KLE’s P. C. Jabin Science College, HubliM. Sc. Chemistry

Syllabus

Choice Based Credit SystemJune 2016 onwards

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SEMESTER – I

CHIT-1.1: INORGANIC CHEMISTRY

UNIT-I: CHEMICAL BONDINGIonic bonding: Properties of ionic compounds, lattice energy, Born-Lande’s equation, Born-Haber cycle and its applications, Kapustinskii equation, Solvation energy, dissolution of ionic compounds in polar solvents and its energetics. The predictive power of thermochemical calculations of ionic compounds, covalent character in ionic compounds. Radius ratio and structure of ionic compounds, efficiency of packing of crystal lattices. Covalent bonding: Valence bond theory, molecular orbital theory, symmetry and overlap, molecular orbital diagrams of diatomic molecules (homo- & hetero- nuclear), triatomic molecules (linear CO 2 & N2O), Walsh diagrams, Bent's rules, Resonance, hybridization, VSEPR theory.Metallic bonding: Characterization of metallic states, band theory, conductors, insulators, semiconductors, defects in solids. 12 hrs

UNIT-II: THE CHEMISTRY OF MAIN GROUP ELEMENTS Hydrogen & its compounds Hydrides-classification, electron deficient, precise & rich hydrides, PH3, SbH3, AsH3, Selenides, Tellurides.Boron group Boron Hydrides, Boranes, Borazines - Preparation, structure & bonding. Interconversion of lower & higher boranes. Metalloboranes and Carboranes.Nitrogen & Oxygen groupOxyacids & oxoanions of Sulphur & NitrigenHalogen group Interhalogens, Pseudohalogen - Synthesis, properties & applications. Structure and bonding in oxyacids & oxoanions of HalogensNoble gases Synthesis, structure & bonding in oxides & fluorides of xenon (with respect to VSEPR) 12 hrs

UNIT-III : ACID BASE CHEMISTRY AND REACTIONS IN NONAQUEOUS SOLVENTS Review of acid-base concepts and a generalized acid-base concept. Measure of acid-base strength: Gas-phase basicities and acidities, Steric effects, Solvation effects. Hard and Soft Acids and Bases (HSAB): Classification, theoretical bases of hardness and softness.Non-Aqueous Solvents: Reactions in liquid NH3, H2SO4 and BrF3. Coordination model of non-aqueous solvents. 12 hrs

UNIT-IV : COORDINATION CHEMISTRY- BONDING, STEREOCHEMSITRY AND MAGNETISM Ligands, coordination, coordination number and geometries. Isomerism in d-block metal complexes. Theories of bonding - VBT, CFTVBT, CFT and their limitations; d-orbital splitting in octahedral, JT-distorted octahedral, square planar, square pyramidal, trigonal bipyramidal, and tetrahedral complexes; CFSE for d 1 to d10 systems, pairing energy, low-spin and high-spin complexes. Molecular Orbital (MOTMOT) theory of selected octahedral and tetrahedral complexes.Evidence for metal-ligand covalent bonding: Nephelauxetic effect, EPR spectroscopy & Crystallography.Magnetic Properties:: Magnetic susceptibility and the spin-only formula, Spin & orbital contributions to the magnetic moment, Temperature effect on eff, Spin crossover, Ferromagnetism, Antiferromagnetism & Ferrimagnetism.

12 hrs 48 hrs

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Books Recommended

1. Cotton, F.A., Wilkinson, G., Murillo, C.A. and Bochmann, M., “Advanced Inorganic Chemistry”, 6th Ed., John Wiley & Sons. 1999.

2. Douglas, B.E., McDaniel,D.H. and Alexander, J.J., “Concepts and Models in Inorganic Chemistry”, 3rd Ed., John Wiley & Sons. 2001.

3. Figgis, B.N., and Hitchman, M.A “Ligand Field Theory and Its Applications”, Wiley Eastern Ltd. 1999.4. Huheey, J.E., Keiter, E.A. and Keiter, R.L., “Inorganic Chemistry Principle of Structure and Reactivity”, 4th Ed,

Pearson Education, Inc. 2003.5. Atkins, P., Overton, T., Rourke, J., Mark, W. and Armstrong, F., “Shriver and Atkins' Inorganic Chemistry”, 4th

Ed, Oxford university press. 2009.6. Elements of Magnetochemistry, R. L. Dutta and A. Syamal, Affiliated East-West, 1993.

CHI (Pr) 1.1: LAB COURSE IN INORGANIC CHEMISTRY

1. Separation and determination of two metal ions involving volumetric and gravimetric methods from the

following: Fe+Ni, Zn+Cu, Cu+Fe, Zn+Ni.

2. Preparation of complexes: Hg[Co(SCN)4], K3[Al(C2O4) 3].3H2O and [Cu(tu)3] 2SO4.H2O

Scheme of Examination

i. Duration of examination: 04 hoursii. Quantitative analysis: 25 marksiii. Preparation of a complex: 10 marksiv. Viva voce and Journal: 05 marksv. Internal Assessment: 10 Marks Total: 50 marks Books recommended

1. Vogel’s Text Book of Quantitative Inorganic Analysis-J. Basett, R. C. Denney, H. Jeffery and J. Mendham, Longmans, Green and company Ltd.

2. Practical Inorganic Chemistry-G. Pass and H. Sutcliff, Chapman and Hall Ltd. (1968).

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CHOT-1.2: ORGANIC CHEMISTRY

UNIT-I: a) Bonding in Organic Molecules: Localised chemical bonding: Hybridisation index, Bonding in cyclopropane, Bond distances, Bond angles, Bond energies, Calculation of Heats of reactions, Bond order.Delocalised chemical bonding: Conjugation, Cross conjugation, Hyperconjugation, Resonance, tautomerism, valence tautomerism. Bonding in Fullerenes.Bonding weaker than covalent: Hydrogen bonding & Inclusion compounds. Electronic, Steric & solvent effect on strength of acids & bases. Basicity and nucleophilicity.Structure and reactivity: HSAB concept. b) Aromaticity: Aromaticity and Huckel’s rule- HMO theory. Benzenoid and Non-benzenoid aromatic compounds. Tropones, Tropolones, Pyrilium cation, Ferrocene. Alternant and non-alternant hydrocarbons. Aromaticity of charged rings (3-8 membered) Non aromatic, Anti-aromatic and homo aromatic systems. Physical methods for the determination: X-ray, UV, and NMR methods. Annulenes and heteroannulenes [10-18]. 12 hrs

UNIT-II: Organic Reaction Mechanisms: Classification of organic reactions – Meaning and Importance of reaction mechanism. Methods of Determination of reaction mechanisms. Kinetic Methods: Order and Molecularity. Non-kinetic Methods: Product identification, Cross over experiments, Study of intermediates, Isotopic labeling, Kinetic isotope effects, Stereochemical studies. Mechanisms of Aliphatic nucleophilic substitutions, SN2, SN1 and SNi pathways. Rearrangements in SN1

reactions. Substitution vs elimination. Dehydration of alcohols, dehydrohalogenation of alkyl halides using optically active substrates (erythro and threo nomenclature). Neighboring group participation by pi and sigma bonds, anchimeric assistance. 12 hrs

UNIT-III: Stereochemistry and Conformational analysis: Elements of symmetry and symmetry operations and point groups in small molecules.Optical Isomerism: Optical activity and chirality. Specific rotation. Molecules with two chiral centers: Fischer-Saw Horse-Newmann projections and their transformations.Enantiomers, Diastereomers, Epimers, threo, erythro and meso compounds, Racemisation, Resolution. Stereochemical correlation. Pseudo-asymmetric compounds.Geometrical Isomerism: E-Z nomenclature, configuration of Geometrical isomers, Syn and Anti isomers.Conformational analysis: Conformational study of 1,2-dichloroethane, 2-aminoethanol, Curtin-Hammett principle.

12 hrs

UNIT-IV: Molecular rearrangement: Classification and general mechanistic pattern for electrophiles, free-radical and nucleophile rearrangements. Mechanism of the following rearrangement reactions: a) C–C migration: Pinacol-Pinacolone, Dienone-Phenol, Benzilic, Favorskii, Neber, Sommelet- Hauser, Anderson, Stevens, Smiles, Shapiro, Fritch-Butenberg-Wiechell.b) C – N migration: Benzidine rearrangement, Hofmann, Curtius, Schmidt, Lossen, Beckmann rearrangement.c) C – O migration : Baeyer-Villiger.d) O – C migration: Baker-Venkatraman, Fries and Witting rearrangements. 12 hrs Total 48 hrs

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Books Recommended

1. Organic Chemistry - P.Y. Bruice, 7th Edition, Pearson Education Pvt. Ltd., New Delhi (2014).2. Organic Chemistry - S. H. Pine, 5th Edition, McGraw-Hill, London (2010).3. Organic Chemistry - R.T. Morrison and R.N. Boyd, 6th Edition Pearson Education Pvt. Ltd., New Delhi (1992).4. Organic Chemistry – C.B.Fryhle and T.W. Graham Solomons, 10th Edition, Wiley India Pvt Ltd, (2012).5. Organic Chemistry - G.M. Loudon, 4th Edition, Oxford University Press, New York (2002).6. Organic Chemistry Volume-I, II - I. L. Finar, 6th Edition, ELBS London (2004).7. Organic Chemistry - F.A. Carey and R.J. Sundberg, 5th Edition, McGraw Hill (2007).8. Organic chemistry- Jonathan Clayden , Nick Greeves , Stuart Warren, 2nd Edition, Oxford University Press (2014).9. March's Advanced Organic Chemistry: Reactions, Mechanisms and Structure- M.B. Smith and J. March, 6th Edition,

Wiley India Pvt Ltd (2012).10. Guidebook to Mechanism in Organic Chemistry - P. Sykes. 6th Edition, Pearson Education (2003).11. Organic reaction mechanisms. V.K. Ahluwalia and R.K. Parashar, 4th Edition, Narosa Publishing House (2010).12. Mechanism and Structure in Organic Chemistry. E.S.Gould.13. Structure and Mechanism in Organic Chemistry. C.K. Ingold. 2nd Edition. CBS Publishers (2000). 14. Stereochemistry of organic compounds. E.L. Eliel and S.H. Wilen, 1st Student edition, Wiley India Pvt Ltd. (2010).15. Stereochemistry – Conformation and Mechanism - P. S. Kalsi, 8th Edition, New Age International Publishers, New

Delhi (2015).16. Stereochemistry of Organic Compounds : Principles and Applications by D. Nasipuri, 3rd Edition, New Age

International Publishers, New Delhi (2011).

CHO (Pr) 1.2: LAB COURSE IN ORGANIC CHEMISTRY

Preparation of the following organic compounds:1. Benzoic acid and Benzyl alcohol from Benzaldehyde (Cannizarro reaction).2. p-Chlorobenzoic acid from p-toluidine.3. Aniline from Benzene. 4. m-Nitroaniline from Nitrobenzene. 5. m-Nitro benzoic acid from Ethyl benzoate. 6. p-Bromoaniline from acetanilide.7. p-Nitroaniline from acetanilide.8. Microscale experiments involving organic preparations.

Books Recommended:1. Vogel’s Textbook of Practical Organic Chemistry Revised - B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell,

5th Edition, Addison Wesley Longman Limited, UK, 1997.2. A Hand book of Organic Chemistry – by H.T.Clarke.3. A Laboratory Manual of Organic Chemistry by B.B.Dey and M.V. Govindachari.4. Lab Experiments in Organic Chemistry – by Arun. Sethi, New Age International Ltd. New Delhi. 2006.5. Experimental Organic Chemistry-L. M. Harwood, and C. J. Moody, Blackwell Scientfic, London, 1989. Scheme of Examination:

Duration of examination: 04 hoursi. Experiments: 35 marksii. Proper Technique 05 marksiii. Viva-Voce & Journal: 10 marks Total: 50 marks

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CHPT-1.3: PHYSICAL CHEMISTRY UNIT-I: Quantum Chemistry–IBlack body radiation, Planck’s theory, Photoelectric effect, Compton effect. Bohr Theory of hydrogen atom, Sommerfeld theory. Wave- particle duality: de Broglie hypothesis, uncertainty principle, the wave nature of electron.Schrodinger equation. Wave function and its interpretation. Normalization and orthogonality, eigen functions and eigen values. Solutions of Schrodinger equation for free particle and particle in three dimensional box. Quantum mechanical degeneracy and tunneling. 12 hrs

UNIT-II: Quantum Chemistry – IIRigid rotator and the harmonic oscillator. Equation for the hydrogen atom in spherical polar coordinates and an indication of the method of its solution, the quantum numbers and their significance. Hydrogen-like atoms, properties of the H-atom wave functions. Electronic energy states of H-atom. Many electron systems and the self consistent field method. Electronic configurations in the periodic table. Pauli Exclusion Principle. Spectroscopic term symbols. Slater determinates. Couplings of angular momenta. Russel-Saunders and J-J coupling and Zeeman effect. 12 hrs

UNIT-III: Reaction Kinetics - IA critical account of collision and transition state theories. Kinetics and Mechanism: Steady state approximation and simple examples relating kinetics to mechanism. Theories of unimolecualr reactions: RRKM theory. Isomerisation of methyl isocyanide. Reaction between ions, influence of ionic strength, salt effects. Chain Reactions: examples of chain reactions, general aspects of chain reactions. Chain length, Chain transfer reactions, Chain inhibition, Kinetics of branching chain reactions, explosion limits. 12 hrs

UNIT-IV: Reaction Kinetics - II: General features of fast reactions, study of fast reactions by flow method, relaxation method, flash photolysis, nuclear magnetic resonance method, pulse radiolysis and shock tube method. Enzyme Catalysis: Mechanism of single substrate reactions, Michaelis-Menten mechanism, influence of pH, temperature and inhibitors. Reaction Dynamics: Potential energy surfaces, methods employed in the construct of potential surfaces, calculating reactions. Effect of solvent, pressure and ionic strength for ion-ion, ion-neutral molecule type reactions, cage effects. 12 hrs

Total 48 hrs

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Books Recommended:

1. Introduction to Quantum Chemistry by A. K. Chandra, Ed. 3, Tata McGraw Hill, New Delhi, 1988.2. Quantum Chemistry by R. K. Prasad, New Age International Publications, New Delhi, 1997.3. Quantum Chemistry by Eyring, Walter and Kimball, John-Wiley, New York.4. Physical Chemistry by G. M. Barrow, McGraw Hill, New York, 1996.5. Fundamentals of Physical Chemistry by Maron and Lando.6. Physical Chemistry by P. W. Atkins, ELBS, London, 1990 (Ed. 4).7. Physical Chemistry by K. Vamulapalli, Prentice Hall of India Pvt. Ltd., New Delhi, 1997.8. Physical Chemistry by Daniels and Alberty, Wiley, New York.9. Physical Chemistry Through Problems by S. K. Dogra and S Dogra, Wiley Eastern, New Delhi.10. A Text Book of Physical Chemistry by Samuel Glasstone, McMillan, London.11. Atomic Structure and Chemical Bonding by Manas Chanda, Tata McGraw Hill Publishing Co., New Delhi.12. Chemical Kinetics by K. J. Laidler, Tata McGraw Hill Publishing Co., New Delhi.13. Kinetics and Reaction Mechanisms by Frost and Pearson, Wiley, New York.14. Thermodynamics for Chemists by S. Glasstone, Van Nostrand, Princeton.15. Thermodynamics by Rajaram and Kuriocose.16. An Introduction to Electrochemistry by S. Glasstone, Van Nostrand, London17. A Text book of Electrochemistry by G.F.A. Kortum and J.O.M. Bockris, Elsevier, New York.18. Modern Electrochemistry by J.O.M. Bockris and A.K.N. Reddy Vol. I and Vol. II, Butterworths, London.19. Kinetics and Mechanism of Chemical transformation by J Rangaswamy and J Kuriwsc, Mc millan 20. Theory of rate processes by S Glasstone, K J Laidler and H Eyring, Mc Grew hill.21. Kinetics of Chemical changes in solution by E S Amis, Mc Millan – 1948.

