Attracting EC Funding
The Human Variome Project
5th Biennial Meeting
19th-23rd May, 2014
Paris
Diana Salmen
Innovative and Personalised Medicine Unit
Health Research Directorate
DG Research & Innovation
Research and Innovation
HORIZON 2020
• The EU’s 2014-20 programme for research & innovation (around € 80 billion)
• A core part of Europe 2020, Innovation Union & European Research Area
• Three priorities: Excellent science, Industrial leadership, Societal challenges
Research and Innovation
Building on the FP7
experience…
Research and Innovation
FP7 'Health' – the largest
multi-national fund…
• …for collaborative research
• …to fund excellence
• …to bring together scientists
• …to tackle global challenges
Research and Innovation
Key figures
6 b€ invested to date
1,000 projects
11,000 teams
3,500 organisations
130 countries
First outcomes (on 329 closed projects = 1/3 of funded projects)
200 patent applications
9,000 publications
3,3 average SJR* publication
30 spin-offs created
* SCImago Journal Ranking
Research and Innovation
International K.O. Mouse Consortium
International Cancer Genomics
Consortium
International cooperation: Working on the big challenges
International Human Microbiome Consortium
Global Research Collaboration for Infectious Disease
Preparedness
International Rare Diseases Research
Consortium
International Initiative for Traumatic Brain
Injury Research
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Global Alliance for Chronic Diseases
International Human Epigenome Consortium
Research and Innovation
International K.O. Mouse Consortium
International Cancer Genomics
Consortium
International cooperation: Working on the big challenges
International Human Microbiome Consortium
Global Research Collaboration for Infectious Disease
Preparedness
International Rare Diseases Research
Consortium
International Initiative for Traumatic Brain
Injury Research
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Global Alliance for Chronic Diseases
International Human Epigenome Consortium
Research and Innovation
www.irdirc.org
200 therapies
and means to
diagnose most rare disease by
2020
Research and Innovation
Basic principles
• Teams up public and private organisations investing in rare diseases research
• Research funders with relevant programmes >$10 million US over a 5-year period can join & work together
• Each organisation funds research its own way
• Funded projects adhere to a common framework
• Agree to share data / standards
Alignment – Flexibility - Commitment
Research and Innovation
Executive Committee Chair: Paul Lasko
Diagnostics
Chair: Kym Boycott
Interdisciplinary
Chair: Hanns Lochmueller
Therapies
Chair: Yann Le Cam
Scientific Committees
Working Groups
EU-funded SUPPORT-IRDiRC provides organisational support for Executive and Scientific Committees and Working Groups
Coordinator: Prof. Ségolène Aymé, INSERM
IRDiRC Governance Structure
Research and Innovation
IRDiRC timeline Exploratory Workshop Reykjavik
Launch Washington
Scientific Committees
Working Groups
IRDiRC 2013
Conference
3000 diagnostics
50 new applications for market
authorisation
Support-IRDiRC
Scientific Secretariat
6000 diagnostics
200 new applications for market
authorisation
2010 2011 2012 2013 2015 2020
Research and Innovation
Europe
E-RARE 2 Consortium (EU)
European Commission
EURORDIS (EU)
Academy of Finland
French Muscular Dystrophy Association
French National Research Agency
French Foundation for Rare Diseases
Children's New Hospitals Management Group (GE)
German Federal Ministry of Education and research
Italian Higher Institute of Health Research
Italian Telethon Foundation
Lysogene (FR)
Netherlands Organisation for Health Research and Development
Prosensa (NL)
Spanish Carlos III Health Institute
UK National Institute for Health Research
Committed members
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Australia
National Health and Medical Research Council
Asia
BGI (CN)
Chinese Rare Disease Consortium
Korea National Institute of Health
North America
Canadian Institutes for Health Research
Genome Canada
FDA Orphan Products Grants Program
Genetic Alliance (US)
Genzyme (US)
Isis Pharmaceuticals (US)
Mendelian Disorders Genome Centres (US NIH)
National Centre for Translational Sciences (US NIH)
National Cancer Institute (US NIH)
National Institute of Neurological Disorders and Stroke (US NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (US
NIH)
National Institute of Child Health and Human Development (US NIH)
National Eye Institute (US NIH)
NKT Therapeutics (US)
NORD (US)
Office of Rare Diseases (US NIH)
PTC Therapeutics (US)
Sanford Research (US)
Shire (US)
Research and Innovation
International K.O. Mouse Consortium
International Cancer Genomics
Consortium
International cooperation: Working on the big challenges
International Human Microbiome Consortium
Global Research Collaboration for Infectious Disease
Preparedness
International Rare Diseases Research
Consortium
International Initiative for Traumatic Brain
Injury Research
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Global Alliance for Chronic Diseases
International Human Epigenome Consortium
Research and Innovation
The International Human Epigenome Consortium (IHEC) is a global consortium with the primary goal of providing free access to high-resolution reference human epigenome maps for normal and disease cell types to the research
community.
EU
Germany
USA
Japan Korea
Canada
http://ihec-epigenomes.org/
Research and Innovation
At a Glance Generate reference maps of human epigenomes for key cellular states
relevant to health and disease. Ambitious goal to complete 1000 epigenomes
Rapid Data Release, Data Coordination, Archiving
Environment Disease Aging
Translation into Improved Human Health
Mechanism Prevention Diagnosis Therapy
Research and Innovation
IHEC Data
Research and Innovation
Horizon 2020
What's new?
Research and Innovation
• Challenge driven
• Broad topics
• Less prescriptive topics
• Two-year work programme
• Stronger focus on the end users
Research and Innovation
• Simplified eligibility criteria
• Simpler rules for grants
• Transparent funding rates
• New SME instrument
• Successful project running quicker
Research and Innovation
• Horizon 2020 is open
• Automatic funding
• Member States
• Associated countries
• Countries in Annex of the WP
• Exceptions
Research and Innovation
Horizon 2020 'Health, demographic
change and wellbeing'
Research and Innovation
• Ageing population
• Increased disease burden
• Unsustainable and unequal healthcare systems
• Healthcare sector under pressure to reform
Research and Innovation
• Translating science to benefit citizens
• Improve health outcomes
• Support a competitive healthcare sector
• Test and demonstrate new healthcare models, approaches and tools
• Promote healthy and active ageing
The Work Programme 2014 - 2015
Call for 'co-ordination activities' 16 topics (11 in 2014, 5 in 2015)
Call 'personalising health and care' 34 topics (15 in 2014, 17 in 2015, 2 open in both years)
+ 8 other actions not subject to calls for proposals
Research & Innovation
EU funding for health research and innovation 2014-2015
Research & Innovation
Understanding
health, ageing &
disease
Improving health
information, data
exploitation and
providing an evidence
base for health policies
and regulation
Integrated,
sustainable,
citizen-centered
care
Innovative
treatments and
technologies
Improving
diagnosis
Implementing personalized medicine in healthcare settings
Effective health
promotion, disease
prevention,
preparedness and
screening
Advancing active
and healthy aging
Research & Innovation
Research & Innovation
Research and Innovation
http://ec.europa.eu/research/participants/portal
Participant Portal– your one-stop shop
Research and Innovation
Thank you
http://ec.europa.eu/research/health
http://ec.europa.eu/programmes/horizon2020