechnology and Bioengineering, 108(7):1579‐1590 

 Curtis SB, Dunbar WS, MacGillivray RTA, 2012. Bacteriophage‐induced aggregation of oil sands 

tailings. To be submitted to Biotechnology and Bioengineering  Dunbar, WS, 2012. Applications of synthetic biology to mineral processing. In preparation  Dunbar, WS  and Russell AD,  2012.  Continuous  cash  flow models  of  non‐market  risks.  To  be 

submitted to Resources Policy  Grieco  S‐HH,  Seungil  L,  Dunbar,  WS,  MacGillivray,  RTA,  and  Curtis,  SB,  2009.  Maximizing 

filamentous  phage  yield  during  computer‐controlled  fermentation.  Bioprocess  and Biosystems Engineering, 32:773‐779 

 Gunson,  AJ,  Klein,  B,  Veiga,  M,  Dunbar,  S,  2010.  Reducing  mine  water  network  energy 

requirements. Journal of Cleaner Production, 18:1328:1338