CHP (Pr)-1.3: LAB COURSE IN PHYSICAL CHEMISTRY

1. Density: Determination of partial molar volume. (e.g. Salts in water and liquids in water, systems)2. Viscosity: Molecular radius of glycerol molecule. 3. Distribution law: Distribution of benzoic acid (or succinic acid, etc.) between water and benzene.4. Thermochemistry:

i. Step -wise heat of neutralization of a polybasic acid (e.g.; NaH2PO4, Na2HPO4 & Na3PO4)ii. Integral heats of solution and heats of dilution of salts. (e.g., KNO3, NaCl etc.)

5. Refractometry: Molar refraction of a solid substance by measuring the refractive indices of its solutions.6. Spectrophotometry:

i. Mixture analysis by absorptiometry/Spectrophotometry.ii. Applicability range (for an absorbing substance in solution) and evaluation of the molar absorbency

index, finding unknown concentration.7. Reaction Kinetics: Acid hydrolysis, catalytic strengths and determination of Ea.8. Potentiometery: Dissociation constant of weak monobasic acids and titration of HCl+CH3COOH with NaOH.9. Electrical conductance:

i. Titration of a weak acid with a weak base and a strong acid with a weak base.ii. Titration of mixture of acids with a strong base.

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Books Recommended:

1. Practical Physical Chemistry by A. M. James and F. E. Prichard, Longmans, London.2. Experiments in Physical Chemistry by Shoemaker and Garland, McGraw Hill, New York.3. Experiments in Physical Chemistry by Daniels, Alberty and Willams, McGraw Hill, New York.4. Experimantal Physical Chemistry by W. G. Palmer, Cabridge University Press, London.5. Advanced Physico-Chemical experiments by J. Rose.6. Text Book of Physical Chemistry by S. Glasstone, , McGraw Hill,London.7. Text book of Quantitative Analysis by A. I. Vogel, ELBS, Harlow.8. Advanced Practical Physical Chemistry by J. B. Yadav, Goel Publishing House.9. Experimental Physical Chemistry by V. D. Athawale and Parul Mathur, New Age International Publishers.10. Advanced Physical Chemistry Experiments by Gurtu and Gurtu, Pragati Prakashan Educational Publishers, 3rd Edition 2007.

Scheme of Examination:

Duration of examination: 04 hoursi. Experiment: 35 marksii. Proper Technique 05 marksiii. Viva-Voce & Journal: 10 marks

Total: 50 marks

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CHAT-1.4: ANALYTICAL AND INDUSTRIAL CHEMISTRY

UNIT-: INTRODUCTION TO METHODS OF CHEMICAL ANALYSIS

Introduction to Chemical Analysis; approaches, definition of terms, concentration units. Classification of analytical methods. Preparing standard solutions and primary standards. Principles and applications of volumetric and Gravimetric analysis. Data analysis: Errors-Types and sources of errors, propagation of errors, accuracy and precision, minimization of errors, significant figures. Mean, Median and Standard deviation. Significance of t- and F-tests and least square analysis. 12 hrs

UNIT-II: SEPARATION TECHNIQUES

Separation techniques: Ion exchange: Types of ion exchange resins, ion exchange capacity, ion exchange equilibria and selectivity coefficient, techniques of ion exchange process. Applications of ion exchangers: Preparation and purification of reagents, removal of interfering ions, and in the separation of lanthanides and actinides. Solvent extraction: Basic principles of solvent extraction, relationship between percentage extraction and distribution ratio and distribution selectivity of an extraction. Extraction Techniques, stripping, back washing. Use of masking out and salting out agents. 12 hrs

UNIT-III: CHROMATOGRAPHY

Chromatography: General principles and classification of chromatographic methods: Paper, Thin-layer, column and liquid chromatography. Gas chromatography: Principles, instrumentation, stationary phases and types of carrier gas used in GC. Methods of sample injection, types of detectors used, programmed temperature GC, plate and plate height in GC. Applications of GC.GC-MS: Principles and applications HPLC and HPTCL: Principles and applications 12 hrs

UNIT-IV: CORROSION AND ITS CONTROL

Introduction, Definition, Chemical and electrochemical theories of corrosion. Galvanic series. Factors affecting corrosion rate (nature of the metal, relative areas of anode and cathode, nature of the corrosion product, nature of the medium-conductivity, pH and temperature). Types of corrosion- galvanic, differential aeration (waterline), intergranular, pitting and stress. Corrosion control- design and selection of material, protective coatings- metal coatings, anodic and cathodic, inorganic coatings (anodizes and phosphate), cathodic protection (sacrificial and impressed current methods) and anodic protection. Surfactants: Introduction. Properties, Type of surfactants, Anionic surfactants, Cationic surfactants, Nonionic surfactants, Amphoteric surfactants. Applications of the surfactants. Harmful effects of surfactants. Fuel Cells: Introduction, difference between conventional cell and a fuel cell, limitations, advantages, applications; types of fuel cells. Construction and working of hydrogen-oxygen and methanol-oxygen fuel cells. 12 hrs

48 hrs

9

Books Recommended

1. Analytical Chemistry, 5th Edn. G. D. Christian, John- Wiley and Sons Inc. 1994.2. Fundamentals of Analytical Chemistry, 7th Edn. D. A. Skoog. D. M. West and F. J.Holler, Saunder College

Publishing, 1996.3. Instrumental Methods of Analysis, H. H. Willard, L. L. Merrit. J. A. Dean and F. A.Settle, CBS Publishers 1996.4. Surfactants Science and Technology – Draw Myers, 3rd Edition, Wiley Interscience. New York.5. Applied Surfactants, Principles and Applications – Thorwat F. Tadros, Wileiinterscience, New York.6. Surfactants and Polymers in Aqueous Solutions- K. holmberg, B. Jonsson, B. Kronberg and B. Lindman, 2nd

Edition, Wiley Publication New York.7. Surfactants Fundamentals and Application in Petroleum Industry- Laurier L. Schramm, Wiley Publications, New

York.

CHG (Pr) 1.4: LAB COURSE IN ANALYTICAL AND INDUSTRIAL CHEMISTRY

1. To study the complex formation between Fe(III) and salicylic acid and to find the formula and stability constant of the complex by colorimetry.

2. To determine the concentration of concentrations of Cu(II) and Fe(III) solution photometrically by titrating it with EDTA.

3. Demonstration of use of masking of agents in volumetric analysis4. Demonstration of TLC and Paper chromatography5. Electrical conductance: Titration of a mixture of acid (i) CH3COOH + H2C2O4 (ii) HNO3 + H2SO4

6. Electrical conductance: Determine the relative strength of chloroacetic acid and acetic by conductivity measurements.

7. Refractometry: Study of variation of R.I with composition (mole fraction) of mixture CCl4 and C6H6

8. Potentiometry: Determination of stability constant of Cu2+ and ethylene diamine (EDA) complex by emf method.

Books Recommended

1. Vogel’s Textbook of Quantitative Chemical Analysis, J. Mendham, R.C. Denney, J. D. Barnes and M.J.K. Thomas, 6th edition, Third Indian Reprint.2003 Pearson Education Pvt. Ltd., New Delhi.

2. Practical Physical Chemistry by A. M. James and F. E. Prichard.3. Experiments in Physical Chemistry by Shoemaker and garland.4. Experiments in Physical Chemistry by W. G. Palmer.5. Experimental Physical Chemistry by V. D. Athwale and Paul Mathur, New Age International Publishers, 2001.

Scheme of Examination

Duration of examination: 04 hoursi. Experiment: 35 marksii. Proper Technique 05 marksiii. Viva-Voce & Journal: 10 marks

Total: 50 marks

10

SEMESTER – II

CHIT-2.1: INORGANIC CHEMISTRY

UNIT-I: COORDINATION CHEMISTRY: STABILITY & REACTION MECHANISMS OF TRANSITION METAL COMPLEXES

Stability of coordination complexesStepwise and overall formation constants, trends in stepwise constants, factors affecting the stability of metal complexes with reference to the nature of metal ion and ligand. Irving-William series, chelate and macrocyclic effect. Determination of stability constants by Polarography and Spectrophotometry. Ligand substitution reactions in octahedral complexes: SN1, SN2 SNICB mechanisms, racemization in coordination compounds, steric effects on substitutions.Ligand Substitution reactions in Square-Planar complexes: Tran’s effect, trans series, applications of trans effect. Electron Transfer Reactions (or Redox reactions): Inner and Outer Sphere electron transfer reactions. 12 hrs

UNIT-II: SYMETRY AND GROUP THEORY

Symmetry operations and symmetry elementsThe point groups of moleculesApplications of symmetry: Polar molecules and Chiral moleculesRepresentations: Representation of symmetry operations as - Matrices

- Reducible & Irreducible Properties and definitions of Group theory, character tables for Cs, Ci, C3v and C2v point groups.The Great orthogonality theorem, character tables and their applications to chemical bonding. 12 hrs

UNIT-III: ORGANOMETALLIC CHEMISTRY: SYNTHESIS, STRUCTURE, AND BONDING

Organotransition metal complexes, Classification, 18-electron and 16-electron rules. Metal alkyls, aryls and olefin complexes: Synthesis, structure, bonding and reactions. Metal π-complexes: Preparation, structure, bonding and important reactions of metal carbonyls. Metal nitrosyls: Introduction, methods of preparation, structure, properties and their applications. Metal clusters: Halide clusters 12 hrs

UNIT-IV : ORGANO METALLIC CATALYSIS

General principles and terminologies, Homogeneous and heterogeneous catalysis. Homogeneous catalysis: hydrogenation of alkenes, Hydroformylation, Wacker oxidation of alkenes, Alkene metathesis, Palladium catalysed C-C bond forming reactions. Heterogeneous catalysis: hydrogenation of alkenes, Ammonia synthesis, Sulfur dioxide oxidation, Fischer-Troposch synthesis, Alkene polymerization.

12 hrs 48 hrs

11

Books Recommended

1. Huheey, J.E., Keiter, E.A. and Keiter, R.L., “Inorganic Chemistry Principle of Structure and Reactivity”, 4th Ed, Pearson Education, Inc. 2003.

2. Atkins, P., Overton, T., Rourke, J., Mark, W. and Armstrong, F., “Shriver and Atkins' Inorganic Chemistry”, 4th Ed, Oxford university press. 2009.

3. Chemical Applications of Group Theory 2nd Edn-F. A. Cotton, Wiley Eastern Ltd (1976).4. Symmetry and Spectroscopy of Molecules, K. Veera Reddy New Age International, (1998).5. Group Theory for Chemists, G. Davidson Macmillan, (1991).6. Organometallic Chemistry, R. C. Mehrotra, New Age International, 2007.7. The Organometallic Chemistry of the Transition Metals, Robert H. Crabtree, John Wiley & Sons Inc, New York,

2014.8. Organometallic Chemistry and Catalysis, Didier Astruc, Springer, 2007

CHI (Pr) 2.1: LAB COURSE IN INORGANIC CHEMISTRY

1. Semi-micro qualitative analysis of mixtures containing two each of common cations and anions and one of the following less familiar elements (Ce, St, Ti, Zr, V, and U)

2. Analysis of solder alloy (Demo)3. Analysis of hematite ore (Demo)

Books Recommended

1. A text book of macro and semi-micro qualitative inorganic analysis-A. I. Vogel, 4th Edition, Orient Longman.2. Vogel’s Qualitative Inorganic Analysis (7th Ed)-G. Svehla, Longman ( 2001)3. Vogel’s Text Book of Quantitative Inorganic analysis-J. Basett, R. C. Denney, G. H. Jeffery and Mendham,

Longmans, Green and Company Ltd.

