T4T3

I-I-I-IoTGTyrMITDITMIT+DITDIT+DITT3T4TGT3T4MIT DIT TG

CNS T3 T4 T3 T4

1:2 3 4T3

antithyroid drugs MTU PTU

1. ***TSH

2.T4 T3 T33.

1. 131I2. 3.

1. 2. T3T4T3T4TSH

22 * 2

131I992mm 131I

5`-T3

/

- insulin dependent diabetes mellitusIDDM - non-insulin dependent diabetes mellitus NIDDM

insulin B DNA

1.2.3.

4. 5. K+K+

1. I 2.NIDDM 3. 4. 5.

1. 2. 3. 4.

rosiglitazone pioglitazone B

1. 2. HDL-C

3. A 4.B BB

PPARPPAR

tolbutamide,D860 chlorpropamide gluburide glipizide glimepiride gliclazide

1. BATPCa2+

()

()ATPK+GLUT-2Ca2+6-K+K+ATPK+

2. 3. 1. 2.

metformin phenformin

acarbose - repaglinide