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ABSTRACTS- ORAL

~ NeointimalHYP~~PlaSi*:~e~,nsightSlntoBasicMechanisms

M aA Towers,PacificC

17’01-1] lntrapericardialNitricOxideDonorReducesN A T fP C O

S B L K M K M K IC aI U S M R Vl nU 1L C C aN C h F

L e nd t a m rb l e r r ei ml i p s p e a pt w m a l i c r dt p r n o f d ia ( s h t i nd

t m w p l n o d s tp r r M R E w e

N d ( N = 1 h d Ng ( m u a c g (

N = d i nw a h n cm f o b i ( r = 1n p c a s ch r b p w o g A ws c a p f a 2 w S sw e m oa I a ( i af l r ( a a ( m at ( w m H g c gT r t N c r n ar both doses, which were significant in the group.

1A(mmz) IAIFL AA (mmz) MAT (mm)

CT 0,48 *0.05 0.47 * 0.02 1.90+ 0,15 0.52 + 0.03LD 0.34+ 0.02 0.30 *0.01 1.48 +0.07 0.41 * 0.01HD o.2e + o.05* 0.27 + 0.03” 1.27+ O.1O* 0.34 * 0.03*

Data are mean + SEM, ” p <0.05 vs control

C oP ed N p sw es ir w t p

b o m t e b i ar

1701-2]f2erotidArteryb@wylndwtionof lndu~ibleNitri~S C N

H in Interferon Regulatory Factor-1Knockout Mice

F L Y R S R S L RP C C U Y

I R F k ( m h bs p l i n o I p ai n o s ( t b s w

p r h u I m t w t (c i i e r n h( w d i l c a ( is er t r ac r ac c o oe G u ai c i c a c ii m i c G b ca c w I U i m if e I p m =t w h p f w b f 7

d H ia i ( m (i n( r u d v i p

s s 4 a r s dr 7 d d h p r s

d s d m h w m= 0 I s r i ev s m m c p at i a T d s t p f ii r w s p p ic r r c i i mh

Platelet Inhibition With Oral Antagonists ToThromboxane, Serotonin, And ADP ReducesNeointimel Proliferation In A HypsrcholesterolemicCanine Coronary Angioplasty Model

H A M L M C L BJ W U T M S T H kH

E s c p p as w s n p ( a c a( a m t h t o ph c r e d m s h( p d s c l

d a c d l 8 m C fp p c w i j p Pr p u t w k a 8 w p mt S d w c ( C = + 6 w d( C = 1 + w t 3 w b 3 wa P w o a t ( s( ( C c vivo pa v a t d b t d

t w e ( + 5 s p c 0 C f( o o 7 c d Q h rthat the intima/madia ratio waa Ieaa in the treated group (0.11 + 0.03 va 0.6+ 0.16, p e 0.01), as was the percent lumen stenosis (6 + 2% vs 36 +8%, p < 0.01). & c o a t ip a p b t p C rn p a P e a s hc c a m w c l

\701-41Combined AlPhavBeta3andplatelet llbflllahlte9rinBlockade Potently Limite Neointimal Hypsrplasiaand Lumen Stenosis in the Porcine Coronary InjuryModel

S.S.S T R D H J R S S MM C R U D M PW

C a m d a i( v i p a ai ( v i p r rs e e 7 c p wc ~ a p a = 2C = n h ( l s fd c a i ( s 1 = I 2 = m 3 = lt N s u o c s i fp m p b 7 d m c

i d 8 m b mi h p a m e c ( as s m c ( m r f 6

h p p C i

Group NI area INJ score A size ALumen size(mm2) (mmz) (mm2) (mm2)

DMP 728 0.85+ 0,13 2.04 k 0,07 2.39 + 0.53 –1.27 + 0.3Control 2.28 + 0.25 1.93 +0.12 2.71 + 0.31 0.25 + 0.19p vslue <0.0001 0.43 0.67 0.0002