Scheme of Examination

i. Duration of examination: 04 hoursii. Quantitative analysis: 30 marksiii. Viva voce and Journal: 05 marksiv. Internal Assessment: 15 Marks Total: 50 marks

12

CHOT-2.2: ORGANIC CHEMISTRY

UNIT-Ia) Reaction Mechanism I: Aliphatic Electrophillic Substitutions : Bimolecular pathways. SE2, SE1 and SEi mechanisms. Reactions involving double bond shifts.Aromatic Electrophillic Substitutions : Halogenation, isotope effects, energy profile diagrams. Kinetic and thermodynamic control. Aromatic Nucleophilic Substitutions : SNAr, SN1 and aryne pathways. Meisenheimer complexes, various nucleophilic displacements. Mannich reaction, chloromethylation, Vilsmeyer-Hack reaction.b) Reaction Mechanism II: i) Addition Reactions: Electrophilic addition across alkenes, dienes.ii) Elimination Reaction : E2, E1, E1CB pathways. Stereochemistry.iii) Hydrolysis of Esters, Mechanism: BAC2, AAC2 12 hrs

UNIT-IIAdvanced Stereochemistry: Prochirality: Homotopic, Enantiotopic and Diastereotopic atoms, groups and faces.Optical activity due to molecular dissymmetry: Allenes, Spiranes, Biphenyls, Atropisomerism, Molecular Crowding.Conformational analysis of cyclohexane. Cis and Trans Decalins. 1,2, 1,3- and 1,4-disubstituted cyclohexanes and cyclohexanones. 3-alkyl ketones and α-halocyclohexanones.

O.R.D, C.D, Cotton effect, octent rule, axial halo ketone rule. 12 hrs

UNIT-IIIChemistry of Heterocycles:Nomenclature, structure, reactivity, synthesis, and chemical reactions of furan, pyrrole, thiophene, pyrazole, pyridine. Indole, Quinoline, Isoquinoline, Thiazole, Imadazole, Benzimidazole, Coumarins, Chromones, Flavones, Isoflavones. Photochemical reactions of some of the heterocycles. 12 hrs

UNIT-IV NEWER Reagents and Reactions: Methods of preparation, mechanism of action and applications of the following reagents in organic synthesis.i) Newer Reagents: a) DCC b) 1,3-Dithiane c) LDA d) DDQ e) Wilkinson catalyst f) Crown ethers g) Bakers yeast Oxidation & Reductions:Oxidations: Oxidations of organic compounds using KMnO4, PCC, PDC, Sarret reagent, Zones reagent, CrO3, K2Cr2O7, OsO4, HIO4, SeO2, Pb(OAc)4 Oppaneur Oxidation.Reductions: Reductions of organic compounds using the following reagents: LiAlH4, NaBH4.Stereochemistry of carbonyl reduction. Birch reduction, Wolf-Kishner reduction. Hydroboration, Catalytic transfer hydrogenation. 12 hrs

Total 48 hrs

13

Books Recommended:

1. Organic Chemistry Volume-I, II - I. L. Finar, 6th Edition, ELBS London (2004).2. Organic Chemistry - F.A. Carey and R.J. Sundberg, 5th Edition, McGraw Hill (2007).3. Organic chemistry- Jonathan Clayden , Nick Greeves , Stuart Warren, 2nd Edition, Oxford University Press `(2014).4. March's Advanced Organic Chemistry: Reactions, Mechanisms and Structure- M.B. Smith and J. March, 6th Edition,

Wiley India Pvt Ltd (2012).5. Guidebook to Mechanism in Organic Chemistry - P. Sykes. 6th Edition, Pearson Education (2003).6. Organic reaction mechanisms. V.K. Ahluwalia and R.K. Parashar, 4th Edition, Narosa Publishing House (2010).7. Modern synthetic reactions – H. O. House, Benjamin Publishers.8. Stereochemistry of organic compounds. E.L. Eliel and S.H. Wilen, 1st Student edition, Wiley India Pvt Ltd. (2010).9. Stereochemistry – Conformation and Mechanism - P. S. Kalsi, 8th Edition, New Age International Publishers, New

Delhi (2015).10. Stereochemistry of Organic Compounds : Principles and Applications by D. Nasipuri, 3rd Edition, New Age

International Publishers, New Delhi (2011).11. Heterocyclic Chemistry. T.L.Gilchrist, 3rd Edition, Pearson Education New Delhi, (2005).12. Heterocyclic Chemistry –J.A. Joule and G.F. Smith, 5th Edition, Wiley-Blackwell Publishers (2013).13. Heterocyclic Chemistry- R. K. Bansal, 5th Edition, New-Age International, New Delhi (2010).

CHO (Pr) 2.2: LAB COURSE IN ORGANIC CHEMISTRY

Quantitative Estimation of the following Organic compounds:1. Acid 2. Acid + Amide.3. Acid + Ester.4. Glucose by Bertrand’s Method 5. Keto estimation by iodo metric method.6. Estimation of amino group by acetylation method.7. Estimation of Hydroxy group by acetylation method.8. Keto enol estimation.

Preparation of derivatives for acids, phenols, amines and carbonyl compounds.

Scheme of examinationi. Duration of examination: 04 hoursii. Experiments: 35 marksiii. Proper technique 05 marksiv. Viva-Voce & Journal: 10 marks

Total: 50 marks

Books Recommended:1. Vogel’s Textbook of Practical Organic Chemistry Revised-B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell, 5th

Edition, Addison Wesley Longman Limited, UK, 1997.2. A Hand book of Organic Chemistry –H.T.Clarke.3. A Laboratory Manual of Organic Chemistry - B.B.Dey and M.V. Govindachari.4. Lab Experiments in Organic Chemistry –Arun. Sethi, New Age International Ltd. New Delhi. 2006.5. Experimental Organic Chemistry-L. M. Harwood, and C. J. Moody, Blackwell Scientfic, London, 1989. 7. Practical Organic Chemistry- W. Kemp, MsGraw Hill, London, 1967.

14

CHPT-2.3: PHYSICAL CHEMISTRY

UNIT- I: Atomic Structure and Atomic SpectraHydrogen spectrum: Alkali spectra and alkali like spectra, spark spectra and arc spectra. Mosely lines.Helium and alkaline earth spectra. Multiplet structure of line spectra, doublet structure of alkali spectra and compound doublets, triplets and singlets of alkaline earths and helium, prohibition of inter combinations. Multiplicities and term symbols. Space quantization. Zeeman effect, normal and anomalous Zeeman effect, Paschen Back effect, Strak effect. 12 hrs

UNIT- II: Molecular SpectroscopyElectromagnetic radiation and its interaction with matter. Atomic and molecular spectra. a) Microwave Spectra: Rotational spectra of rigid and non-rigid planar simple molecules. Rotational spectra of polyatomic molecules(linear, symmetric top and asymmetric top molecules). Stark effect and techniques.b) Infrared Spectra: Vibrational spectra of harmonically vibrating diatomic molecules, anharmonic case. Morse potential function and dissociation energy. The diatomic vibrating rotator, the vibrations of polyatomic molecules, specific group vibrations. Applications of infrared spectroscopy.d) Electronic Spectra: Electronic spectroscopy of diatomic molecules. Born-Oppenheimer approximation. Vibrational course structure of electronic transitions: The v' and v" progressions. Deslandres table. Intensity: the Franck-Condon principle. Predissociation. 12 hrs

UNIT- III: Thermodynamics - I Thermodynamic criteria for spontaneous chemical changes. Standard free energies and their determination. Relation between free energy change and equilibrium constant. The pressure dependence of free energy of non-ideal gases, fugacity. Standard state for non-ideal gas. Equilibrium constants in non-ideal systems. Temperature dependence of free energy and equilibrium constant. Evaluating the entropy and Gibb’s function. The third law of thermodynamics. Third law entropies standard molar Gibbs function. 12 hrs

UNIT- IV: Thermodynamics - IIA review of the thermodynamics of ideal solutions. Non-ideal liquid systems. Partial miscibility. Activity and activity coefficients of components of solutions- Variation of activity with temperature and pressure. Determination of activity coefficients by vapour pressure, depression in freezing point, solubility measurements and by electrical methods. Partial molar quantities and their determination by intercept method and from density measurements. Chemical potential and its significance. Variation of chemical potential with temperature and pressure. Gibbs-Duhem equation and the calculation of activity of a component in solutions. Duhem-Margules equation. Ternary systems: Application of phase rule to three component systems: Systems of three liquids and systems of two salts and a liquid.

12 hrs Total: 48 hrs

15

Books Recommended:

1. Fundamentals of Molecular Spectroscopy by C. N. Banwell, Tata McGraw Hill Publishing Co., New Delhi.2. An introduction to Molecular Spectroscopy by G. M. Barrow, McGraw Hill, New York.3. Molecualr Spectra and Molecular Structure:I Spectra of Diatomic Molecules by G. Herzberg, Van Nostrand,

Princeton.4. Physical Chemistry by P. W. Atkins, ELBS, London.5. Physical Chemistry by G. M. Barrow, McGraw Hill, New York.6. Atomic and Molecular Spectroscopy by M. C. Gupta, New Age International Publishers, New Delhi.7. Thermodynamics for Chemists by S. Glasstone, Van Nostrand, Princeton.8. Thermodynamics by Rajaram and Kuriocose.

CHP (Pr)-2.3: LAB COURSE IN PHYSICAL CHEMISTRY

1. Surface Tension:a) Variation of surface tension of aqueous solutions of n-propyl alcohol with concentration and determination

of the limiting cross sectional area of the molecule.b) Effect of added salt on surface tension of water

2. Solubility: Heat of solution of an organic compound by solubility experiments and the effect of addition of an electrolyte on the solubility.

3. Phase Equilibria: Equilibrium constant of the reaction: KI+I2 KI3

4. Thermochemistry: Heat of neutralization of a weak acid and calculation of its heat of ionization.5. Spectrophotometry: Investigation of complex formation. (eg., Fe3+ + Salicyclic acid system: formula, stability,

ΔG value calculation and pH effects).6. Electric conductance:

a. Verification of the Onsagar equation for strong electrolytes.b. Equivalent conductance of a weak electrolyte (e.g.aceticacid, formic acid) using Kohlrausch's law

7. Reaction Kinetics:a. Salt effect on the persulphate-iodide reaction.b. Iodination of acetone.

8. EMF of Cells:a. Titration of Fe2+ with Ce2+ or Cr6+ and determination of the formal redox potentials of the couplexes of

Fe3+/Fe2+ and Ce4+/ Ce3+ or Cr6+ / Cr3+. b. Titration of Zn2+ with Fe(CN)6

4- and determination of the empirical formula of the complex formed.9. Adsorption: Investigate the Adsorption of oxalic acid by activated charcoal from KMnO4 and examine the validity of classical and Langmuirs adsorption isotherm.

16

Books Recommended:1. Findlay’s Practical Physical Chemistry, 9th edition, revised by B. P. Levitt, Longman, London.2. Practical Physical Chemistry by A. M. James and F. E. Prichard, Longman, London.3. Experiments in Physical Chemistry by Shoemaker and Garland, McGraw Hill, New York.4. Experiments in Physical Chemistry by Daniels, Alberty and Willams McGraw Hill, New York.5. Laboratory Physical Chemistry by Oelke/M.A.C.T.L.A.C.6. Experimental Physical Chemistry by W. G. Palmer, C.U.P., London.7. Advanced Physico-Chemical Experiments by J. Rose.8. Text Book of Physical Chemistry by S. Glasstone, Macmillon and Co., London.9. Text Book of Quantitative Analysis by A. I. Vogel, ELBS, Harlow.10. Advanced Practical Physical Chemistry by J. B. Yadav. Goel Publishing House.11. Experimental Physical Chemistry by V. D. Athawale and Parul Mathur, New Age International Publishers.12. Advanced Physical Chemistry Experiments by Gurtu and Gurtu, Pragati Prakashan Educational Publishers,

3rd Edition, 2007.

Scheme of examination

i. Duration of examination : 04 hoursii. Experiments : 35 marksiii. Proper Technique : 05 marksiv. Viva-Voce & Journal : 10 marks

Total: 50 marks

17

CHST-2.4: SPECIAL TOPICS IN CHEMISTRY

UNIT-I: CHEMISTRY OF NANOSCIENCE AND NANOTECHNOLOGY

Basic nanotechnology science and chemistry concepts, basic nanostructures, thin films, nanofoam, nanoclusters, smart nanostructures, manufacturing techniques of nanomaterials. Poly olefin Nano-composites & Clay based nanocomposities. Properties of nano cyrstalline materials. Applications of Nanomaterials. 12 hrs

UNIT-II: MEDICINAL CHEMISTRYModern theories of drug action, concept of receptors, computer aided drug design. Quantitative Structure- Activity Relationship (QSAR) studies:Introduction, physicochemical properties - pKa, electronic effects and Hammett constants(σ), lipophilicity constant(π), steric effects and Taft’s constant, linear and nonlinear relationship between biological activity and Hammett/ Lipophilicity Substituent constants. Lipenski rule of five. Hansch analysis.

Structure, stereochemistry and special features of:

i. Hypnotics and sedatives: Veronal, Phenobarbital (luminal)ii. Antihypertensive drugs : Hydrilazine, minoxidiliii. Anesthetics : XylocaineiV. Antileprosil drugs : Dapsone 12 hrs

UNIT-III: BIOPHYSICAL CHEMISTRY

Structure of Biomolecules: protein, nucleic acid, carbohydrates and lipids. Bimolecular complexes: Protein-ligand, Enzyme- substrate and Drug-DNA complexes. Techniques to study of bimolecular structure & interactions: Electronic, Fluorescence, CD spectral techniques and viscosity measurement. 12 hrs

UNIT-IV: SUPRAMOLECULAR CHEMISTRY AND BIOORGANIC CHEMISTRY (ENZYMES)

Supramolecular chemistrySupramolecular chemistry: Introduction, definitions, non-covalent forces and interactions in supramolecules, macrocycles and supramolecules (crown ethers, cryptates, fullerenes, dendrimers, and porphyrins), coordination driven self-assembly of supramolecular two and three dimensional architectures, host-guest chemistry, metal- organic frameworks and their applications.

