Association of the chemokine stromal-derived factor-1 (SDF-1)

genetic polymorphism with transaminitis in HIV-infected Thais

who are on combined anti-retroviral therapy

T. Chiraunyanann1,2

, K. Changsri3, W. Sretapunya

4, K. Yuenyongchaiwai

5, C. Akekawatchai

3

1Bureau of AIDS, TB & STIs, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand,

2Graduate Program in Medical Technology,

3Department of Medical Technology,

Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand, 4Nakhon Nayok Hospital, Nakhon Nayok, Thailand,

5Department of Physical Therapy, Faculty of Allied Health Sciences, Pathumthani, Thailand

Table 1. Characteristics and clinical features of HIV-1 patients

classified according to SDF-1 genotypes.

Table 2. Univariate and multivariate analysis of risks for trans-

aminitis in HIV patients.

PRESENTED AT THE 21ST

INTERNATIONAL AIDS CONFERENCE - DURBAN, SOUTH AFRICA

Characteristic All N (%)

SDF-1 p-value AA vs GA

N (%) GG

N (%) Patients 164 (100) 71 (43.3) 93 (56.7)

Age

≤30 27 (16.5) 15 (9.1) 12 (7.3)

31-40 65 (39.6) 26 (15.9) 39 (23.8)

41-50 42 (25.6) 19 (11.6) 23 (14.0)

>50 30 (18.3) 11 (6.7) 19 (11.6) 0.468

Gender

Male 90 (54.9) 44 (26.8) 46 (28.0)

Female 74 (45.1) 27 (16.5) 47 (28.7) 0.111

CD4+ T cell count (n=141)

151,000) 137 (93.2) 56 (38.1) 81 (55.1)

Grade 1 (75,000 - 150,000) 8 (5.4) 5 (3.4) 3 (2.0)

Grade 2 (50,000 -