Pharmacokinetics disposition (absorption) (distribution) (metabolism) (excretion)
1 2 3 4
pKapH
active transport1 2 3 4
(absorption) (per os) (sublingual) (per rectum)
(first pass elimination)
() (intravenous injection,iv) (intravenous infusion,iv in drop) (intramuscular injection,im) (subcutaneous injection,sc)
5 m 10 m
(distribution) D + P DP 99% 1% 98% 2% +
131
pH pH7.4 pH7.0
biotransformation; drug metabolism : ,
P450cytochrome P450 enzymatic system : + + +
(excretion)
1. 2.pH 3. (
1. 2.pH
. Cmax) (Tpeak) (latent period) (persistent period)
-
F=AUC 100%AUC
F=AUC100 %AUC
.. FAUCTpeakCmax
MTCMEC
. CL LKg-1 h-1
Vd c A A (mg) Vd = C0 (mg L-1)
(half-life time t1/2)
. . . .
..
t1/2=0.693/k
5t1/2
. t1/2=C0/2k0