EnzymesEnzymes: Classification, mechanisms of enzyme action; concept of active site and energetic of enzyme substrate complex formation; specificity of enzyme action. Catalysis – general acid-base and covalent catalysis. pH and temperature effect on enzymatic reactions. Enzyme inhibition. Production and purification of crude enzyme extracts from plant, animal and microbial sources; development of enzymatic assays. 12 hrs

48 hrs

18

Books Recommended

1. Nano the essentials – Pradeep T.2. Nano Technology – Sylvin M3. Nano Technology an Introduction -Turner Anthony 4. Nano Technology and Molecular Manu – Killman J F.5. Nano Technology Assessment and Facturing Perspectives – Schmid E T.6. Nano Technology a Fundamental approach – Kumar U.7. Nano Electronics – Diwan P Bharadwaj 8. The Biochemistry of nucleic acids - R.L. Adam and others 9. Biochemistry – Mathews, Holde and Ahernh, Pearson Education.10. Text book of biochemistry - O. P. Agarwal11. Text book of biochemistry – Jain12. Principles of biochemistry – Lehninger13. Text book of biochemistry - Sathya Narayana14. Text book of Environmental chemistry with Green Chemistry by A. K. Das.15. J. W. Steed, J. L. Atwood, Supramolecular Chemistry, 2nd edition, John Wiley & Sons Ltd., (2009)16. J. W. Steed, D. R. Turner, K. Wallace, Core Concepts in Supramolecular Chemistry and Nanochemistry, 1st

edition, Wiley, (2007). 17. H. Dodziuk, Introduction to Supramolecular Chemistry, 1st edition, Springer, (2001).18. A. Katsuhiko, Supramolecular Chemistry - Fundamentals and Applications, 1st edition Springer, (2006)

CHS (Pr) 2.4: LAB COURSE IN ORGANOIC BINARY MIXTURE SEPARATION & ANALYSIS

1. Separation and analysis of an organic binary mixture (without solvent ether) containing acids, phenols, bases

and neutral compounds (analysis of one compound with derivative).

REFERENCES

1. Vogel’s Textbook of Practical Organic Chemistry Revised - B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R.

Tatchell, 5th Edition, Addison Wesley Longman Limited, UK, 1997.2. A Hand book of Organic Chemistry – by H.T.Clarke.

Scheme of examination

i. Duration of examination : 04 hoursii. Experiments : 35 marksiii. Proper Technique : 05 marksiv. Viva-Voce & Journal : 10 marks

Total: 50 marks

19

OPEN ELECTIVE PAPER (II SEMESTER)

CHET - 1: SEPARATION AND ANALYTICAL TECHNIQUES

UNIT I: SOLVENT EXTRACTION AND CHROMATOGRAPHY

Principles of solvent extraction, Distribution coefficient, Distribution ratio, Percentage extraction. Solid phase extraction. Applications of solvent & solid phase extraction.

Principle types of chromatographyGas chromatographyGas chromatography: Principles, Instrumentation, GC Columns, Stationary phases, carrier gas used in GC, GC detectors. Applications of GC.

Liquid ChromatographyLiquid Chromatography: HPLC – Principles, Basic components of HPLC, Mobil-phase supply system, Sample injection system, Column and Detectors. Applications of HPLC.

Thin-layer and column chromatography: Principles and applications 12 hrs

UNIT II: CLINICAL AND ENVIRONMENTAL SAMPLING AND AUTOMATION IN MEASUREMENTS

Clinical sampling and analysisClinical sampling and analysis: Composition of blood, collection and preservation of samples, clinical analysis, Immunoassay.

Environmental sampling and analysis:Environmental sampling and analysis: Getting meaningful sample, Air sample collection and analysis, Water sample collection and analysis, Soil and sediment sampling.

Automation in measurementsAutomation in measurements: Principles of Automation, Automated instruments –Continuous analyser, Discrete analyser, Automatic Instrument, Flow Injection Analysis (FIA), Sequential Injection Analysis (SIA).

12 hrs

Books Recommended

1. Analytical Chemistry, 5th Edn. G. D. Christian, John- Wiley and Sons Inc. 1994.2. Fundamentals of Analytical Chemistry, 7th Edn. D. A. Skoog. D. M. West and F. J.Holler, Saunder College

Publishing, 1996.3. Instrumental Methods of Analysis, H. H. Willard, L. L. Merrit. J. A. Dean and F. A.Settle, CBS Publishers 1996.

20

SEMESTER – III

CHIT-3.1: INORGANIC CHEMISTRY

UNIT-I: Electromagnetic radiation and Electronic (UV - Visible) SpectroscopyCharacterisation of electromagnetic radiation, quantization of energy, interaction of electromagnetic radiation with matterElectronic (UV - Visible) SpectroscopyPrinciple and TheoryElectronic spectra of coordination compounds: Energy states from spectral terms of dn configurations, Selection rules for ligand-field and charge transfer transitions in metal complexes, Relaxation in Selection Rules Nature of Electronic Spectral Bands: Band Intensities, Band Widths and factors influencing themSplitting of various terms, Orgel diagrams of octahedral and tetrahedral dn complexes Ligand field parameters, Racah parameters, Nephelauxetic parameter, Calculation of 10Dq Values, Charge transfer bands – LMCT & MLCT Luminescence and Phosphorescent complexes. 12 hrs

UNIT-II: Infrared and Raman SpectroscopyPrinciple and Theory – rotational-vibrational energy levels, Fundamental vibrations for a molecule, IR active bands, Selection rulesInfrared spectra of simple molecules and coordination compounds,Changes in infrared spectra of donor molecules upon coordination (N,N-dimethylacetamide, urea, DMSO, ammine, cyano, cyanato and thiocyanato complexes), mono and multinuclear carbonyl complexes, nitrosyls, phosphine complexes. Change in spectra accompanying change in symmetry upon coordination (NO 3

-, SO42-, NO2

-, and ClO4

-), hydrogen bonding.Raman Spectroscopy: Raman Effect - Rayleigh and Raman scattering, Stokes’ and anti-Stokes’ radiation, Molecular polarizability, Raman selection rules. Rule of mutual exclusion; rotation-vibration Raman spectra of diatomic molecules. 12 hrs

UNIT-II: Resonance Spectroscopy Nuclear Magnetic Resonance Spectroscopy [NMR]Principle and Theory,Magnetic properties of nuclei, population of energy levels, the Larmar precession, Chemical shift – Chemical environment, integration, coupling constant, magnetic versus chemical equivalence, decoupling, relaxation processes, Analysis of 1H NMR spectra of simple organic and inorganic compoundsSpectra of paramagnetic complexes, contact shift, shift reagents.Electron Spin Resonance Spectroscopy [ESR]Principle- Selection Rules, g value and its significance. Hyperfine interaction, Zero-field splitting, Kramer’s degeneracy. Factors affecting magnitude of g values. Applications to the study of free radicals, Coordination compounds (Evidence for Metal-Ligand Bond covalency). 12 hrs UNIT-III: Bioinorganic ChemistryThe essential and trace elements in biological system and their applications, biological metal-coordination sites. Sodium and potassium transport, porphyrins, metalloenzymes, oxygen transport, electron-transfer reactions, nitrogen fixation, photosystems, metal complexes in medicine. Platinum complexes in cancer therapy:: Discovery, applications and Structure Activity Relationships. Cis-platin (cis Pt(NH3)2Cl2) mode of action. Drug resistance and DNA repair mechanism. 12 hrs 48 hrs

21

Books Recommended

1. Drago, R.S., “Physical Methods in Inorganic Chemistry”, Reinhold Publishing Corp., East West Press Ltd. 1986.2. Banwell, C.N. and McCash, E.L.M.,“Fundamentals of Molecular Spectroscopy”, 4th Ed. McGraw-Hill N. Y. 1999.3. Huheey, J.E., Keiter, E.A. and Keiter, R.L., “Inorganic Chemistry Principle of Structure and Reactivity”, 4th Ed,

Pearson Education, Inc. 2003.4. Atkins, P., Overton, T., Rourke, J., Mark, W. and Armstrong, F., “Shriver and Atkins' Inorganic Chemistry”, 4th

Ed, Oxford university press. 2009.5. Inorganic Chemistry of Biological Processes, 2nd Edn. M. N. Hughes, Wiley, 1988.6. Bioinorganic Chemistry, I. Bertini. H. B. Gray, S. J. Lippard and J. S. Valentine, Viva Books, 1998.7. Bioinorganic Chemistry, A.K. Das, Books and Allied (P) Ltd, 2007.8. Principles of Bioniorganic Chemistry, S. J. Lippard and J. M. Berga, Panima Publishing Corporation.

CHI (Pr) 3.1: LAB COURSE IN INORGANIC CHEMISTRY

A) Preparation of selected coordination compounds

1. Copper-glycine complex: cis-and trans forms2. CuCl2DMSO complex3. Pentammine chloro cobalt (III) chloride4. Tris(thiourea) copper(I) sulphate5. N,N- bis(Salicylaldehyde)ethylinediamine copper(II)6. Tris(acetylacetanato)manganese(III)

B) Characterization

1. Metal and anion determination in above complexes2. IR, Electronic, NMR, and Magnetic studies wherever possible.3. Interpretation of IR spectra.

Scheme of Examination

i. Duration of examination: 04 hoursii. Interpretation of given spectra: 15 marksiii. Preparation of a complex: 15 marksiv. Viva voce and Journal: 05 marksv. Internal Assessment: 15 Marks Total: 50 marks

Books recommended

1. Vogel’s Text Book of Quantitative Inorganic Analysis-J. Basett, R. C. Denney, H. Jeffery and J. Mendham, Longmans, Green and company Ltd.

2. Practical Inorganic Chemistry-G. Pass and H. Sutcliff, Chapman and Hall Ltd. (1968)

22

CHOT-3.2: ORGANIC SPECTROSCOPY

UNIT – I: Electronic, Chiroptical and Vibrational Spectroscopy: Electronic and Chiroptical Spectroscopy: Introduction. Energy considerations. Experimental methods. Beer-Lambert’s law. Theory and classification of electronic transitions. Terminology, substituent and solvent effects. Woodword – Fieser rules for calculation of λ max UV spectral study of alkenes, dienes, polyenes, carbonyl and aromatic compounds. Steric effects. Vibrational Spectroscopy: Introduction and Experimental methods. Units, Notation and Regions. Dispersive and FT-IR. Sampling techniques. Complimentarity of IR and Raman. Fundamental vibrations, overtones, Group frequencies, factors affecting group frequencies; Conjugation, inductive, resonance, steric effects. Mechanical coupling, Fermi resonance, Applications of IR in the study of H-bonding, stereoisomerism, tautomerism.Identification of the following organic compounds by IR : Alkanes, Alkenes, Alkynes, Aromatic compounds, Aldehydes, Ketones, Alcohols, Thiols, Acids, Acid chlorides, Amides, Amines, Esters, Halides, Nitro compounds, etc. 12 hrs UNIT – II: Proton Magnetic Resonance Spectroscopy: Introduction- Magnetic properties of nuclei- Resonance condition. Field Frequency diagram. Precession of Nuclei, Relaxation- CW and PFT-methods-Instrumentation and Sample handling.Chemical shift standard used in NMR Spectroscopy, factors affecting chemical shift, inductive effect, van der Waal’s forces, H- bonding, anisotropy. Mechanism of shielding and deshielding in Alkenes, Alkyl halides, Alkynes, Aromatic compounds, Carbonyl compounds and Annulenes. Chemical shifts of Different types of Organic compounds. Empirical rules. Spin-spin coupling, geminal-vicinal coupling-Relative intensities. Karplus equation-curve. Equivalence of protons- chemical and magnetic equivalence. Proton attached to elements other than carbon. Exchange phenomena, Temperature effects, simplification of complex spectra – spin decoupling, Lanthanide Shift reagents, nuclear Overhauser effect.

12 hrs

UNIT – III: Multi-Nuclear NMR and Correlation Spectroscopy: 13C-NMR. Broad Band and Off resonance decoupling methods of detection. 13C-Chemical shifts of different classes of Organic compounds- Alkanes, Alkyl halides, Alkenes, Alcohols, Ethers, Carbonyl compounds and Aromatic compounds. 13C –H Coupling DEPT. Introductory aspects of 11B, 15N, 19F, 31P - NMR. Correlation NMR spectroscopy: Theory, Pulse sequences, FT-methods. 1H - 1H (COSY) and 13C – H (HETEROCOSY) methods. MRI, ESR – Spectroscopy: Theory, hyper fine splitting, factors affecting g- values, zero filed splitting, Kramer’s rule of degenerisation, application. 12 hrs

UNIT – IV: Mass Spectroscopy and Composite Problems: Ionisation and Mass analysis.Instrumentation, methods of ionization, EI, CI, DI, SI – Methods.Fragmentation: Principles, odd and EE ions, molecular ion and base peak, nitrogen rule, metastable ions, isotope effects in chloro and bromo compounds. Stevenson rule.Fragmentation of - i) Normal and branched alkanes. ii) Alkenes. iii) Benzene and its derivativesiv) Alcohols v) Aldehydes vi) Ketones vii) Acids viii) Esters ix) Ethers x) Amines xi) Nitro compounds x) Halo compounds xii) Peptides. McLafferty and McLafferty + 1 rearrangement. Calculation of molecular formula. Composite problems: Calculation of H- deficiency Index.Applications of UV, IR, NMR and MS methods and chemical reactions in structure elucidation of organic compounds. 12 hrs Total: 48 hrs

23

Books Recommended1. Introduction to Spectroscopy –D. L. Pavia, G. M. Lampman, G. S. Kriz and J. A. Vyvyan,

Cengage Learning, (2014).2. Spectroscopic Identification of organic compounds –R.M. Silverstein, F.X. Webster, D.J. Kiemle, D.L. Bryce,

8th Edition, Wiley India Private Limited (2015).3. Organic Spectroscopy – by William Kemp, 3rd Edition, Palgrave publishers, (2008).4. Organic Structural Spectroscopy –J.B. Lambert, S. Gronert , H.F. Shurvell, D. Lightner, R.G. Cooks, 2nd Edition,

Pearson (2013).5. Organic Spectroscopy – by D.W.Brown, A.J.Floyd and M.Sainsbury, John Wiley and Sons.6. Applications of Absorption Spectroscopy of Organic Compounds – by J.R Dyer Prentice Hall Publishers, New

Delhi (1978).7. Interpretation of Mass Spectroscopy – by McLafferty.8. Organic Spectroscopy – by V.R. Dani, Tata McGraw-Hill, Ltd (1995).9. Spectroscopy of Organic Compounds – by P.S. Kalsi, 6th Edition, New Age International Publishers, New

Delhi (2004).10. Organic Spectroscopy–Principles and Applications. Jag Mohan (Narosa Publishing House) 2001.11. Spectroscopic methods in organic chemistry – D. H. Williams and I. Flemming Mc Graw Hill. 12. Nuclear Magnetic Resonance – Basic Principles- Atta-Ur-Rehman, Springer- Verlag (1986). 13. One and Two dimensional NMR Spectroscopy- - Atta-Ur-Rehman, Elsevier (1989). 14. Organic structure Analysis- Phillip Crews, Rodriguez, Jaspars, Oxford University Press (1998).

15. Organic structures from spectra- L.D. Field, J.R. Kalman, and S. Sternhell, 4th Ed. John Wiley and sons Ltd. 16. NMR spectroscopy of Organic compounds. Jackmann and S. Sternhell.

CHO (Pr) 3.2: LAB COURSE IN ORGANIC CHEMISTRY

Organic synthesis/Spectral analysis of organic compounds (IR, UV, PMR, NMR, 13C NMR, Mass spectra).

Books Recommended

1. Vogel’s Textbook of Practical Organic Chemistry Revised by B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell, 5th Edition, Addison Wesley Longman Limited, UK, 1997.2. A Hand book of Organic Chemistry – by H.T.Clarke.3. A Laboratory Manual of Organic Chemistry by B.B.Dey and M.V. Govindachari.4. Lab Experiments in Organic Chemistry – by Arun. Sethi, New Age International Ltd. New Delhi. 2006.

5. Organic structures from spectra- L.D. Field, S. Sternhell and J.R. Kalman, 5th Edition. John Wiley and sons Ltd (2013).

Scheme of ExaminationDuration of examination: 04 hoursExperiments: 35 marksProper Technique: 05 marksJournal and Viva: 10 marksTotal: 50 marks

24

CHPT - 3.3: PHYSICAL CHEMISTRY

UNIT – I: Diffraction Studies:X-Ray Diffraction: Reciprocal lattice, indexing of single crystal rotation photographs, determination of molecular parameters, the structure factor calculations, Fourier series and the phase problems. Refinements of Fourier procedures. Neutron diffraction: Neutron diffraction and differences from X-Ray diffraction. Electron diffraction: Theoretical principles, structure analysis: Visual comparison of intensities, radial distribution function and its refinements. The rotating sector method. 12 hrs

UNIT-II: Raman Spectroscopy : Theories of Raman Effect, concept of polarizibility and polarizibility ellipsoid. Vibrational Raman Spectra, Rotational Raman Spectra of Molecules. Symmetry selection rule and prohibition of inter combination. Influence of nuclear spin case of homonuclear diatomic molecules. Rotaional Vibrational Raman Spectra, principle of mutual exclusion, polarization of Raman lines and ortho and para-modifications. An introduction to laser resonance Raman Spectroscopy. Elucidation of structure of molecule, e.g. H 2O, N2O, CO2 by Raman Spectra. 12 hrs

UNIT-IIIa) Electrochemistry - I: Ionic atmosphere, physical significance of k (kappa), Debye-Huckel theory to the problem of activity coefficient, Debye-Huckel limiting law, Deby Huckel equation for appreciable concentration. The Huckel and Bronsted equation, qualitative verification of Debye-Huckel equation, Debye-Huckel onsagar conductance equation, Bjerrum theory of ion association-triples ion-conductance minima.

b) Electrical double layer: Introduction to electrode-electrolyte interface. Thermodynamics of electrified interfaces, Derivation of electrocapillary-Lipmann equation. Suface excess, determination of charge density on the electrode. Structure of electrified interfaces. Helmholtz-Perrin, Guoy-Chapman and Sterm models.

12 hrs

UNIT-IV: Electrochemistry - II: Irreversible electrode process: Polarization and over voltage, types of overvoltages. Electrolytic polarization, dissolution and deposition potential. Determination of anode and cathode over potential, concentration polarization. Variation of current with cell voltage, metal deposition overvoltages, thickness of diffusion layer, derivation of Butler-volmer equation, Tafel equation. Exchange current density, factors affecting exchange current density. Influence of current density, pH, temperature, rate of growth of deposits on over voltage. Theories of overvoltage: Bubble formation, combination of atoms, Ion discharge and proton transfer as slow process.

12 hrs Total: 48 hrs

25

Books Recommended

1. Electrochemistry- S. Glasstone, D. Van Nostrand , 19652. Advanced Physical Chemistry- Gurdeep Raj, Goel Publishing House3. Basic chemical Kinetics- G. L. Agarwal, Tata-McGraw Hill4. Physical Chemistry – P. W. Atkins, Oxford University press, VIIth edition,2002.5. Physical Chemistry – G. M. Barrow, Tata-McGraw Hill, Vth edition, 2003.6. An Introduction to Electrochemistry by S. Glasstone7. Modern Electrochemistry Vol. I & II by J. O. M. Bockris and A.K.N. Reddy .8. Physical Chemistry by S. Glasstone9. Electrolytic Solutions by R. A. Robinson and R. H. Strokes10. Physical Chemistry by P. W. Atkins. ELBS.11. Modern Electrochemistry-Vol.1 & 2 J..O.M.Bockris and A.K.N. Raddy, Plenum, New York (1978)12. Electron Diffraction- T.B. Rymer, Methuen, London,197013. Neutron Diffraction - G.E.Becon14. X-Ray Crystallography-Buerger15. Diffraction Methods- Wernard16. Chemical Crystallography-L.W.Bunn. N.Y.and Oxford,194517. Crystals and X-Rays K.landsdale, N.Y.194518. Crystal Structure Analysis- M.J.Berger, John Wiley and Sons, N.Y.196019. The Determination of Molecular Structure- P.J.Wheatley, Clarendon, Oxford,196020. Physical Chemistry-G.M.Barrow, McGraw Hill, New York, 199121. X-ray Diffraction - D.B.Cullity, Mass Addison, Wesley,1978.22. Raman and its effect by Venkataraman

CHP (Pr)-3.3: LAB COURSE IN PHYSICAL CHEMISTRY

1. Solubility: Heat of solution (e.g. oxalic acid, benzoic acid etc.) by solubility experiments.2. Phase Equilibria: I) Molecular weight of benzene (or nitrobenzene) by steam distillation.

II) Vapour pressure of chloro benzene by steam distillation. 3. Refractometry: a)Variation of refractive index with composition of mixture (Eg.CCl4 & CH3COOC2H5) b) Electron polarization and electron polarisibility of a liquid4. Polarimetry: Percentage composition of two optically active substances (e.g, d- sucrose and d- tartaric acid)5. Electrolytic Conductance: Varification of Onsager equation applied to electrolyte.6. Reaction Kinetics: Hydrolysis of methyl acetate- i) Catalytic coefficients (or strengths of acids) ii) Arrhenius parameter.7. Emf of cells:a) Standard electrode potential of reversible metal- metal ions at room temperature.b) Solubility of sparingly soluble salts. 8. Viscosity : Molecular weight determination of higher polymers.

26

Books Recommended

1. Findlay`s Practical Physical Chemistry, 9th edition, revised by B.P.Levitt.2. Practical Physical Chemistry by A.M.James and F.E.Prichard3. Experiments in Physical Chemistry by Shoemaker and Garland4. Experiments in Physical Chemistry by Daniels, Alberty and Williams et.al.5. Laboratory Physical Chemistry by Oelke/ M.A.C.T.L.A.C. 6. Experimental Physical Chemistry by W.G. Palamer7. Advanced Physico-chemical experiments by J.Rose8. Experimental Physical Chemistry by V.D.Athwale and Paul Mathur, New Age International Publishers.9. Text book of Physical Chemistry by S.Glasstone10. Text book of quantitative analysis by A.I.Vogel11. Advanced Practical Physical Chemistry by J.B. Yadhav, Goel Publishing house, Meerut.

Scheme of Examinationi. Duration of examination: 04 hoursii. Experiment: 35 marksiii. Proper Technique 05 marksiv. Viva-Voce & Journal: 10 marks

Total: 50 marks

27

Organic Chemistry Specialization (Group A)

CHOT(Sp)-3.4: CHEMISTRY OF NATURAL PRODUCTS AND BIOMOLECULESUNIT–Ia) Carbohydrates: Conformational representation of monosaccharide. Mechanism of Mutarotation- Base catalysed isomerisation of aldoses and ketoses. Epimerisation, Anomeric effect. Glycosides. Disaccharides: Structural determination of Lactose, Maltose and Sucrose.Polysaccharides: Structure and degradation of starch, cellulose and glycogen.

b) Steroids & Steroidal Harmones : Structure, synthesis, stereochemistry and spectral features of - Cholesterol. Steroidal Hormones: Estrogenic hormones – Estrone.Androgenic hormones – Androsterone. Corpus Luteum hormones – Progesterone. 12 hrs

UNIT-IIa) Alkaloids & Terpenoids:Structure, synthesis, stereochemistry and spectral properties (wherever applicable) of Alkaloids: Quinine, cinchonine, hygrine, heptaphylline, papaverine, reserpine, morphine. Photochemical synthesis of nuciferene, corydaline, tylophorine.b) Terpenoids: Zingiberene, α-Pinene, Camphor, citronellol, α-terpineol, citral, geraniol, menthol.

c) Vitamins: Biological importance & synthesis of Vitamins: Vitamin-A, Vitamin-B1 (Thiamine), Vitamin-B2,

Vitamin-B6 (Pyridoxine), Vitamin-C, Vitamin-E, Vitamin-H and Vitamin K. 12 hrsUNIT–IIIa) Prostaglandins and Lipids: Prostaglandins: Introduction, nomenclature, classification and biological role of Prostaglandins. Structure elucidation and stereochemistry of PGE1. Synthesis of prostaglandins by Corey, upjohn and Stork routes, cyclopentane epoxide.Lipids: Sphingolipids and Glycolipids, Phospholipids and Cyano lipids Naturally occurring fatty acids and their triglycerides, Essential fatty acids, unusual fatty acids. Methods of isolation: Gunstone’s partition method. Reactions of fatty acids – Fischer and trans-esterification, Oxidation and Acyl group transfer reactions. Analytical values – Cetane number. Emulsions and Biodiesel. Classical & modern methods of separation & isolation of fatty acids from oils, Oleochemicals & Industrial Applications, 12 hrs

UNIT-IV: Biomolecules a) α-amino acids peptides & proteins:α–amino acids, physiological properties, synthesis of peptides including merrifield SPPS, Oxytocin, Glutathione synthesis. Peptide bond formation, Structure and Stereochemistry. Peptide linkage, Primary structure of peptides. C-terminal amino acid determination, N-terminal amino acid determination. Application of Dansyl chloride, Partial hydrolysis of peptides, Edmann’s method, 2,4-DNFB, hydrazinolysis. Structure of proteins, primary, secondary, tertary, and quaternary structure. Selective peptide bond cleavage. b) Nucleic Acids:Structure and synthesis of Nucleosides-Nucleotides. Methods of formation of internucleotide bonds. Polynucleotides, structure, formation and hydrolysis products of DNA and RNA. Role of nucleic acids in protein synthesis. Genetic code. 12 hrs

Total: 48 hrs

28

Books Recommended

1. Sterioids –Fieser and Fieser.2. Organic Chemistry Volume-I, II - I. L. Finar, 6th Edition, ELBS London (2004).3. Advanced Organic Chemistry part A and B –F.A. Carey and R.J. Sundberg, 4th Edition, Plenum Publishers (2000).4. The Alkaloids Volume II – IV –K.W.Bentley.5. The Chemistry of Alkaloids –S.W.Pelletier.6. Terpenoids Volume I and II –P. De Mayo.7. Prostaglandins –A. Mitra.8. Industrial Oil and Products Volume – I - A. Baileys9. Introduction to the Chemistry and Biochemistry of fatty acids and their Glycerides-F.D. Gunstone, Chapman and Hall, London (1980).10. Introduction to Nucleic acids - Harber, Domagle and Muller.11. Chemistry of Carbohydrates –G.C.Percival.12. Carbohydrates – Chemistry and Biochemistry –Pigman and Harton.

CHO (Sp- Pr) 3.4: LAB COURSE IN ORGANIC CHEMISTRY (Specialization)

a) Chromatography:

Chromatographic Techniques: Demonstration of TLC and column Chromatography.

b) Estimation:

i) Estimation of nitrogen by Kjeldahl Method.

ii) Estimation of nitro group by reduction.

iii) Estimation of saponifaction value of an oil or fat.

iv) Estimation of iodine number of an unsaturated compound.

v) Estimation of keto group by oxime method.

Scheme of ExaminationDuration of examination: 04 hoursExperiments: 35 marksProper Technique: 05 marksJournal and Viva: 10 marksTotal: 50 marks

29

Physical Chemistry Specialization (Group B)

CHPT(Sp)-3.4: Polymer Chemistry

Unit I - Polymer Chemistry I

Introduction to Polymer Science: Basic concepts, History of polymers, Classification of polymers as biological – nonbiological, linear branched network, condensation, addition, homo- and hetero- chain, thermoplastic - thermosetting. Chemical and geometrical structure of polymer molecules, Stereo-regular polymers, Optical and geometrical isomerism .

Molecular Weight and Molecular Weight Determination: Molecular weight distribution, Number average and Weight average molecular weight. Methods for determination of molecular weight – Cryoscopy, Ebulliometry, End group analysis, light scattering, viscosity, ultracentrifugation .

Techniques of free radical polymerisation: Bulk, solution, suspension, emulsion and precipitation polymerization. 12 hrs

Unit II - Polymer Chemistry II

Reaction of Polymers: Functional group reaction, ring forming reactions and block and graft copolymer formation. Crosslinking reactions: Peroxide crosslinking, sulphur vulcanization, radiation crosslinking, photo crosslinking, electron beam crosslinking and miscellaneous reactions. Elastomers.

Kinetics and Thermodynamics of Polymerization: Kinetics of addition, condensation and radiation induced polymerization. Thermodynamics of polymer solutions, The Flory-Huggins Theory, Flory Krigbaum and modified Flory-Huggins Theory.

Copolymerization: Kinetics of copolymerization, Copolymer equation, Monomer reactive ratios, Instantaneous composition of polymer. 12 hrs

Unit III - Polymer Chemistry III

Properties of Polymers: Crystalline melting point, The glass transition temperature (Tg), States of aggregation, states of phase, Factors influencing Tg. Determination of Tg by dilatometry, calorimetry. Heat distortion temperature. Properties involving large deformations, melt viscosity, tensile strength, stress, strain, crazing, shear banding, solubility and related properties, electrical and related properties

Polymers of Commercial Importance: Polyethylene, Poly isoprene, Polyacrylics, Polyesters, Nitrile polymers, Polycarbonates, Polyurethanes, Polytetrafluroethylene.

12 hrs

Unit IV - Polymer Chemistry IV

Conducting Polymers and Polymer Gels: Structure, properties, characterization and applications.Polymer Processing: Plastic technology – molding, extrusion. Fibre technology – textile and fabric properties, spinning, Fibre after treatments.

Polymer Degradation, Stability and Environmental Issues: Types of degradation, Thermal degradation, Mechanical degradation, Photodegradation, Degradation by high energy radiation. Chemical, hydrolytic and UV stability. Recycling and biodegradation.

12 hrs

48 hrs

30

References

1. Polymer Science and Technology by Joel R. Fried Third edition, 2002. 2. Polymer Science, V.R.Gowarikar , N.V.Vishwanathan and Jaydev Sreedhar Reprint edition, 2002. 3. Text book of Polymer Science, Fred W. Billmeyer Jr. Third edition, 2000. 4. Principles of Polymerization, George Odian, Third edition 2002.5. Handbook on Conducting Polymers – T.A.Skotheim, Ed Marcel Dekker Inc, New York, 1 and2, 1986.6. Polymer Chemistry: An Introduction-Malcolm P. Stevens, Oxford University Press, 1999.7. Contemporary Polymer Chemistry- Harry R. Allcock and Frederick W. Lampe, Printice-Hall, 1981.8. Principles of Polymer Chemistry-P. Bahadur and N. V. Shastri, Narosa Publisher, 20029. Polymer Chemistry Properties and Applications-Andrew Peacock and Allison Calhoun, Hanser

Publisher, 2006.

CHP (Sp-Pr)-3.4: LAB COURSE IN PHYSICAL CHEMISTRY

1. Surface Tension:a) Variation of surface tension of aqueous solutions of a liquid (n-propyl alcohol) with concentration and

determination of limiting cross sectional area of the alcohol molecule.

b) Interfacial tension between two immiscible liquids (e.g., benzene & water at room temperature).c) Determine the surface tension of a mixture of two miscible liquids and hence the parachor of the mixture.

d) Critical micelle concentration of a soap molecule (e.g., Potassium laureate).

2. Thermochemistry: Heat of neutralization of weak and strong acid.

3. Electrolytic Conductance: Conductometric titrations:

a) Weak acid Vs weak base

b) Moderately weak acid like salicylic acid Vs NaOH (Salt line method and alkali method). c) Dilute solution of a weak acid (0.01 to 0.001N) Vs NaOH by addition of solvent of low dielectric constant,

using ammonia and NaOH titrants and by double alkali method.

4. Reaction Kinetics: Auto catalysis: Mn(VII) oxidation of oxalic acid in the presence of H2SO4.

5. Emf of Cells:a) Acid and base dissociation constants of an amino acid and its iso-electric point.b) Titration of Fe2+ with Ce4+ and determination of the formal redox potential of Fe3+/Fe2+ and Ce4+/Ce3+.

c) Mean ionic activity coefficent of hydrochloric acid at different concentrations using a concentration cell without transference: influence of ionic strength on the mean ionic activity coefficient.

31

6. Spectrophotometry: To determine the concentration of Ni in solution by spectrophotometric titration 7. pH meter: a) Determination of strength of unknown solution of acids (strong, weak, etc) b) Determination of pH of buffer solutions.

8. Absortiometry:a) Applicability range (for an absorbing substance in solution) and evaluation of the molar absorbency index,

finding unknown concentration.b) Mixture analysis by absorptiometry.

Books Recommended:

1. Findlay`s Practical Physical Chemistry, 9th edition, revised -B. P. Levitt.2. Practical Physical Chemistry - A. M. James and F. E. Prichard.3. Experiments in Physical Chemistry - Shoemaker and Garland.4. Experiments in Physical Chemistry - Daniels, Alberty and Williams et.al.5. Laboratory Physical Chemistry -Oelke/ M.A.C.T.L.A.C, 1969.6. Experimental Physical Chemistry - W.G. Palmer7. Advanced Physico-Chemical Experiments - J. Rose8. Experimental Physical Chemistry - V .D. Athwale and Paul Mathur, New Age International Publishers, 2001.9. Text Book of Physical Chemistry - S. Glasstone10. Text Book of Quantitative Analysis - A. I. Vogel, 1996.11. Advanced Practical Physical Chemistry - J. B. Yadhav, Goel Publishing House, Meerut, 1999.

Scheme of Examination

i. Duration of examination : 04 hoursii. Experiment : 35 marks

iii. Viva-Voce & Journal : 05 marksiv. Internal assessment : 10 marks

Total : 50 marks

32

OPEN ELECTIVE PAPER

CHET- 2: INSTRUMRNTAL METHODS OF CHEMICAL ANALYSIS

UNIT – I: SPECTRAL METHODS OF CHEMICAL ANALYSIS Electromagnetic spectrumProperties of electromagnetic radiation Electronic (UV - Visible) SpectroscopyPrinciple and Theory, Experimental method-Instrumentation, UV spectral study of alkenes, dienes, carbonyl and simple aromatic compounds and transition metal complexes. Substituent and solvent effects on λ max values. Infrared SpectroscopyPrinciple and Theory Experimental method – Instrumentation (Dispersive and FTIR)IR active bands - Selection rules. Fundamental vibrations, overtones, Group frequencies. Factors affecting group frequencies; Conjugation, inductive, resonance, steric effects.Identification of the simple organic compounds by IR: Alkanes, Alkenes, Alkynes, Aldehydes, Ketones, Alcohols, Amines and transition metal complexes. 12 hrs

UNIT – II: ELECTROCHEMICAL METHODS OF CHEMICAL ANALYSIS Basic introduction to electrochemistry. Types of electrochemical techniques - Bulk techniques and Interfacial techniques. Conductometry: Introduction, important laws, terms and relations, conductance measurements and important applications of conductance measurements.Potentiometry: Introduction, types of potentiontiometric titrations, advantages of potentiontiometric titrations. Cyclic voltametry: Introduction, important terms used, instrumentations and applications. 12 hrs

Books Recommended

1. Introduction to Spectroscopy – by D. L. Pavia, G. M. Lampman and G. S. Kriz, Saunders Golden Sunburst Series London, (1979).

2. Spectroscopic Identification of organic compounds – by R. M. Silverstein and F. X. Webster, 6 th Edition, Wiley and Sons, India Ltd (2006).

3. Organic Spectroscopy – by William Kemp, 3rd Edition, Palgrave publishers, (2002).4. Spectroscopy of Organic Compounds – by P. S. Kalsi, 4th Edition, New Delhi (2005).5. Analytical Chemistry, 5th Edn. G. D. Christian, John- Wiley and Sons Inc. 1994.6. Fundamentals of Analytical Chemistry, 7th Edn. D. A. Skoog. D. M. West and F. J.Holler, Saunder College

Publishing, 1996.7. Instrumental Methods of Analysis, H. H. Willard, L. L. Merrit. J. A. Dean and F. A.Settle, CBS Publishers 1996.

33

SEMESTER –IV

ORGANIC CHEMISTRY (Group A)CHOT 4.1: PHOTOCHEMISTRY, PERICYCLIC REACTIONS, RETROSYNTHETIC ANALYSIS AND GREEN

CHEMISTRY

UNIT – I: Organic PhotochemistryPrinciples of photochemistry, photochemical processes, Energy transfer and photosensitization.Photochemical Reactions: Photoreduction, Norish type – I, type – II cleavages- Di-Pi methane rearrangement, Optical pumping. Photochemistry of cyclohexadienones, Photo Fries Rearrangement, Paterno Buchi reaction, Barton reaction. Photochemistry of alkenes, benzenes, cyclohexanes, Photochemistry of vision.

12 hrs

UNIT – II: Pericyclic ReactionsClassification and features, Molecular orbital symmetry. Frontier orbitals of ethylene and 1,3-butadiene, 1,3,5-hexatriene and allyl systems.Electrocyclic processes: Woodward Hoffmann rules for 4n and (4n + 2) π systems.Cycloaddition reactions: Diels-Alder reaction, (2+2) and (4+2) cycloaddition reactions, Supra facial and Antra facial addition.Significance of the reactions: Sigmatropic rearrangement, supra and antra facial hydrogen shifts. Claisen Cope, Oxy cope and Aza cope rearrangements. Vitamin-D group isomerisation. Mobius System.

12 hrs

UNIT – III: Retrosynthetic AnalysisDisconnection approach – Terminology, synthon, synthetic equivalent, functional group interconversion. One group C – X and two group disconnections. Applications of C – C disconnection in the synthesis of substituted 1,2- 1,3- and 1,4 – bifunctional compounds.Retrosynthetic analysis and synthetic route for Alcohols, Benzocaine, Acetone cyanohydrin, p-Methoxy acetophenone, 6-Methyl quinoline, Pirindol, 6-methoxy indole – 3 – acetic acid. Application to the synthesis of Juvabione, Taxol, Longifolene, Prelog-Djerasi Lactone, colchine, prostaglandin E, cholesterol.

12 hrs

UNIT – IV: Green ChemistryMicrowave synthesis: Introduction, reaction vessel, reaction medium, concept, specific effects, atom efficiency, percentage atom utilization, advantage and limitation. N-alkylation and alkylation of active methylene compounds. Condensation of active methylene compounds with aldehydes. Synthesis of Ibuprofen by BHC and BOOTS approaches. Diels-Alder reaction Leuckorts reductive amination of lactones. Oxidation of alcohols and sulphides.Supra MoleculesModern Technology: Modern Techniques in Organic synthesis. Brief outlines of Ultra-sound, Clay catalyzed techniques and use of Ionic liquids and polymer supports in organic synthesis.Phase Transfer Catalysis & crown ether. Super Critical fluid extractions.

12 hrs Total 48 hrs

34

Books Recommended

1. Molecular Photochemistry –N.J. Turro.2. Molecular Reactions and Photochemistry –Depoy and Chapman.3. Organic Photochemistry –J.M.Coxan and B.Halton, Cambridge University Press, London (1974).4. Principles of Organic Synthesis –R.O.C.Norman and J.M.Coxon, 3rd Edition, Nelson Thrones, UK (2003).5. Organic Synthesis –The Disconnection Approach - Stuart Warren6. Organic Reaction Mechanism –R.K.Bansal, 3rd Edition, Tata McGraw Hill (2006).7. Molecular rearrangements – I and II –P.de. Mayo.8. Mechanisms of Molecular Migrations. Vol-I & II –B.S. Thyagarajan, 1st Edition, Wiley-Interscience, London 1979.9. Molecular Transformations in Organic Chemistry –D.Ranganathan and S. Ranganathan, 1st Edition, McMillan India, New Delhi (1975).10. Modern Synthetic Organic Chemistry –H.O.House, W.A.Benjamin INC, New York(1969).11. Modern Methods of Organic Synthesis –Carruthers.12. Organic Chemistry Volume-I, II - I. L. Finar, 6th Edition, ELBS London (2004). 13. Green Chemistry. Ahluwalia.

CHO (Pr) 4.1: LAB COURSE IN ORGANIC CHEMISTRY

Identification of the Nature, Bulk separation, Purification and Qualitative analysis (using ether) of the ternary mixture of the following classes: Acids, Bases, Phenols and Neutral compounds (any one component with derivative).

Scheme of ExaminationDuration of examination: 04 hoursExperiments: 35 marksProper Technique: 05 marksJournal and Viva: 10 marksTotal: 50 marks

Books Recommended:1. Vogel’s Textbook of Practical Organic Chemistry Revised by B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell, 5th Edition, Addison Wesley Longman Limited, UK, 1997.2. A Hand book of Organic Chemistry – by H.T.Clarke.3. A Laboratory Manual of Organic Chemistry by B.B.Dey and M.V. Govindachari.4. Lab Experiments in Organic Chemistry – by Arun. Sethi, New Age International Ltd. New Delhi. 2006.

35

CHOT 4.2: HETROCYCLIC AND MEDICINAL CHEMISTRY

UNIT – IHeterocyclic chemistry-1:Nomenclature, structure, synthesis & reactions of 3, 4 & 7 membered hetrocyclic compounds with one hetro atom.Three membered : Oxiranes, Aziridines and Thiiranes.Four membered : Oxetanes, Azetidines and Thietanes.Seven membered : Oxepines, Azepines and Thiepines. 12 hrs

UNIT – IHeterocyclic chemistry-2:Transformations, Photochemistry and rearrangements in Heterocycles. a) Transformations: 1) Coumarins to Benzofurans.

2) Sydnones to Pyrazoles3) Chromones to Pyrazoles4) Furans to Pyridines5) Pyrroles to Pyridines

b) Heterocycles in functional group transformations:1) Alkanes from Thiophenes.2) Cycloalkanes from Pyrazolines3) Dienes from Pyrroles.4) Alcohols from Isoxazodiolines5) Esters from Trichlorocyanuric acid6) Acetylenes from 1,2,3-selenadiazoles and7) Deoxygenation of phenols from tetrazoles.

c) Rearrangement in Heterocycles: i) Dimroth rearrangement ii) Boultan-Katritzky rearrangement

iii) Fischer Indole cyclisation. 12 hrs

UNIT – III: Medicinal Chemistry-1:Modern theories of drug action, concept of receptors, computer aided drug design, Qualitative and quantitative SAR.Structure, stereochemistry and special features of –i) Sulfa Drugs: Sulfadiazine, Sulfamethazine Sulfaguanidine & Sulfa isoxozoles.ii) Analgesics: Classification of Narcotic and Non-narcotic analgesics. a) Narcotic: Opium, Morphine, Benzoporphan, Phenazocine and Metopon. b) Non-narcotic: 4-Phenylpiperidines- Pethidine, Diisopropylamines. Methadone, Pyrazolones and Antipyrine.iii) Anti-Fertility Drugs: Steroidal and non-steroidal compounds: Norethindrone, Mestranil & Norgestrol.

12 hrs

UNIT – IV: Medicinal Chemistry-2:i) Antineoplastic Agents: Chlorabucil, Sarcolycin, Dopan and Cyclophosphoramide. ii) Pteridines: Amethopterin, Pyrimidines & 5-fluoro uracil, Cis-platines, Anti-platines etc. iii) Antibiotics: Structure, Synthesis, stereochemistry and spectral features of the following antibiotics -Natural penicillins, semi-synthetic penicillins, Patulin, Chloramphenicol & Steptomycin.iv) Structural features and uses of common antibiotic drugs: Norfloxacin, Rifamycin and Amoxicillin.

12 hrs Total: 48 hrs

36

Books Recommended

1. Organic Chemistry Volume-I, II - I. L. Finar, 6th Edition, ELBS London (2004).2. An Introduction of the Chemistry of Heterocyclic Compounds - R.M.Achenson, 4th Edition, John Wiley and Sons.3. Heterocyclic Chemistry –A.R. Katritzky and J.J.Logowskii.4. Heterocyclic Chemistry –T.L.Gilchrist, 3rd Edition, Pearson Education Delhi (2005).5. Heterocyclic Chemistry –J.A. Joule and G.F. Smith, 5th Edition, Wiley-Blackwell Publishers (2013).6. Heterocyclic Chemistry –R.K.Bansal,3rd Edition, New Age International Publishers (2002).7. Medicinal Chemistry Volume – I and II –A. Burger, Wiley-Interscience New York (1988).8. Progress in Medicinal Chemistry Volume 1-8. Edited - G.P.Ellis and G.B.West. North Holland New York (1974).9. Introduction to Medicinal Chemistry. G.L. Patrick.

CHO (Pr) 4.2: LAB COURSE IN ORGANIC CHEMISTRYIsolation and Characterization of the following Natural products:

1. Nicotine from tobacco.2. Hesperidine from orange peel.3. Caffeine from tea leaves.4. Piperine form black pepper.5. Eugenol from cloves.6. Lycopene from tomato.7. Ricinoleic acid from castor seeds.8. Casein from milk9. Trimyristin from nutmeg.

Books Recommended

1. Unitized Experiments in Organic Chemistry- Brewester and McEveen2. Vogel’s Textbook of Practical Organic Chemistry Revised -B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell, 5th Edition, Addison Wesley Longman Limited, UK, 1997.3. A Hand book of Organic Chemistry –H.T.Clarke.4. A Laboratory Manual of Organic Chemistry - B.B.Dey and M.V. Govindachari.5. Lab Experiments in Organic Chemistry –Arun. Sethi, New Age International Ltd. New Delhi. 2006.6. Natural products, A Laboratory Guide - R.Ikan Academic Press,London 1969.

Scheme of ExaminationDuration of examination: 04 hoursSample (Yield + Purity) 35 marksProper Technique: 05 marksJournal and Viva: 10 marksTotal : 50 marks

37

CHOT 4.3: ADVANCED ORGANIC CHEMISTRY UNIT – I: StereochemistryStereoselectivity in organic synthesis, stereospecific and stereoselective reaction, Principle of stereoselectivity, stereoselectivity in addition, elimination and substitution reaction.Asymmetric synthesis, enantioselective and distereoselectivity in acyclic system, addition of nucleophiles to carbonyl groups, correlation of configuratio0n, Cram’s rule and Prelog’s rule for diastereoselction. Asymmetric epoxidation, stereoselectivity in carbene addition, stereochemistry of catalytic hydrogenation. Asymmetric transformations.Stereochemistry of nitrogen compounds: Quaternary ammonium salts, amines, tertiary amine oxides, oximes – Determination of configuration of aldoximes and ketoximes. Stereochemistry of cyclic compounds containing nitrogen. 12 hrs

UNIT-II: Synthetic Reagents and Reactions

Preparation and application of the following in organic synthesis: Organo magnesium, Organo lithium, Organo copper and Organo borane reagents.Organo silicon reagents: reactions involving β-carbocations and α-carbanions, utility of trimethyl silyl halides, cyanides and triflates.

Protecting groups: a) Protection of alcohols by ether, silyl ether and ester formation b) Protection of 1,2-diols by acetal, ketal and carbonate formation c) Protection of carbonyls by acetal, ketal and thiol acetal (Umpolung) groups.

Multicomponent Reactions: Biginelli, Ugi and Passerini reactions. 12 hrs

UNIT – III: Newer Reagents and ReactionsMechanism and strategic applications of the following named reaction in organic synthesis.a) Diazomethane, b) Gilman reagent, c) Suzuki reaction, d) Heck reaction, e) Sonogashira reaction, f) Negishi reaction, g) Shapiro reaction, h) Prins reaction i) Mitsunobu reaction, j) Simmon-Smith reaction, k) Pauson-Khand reaction, l) Huisgen 1,3-dipolar cycloaddition reaction, m) Baylis-Hilman reaction. n) Robinson annulations, o) Junjappa-Ila aromatic and heteroaromatic annulations.

12 hrs

UNIT – IV Porphyrins, Carotenoids and Insecticides:a) Porphyrins: Introduction, detailed study of structure and synthesis of haemin and chlorophyll-a. Vitamin B12

as coenzyme in molecular rearrangement reactions.b) Carotenoids: Introduction, isolation, structure and synthesis of β-carotene. Biosynthesis of β -carotene.c) Insecticides: Introduction, classification, mode of action and synthesis of chlorinated insecticides (DDT and BHC). Organophosphorus insecticides – Parathion, DDVP.Carbamate insecticides – Sevin, Beygon.Insect Pheromones: Introduction, classification and use in insect control. Synthesis of Grandisol, Farnesol, Bomykol and Disparlure.

12 hrs Total 48 hrs

38

Books recommended

1. Stereochemistry of organic compounds. E.L. Eliel and S.H. Wilen, 1st Student edition, Wiley India Pvt Ltd. (2010).2. Stereochemistry – Conformation and Mechanism - P. S. Kalsi, 8th Edition, New Age International Publishers, New

Delhi (2015).3. Stereochemistry of Organic Compounds : Principles and Applications by D. Nasipuri, 3rd Edition, New Age

International Publishers, New Delhi (2011).4. Principles of Organic Synthesis –R.O.C.Norman and J.M.Coxon, 3rd Edition, Nelson Thrones, UK (2003).5. Organic chemistry- Jonathan Clayden , Nick Greeves , Stuart Warren, 2nd Edition, Oxford University Press (2014).6. Strategic Applications of Named Reactions in Organic Synthesis (Reprint Black & White Edition), Elsevier Publishers.

CHO (Pr) 4.3: LAB COURSE IN ORGANIC CHEMISTRY

Multi Step Synthesisi) Fries rearrangementii) Beckmann rearrangementiii) Benzilic acid rearrangementiv) Sandmeyers rearrangementv) Preparation of Benzocainevi) Preparation of 2,4-dinitrodiphenylamine from chlorobenzene.

Scheme of ExaminationDuration of examination: 04 hoursExperiments: 35 marksProper Technique: 05 marksJournal and Viva: 10 marks Total: 50 marks

Books Recommended1. Vogel’s Textbook of Practical Organic Chemistry Revised -B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell, 5th Edition, Addison Wesley Longman Limited, UK, 1997.2. A Hand book of Organic Chemistry –H.T.Clarke.3. A Laboratory Manual of Organic Chemistry - B.B.Dey and M.V. Govindachari.4. Lab Experiments in Organic Chemistry –Arun. Sethi, New Age International Ltd. New Delhi. 2006.

CHOPJ 4.4: PROJECT WORK(150 marks)

The project work may include in plant training in Industries/short term work in other educational institutions/R&D organizations/Data mining/Review of current literature/Theoretical methods/computer applications. Experimental work may involve studies on synthesis/measurements/study of properties/characterization by physical methods/activities for reported/unreported research or any suitable combination thereof In case of the students who would work outside the campus, the supervising staff member may visit to the work place at least once during the period and may be eligible for TA-DA as per the college rules.

39

SEMESTER –IV Physical Chemistry Specialization (Group B)

CHPT 4.1: Solid state Chemistry, Catalysis and Statistical Thermodynamics

Unit I-Solid State Chemistry-ITypes of solids: Ionic, covalent, metallic molecular and hydrogen bonded crystals Imperfections and related phenomenon: Defects in solids: point defects line defects, diffusion in solids- mechanism, elastic and plastic deformations.physical properties crystals: Electrical properties, Optical properties: Magnetic properties, Thermal properties and Mechanical properties. Crystal growth techniques: General principles, growth from solution, growth from melts, growth from vapour.

12 hrs

Unit-II -Solid State Chemistry-IIProperties of metals and semiconductors: band theory, intrinsic and extrinsic semiconductors, p-n junctions, optical properties, photoconductivity of crystals.Super conductors: Occurrence of super conductivity, its destruction by magnetic fields, microwave and I.R properties, isotope effect, B.C.S. theory of superconductivity, presistant currents.

12 hrs

Unit-III-CatalysisGeneral acid-base catalysis and specific acid-base catalysis: Bronsted relation and linear free energy changes, Zucker-Hammett hypothesis and Bunnett hypothesis.Fundamentals of adsorption and catalysis: Physical and Chemical adsorption – adsorption isotherms: evaluation, chemisorption on metals and metal oxides. Catalysis: concept of activity, selectivity, poisoning, promotion and deactivation. Types of catalysis: homogeneous, heterogeneous. Heterogeneous catalysis and catalytic kinetics: concept of Langmuir-Hinshelwood. Preparation and Characterization of Catalyst: general methods for preparation of catalysts. Activation of catalysts: calcinations, reduction. Catalyst characterization: surface area, pore size distribution, particle size determination, XPS, AES, UV-Vis, FT-IR and thermal methods. Nanomaterials as catalysts: Physico-chemical considerations of nanomaterials. Size-dependent properties.

12 hrs

Unit-IV- Statistical thermodynamicsStatistical thermodynamics: Molecular energy levels, Boltzmann distribution law, partition functions and ensembles, calculation of translational, rotational and vibrational partition functions, statistical thermodynamics and second law, calculation of different thermodynamic functions such as energy, heat capacity, entropy, free energy, equilibrium constants, application of statistical thermodynamics, principle of equipartition of energy, Maxwell-Boltzmann, Fermi-Dirac and Bose-Einstein statistics. 12 hrs

Total 48 Hrs

40

Text Books

1. Introduction of Solids L.V Azaroff , Tata McGraw Hill 2. Principles of the solid state H. V. Keer, Wiley Eastern (1993) 3. Selected topics in solid state physics Vol. 12, The growth of crystals from liquids – J. C. Brice, North

Holland/American Elsevier (1973) 4. Defects and diffusion in solids. S. Mrowec Elseivier publ.(1960) 5. Treatise on solid state chemistry, ED-N.B. Hannay, Plenum press Vol –2 (1975) 6. W. Adamson, Physical Chemistry of Surfaces , Wiley Intersciences, 1990 (5th edition) 1990. 7. Bond, G C, Heterogeneous Catalysis: Principles and Application. Oxford University Press 1987 8. D.K. Chakrabarty and B. Viswanathan, Hetergogeneous Catalysis, Hardcover - Oct 2008 New Age International

Publishers) 9. B.C. Gates, Catalytic Chemistry, John Wiley and Sons Inc. (1992). 10. G. Cao, Nanostructures and Nanomaterials - Synthesis, Properties and Applications, World-Scientific, 2004. 11. Physical Chemistry, P. W. Atkins, Sixth Edition, Oxford University Press, Oxford (1998) 12. Physical Chemistry, G. M. Barrow, Fifth Edition, Tata McGraw Hill, New Delhi (1994)

CHP (Pr) -4.1: LAB COURSE IN PHYSICAL CHEMISTRY1. Viscosity

Determination of chain linkage in poly(vinyl alcohol) by viscosity measurements.2. Solubility

Variation of solubility of Ca(OH)2 in NaOH solution and hence determination of the solubility product of Ca (OH)2.

3. Thermochemistrya) Heat of neutralisation of HCl and CH3COOH and thier relative strength.b) Heat of reaction (precipitation/formation) of BaSO4.c) Heat of transition of Glauber's salt (Na2SO4.10H2O)

4. Absorptiometrya) Dissociation constant of a weak acidb) Absorptiometric titrations of Fe(II) with KMnO4

5. Electrolytic Conductancea) Conductometric titrations :acid mixtures Vs NaOH

Oxalic acid + hydrochloric acid mixture Vs NaOHb) Conductometric titrations : Sodium acetate (or oxalate Vs NaOH)c) Conductometric titrations : HCl+NH4Cl Vs NaOH

6. EMF of Cells Degree of hydrolysis and Kh of aniline hydrochloride

7. PolarimetryKinetics of inversion of sucrose and determination of catalytic coefficient.

8. Computer applications The students will be taught to learn how to operate a PC and how to run standard programs and packages such as MS-WORD, EXCEL, ORIGIN, SIGMA PLOT, CHEM SKETCH etc. and solve chemistry problems. Problems will be taken preferably from physical chemistry for plotting first and second derivative curves, linear plots etc. Problems from chemical kinetics, polymer chemistry, analytical chemistry, electrochemistry, spectroscopy etc. will be solved.

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Books Recommended

1. Findlay's Practical Physical chemistry, 9th edition, revised by B.P. Levitt.2. Practical Physical Chemistry by A.M.James and F.E.Prichard3. Experiments in Physical Chemistry by Shoemaker and garland4. Experiments in Physical Chemistry by Daniels, Alberty and Williams et.al.5. Laboratory Physical Chemistry by Oelke / M.A.C.T.L.A.C, 1969.6. Experiments in Physical Chemistry by W.G.Palmer7. Advanced Physico-Chemical experiments by J.Rose8. Experimental Physical Chemistry by V.D.Athwale and Paul Mathur , New Age International Publishers, 2001.9. Text Book of Physical Chemistry by S.Glasstone, 1969.10. Text Book of quantitative analysis by A.I.Vogel, 1996.11. Advanced Practical Physical Chemistry by J.B.Yadhav, Goel Publishing House, Meerut, 1999.12. Computers and their applications to Chemistry, Ramesh Kumari, Narosa

Scheme of Examination:

i. Duration of examination : 04 hoursii. Experiment : 35 marks

iii. Viva-Voce & Journal : 05 marksiv. Internal assessment : 10 marks

Total : 50 marks

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CHPT 4.2: Quantum Chemistry and Group Theory

Unit-I Approximate methods

The variational method, treatment of excited states. Applications to quantum chemistry. Time-independent perturbation method: nondegenerate and degenerate cases, Introduction to time-dependent perturbation method. Application 12Hrs

Unit II - Chemical bonding

Molecular orbital and valence bond theories of chemical bonding, comparison of the two applications to hydrogen molecule ion, H2 molecule, improvements in the Hitler-London wave functions, Slater orbital and SCF method for many electron atoms, Bonding an antibonding molecular orbital. Molecular orbital theory applied to homonuclear and heteronuclear diatomic molecules.

12Hrs

Unit III - Polyatomic molecules

Localized and non localized molecule orbital, hybridization and direct valence. Conjugated and aromatic molecules. Simple Huckel molecular orbital theory and M.O. description of normal and cyclic butadiene, ethylene and aromatic molecules (benzene as an example), Calculation of delocalization energies, fractional bond orders, charge density calculation extended Huckel theory.

12Hrs

Unit IV – Symmetry Properties of Molecules and Group Theory

Molecular point GroupsRepresentations of groups: Great orthogonality theorem, Symmetry species and character tables. Properties of characters of representations. (mathematical part) Reducible and irreducible representations. Normal mode analysis: Analysis of reducible representations. Number of normal modes of vibrational symmetry types.Application to IR and Raman spectroscopy: Rule of mutual exclusion, I.R. and Raman active fundamentals.Application to U.V. and Visible spectroscopy: UV-Visible spectra of simple molecules.

12 Hrs

Total 48Hrs

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Text Books

1. Quantum Chemistry, I. N. Levine, Fifth Edition, Prentice Hall, New York(1998) 2. Quantum Chemistry, D. A. McQuarrie, Viva Books, New Delhi (2003) 3. An introduction to quantum chemistry, Suresh Kumar Sharma, Pragati Prakashan, 2014 4. Quantum Mechanics- L.Pauling and E.B. Wilson, McGraw Hill.5. Contemporary Quantum Chemistry-J.Goodisman, Plenum/Rosetta.6. Physical Chemistry -P.W.Atkins, Claredon Press, Oxford 1970.7. Molecular Quantum Mechanics-P.W.Atkins, Claredon Press, Oxford 19708. Introductory Quantum Chemistry- A.K.Chandra Tata McGraw Hill, New Delhi,1994.9. Quantum Chemistry-R. K. Prasad, New Age International Publishers New Delhi, 1997. 10. Molecular Symmetry -D.S.Schonlnd, Van Nostrand Comp.London,196511. Symmetry, Orbitals and Spectra -Jeffe and Orchin, -Jeffe and Orchin, Wiley Inter Science, New York,1971.12. Molecular Structure : A physical Approach-J.C.D.Brand and J.C. Speakman, Edward Arnold Ltd. London13. Group Theory in Chemistry- V. Ramakrishnan and M. S. Gopinathan, Vishal Publishers, Jalandhar,1988.14. Chemical application and group Theory: F.A. Cotton, 3rd edition (1999)15. Symmetry in Chemistry: H. Jaffe’ and M. Orchin (2002)Group theory and its chemical application: P.K. Bhattacharya, 2nd edn. (1989) (Himalaya Publication)

CHP (Pr) -4.2: LAB COURSE IN PHYSICAL CHEMISTRY

1. Surface Tensiona) Comparison of cleansing powers of two detergent samples.b) Comparison of a mixture of two liquids

2. Phase Equilibriaa) Phase diagram of napthalene and diphenyl system.b) Phase diagram of acetamide and salicylic acid or picric acid and benzene.

3. Electrolytic Conductance Conductometric titrations : H2SO4 + CH3COOH + CuSO4 Vs NaOH

4. Reaction Kineticsa) Decomposition of H2O2 catalysed by iodide ions.b) Iodination of acetonec) Study of kinetics of hydrolysis of tertiary buty halided) Saponification of ethylacetate by titration method and conductometric method.

e) Chromic acid oxidation of 2-propanol and determination of i) effect of addition of Mn(II) ii) substituent effects oxidation of benzyl alcohols.

5. EMF of Cellsa) Titration of HCl + CH3COOH with NaOHb) Stability of the complex Ag(NH3)2 (concentration cells)

6. Solubilitya) Variation of solubility of potassium hydrogen tartarate with ionic strength involving a common ion and

determination of mean ionic activity coefficients.b) Influence of ionic strength on the solubility of CaSO4 and determination of its thermodynamic solubility

product and mean ionic activity.

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7. Spectrophotometry:Construct the calibration curves for Fe+-KCNS system and Cu2+ - NH3 system and there by estimate

the amount of respective salt present in the given system8. Computer applications

The students will be taught to operate a PC and how to run standard programs and packages such as MS-WORD, EXCEL, ORIGIN, SIGMA PLOT, CHEM SKETCH etc. and solve chemistry problems. Problems will be taken preferably from physical chemistry for plotting first and second derivative curves, linear plots etc. Problems from chemical kinetics, polymer chemistry, analytical chemistry, electrochemistry, spectroscopy etc. will be solved.

Books Recommended

1. Findlay's Practical Physical Chemistry, 9th edition, revised by B.P. Levitt.2. Practical Physical Chemistry by A. M. James and F. E. Prichard3. Experiments in Physical Chemistry by Shoemaker and Garland4. Experiments in Physical Chemistry by Daniels, Alberty and Williams.5. Laboratory Physical Chemistry by Oelke / M.A.C.T.L.A.C, 1969.6. Experiments in Physical Chemistry by W .G. Palmer7. Advanced Physico-Chemical Experiments by J .Rose8. Experimental Physical Chemistry by V. D. Athwale and Paul Mathur, New Age International Publishers, 2001.9. Text Book of Physical Chemistry by S. Glasstone, McGraw Hill, 1969.10. Text Books of Quantitative Analysis by A. I. Vogel, 1996.11. Advanced Practical Physical Chemistry by J. B. Yadhav, Goel Publishing House, Meerut, 1999.12. Computers and their applications to Chemistry, Ramesh Kumari, Narosa

Scheme of Examination

i. Duration of examination : 04 hoursii. Experiment : 35 marks

iii. Viva-Voce & Journal : 05 marksiv. Internal assessment : 10 marks

Total : 50 marks

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CHPT 4.3: Spectroscopy, Polarography and Cyclic voltametry

Unit I - Nuclear magnetic resonance (NMR) spectroscopyMagnetic properties of nuclei, theoretical principles underlying NMR and experimental set up shielding and deshielding mechanisms and concept of chemical shift. High resolution NMR. spin-spin coupling, coupling constants and elucidation of structure by NMR spectra. Kinetic applications.

12 hrsUnit II - Electron spin resonance spectroscopy: Theoretical principles and instrumentation. ESR spectra of hydrogen and nitrogen atom, semi-quino ion, naphthalene negative ion, methyl radical and methyl substituted radicals, zero filed splitting, Kramers degeneracy. Measurements of distribution of unpaired electrons in radicals. Study of coordination compounds by ESR techniques. 12 hrs

Unit III - Mass spectroscopy, Polarography and cyclic voltametry Mass spectrometry: Instrumentation and theoretical principles, determination of empirical formula, fragmentation patterns and correlation with structure. Appearance potentials and ionization potentials. Polarography and cyclic voltametry: Principles, instrumentations and applications. 12 hrs

Unit IV - Photo electron spectroscopy & Mossbauer spectroscopy:Photo electron spectroscopy: Valence and binding energies shift in energies due to chemical effects and Augar transition. Instrumentation. Applications to free molecules and surfaces. Mossbauer spectroscopy : Principles, instrumentation, resonance line shifts, chemical shifts, quadruple interactions and magnetic interactions. Application of Mossbauer spectroscopy.

12 hrs Total 48 Hrs

Books Recommended

1. Nuclear Magnetic Resonance- E.R.Andrew, Cambridge University Press, Cambridge, 1955.2. Nulcear Magentic Resonance-J.D. Roberts, McGraw Hill Book Co. N.Y. 1959.3. Microwave Spectroscopy-C.H. Townes and A.L. Schawlow, McGraw Hill Book Co. N.Y. 1955.4. Treatise on Physical Chemistry-H.S.Taylor and S. Glasstone, Vol. I and II, D.Van Nostrand, N.Y. 1957.5. Basic Principles of Spectroscopy-Raymand Chang. McGraw Hill, Kogakusha Tokyo, 1971.6. Theoretical Chemistry-S. Glasstone.7. Instrumental Methods of Analysis-Willard, Merit and Dean, Tata McGraw Hill, New Delhi, 1993.8. Introduction to Magnetic resonance-A Carrington and A.D.. Mclachlan, Harper Rao.9. Introduction to Molecular Spectroscopy-G. M. Barrow, McGraw Hill, New York.10. Physical Methods in Inorganic Chemistry - R. S. Drago, East-West Press, New Delhi11. Molecular Spectroscopy - J. D. Graybeal, McGraw Hill.12. Spectroscopy, Vol.I,II and III. Ed.-Walker and Straughan, Chapman Hall, 1976.13. Infrared and Raman Spectra of Polyatomic Molecules - G. Hertzberg, Van Nostrand, New York, 1954.14. Absorption Spectroscopy-R.P.Bauman, Wiley New York,1952.15. Introduction to Photoelectron Spectroscopy - P.K.Ghosh., John Wiley

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16. Photoelectron Spectroscopy - T.H.D. Eland. Butterworth, London, 1974.17. Fundamentals of Molecular spectroscopy-C. N. Banwell, Tata McGraw Hill, New York,2001.18. Magneto chemistry - P.Selwood , Interscience, New York, 1956.19. Techniques in Organic Chemistry, Vol.I. Interscience, 196320. Mass Spectroscopy : Organic Applications-K.Beiman, McGraw Hill.21. Introduction to Mass Spectroscopy and its Applications-R.W. Kiser, Prentice Hall, Englewood-Cliff (NJ) 1965.22. Basic Principle of Spectroscopy - Raymond Chang, McGraw Hill Kogakusha Tokyo,1971.23. Physical Chemistry G.M.Barrow- McGraw Hill, New York, 1991.24. Instrumental Methods of Analysis-Willard, Merritt and Dean, Tata MacGraw Hill, New Delhi, 1993.25. Molecular Interpretation of Mass Spectroscopy- F. W. Mclafferty and W. A. Benzamin.26. Molecular Spectroscopy -I.N.Levin, Interscience.27. Electrochemical Methods: Fundamentals and Applications –A. J. Bard and L. R. Faulkner, Wiley, 2nd Edn, 2002.

CHP (Pr) 4.3: LAB COURSE IN PHYSICAL CHEMISTRY

1. Surface TensionMolecular surface energy and association factor.

2. Phase Equilibriaa) Formula of the complex formed between copper ions and ammonia by distribution method.b) Phase diagram of a three component system: water,benzene and ethanol or acetic acid, water and

chloroform or benzene.3. Thermochemistry

Stepwise heat of neutralization of polybasic acid4. Refractometry

Molar refraction of a solid substance by dissolving it in a solvent.5. Absorptiometry

a) Investigation of complex formation of absorptiometry (e.g. Fe (III) salicylic acid, formula, stability constant, free energy and pH effects Fe (III)- sulfosalicylic acid and Ni-1,10-Phenanthroline).

b) Composition of Cu(II)and Fe(III) solution by photometric titration with EDTAc) Ionization constant of bromphenol blue.

6. Electrolytic conductanceEquivalent conductance of a weak electrolyte (e.g.aceticacid, formic acid)using Kohlrausch's law

7. Reaction Kineticsa) Chromic acid oxidation of 2-propanol and determination of i) order ii) effect of added oxalic acid b)Oxidation of benzyl alcohols by Chromic acid c) Decomposition of oxalic acid in solution photosensitized by uranyl sulphate.

8. EMF of cellsa) Determination of the molecular state and the given calculation of the association/dissociation constant of

the given soluteb) Determination of Hammet constant of ortho-, meta- and para amino/nitro benzoic acid by pH

measurements.9. Computer applications

The students will be taught to operate a PC and how to run standard programs and packages such as MS-WORD, EXCEL, ORIGIN, SIGMA PLOT, CHEM SKETCH etc. and solve chemistry problems. Problems will be taken preferably from physical chemistry for plotting first and second derivative curves, linear plots etc. Problems from chemical kinetics, polymer chemistry, analytical chemistry, electrochemistry, spectroscopy etc. will be solved.

47

Books Recommended

1. Findlay's Practical Physical chemistry, 9th edition, revised by B.P. Levitt.2. Practical Physical Chemistry by A.M.James and F.E.Prichard.3. Experiments in Physical Chemistry by Shoemaker and garland.4. Experiments in Physical Chemistry by Daniels, Alberty and Williams et.al.5. Laboratory Physical Chemistry by Oelke / M.A.C.T.L.A.C, 1969.6. Experiments in Physical Chemistry by W.G.Palmer.7. Advanced Physico-Chemical experiments by J.Rose.8. Experimental Physical Chemistry by V.D.Athwale and Paul Mathur , New Age International Publishers, 2001.9. Text Book of Physical Chemistry by S.Glasstone, McGraw Hill, 1969.10. Text Book of quantitative analysis by A.I.Vogel, 1996.11. Advanced Practical Physical Chemistry by J.B.Yadhav, Goel Publishing House, Meerut, 1999.12. Computers and their applications to Chemistry, Ramesh Kumari, Narosa

Scheme of Examination:

i. Duration of examination : 04 hoursii. Experiment : 35 marks

iii. Viva-Voce & Journal : 05 marksiv. Internal assessment : 10 marks

Total : 50 marks

CHPPJ 4.4: PROJECT WORK(150 marks)

It may include in plant training in Industries/short term work in the Department/other educational Institutions/ R & D organizations/ Data Mining/ Review of current literature/ theoretical methods /computer applications, etc. Experimental work may involve studies on synthesis/characterization /properties/measurements/activities for reported/unreported research or any suitable combination thereof. In case of the students who will work outside the campus, the supervising staff member shall visit the place at least once during the tenure and hence he/she may be eligible for TA/DA as per the University rules.

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